phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide has been researched along with Disease Models, Animal in 17 studies
phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model." | 7.77 | The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011) |
| " Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model." | 3.77 | The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011) |
| "Mice with the DYT1 dystonia mutation exhibit an enhanced response to mu receptor activation, dependent on selective receptor gene upregulation." | 1.48 | Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia. ( Bonsi, P; Mercuri, NB; Meringolo, M; Pisani, A; Ponterio, G; Santoro, M; Sciamanna, G; Tassone, A; Vanni, V, 2018) |
| " They may open new perspectives for the development of opiorphin analogues with greater bioavailability and physicochemical characteristics in the pursuit of new medications for the treatment of panic disorder." | 1.43 | Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray. ( Audi, EA; Bonfim, AJ; Graeff, FG; Kitayama, M; Maraschin, JC; Rangel, MP; Zangrossi, H, 2016) |
| "This quinpirole effect was completely abolished by MOR antagonist CTOP at subclinical concentration (1 μmol/L) in nerve-injured rats, but was unaltered in sham-operated rats." | 1.40 | Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury. ( Aira, Z; Azkue, JJ; Barrenetxea, T; Buesa, I; Gómez-Esteban, JC, 2014) |
| "Pain was induced by formalin injection into the hindpaw." | 1.37 | Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats. ( Choi, JI; Kim, CM; Kim, KS; Kim, WM; Kim, YO; Lee, HG; Yoon, MH, 2011) |
| " Subclinical MOR activation (10 nM DAMGO) produced a leftward shift in (D-Ala2)-Deltorphin II dose-response curve in non-ligated rats (IC50 16." | 1.35 | Depression of C fibre-evoked spinal field potentials by the spinal delta opioid receptor is enhanced in the spinal nerve ligation model of neuropathic pain: involvement of the mu-subtype. ( Aguilera, L; Aira, Z; Azkue, JJ; Bilbao, J; Buesa, I; Mozas, M; Salgueiro, M; Urrutia, A; Zimmermann, M, 2008) |
| "To determine whether 1DMe could correct hyperalgesia and restore morphine efficacy in mononeuropathic (MN) and diabetic (D) rats we examined the spinal effect of 1DMe in MN and D rats without and after spinal blockade of mu- and delta-opioid receptors with CTOP and naltrindole, respectively." | 1.30 | Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats. ( Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ponterio, G | 1 |
| Tassone, A | 1 |
| Sciamanna, G | 1 |
| Vanni, V | 1 |
| Meringolo, M | 1 |
| Santoro, M | 1 |
| Mercuri, NB | 1 |
| Bonsi, P | 1 |
| Pisani, A | 1 |
| Aira, Z | 2 |
| Barrenetxea, T | 1 |
| Buesa, I | 2 |
| Gómez-Esteban, JC | 1 |
| Azkue, JJ | 2 |
| Maraschin, JC | 1 |
| Rangel, MP | 1 |
| Bonfim, AJ | 1 |
| Kitayama, M | 1 |
| Graeff, FG | 1 |
| Zangrossi, H | 1 |
| Audi, EA | 1 |
| Urrutia, A | 1 |
| Salgueiro, M | 1 |
| Bilbao, J | 1 |
| Mozas, M | 1 |
| Aguilera, L | 1 |
| Zimmermann, M | 1 |
| Bianchi, E | 1 |
| Norcini, M | 1 |
| Smrcka, A | 1 |
| Ghelardini, C | 2 |
| Galeotti, N | 1 |
| Vivoli, E | 1 |
| Bilia, AR | 1 |
| Bergonzi, MC | 1 |
| Bartolini, A | 1 |
| Pozza, DH | 1 |
| Potes, CS | 1 |
| Barroso, PA | 1 |
| Azevedo, L | 1 |
| Castro-Lopes, JM | 1 |
| Neto, FL | 1 |
| Gross, GJ | 1 |
| Baker, JE | 1 |
| Hsu, A | 1 |
| Wu, HE | 1 |
| Falck, JR | 1 |
| Nithipatikom, K | 1 |
| Yoon, MH | 1 |
| Kim, KS | 1 |
| Lee, HG | 1 |
| Kim, CM | 1 |
| Kim, WM | 1 |
| Choi, JI | 1 |
| Kim, YO | 1 |
| Zhang, Y | 2 |
| Meng, X | 2 |
| Li, A | 2 |
| Xin, J | 2 |
| Berman, BM | 2 |
| Lao, L | 2 |
| Tan, M | 2 |
| Ren, K | 2 |
| Zhang, RX | 2 |
| Heinl, C | 1 |
| Drdla-Schutting, R | 1 |
| Xanthos, DN | 1 |
| Sandkühler, J | 1 |
| Szentirmay, AK | 1 |
| Király, KP | 1 |
| Lenkey, N | 1 |
| Lackó, E | 1 |
| Al-Khrasani, M | 1 |
| Friedmann, T | 1 |
| Timár, J | 1 |
| Gyarmati, S | 1 |
| Tóth, G | 1 |
| Fürst, S | 1 |
| Riba, P | 1 |
| Narita, M | 1 |
| Kaneko, C | 1 |
| Miyoshi, K | 1 |
| Nagumo, Y | 1 |
| Kuzumaki, N | 1 |
| Nakajima, M | 1 |
| Nanjo, K | 1 |
| Matsuzawa, K | 1 |
| Yamazaki, M | 1 |
| Suzuki, T | 1 |
| Back, SK | 1 |
| Lee, J | 1 |
| Hong, SK | 1 |
| Na, HS | 1 |
| Nakayama, D | 1 |
| Watanabe, C | 1 |
| Watanabe, H | 1 |
| Mizoguchi, H | 1 |
| Sakurada, T | 1 |
| Sakurada, S | 1 |
| Courteix, C | 1 |
| Coudoré-Civiale, MA | 1 |
| Privat, AM | 1 |
| Zajac, JM | 1 |
| Eschalier, A | 1 |
| Fialip, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| -Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients[NCT05855577] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Disease Models, Animal
| Article | Year |
|---|---|
Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
Topics: Acetylcholine; Action Potentials; Adenosine Triphosphate; Analgesics, Opioid; Animals; Calcium; Chol | 2018 |
Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Dopamine Agonist | 2014 |
Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2016 |
Depression of C fibre-evoked spinal field potentials by the spinal delta opioid receptor is enhanced in the spinal nerve ligation model of neuropathic pain: involvement of the mu-subtype.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2008 |
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
Topics: Animals; Cyclohexanes; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Explor | 2009 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liq | 2010 |
Nociceptive behaviour upon modulation of mu-opioid receptors in the ventrobasal complex of the thalamus of rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Ankle; Behavior, Animal; Disease Models, Animal; | 2010 |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protei | 2010 |
Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
Topics: Affect; Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Electroacupunc | 2011 |
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacu | 2011 |
Distinct mechanisms underlying pronociceptive effects of opioids.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela | 2011 |
Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ | 2013 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; | 2006 |
Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy.
Topics: Amino Acid Sequence; Animals; Axotomy; Disease Models, Animal; Hyperalgesia; Injections, Intraperito | 2006 |
A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkeph | 2007 |
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimenta | 1999 |