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phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Morphine Dependence

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide has been researched along with Morphine Dependence in 5 studies

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors

Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.

Research Excerpts

ExcerptRelevanceReference
"Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity."5.29Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996)
"treatment with naltrindole elicited increases in Glu and Asp that were similar, although less marked, than those precipitated by CTOP treatment."5.29Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence. ( Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H, 1996)
"Naloxone was proposed to act as a negative antagonist (inverse agonist) blocking mu* activity, whereas D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) appeared to act as a neutral antagonist having no effect on mu* activity."1.29Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice. ( Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z, 1996)
"treatment with naltrindole elicited increases in Glu and Asp that were similar, although less marked, than those precipitated by CTOP treatment."1.29Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence. ( Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H, 1996)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Banach, T1
Zurowski, D1
Gil, K1
Weisbrodt, NW1
Rosenfeld, G1
Thor, PJ1
Bilsky, EJ1
Bernstein, RN1
Wang, Z1
Sadée, W1
Porreca, F1
Feng, YZ1
Zhang, T1
Tokuyama, S1
Zhu, H1
Rockhold, RW1
Ho, IK1
Baumeister, AA1
Richard, AL1
Richmond-Landeche, L1
Hurry, MJ1
Waguespack, AM1
Gulya, K1
Kriván, M1
Nyolczas, N1
Sarnyai, Z1
Kovács, GL1

Other Studies

5 other studies available for phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Morphine Dependence

ArticleYear
Peripheral mechanisms of intestinal dysmotility in the morphine tolerant and dependent rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57, Issue:1

    Topics: Animals; Colon; Drug Tolerance; Duodenum; Gastrointestinal Motility; Male; Morphine; Morphine Depend

2006
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Dru

1996
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
    Neurochemical research, 1996, Volume: 21, Issue:1

    Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; M

1996
Further studies of the role of opioid receptors in the nigra in the morphine withdrawal syndrome.
    Neuropharmacology, 1992, Volume: 31, Issue:9

    Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response R

1992
Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
    European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3

    Topics: Animals; Body Temperature; Body Weight; Brain; Drug Tolerance; Injections, Intraventricular; Male; M

1988