Compounds > phenylbutazone
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phenylbutazone and Acute Liver Injury, Drug-Induced

phenylbutazone has been researched along with Acute Liver Injury, Drug-Induced in 58 studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Research Excerpts

ExcerptRelevanceReference
"A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy."7.65Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977)
"A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy."3.65Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977)
" About 50% of patients given salicylate in full anti-inflammatory dosage develop minor abnormalities of liver function."2.37Liver damage with non-narcotic analgesics. ( Prescott, LF, 1986)
"10 Phenylbutazone may cause liver injury and other analgesics can cause hypersensitivity reactions in which the liver is involved."2.36Hepatotoxicity of mild analgesics. ( Prescott, LF, 1980)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Phenylbutazone is a potent nonsteroidal, anti-inflammatory drug often used by veterinarians to treat racetrack animals."1.28Poisoning with equine phenylbutazone in a racetrack worker. ( Newton, TA; Rose, SR, 1991)
"Those with toxic epidermal necrolysis had 100% mortality."1.27Drug eruptions from phenylbutazone in Jamu. ( Giam, YC; Lim, A; Tan, T; Tham, SN, 1986)
" This is caused by several non steroidal antirheumatic drugs, especially upon longer administration, or in higher dosage or both, may be acting as potential hepatotoxic."1.25[Non-steroidal antirheumatic therapy and the liver]. ( Frank, O, 1975)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199051 (87.93)18.7374
1990's2 (3.45)18.2507
2000's0 (0.00)29.6817
2010's5 (8.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
ANTREASIAN, B1
ROTH, MI1
TAVEL, ME1
TERZANI, A1
BIRO, F1
KASA, L1
BIRO, G1
NAD, A1
KOWALEWSKI, S1
ROTTHAUWE, HW1
HAUKE, H1
HARVEY, P1
FIOCCA, S1
NAVASSA, G1
ECKER, JA1
BHATIA, A1
CHANDRA, SV1
SINGH, GB1
Valerdiz Casasola, S1
Linares Rodríguez, A1
Recarte Alvarez, J1
Rodrigo Sáez, L1
Prescott, LF3
Wright, R1
Critchley, JA1
Balali-Mood, M1
Manoukian, AV1
Carson, JL1
Gopinath, C1
Ford, JH1
Tolot, F2
Prost, G2
Guignot, B2
Pelletier, M2
Mayer, TR1
Krtek, V1
Chlumský, J1
Ishak, KG1
Kirchner, JP1
Dhar, JK1
Leber, HW1
Knauff, S1
Filipová, J1
Filip, J1
Fowler, PD1
Woolf, D1
Alexander, S1
Anker, N1
Skovbjerg, H1
Frank, O1
Newton, TA1
Rose, SR1
Ostapchuk, NA1
Schlegel, SI1
Paulus, HE1
Giam, YC1
Tham, SN1
Tan, T1
Lim, A1
Altmann, HW1
Ivlev, AS1
Polunina, TE1
Heidelmann, G1
Porst, H2
Liebscher, K1
Kunze, KD1
Tschöpel, L1
O'Brien, WM1
Bagby, GF1
Wouters, JM1
van Rijswijk, MH1
van de Putte, LB1
Visintini, E1
Sun, DC1
Cuthbert, MF1
Saratikov, AS1
Gibelgaus, LG1
Pritchep, TR1
Korolenko, TA1
Kondakova, EA1
Berthelot, P1
Fossati, C1
Navràtil, M1
Pàtkovà, V1
Spickovà, V1
Cernỳ, M1
Dhatt, PS1
Singh, H1
Gupta, HL1
Arya, RK1
Bode, C1
Martini, GA1
Pidémskiĭ, EL1
Cherednichenko, RP1
Chukichev, EM1
Coltorti, M1
Cuccurullo, L1
Del Vecchio-Blanco, C1
Scuro, LA1
Naccarato, R1
Fagiolo, V1
Previato, G1
Rizzo, A1
Catterall, RD1
Read, AE1
Grottum, KA1
Muscat-Baron, JM1
Freeman, DM1

Reviews

12 reviews available for phenylbutazone and Acute Liver Injury, Drug-Induced

ArticleYear
[Hepatitis caused by drugs. 5].
    Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 62, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Deoxyepinephrine; Erythromycin; Gold; Humans

1982
Hepatotoxicity of mild analgesics.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 2

    Topics: Acetaminophen; Adult; Analgesics; Aspirin; Chemical and Drug Induced Liver Injury; Child; Humans; Ph

1980
Drug-induced chronic hepatitis.
    Springer seminars in immunopathology, 1980, Volume: 3, Issue:3

    Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Female; Granuloma

1980
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
    Drug safety, 1996, Volume: 15, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injur

1996
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
    Semaine des hopitaux. Therapeutique, 1976, Volume: 52, Issue:3

    Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera

1976
Non-steroidal and analgesic therapy in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen

1986
Liver damage with non-narcotic analgesics.
    Medical toxicology, 1986, Volume: 1 Suppl 1

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver

1986
Rare adverse reactions to nonsteroidal antiinflammatory drugs (3).
    The Journal of rheumatology, 1985, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury;

1985
Mechanisms and prediction of drug-induced liver disease.
    Gut, 1973, Volume: 14, Issue:4

    Topics: Adenosine Triphosphate; Age Factors; Animals; Bilirubin; Biotransformation; Carbon Isotopes; Carbon

1973
[Liver damage due to drugs. I].
    La Clinica terapeutica, 1974, Jan-15, Volume: 68, Issue:1

    Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Re

1974
More about isonicotinic acid hydrazide toxicity.
    Food and cosmetics toxicology, 1970, Volume: 8, Issue:5

    Topics: Adenocarcinoma; Adenofibroma; Adenoma; Animals; Carcinoma; Chemical and Drug Induced Liver Injury; C

1970
[Toxic liver injury].
    Medizinische Klinik, 1970, Jan-02, Volume: 65, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Contraceptives, Oral; Dia

1970

Other Studies

46 other studies available for phenylbutazone and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Toxic hepatitis following the use of phenylbutazone (butazolidan) report of a fatal case.
    The Journal of the Indiana State Medical Association, 1958, Volume: 51, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Humans; Phenylbutazone; Viral Vaccin

1958
[DAMAGE FROM THERAPY].
    La Clinica terapeutica, 1963, Oct-15, Volume: 27

    Topics: Adrenal Cortex Hormones; Anemia; Anemia, Aplastic; Anticoagulants; Antipyrine; Blood Group Incompati

1963
[ON THE EFFECT OF BUTAZOLIDIN ON THE LIVER PARENCHYMA].
    Arkhiv patologii, 1963, Volume: 25

    Topics: Chemical and Drug Induced Liver Injury; Hepatitis; Histological Techniques; Liver Function Tests; Ph

1963
[3 CASES OF POISONING IN CHILDHOOD WITH IRGAPYRIN, BUTAZOLIDIN AND TOMANOL].
    Annales paediatrici. International review of pediatrics, 1964, Volume: 202

    Topics: Adolescent; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induc

1964
DRUG REACTIONS INVOLVING THE ALIMENTARY TRACT.
    The Medical journal of Australia, 1964, Feb-15, Volume: 1

    Topics: Anticoagulants; Bismuth; Chemical and Drug Induced Liver Injury; Chlorothiazide; Drug Therapy; Esoph

1964
[CLINICAL AND HISTOPATHOLOGICAL ASPECTS OF INTRAHEPATIC CHOLESTASIS].
    Minerva medica, 1964, Jul-28, Volume: 55

    Topics: Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes M

1964
PHENYLBUTAZONE HEPATITIS.
    The American journal of gastroenterology, 1965, Volume: 43

    Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis; Hepatitis A; Liver; Path

1965
CORRELATION OF HEPATIC INJURY & PEPTIC ULCERATION INDUCED BY PHENYLBUTAZONE IN DOGS.
    Indian journal of experimental biology, 1965, Volume: 3

    Topics: Chemical and Drug Induced Liver Injury; Dogs; Hepatitis; Peptic Ulcer; Phenylbutazone; Research; Tox

1965
Phenylbutazone overdosage: abnormal metabolism associated with hepatic and renal damage.
    British medical journal, 1980, Oct-25, Volume: 281, Issue:6248

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Female; Half-Life; Humans; Kidney Diseases; Oxyp

1980
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
    British journal of experimental pathology, 1975, Volume: 56, Issue:5

    Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT;

1975
[Multiple manifestations of intolerance of a combination of anti-inflammatory drugs. Role of phenylbutazone].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975, Dec-09, Volume: 51, Issue:48

    Topics: Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury; Duodenal Ulcer; Erythema;

1975
Phenylbutazone-induced hepatitis.
    Minnesota medicine, 1979, Volume: 62, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged; Phenylbutazone

1979
[Hepatic cholestasis due to benetazone].
    Vnitrni lekarstvi, 1979, Volume: 25, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Hip Joint; Humans; Joint Diseases

1979
Clinicopathological Conference. Diagnostic difficulties in a case of polypharmacy. Demonstrated at the Royal College of Physicians of London.
    British medical journal, 1977, Jan-22, Volume: 1, Issue:6055

    Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Vir

1977
Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Cholestasis; Diazepam; Granuloma; Hu

1977
Influence of silymarin on drug metabolizing enzymes in rat and man.
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:8

    Topics: Adult; Aminopyrine; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury;

1976
[Acute toxic liver lesion through industrial noxious substances and drugs in higher than therapeutic doses].
    Vnitrni lekarstvi, 1975, Volume: 21, Issue:1

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Child, Preschool; Czechoslovakia; Humans; Inf

