phenylalanine and Multiple Myeloma

phenylalanine has been researched along with Multiple Myeloma in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (32.43)	18.7374
1990's	2 (5.41)	18.2507
2000's	2 (5.41)	29.6817
2010's	3 (8.11)	24.3611
2020's	18 (48.65)	2.80

Authors

Authors	Studies
Banerjee, R; Goodman, A; Kelkar, AH; Midha, S; Mohyuddin, GR; Prasad, V	1
Jessee, JK	1
Gonsalves, WI; Kapoor, P	1
Alekseeva, Y; Bakker, NA; Byrne, C; Coriu, D; Delimpasi, S; Dimopoulos, MA; Doronin, V; Hájek, R; Harmenberg, J; Lazzaro, A; Legiec, W; Liberati, AM; Maisnar, V; Masszi, T; Mateos, MV; Mikala, G; Minarik, J; Moody, V; Pour, L; Richardson, PG; Robak, P; Rosiñol, L; Salogub, G; Schjesvold, FH; Sonneveld, P; Špička, I; Symeonidis, A; Thuresson, M	1
Bakker, NA; Schjesvold, FH; Sonneveld, P	1
Hadidi, SA	1
Emeh, P; Eskelinen, A; Gebraad, A; Heckman, CA; Kuismanen, K; Lehmann, F; Manninen, M; Miettinen, JJ; Miettinen, S; Nupponen, NN; Ohlsbom, R; Pakarinen, TK; Slipicevic, A	1
Dimopoulos, MA; Gay, F; Mateos, MV; Nadeem, O; Ocio, EM; Richardson, PG; Schjesvold, F; Touzeau, C	1
Efebera, YA; Larocca, A; Leleu, X; Mateos, MV; Nadeem, O; Paner, A; Richardson, PG; Rodríguez-Otero, P	1
Fu, ZZ; Huang, QL; Jiang, RY; Wu, DP; Wu, XJ; Yan, S; Yang, BY; Yang, LL; Zhao, RR	1
Acs, K; Diao, Y; Färnegårdh, K; Färnegårdh, M; Fasth, KJ; Hammer, K; Lehmann, F; Svensson Gelius, S; Westermark, U	1
Aschan, J; Pour, L; Robak, P; Schjesvold, F; Sonneveld, P	1
Anderson, K; Bringhen, S; Byrne, C; Chauhan, D; Harmenberg, J; Mellqvist, UH; Nordström, E; Paba-Prada, C; Palumbo, A; Plesner, T; Reeves, B; Richardson, PG; Sonneveld, P; Voorhees, P; Zubair, H	1
Gullbo, J; Hajek, R; Hassoun, H; Larocca, A; Leleu, X; Oriol, A; Paner, A; Richardson, PG; Rodríguez-Otero, P; Schjesvold, FH	1
Alegre, A; Anderson, KC; Bakker, NA; Bladé, J; Byrne, C; Cavo, M; Harmenberg, J; Hassoun, H; Hiemenz, JW; Larocca, A; Laubach, JP; Leleu, X; Maisel, C; Mateos, MV; Mazumder, A; Moreb, JS; Nadeem, O; Oriol, A; Paner, A; Raptis, A; Richardson, PG; Rodriguez-Otero, P; Thuresson, M; Thuresson, S; Touzeau, C	1
Bringhen, S; Byrne, C; Harmenberg, J; Mellqvist, UH; Nordström, E; Obermüller, J; Plesner, T; Reeves, B; Richardson, PG; Sonneveld, P; Voorhees, PM	1
Hillengass, J; Holstein, SA; McCarthy, PL	1
Al-Janazreh, H; Canale, FA; Cutrona, G; D'Arrigo, G; Gentile, M; Martino, EA; Martino, M; Mendicino, F; Morabito, F; Morabito, L; Neri, A; Todoerti, K; Tripepi, G; Vigna, E	1
Anderson, KC; Chauhan, D; Lewensohn, R; Munshi, N; Paba-Prada, C; Ray, A; Richardson, P; Spira, J; Viktorsson, K	1
Delforoush, M; Enblad, G; Gullbo, J; Larsson, R; Strese, S; Wickström, M	1
Anderson, KC; Chauhan, D; Das, DS; Gullbo, J; Nordström, E; Ravillah, D; Ray, A; Richardson, PG; Song, Y	1
CASTELLANO, M; LOVISETTO, P	1
CASTELLANO, M; CATTANEO, C	1
STEVE BOCCIARELLI, D; VIOLANTE, A	1
AUSTIN, C; BERGSAGEL, DE; GRIFFITH, KM; SPRAGUE, CC	1
BARCELO, P; PUIGDOLLERS, JM; SANS-SABRAFEN, J	1
Barlogie, B; Condino, J; Gazitt, Y; Hoffman, R; Jagannath, S; Lee, B; Reading, CC; Tricot, G; Vesole, DH; Wickrema, A	1
Antcliff, J; Croucher, PI; Hargreaves, PG; Lawry, J; Murphy, G; Russell, RG; Wang, F	1
Harada, N; Hata, H; Matsuno, F; Matsuzaki, H; Mitsuya, H; Nagasaki, A	1
Ackermann, J; Assmann, I; Drach, J; Hübl, W; Ludwig, H; Schuster-Kolbe, J; Strasser, K; Zojer, N	1
Doellgast, GJ; Plaut, AG	1
Davidson, JF; Stankler, L	1
Griendl, W; Pittermann, E; Stacher, A	1
Pick, AI	1
Krueger, RG; Shutt, RH	1
Mach, B; Mechler, B	1
Barth, WF; Decker, JL; Waldmann, TA; Willerson, JT	1

