phenylalanine and Disease Models, Animal

phenylalanine has been researched along with Disease Models, Animal in 328 studies

Research

Studies (328)

Timeframe	Studies, this research(%)	All Research%
pre-1990	77 (23.48)	18.7374
1990's	30 (9.15)	18.2507
2000's	89 (27.13)	29.6817
2010's	105 (32.01)	24.3611
2020's	27 (8.23)	2.80

Authors

Authors	Studies
Avdeef, A; Tam, KY	1
Gu, X; Hong, S; Liang, L; Xu, F; Zhan, X; Zheng, S; Zhu, T	1
Dijkstra, AM; Heiner-Fokkema, MR; Hovens, IB; Huijbregts, SCJ; Kema, IP; Romani, C; van der Goot, E; van der Zee, EA; van Spronsen, FJ; van Vliet, D; van Vliet, N	1
Anarat-Cappillino, G; Bangari, DS; Berthelette, P; Cornell, CS; Gans, J; Geller, S; Hossain, M; Jackson, R; Kyostio-Moore, SRM; Manek, R; Ryan, S; Singh, K; Xu, EY; Yu, D; Zhang, YV	1
Fukuo, Y; Futamura, G; Hiramatsu, R; Hu, N; Kashiwagi, H; Kawabata, S; Miyatake, SI; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M; Watanabe, T; Yoshimura, K	1
de Blaauw, P; Heiner-Fokkema, MR; Kema, IP; van der Goot, E; van der Zee, EA; van Faassen, HJR; van Ginkel, WG; van Spronsen, FJ; van Vliet, D	1
Ahring, KK; Brüel, A; Brøndum-Nielsen, K; Christensen, M; Dagnæs-Hansen, F; Jensen, E; Jensen, TG; Johannsen, M; Johansen, KS; Kjolby, M; Lund, AM; Madsen, JG; Møller, LB; Pedersen, M; Sørensen, LK	1
Boutros, S; Dudley, S; Harding, CO; Krenik, D; Raber, J; Rimann, N; Scherer, T; Thöny, B; Winn, SR	1
Ebrahimi, SA; Jafari-Sabet, M; Najafizadeh, P; Rahimi-Moghaddam, P; Sadegipour, A; Torab, M	1
Arthur, RM; Banik, SM; Carl, CS; Contrepois, K; He, Y; Jansen, RS; Kiens, B; Kim, JT; Li, VL; Liu, H; Loh, KY; Long, JZ; Lyu, X; Michael, B; Moeller, BC; Richter, EA; Snyder, MP; Stahl, A; Tanzo, JT; Terrell, SM; Tung, AS; van de Wetering, K; Voldstedlund, CT; Wallis, GA; Wei, W; Wiggenhorn, AL; Xu, Y; Yang, AC; Zushin, PH	1
Chen, YW; Chou, FI; Lee, YJ; Lin, YC; Wang, SY	1
Das, A; Ojha, DK; Reddy, KS; Sahu, W; Suar, M	1
Cho, KM; Jo, JK; Kim, EJ; Kim, HW; Kim, JH; Kwon, SJ; Lee, G; Nguyen, CD; Park, SE; Seo, SH; Son, HS	1
Gao, J; Li, Y; Song, J; Wu, K; Xu, H; Yang, Y; Zhang, Y; Zhao, M; Zheng, Y; Zhou, L	1
Chang, S; Chu, X; Ding, J; Du, C; Feng, T; Ge, C; Geng, M; Gong, Y; Huang, X; Lian, W; Lin, F; Liu, J; Ruan, L; Sun, G; Wang, H; Wang, T; Wang, X; Xiao, S; Xie, Z; Yan, S; Yang, D; Yang, J; Zhang, G; Zhang, H; Zhang, J; Zhang, Q	1
Berguig, GY; Bullens, S; Creer, AY; Martin, NT; Murphy, R; Olbertz, J; Pacheco, G; Weng, HH; Xie, L; Zhang, L	1
