phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide has been researched along with Morphine Dependence in 5 studies
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 5.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| "treatment with naltrindole elicited increases in Glu and Asp that were similar, although less marked, than those precipitated by CTOP treatment." | 5.29 | Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence. ( Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H, 1996) |
| "Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity." | 1.29 | Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996) |
| "treatment with naltrindole elicited increases in Glu and Asp that were similar, although less marked, than those precipitated by CTOP treatment." | 1.29 | Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence. ( Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banach, T | 1 |
| Zurowski, D | 1 |
| Gil, K | 1 |
| Weisbrodt, NW | 1 |
| Rosenfeld, G | 1 |
| Thor, PJ | 1 |
| Bilsky, EJ | 1 |
| Bernstein, RN | 1 |
| Wang, Z | 1 |
| Sadée, W | 1 |
| Porreca, F | 1 |
| Feng, YZ | 1 |
| Zhang, T | 1 |
| Tokuyama, S | 1 |
| Zhu, H | 1 |
| Rockhold, RW | 1 |
| Ho, IK | 1 |
| Baumeister, AA | 1 |
| Richard, AL | 1 |
| Richmond-Landeche, L | 1 |
| Hurry, MJ | 1 |
| Waguespack, AM | 1 |
| Gulya, K | 1 |
| Kriván, M | 1 |
| Nyolczas, N | 1 |
| Sarnyai, Z | 1 |
| Kovács, GL | 1 |
5 other studies available for phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Morphine Dependence
| Article | Year |
|---|---|
Peripheral mechanisms of intestinal dysmotility in the morphine tolerant and dependent rats.
Topics: Animals; Colon; Drug Tolerance; Duodenum; Gastrointestinal Motility; Male; Morphine; Morphine Depend | 2006 |
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Dru | 1996 |
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; M | 1996 |
Further studies of the role of opioid receptors in the nigra in the morphine withdrawal syndrome.
Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response R | 1992 |
Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
Topics: Animals; Body Temperature; Body Weight; Brain; Drug Tolerance; Injections, Intraventricular; Male; M | 1988 |