Reviews

4 review(s) available for phenylalanine and Multiple Myeloma

Article	Year
Pepaxto: A New Peptide-Drug Conjugate for Heavily Pretreated Relapsed and Refractory Multiple Myeloma. The Annals of pharmacotherapy, 2022, Volume: 56, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Humans; Melphalan; Multiple Myeloma; Peptides; Phenylalanine	2022
Melphalan flufenamide for relapsed/refractory multiple myeloma. Drugs of today (Barcelona, Spain : 1998), 2022, Volume: 58, Issue:8 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Humans; Melphalan; Multiple Myeloma; Phenylalanine	2022
Melflufen for relapsed and refractory multiple myeloma. Expert opinion on investigational drugs, 2020, Volume: 29, Issue:10 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Humans; Melphalan; Multiple Myeloma; Phenylalanine; Recurrence; Survival Rate	2020
Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma. Drug design, development and therapy, 2021, Volume: 15 Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Humans; Melphalan; Multiple Myeloma; Phenylalanine	2021

Trials

5 trial(s) available for phenylalanine and Multiple Myeloma

Article	Year
Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study. The Lancet. Haematology, 2022, Volume: 9, Issue:2 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; COVID-19 Drug Treatment; Dexamethasone; Female; Humans; Lenalidomide; Male; Melphalan; Middle Aged; Multiple Myeloma; Phenylalanine; SARS-CoV-2; Thalidomide	2022
OCEAN: a randomized Phase III study of melflufen + dexamethasone to treat relapsed refractory multiple myeloma. Future oncology (London, England), 2020, Volume: 16, Issue:11 Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Dexamethasone; Drug Resistance, Neoplasm; Humans; Lenalidomide; Melphalan; Multiple Myeloma; Phenylalanine; Progression-Free Survival; Randomized Controlled Trials as Topic; Recurrence; Thalidomide	2020
Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1-2 study. The Lancet. Haematology, 2020, Volume: 7, Issue:5 Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Melphalan; Middle Aged; Multiple Myeloma; Neoplasm Recurrence, Local; Phenylalanine	2020
Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021, 03-01, Volume: 39, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Disease Progression; Drug Resistance, Neoplasm; Europe; Female; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Phenylalanine; Progression-Free Survival; Recurrence; Time Factors; United States	2021
Melflufen plus dexamethasone in relapsed/refractory multiple myeloma: long-term survival follow-up from the Phase II study O-12-M1. British journal of haematology, 2021, Volume: 193, Issue:6 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Phenylalanine; Survival Rate	2021

