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phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Disease Models, Animal

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide has been researched along with Disease Models, Animal in 17 studies

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model."7.77The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011)
" Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model."3.77The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011)
"Mice with the DYT1 dystonia mutation exhibit an enhanced response to mu receptor activation, dependent on selective receptor gene upregulation."1.48Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia. ( Bonsi, P; Mercuri, NB; Meringolo, M; Pisani, A; Ponterio, G; Santoro, M; Sciamanna, G; Tassone, A; Vanni, V, 2018)
" They may open new perspectives for the development of opiorphin analogues with greater bioavailability and physicochemical characteristics in the pursuit of new medications for the treatment of panic disorder."1.43Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray. ( Audi, EA; Bonfim, AJ; Graeff, FG; Kitayama, M; Maraschin, JC; Rangel, MP; Zangrossi, H, 2016)
"This quinpirole effect was completely abolished by MOR antagonist CTOP at subclinical concentration (1 μmol/L) in nerve-injured rats, but was unaltered in sham-operated rats."1.40Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury. ( Aira, Z; Azkue, JJ; Barrenetxea, T; Buesa, I; Gómez-Esteban, JC, 2014)
"Pain was induced by formalin injection into the hindpaw."1.37Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats. ( Choi, JI; Kim, CM; Kim, KS; Kim, WM; Kim, YO; Lee, HG; Yoon, MH, 2011)
" Subclinical MOR activation (10 nM DAMGO) produced a leftward shift in (D-Ala2)-Deltorphin II dose-response curve in non-ligated rats (IC50 16."1.35Depression of C fibre-evoked spinal field potentials by the spinal delta opioid receptor is enhanced in the spinal nerve ligation model of neuropathic pain: involvement of the mu-subtype. ( Aguilera, L; Aira, Z; Azkue, JJ; Bilbao, J; Buesa, I; Mozas, M; Salgueiro, M; Urrutia, A; Zimmermann, M, 2008)
"To determine whether 1DMe could correct hyperalgesia and restore morphine efficacy in mononeuropathic (MN) and diabetic (D) rats we examined the spinal effect of 1DMe in MN and D rats without and after spinal blockade of mu- and delta-opioid receptors with CTOP and naltrindole, respectively."1.30Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats. ( Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM, 1999)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's5 (29.41)29.6817
2010's11 (64.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ponterio, G1
Tassone, A1
Sciamanna, G1
Vanni, V1
Meringolo, M1
Santoro, M1
Mercuri, NB1
Bonsi, P1
Pisani, A1
Aira, Z2
Barrenetxea, T1
Buesa, I2
Gómez-Esteban, JC1
Azkue, JJ2
Maraschin, JC1
Rangel, MP1
Bonfim, AJ1
Kitayama, M1
Graeff, FG1
Zangrossi, H1
Audi, EA1
Urrutia, A1
Salgueiro, M1
Bilbao, J1
Mozas, M1
Aguilera, L1
Zimmermann, M1
Bianchi, E1
Norcini, M1
Smrcka, A1
Ghelardini, C2
Galeotti, N1
Vivoli, E1
Bilia, AR1
Bergonzi, MC1
Bartolini, A1
Pozza, DH1
Potes, CS1
Barroso, PA1
Azevedo, L1
Castro-Lopes, JM1
Neto, FL1
Gross, GJ1
Baker, JE1
Hsu, A1
Wu, HE1
Falck, JR1
Nithipatikom, K1
Yoon, MH1
Kim, KS1
Lee, HG1
Kim, CM1
Kim, WM1
Choi, JI1
Kim, YO1
Zhang, Y2
Meng, X2
Li, A2
Xin, J2
Berman, BM2
Lao, L2
Tan, M2
Ren, K2
Zhang, RX2
Heinl, C1
Drdla-Schutting, R1
Xanthos, DN1
Sandkühler, J1
Szentirmay, AK1
Király, KP1
Lenkey, N1
Lackó, E1
Al-Khrasani, M1
Friedmann, T1
Timár, J1
Gyarmati, S1
Tóth, G1
Fürst, S1
Riba, P1
Narita, M1
Kaneko, C1
Miyoshi, K1
Nagumo, Y1
Kuzumaki, N1
Nakajima, M1
Nanjo, K1
Matsuzawa, K1
Yamazaki, M1
Suzuki, T1
Back, SK1
Lee, J1
Hong, SK1
Na, HS1
Nakayama, D1
Watanabe, C1
Watanabe, H1
Mizoguchi, H1
Sakurada, T1
Sakurada, S1
Courteix, C1
Coudoré-Civiale, MA1
Privat, AM1
Zajac, JM1
Eschalier, A1
Fialip, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients[NCT05855577]Phase 450 participants (Anticipated)Interventional2023-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

17 other studies available for phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Disease Models, Animal

ArticleYear
Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
    Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:2

    Topics: Acetylcholine; Action Potentials; Adenosine Triphosphate; Analgesics, Opioid; Animals; Calcium; Chol

2018
Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury.
    Pain, 2014, Volume: 155, Issue:12

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Dopamine Agonist

2014
Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray.
    Neuropharmacology, 2016, Volume: 101

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini

2016
Depression of C fibre-evoked spinal field potentials by the spinal delta opioid receptor is enhanced in the spinal nerve ligation model of neuropathic pain: involvement of the mu-subtype.
    Neuropharmacology, 2008, Volume: 55, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2008
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
    Journal of neurochemistry, 2009, Volume: 111, Issue:1

    Topics: Animals; Cyclohexanes; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Explor

2009
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
    The journal of pain, 2010, Volume: 11, Issue:2

    Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liq

2010
Nociceptive behaviour upon modulation of mu-opioid receptors in the ventrobasal complex of the thalamus of rats.
    Pain, 2010, Volume: 148, Issue:3

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Ankle; Behavior, Animal; Disease Models, Animal;

2010
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protei

2010
Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats.
    The journal of pain, 2011, Volume: 12, Issue:7

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship,

2011
Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Affect; Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Electroacupunc

2011
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
    Brain research, 2011, Sep-26, Volume: 1414

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacu

2011
Distinct mechanisms underlying pronociceptive effects of opioids.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela

2011
Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice.
    Brain research bulletin, 2013, Volume: 90

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ

2013
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4

    Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides;

2006
Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Axotomy; Disease Models, Animal; Hyperalgesia; Injections, Intraperito

2006
A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkeph

2007
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimenta

1999