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phenylbutazone and Aging

phenylbutazone has been researched along with Aging in 16 studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin)."7.66The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis. ( Graber, J; Gruber, J; Reinthaler, M; Singer, F; Thumb, N, 1982)
"By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin)."3.66The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis. ( Graber, J; Gruber, J; Reinthaler, M; Singer, F; Thumb, N, 1982)
" Pharmacokinetic variables were calculated, using 1- and 2-compartment open models."1.29Pharmacokinetics of phenylbutazone in neonatal foals. ( Crisman, MV; Gerken, DF; Sams, RA; Wilcke, JR, 1993)
"Phenylbutazone (PBZ) was administered intravenously as a single dose (10 mg/kg) to adult male and 1-day-, 10-day-, 4-week- and 6 week-old male goats."1.29The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats. ( Eltom, SE; Guard, CL; Schwark, WS, 1993)
" The pharmacokinetic data derived from 1-month-old calves revealed a longer persistence (elimination half-lives twice as long, total body clearance 40-50% lower) of PBZ in the body than in the other two groups of calves aged 3-6 months."1.28Age-dependent pharmacokinetics of phenylbutazone in calves. ( Kozjek, F; Nouws, JF; Primozic, S; van Ginneken, CA; Volner, Z, 1990)
"4 mg/kg bodyweight) of phenylbutazone was administered intravenously and orally to six Welsh mountain ponies to provide data on the pharmacokinetics and bioavailability of the drug."1.27Pharmacokinetics of phenylbutazone in two age groups of ponies: a preliminary study. ( Lees, P; Maitho, TE; Taylor, JB, 1985)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199013 (81.25)18.7374
1990's3 (18.75)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LENFELD, J1
KUZELL, WC1
GLOVER, RP1
GIBBS, JO1
BLAU, RA1
Heimpel, H1
Heit, W1
Singer, F1
Gruber, J1
Graber, J1
Reinthaler, M1
Thumb, N1
Miller, ML1
Hiramoto, RN1
Soong, SJ1
Samuelson, CO1
Ward, JR1
Wilcke, JR1
Crisman, MV1
Sams, RA1
Gerken, DF1
Eltom, SE1
Guard, CL1
Schwark, WS1
Seixas, FA1
Kaiser, H1
Triggs, EJ1
Nation, RL1
Long, A1
Ashley, JJ1
Volner, Z1
Nouws, JF1
Kozjek, F1
van Ginneken, CA1
Primozic, S1
Sallingová, Z1
Nicák, A1
Morgan, J1
Furst, DE1
Lees, P1
Maitho, TE1
Taylor, JB1
Petrin, A1
O'Malley, K1
Stevenson, IH1
Crooks, J1

Reviews

2 reviews available for phenylbutazone and Aging

ArticleYear
Drug-induced aplastic anaemia: clinical aspects.
    Clinics in haematology, 1980, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Anemia, Aplastic; Child; Child, Preschool; Chloramphenicol; Colchici

1980
Implications of drug therapy in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Aged; Aging; Anti-Inflammatory Agents; Antihypertensive Agents; Diuretics; Drug Interactions; Humans

1986

Other Studies

14 other studies available for phenylbutazone and Aging

ArticleYear
[Effect of rat's age and sex on the course of inflammation and on phenylbutazone sensitivity].
    Ceskoslovenska fysiologie, 1959, Volume: 8, Issue:2

    Topics: Aging; Animals; Inflammation; Phenylbutazone; Rats

1959
EFFECT OF SULFINPYRAZONE ON SERUM URIC ACID IN GOUT. A LONG-TERM STUDY.
    Geriatrics, 1964, Volume: 19

    Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbu

1964
The use of thermography in the evaluation of the anti-inflammatory activity of feprazone on rheumatoid arthritis.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:4

    Topics: Aging; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Feprazone; Humans; Male; Middle Aged

1982
Acute colchicine and vinblastine toxicity in 6-sulfanilamidoindazole-pretreated rats.
    Toxicology and applied pharmacology, 1981, Sep-30, Volume: 60, Issue:3

    Topics: Aging; Animals; Colchicine; Indazoles; Kidney; Lethal Dose 50; Male; Phenylbutazone; Rats; Rats, Inb

1981
Pharmacokinetics of phenylbutazone in neonatal foals.
    American journal of veterinary research, 1993, Volume: 54, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Female; Horses; Injections, Intravenous; Male; Metabolic Clearance

1993
The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats.
    Journal of veterinary pharmacology and therapeutics, 1993, Volume: 16, Issue:2

    Topics: Aging; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Goats; Half-Life; Injections,

1993
Drug/alcohol interactions: avert potential dangers.
    Geriatrics, 1979, Volume: 34, Issue:10

    Topics: Aged; Aging; Alcohol Drinking; Alcoholism; Antidepressive Agents, Tricyclic; Aspirin; California; Di

1979
[Special problems of anti-rheumatic drug therapy in the aged].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1978, Volume: 5

    Topics: Aged; Aging; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Indomethacin;

1978
Pharmacokinetics in the elderly.
    European journal of clinical pharmacology, 1975, Volume: 8, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aging; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Metabol

1975
Age-dependent pharmacokinetics of phenylbutazone in calves.
    The veterinary quarterly, 1990, Volume: 12, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cattle; Chromatography, High Pressure Liquid; Female; Half-Life; P

1990
[Pharmacokinetic parameters in old rats as a possible cause of side effects of drugs in old age].
    Ceskoslovenska fysiologie, 1989, Volume: 38, Issue:3

    Topics: Aging; Animals; Male; Phenylbutazone; Rats; Rats, Inbred Strains; Sodium Salicylate; Sulfameter; Sul

1989
Pharmacokinetics of phenylbutazone in two age groups of ponies: a preliminary study.
    The Veterinary record, 1985, Mar-02, Volume: 116, Issue:9

    Topics: Administration, Oral; Aging; Animals; Biological Availability; Female; Horses; Injections, Intraveno

1985
[Pharmacokinetics of drugs in the elderly].
    International journal of clinical pharmacology, therapy and toxicology, 1974, Volume: 9, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Antipyrine; Digoxin; Dihydrostreptomycin Sulfate; Glomerular Filtra

1974
Drug metabolism in a geriatric population.
    Clinical science, 1971, Volume: 41, Issue:2

    Topics: Adult; Aged; Aging; Antipyrine; Half-Life; Humans; Phenylbutazone

1971