Other Studies

28 other study(ies) available for phenylalanine and Multiple Myeloma

Article	Year
Synthetic control arms in studies of multiple myeloma and diffuse large B-cell lymphoma. British journal of haematology, 2022, Volume: 196, Issue:5 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Biological Products; Clinical Trials as Topic; Drug Discovery; Humans; Lymphoma, Large B-Cell, Diffuse; Melphalan; Multiple Myeloma; Phenylalanine; Receptors, Antigen, T-Cell	2022
Melflufen for multiple myeloma: a promise unfulfilled? The Lancet. Haematology, 2022, Volume: 9, Issue:2 Topics: Humans; Melphalan; Multiple Myeloma; Phenylalanine	2022
Melflufen in multiple myeloma: the conclusion matters - Authors' reply. The Lancet. Haematology, 2022, Volume: 9, Issue:4 Topics: Humans; Melphalan; Multiple Myeloma; Phenylalanine	2022
Melflufen in multiple myeloma: the conclusion matters. The Lancet. Haematology, 2022, Volume: 9, Issue:4 Topics: Humans; Melphalan; Multiple Myeloma; Phenylalanine	2022
Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen. Cells, 2022, 05-07, Volume: 11, Issue:9 Topics: Bone Marrow; Bortezomib; Doxorubicin; Humans; Melphalan; Mesenchymal Stem Cells; Multiple Myeloma; Phenylalanine	2022
Melflufen for the treatment of multiple myeloma. Expert review of clinical pharmacology, 2022, Volume: 15, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Europe; Melphalan; Multiple Myeloma; Phenylalanine	2022
[Preliminary exploration of the metabolic profile and metabolic pathways in newly diagnosed multiple myeloma]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2022, Dec-23, Volume: 44, Issue:12 Topics: Adult; Aged; Biomarkers; Cysteine; Female; Humans; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methionine; Middle Aged; Multiple Myeloma; Phenylalanine; Reproducibility of Results; Serine; Threonine	2022
A rapid intracellular enrichment of alkylating payload is essential for melphalan flufenamide potency and mechanism of action. Biochemical and biophysical research communications, 2023, 05-14, Volume: 656 Topics: Antineoplastic Agents, Alkylating; Humans; Melphalan; Multiple Myeloma; Phenylalanine	2023
Melflufen: A Next-Generation Nitrogen Mustard. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021, 03-01, Volume: 39, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; Humans; Melphalan; Multiple Myeloma; Phenylalanine; Treatment Outcome	2021
In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jun-01, Volume: 19, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Movement; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Humans; Melphalan; Mice; Multiple Myeloma; Neovascularization, Pathologic; Phenylalanine; Tumor Burden; Xenograft Model Antitumor Assays	2013
In vitro and in vivo activity of melflufen (J1)in lymphoma. BMC cancer, 2016, Apr-04, Volume: 16 Topics: Animals; Cell Line, Tumor; Cell Proliferation; G2 Phase Cell Cycle Checkpoints; Humans; Lymphoma; Melphalan; Mice; Multiple Myeloma; Phenylalanine; Xenograft Model Antitumor Assays	2016
A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. British journal of haematology, 2016, Volume: 174, Issue:3 Topics: Antineoplastic Agents, Alkylating; Apoptosis; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Histones; Humans; Kinetics; Melphalan; Multiple Myeloma; Phenylalanine; Phosphorylation; Signal Transduction; Tumor Cells, Cultured	2016
[P-bis-(beta-chloroethyl) aminophenylalanine (sarcolysin) in antiblastic chemotherapy with special reference to lymphatic blood diseases]. Haematologica, 1958, Volume: 43, Issue:4 Topics: Hodgkin Disease; Humans; Leukemia; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Melphalan; Multiple Myeloma; Nitrogen Mustard Compounds; Phenylalanine; Plasma Cells; Sarcoma	1958
[Repeated remissions in a case of beta-plasmocytoma; variations in the blood protein picture during p-bis(2-chloroethyl)-aminophenylalanine therapy]. Minerva medica, 1959, Jul-21, Volume: 50 Topics: Blood Proteins; Humans; Multiple Myeloma; Neoplasms; Phenylalanine; Plasma Cells; Plasmacytoma	1959
[Morphological modifications of the characteristic pathological cells of the Oberling, Guerin and Guerin myeloma in rats treated with bis(beta-chloroethyl)-p-aminophenyl alanine]. Rendiconti - Istituto superiore di sanita, 1960, Volume: 23 Topics: Alanine; Animals; Antineoplastic Agents; Multiple Myeloma; Phenylalanine; Plasma Cells; Rats	1960
Evaluation of new chemotherapeutic agents in the treatment of multiple myeloma. IV. L-Phenylalanine mustard (NSC-8806). Cancer chemotherapy reports, 1962, Volume: 21 Topics: Antineoplastic Agents; Cell- and Tissue-Based Therapy; Melphalan; Multiple Myeloma; Mustard Plant; Phenylalanine; Plasma; Plasma Cells	1962
[di-(2-chloroethyl)amino]-L-phenylalanine ("Melphalan")]. Revista espanola de reumatismo y enfermedades osteoarticulares, 1962, Volume: 9 Topics: Humans; Melphalan; Multiple Myeloma; Phenylalanine	1962
Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells. Blood, 1995, Jul-01, Volume: 86, Issue:1 Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, CD34; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Blood Component Removal; CD56 Antigen; Cell Separation; Centrifugation; Consensus Sequence; Countercurrent Distribution; Cyclophosphamide; DNA Primers; Feasibility Studies; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Immunoglobulin Heavy Chains; Immunophenotyping; Membrane Glycoproteins; Multiple Myeloma; N-Glycosyl Hydrolases; Neoplastic Stem Cells; Phenylalanine; Plasma Cells; Polymerase Chain Reaction; Thy-1 Antigens	1995
Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor. British journal of haematology, 1998, Volume: 101, Issue:4 Topics: Bone Marrow Cells; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Phenylalanine; Protease Inhibitors; Receptors, Interleukin-6; Tetradecanoylphorbol Acetate; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Tumor Cells, Cultured	1998
Down-regulation of CD98 in melphalan-resistant myeloma cells with reduced drug uptake. Acta haematologica, 2000, Volume: 103, Issue:3 Topics: Antigens, CD; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ethyl Methanesulfonate; Fusion Regulatory Protein-1; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Humans; Melphalan; Multidrug Resistance-Associated Proteins; Multiple Myeloma; Mutagenesis; Neoplasm Proteins; Phenylalanine; Structure-Activity Relationship; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles	2000
Chromosomal aberrations are shared by malignant plasma cells and a small fraction of circulating CD19+ cells in patients with myeloma and monoclonal gammopathy of undetermined significance. British journal of haematology, 2002, Volume: 117, Issue:4 Topics: Aged; Aged, 80 and over; Antigens, CD19; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Clone Cells; Disease Progression; Disulfides; Gene Deletion; Genes, Immunoglobulin; Genes, p53; Genes, Retinoblastoma; Humans; Immunoglobulin G; Immunoglobulin Light Chains; Immunohistochemistry; In Situ Hybridization, Fluorescence; Membrane Glycoproteins; Middle Aged; Multiple Myeloma; Paraproteinemias; Phenylalanine; Plasma Cells; Polymerase Chain Reaction; Proteoglycans; RNA, Messenger; Syndecan-1; Syndecans; T-Lymphocytes	2002
Purification of human IgA by salt-mediated hydrophobic chromatography. Immunochemistry, 1976, Volume: 13, Issue:2 Topics: Blood Proteins; Chromatography, Agarose; Chromatography, Gel; Humans; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Multiple Myeloma; Phenylalanine	1976
Multiple extra-medullary plasmacytomas of the skin. Case report with a note on prognosis. The British journal of dermatology, 1974, Volume: 90, Issue:2 Topics: Adult; Bence Jones Protein; Blood Sedimentation; gamma-Globulins; Humans; Immunoelectrophoresis; Immunoglobulin A; Male; Multiple Myeloma; Mustard Compounds; Neoplasms, Multiple Primary; Phenylalanine; Plasmacytoma; Radiotherapy Dosage; Skin Neoplasms	1974
[Effect of a new cytostatic agent (peptichemio) on malignant neoplasms]. Wiener medizinische Wochenschrift (1946), 1974, Apr-06, Volume: 124, Issue:14 Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Colonic Neoplasms; Female; Hodgkin Disease; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Multiple Myeloma; Nitrogen Mustard Compounds; Peptides; Phenylalanine; Polycythemia; Uterine Neoplasms	1974
[The treatment of multiple myeloma]. Harefuah, 1974, Jun-02, Volume: 86, Issue:11 Topics: Alkylating Agents; Cyclophosphamide; Humans; Multiple Myeloma; Phenylalanine	1974
The effect of actinomycin D and 5-azacytidine on macromolecular synthesis in murine myeloma tumor cells. Journal of immunology (Baltimore, Md. : 1950), 1972, Volume: 108, Issue:3 Topics: Animals; Cell Line; Cell-Free System; Cytidine; Dactinomycin; Electrophoresis, Disc; Genetic Code; Half-Life; Immunogenetics; Immunoglobulin G; Leucine; Mice; Multiple Myeloma; Myeloma Proteins; Phenylalanine; Rabbits; RNA, Messenger; Tritium; Uridine; Valine	1972
Preparation and properties of ribosomal subunits from mouse plasmocytoma tumors. European journal of biochemistry, 1971, Aug-25, Volume: 21, Issue:4 Topics: Animals; Centrifugation, Density Gradient; Centrifugation, Zonal; Chemical Phenomena; Chemistry; Electrophoresis, Disc; Female; Liver; Magnesium; Mice; Multiple Myeloma; Osmolar Concentration; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Phenylalanine; Plasmacytoma; Potassium Chloride; Rats; Rats, Inbred Strains; Ribosomes; RNA, Neoplasm; Tissue Extracts	1971
Primary amyloidosis. Clinical, immunochemical and immunoglobulin metabolism. Studies in fifteen patients. The American journal of medicine, 1969, Volume: 47, Issue:2 Topics: Adult; Agammaglobulinemia; Amyloidosis; Bence Jones Protein; Bone Marrow; Bone Marrow Cells; Electrophoresis; Hemorrhagic Disorders; Hepatomegaly; Humans; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulin M; Kidney; Male; Middle Aged; Multiple Myeloma; Phenylalanine; Salivary Glands; Serum Globulins; Tongue; Xerophthalmia; Xerostomia	1969