phenylbutazone has been researched along with Aging in 16 studies
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin)." | 7.66 | The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis. ( Graber, J; Gruber, J; Reinthaler, M; Singer, F; Thumb, N, 1982) |
| "By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin)." | 3.66 | The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis. ( Graber, J; Gruber, J; Reinthaler, M; Singer, F; Thumb, N, 1982) |
| " Pharmacokinetic variables were calculated, using 1- and 2-compartment open models." | 1.29 | Pharmacokinetics of phenylbutazone in neonatal foals. ( Crisman, MV; Gerken, DF; Sams, RA; Wilcke, JR, 1993) |
| "Phenylbutazone (PBZ) was administered intravenously as a single dose (10 mg/kg) to adult male and 1-day-, 10-day-, 4-week- and 6 week-old male goats." | 1.29 | The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats. ( Eltom, SE; Guard, CL; Schwark, WS, 1993) |
| " The pharmacokinetic data derived from 1-month-old calves revealed a longer persistence (elimination half-lives twice as long, total body clearance 40-50% lower) of PBZ in the body than in the other two groups of calves aged 3-6 months." | 1.28 | Age-dependent pharmacokinetics of phenylbutazone in calves. ( Kozjek, F; Nouws, JF; Primozic, S; van Ginneken, CA; Volner, Z, 1990) |
| "4 mg/kg bodyweight) of phenylbutazone was administered intravenously and orally to six Welsh mountain ponies to provide data on the pharmacokinetics and bioavailability of the drug." | 1.27 | Pharmacokinetics of phenylbutazone in two age groups of ponies: a preliminary study. ( Lees, P; Maitho, TE; Taylor, JB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LENFELD, J | 1 |
| KUZELL, WC | 1 |
| GLOVER, RP | 1 |
| GIBBS, JO | 1 |
| BLAU, RA | 1 |
| Heimpel, H | 1 |
| Heit, W | 1 |
| Singer, F | 1 |
| Gruber, J | 1 |
| Graber, J | 1 |
| Reinthaler, M | 1 |
| Thumb, N | 1 |
| Miller, ML | 1 |
| Hiramoto, RN | 1 |
| Soong, SJ | 1 |
| Samuelson, CO | 1 |
| Ward, JR | 1 |
| Wilcke, JR | 1 |
| Crisman, MV | 1 |
| Sams, RA | 1 |
| Gerken, DF | 1 |
| Eltom, SE | 1 |
| Guard, CL | 1 |
| Schwark, WS | 1 |
| Seixas, FA | 1 |
| Kaiser, H | 1 |
| Triggs, EJ | 1 |
| Nation, RL | 1 |
| Long, A | 1 |
| Ashley, JJ | 1 |
| Volner, Z | 1 |
| Nouws, JF | 1 |
| Kozjek, F | 1 |
| van Ginneken, CA | 1 |
| Primozic, S | 1 |
| Sallingová, Z | 1 |
| Nicák, A | 1 |
| Morgan, J | 1 |
| Furst, DE | 1 |
| Lees, P | 1 |
| Maitho, TE | 1 |
| Taylor, JB | 1 |
| Petrin, A | 1 |
| O'Malley, K | 1 |
| Stevenson, IH | 1 |
| Crooks, J | 1 |
2 reviews available for phenylbutazone and Aging
| Article | Year |
|---|---|
Drug-induced aplastic anaemia: clinical aspects.
Topics: Adolescent; Adult; Aged; Aging; Anemia, Aplastic; Child; Child, Preschool; Chloramphenicol; Colchici | 1980 |
Implications of drug therapy in the elderly.
Topics: Aged; Aging; Anti-Inflammatory Agents; Antihypertensive Agents; Diuretics; Drug Interactions; Humans | 1986 |
14 other studies available for phenylbutazone and Aging
| Article | Year |
|---|---|
[Effect of rat's age and sex on the course of inflammation and on phenylbutazone sensitivity].
Topics: Aging; Animals; Inflammation; Phenylbutazone; Rats | 1959 |
EFFECT OF SULFINPYRAZONE ON SERUM URIC ACID IN GOUT. A LONG-TERM STUDY.
Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbu | 1964 |
The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis.
Topics: Aging; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Feprazone; Humans; Male; Middle Aged | 1982 |
Acute colchicine and vinblastine toxicity in 6-sulfanilamidoindazole-pretreated rats.
Topics: Aging; Animals; Colchicine; Indazoles; Kidney; Lethal Dose 50; Male; Phenylbutazone; Rats; Rats, Inb | 1981 |
Pharmacokinetics of phenylbutazone in neonatal foals.
Topics: Aging; Animals; Animals, Newborn; Female; Horses; Injections, Intravenous; Male; Metabolic Clearance | 1993 |
The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats.
Topics: Aging; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Goats; Half-Life; Injections, | 1993 |
Drug/alcohol interactions: avert potential dangers.
Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di | 1979 |
[Special problems of anti-rheumatic drug therapy in the aged].
Topics: Aged; Aging; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; | 1978 |
Pharmacokinetics in the elderly.
Topics: Acetaminophen; Adult; Aged; Aging; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Metabol | 1975 |
Age-dependent pharmacokinetics of phenylbutazone in calves.
Topics: Aging; Animals; Animals, Newborn; Cattle; Chromatography, High Pressure Liquid; Female; Half-Life; P | 1990 |
[Pharmacokinetic parameters in old rats as a possible cause of side effects of drugs in old age].
Topics: Aging; Animals; Male; Phenylbutazone; Rats; Rats, Inbred Strains; Sodium Salicylate; Sulfameter; Sul | 1989 |
Pharmacokinetics of phenylbutazone in two age groups of ponies: a preliminary study.
Topics: Administration, Oral; Aging; Animals; Biological Availability; Female; Horses; Injections, Intraveno | 1985 |
[Pharmacokinetics of drugs in the elderly].
Topics: Adult; Age Factors; Aged; Aging; Antipyrine; Digoxin; Dihydrostreptomycin Sulfate; Glomerular Filtra | 1974 |
Drug metabolism in a geriatric population.
Topics: Adult; Aged; Aging; Antipyrine; Half-Life; Humans; Phenylbutazone | 1971 |