1975
Phenylbutazone and hepatitis.
    Rheumatology and rehabilitation, 1975, Volume: 14, Issue:2

    Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Fu

1975
[Granulomatous liver disease induced by phenylbutazone].
    Ugeskrift for laeger, 1975, Dec-15, Volume: 137, Issue:51

    Topics: Chemical and Drug Induced Liver Injury; Female; Granuloma; Humans; Middle Aged; Phenylbutazone

1975
[Non-steroidal antirheumatic therapy and the liver].
    Acta medica Austriaca, 1975, Volume: 2, Issue:4

    Topics: Alkaline Phosphatase; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver;

1975
Poisoning with equine phenylbutazone in a racetrack worker.
    Annals of emergency medicine, 1991, Volume: 20, Issue:2

    Topics: Acute Kidney Injury; Adult; Animals; Chemical and Drug Induced Liver Injury; Coma; Dogs; Drug Overdo

1991
[Activity of lysosomal enzymes in drug-induced lesions of the liver].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 108, Issue:10

    Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cathepsins; Chemical and Drug Induced Liver Injury;

1989
Drug eruptions from phenylbutazone in Jamu.
    Annals of the Academy of Medicine, Singapore, 1986, Volume: 15, Issue:1

    Topics: Adult; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Drug Eruptions; Female; Huma

1986
Morphological changes in the liver due to phenazone and its derivatives.
    Agents and actions. Supplements, 1986, Volume: 19

    Topics: Antipyrine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatty Liver; Granulom

1986
[Drug-induced lesion of the liver].
    Voenno-meditsinskii zhurnal, 1987, Issue:6

    Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury;

1987
[Ketazone hepatosis--a possibility for the development of secondary hypouricemia].
    Zeitschrift fur arztliche Fortbildung, 1986, Volume: 80, Issue:1

    Topics: Adult; Arthritis; Chemical and Drug Induced Liver Injury; Gout; Humans; Liver Function Tests; Male;

1986
[Morphology and pathogenesis of liver injury produced by dihydralazine , propranolol and ketophenylbutazone].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Immunity, Cellular; Live

1985
Adult onset Still's disease in the elderly: a report of two cases.
    The Journal of rheumatology, 1985, Volume: 12, Issue:4

    Topics: Aged; Arthritis; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Diagnosis, Differentia

1985
[Iatrogenic damage in therapy with phenylbutazone].
    Minerva medica, 1971, Feb-24, Volume: 62, Issue:16

    Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Drug Eruptions; Endocrine System Di

1971
Iatrogenic gastrointestinal diseases in the aged.
    Geriatrics, 1972, Volume: 27, Issue:9

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Cathartics; Chemical and Drug Induced Li

1972
Adverse reactions to non-steroidal antirheumatic drugs.
    Current medical research and opinion, 1974, Volume: 2, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Chemical and Drug Induced Liv

1974
Effect of some pyrazolone derivatives on lysosomes of rat liver.
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:10

    Topics: Acid Phosphatase; Aminobenzoates; Analgesics; Animals; Antipyrine; Carbon Tetrachloride Poisoning; C

1974
[Liver disorders in children in phenylbutazone poisoning].
    Ceskoslovenska gastroenterologie a vyziva, 1973, Volume: 27, Issue:8

    Topics: Age Factors; Chemical and Drug Induced Liver Injury; Child, Preschool; Humans; Infant; Phenylbutazon

1973
Fatal hepatitis due to phenylbutazone in a child.
    Indian journal of pediatrics, 1973, Volume: 40, Issue:307

    Topics: Adolescent; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Humans; Male; Phenylbutazon

1973
[The effect of various anti-inflammatory preparations on phagocytosis in experimental hepatitis].
    Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1969, Volume: 46, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver I

1969
[Clinical and morphological findings on 2 cases of icterus induced by butazolidines].
    Il Policlinico. Sezione pratica, 1970, Volume: 77, Issue:10

    Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver; Male; M

1970
[Hepatocellular jaundice due to acute phenylbutazone poisoning. (Clinical observations and morphologic findings using the optic and electron microscopes].
    Il Policlinico. Sezione pratica, 1967, Apr-17, Volume: 74, Issue:16

    Topics: Adolescent; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Liver; Microsc

1967
Fatal reaction to phenylbutazone in a patient with Reiter's disease.
    The British journal of venereal diseases, 1968, Volume: 44, Issue:2

    Topics: Adult; Arthritis, Reactive; Chemical and Drug Induced Liver Injury; Humans; Jaundice; Liver; Male; N

1968
Drugs and liver disease.
    Bristol medico-chirurgical journal (1963), 1969, Volume: 84, Issue:312

    Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug

1969
[Liver damage due to phenylbutazone and chlorpropamide].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1966, Aug-15, Volume: 86, Issue:16

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Female; Humans; Liver Function Tests;

1966
Toxic hepatitis following phenylbutazone therapy.
    The British journal of clinical practice, 1966, Volume: 20, Issue:8

    Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Phenylbutazone

1966