Inoue, Y; Kanamori, K; Matsui, M; Nishiyama, N; Nomoto, T; Suzuki, M; Takemoto, H; Tomoda, K; Yao, Y	1
Picklo, MJ; Rust, BM; Yan, L	1
Dudley, S; Fedorov, L; Harding, CO; Richards, DY; Rimann, N; Thöny, B; Winn, SR	1
Benne, JA; Christ, SE; Dobrowolski, SF; Ghaloul-Gonzalez, L; Gollin, SM; Hansen, SA; Johnson, MA; Koppes, EA; Leshinski, A; Lewis, DW; Lichter-Konecki, U; Murphy, SL; Newsome, JT; Nicholls, RD; Prather, RS; Redel, BK; Samuel, MS; Skvorak, KJ; Spate, LD; Vockley, J; Wagner, RA; Walters, EM; Wells, KD; Wu, YL; Yates, ME; Yerle, M	1
Choo, MS; Joung, Y; Jue, M; Kim, JK; Lee, S; Namgoong, JM; Ryu, CM; Shin, DM	1
Burdock, GA; Cowley, AB; Li, QS	1
Blair, HC; Dobrowolski, SF; Goetzman, ES; Phua, YL; Spridik, K; Sudano, C; Tourkova, IL; Vockley, J	1
Lin, IT; Lin, MY; Wang, IJ; Wu, YC	1
Aldabe, R; Allen, KL; Cao, W; Douar, A; González-Aseguinolaza, G; Hillin, LG; Kaiser, RA; Lillegard, JB; Martinez, M; Trigueros-Motos, L; VanLith, CJ; Weber, ND	1
Liu, S; Liu, Z; Pi, Z; Song, F; Wang, A; Zheng, Z	1
Abatan, A; Adnot, S; Breau, M; Bréhat, J; Czibik, G; d'Humières, T; Delmont, T; Derumeaux, G; Halfaoui, M; Hatem, S; Liang, H; Marion, O; Martel, C; Mezdari, Z; Morin, D; Murat Altintas, D; Naushad, S; Pini, M; Radu, C; Sarwar, R; Sawaki, D; Suffee, N; Yavari, A; Zhang, Y	1
Blau, N; Calin, GA; Chatterjee, SS; Coarfa, C; Egranov, SD; Feillet, F; Guéant, JL; Gunaratne, PH; Han, L; Hawke, DH; Hsiao, H; Hu, Q; Hung, MC; Jun, Y; Li, C; Li, Y; Li, YC; Liang, K; Liao, L; Lin, C; Muntau, AC; Namour, F; Nguyen, TK; Pan, Y; Putluri, N; Schiff, M; Sutton, VR; Tan, Z; Tsai, KL; Xing, Z; Xu, J; Yang, L; Ye, Y; Zhang, S; Zhang, Y; Zhang, Z	1
Blair, HC; Dobrowolski, SF; Larrouture, QC; Sudano, CR; Tourkova, IL	1
Agten, SM; Arts, M; Balluff, B; Dubois, LJ; Eijkel, GB; Ellis, SR; Hackeng, TM; Heeren, RMA; Lieuwes, NG; Olde Damink, SWM; Pierzchalski, KA; Soons, Z; van Loon, LJC	1
Cooper, JD; Corado, CR; Goldfinger, M; Laipis, PJ; O'Neill, CA; Tsuruda, LS; Zeile, WL	1
Jayaprakash, P; Kieć-Kononowicz, K; Latacz, G; Nurulain, SM; Oz, M; Sadek, B; Szymańska, E	1
Babiloni, C; Bastlund, JF; Bentivoglio, M; Bertini, G; Bordet, R; Christensen, DZ; Colavito, V; Del Percio, C; Dix, S; Drinkenburg, W; Fabene, PF; Ferri, R; Forloni, G; Frasca, A; Limatola, C; Lopez, S; Noe, FM; Pedersen, JT; Richardson, JC	1
Gershon, MD; Gluck, K; Gross Margolis, K; Israelyan, N; Iuga, A; Li, Z; Saurman, V; Stevanovic, K; Talavera, M; Vittorio, J; Welch, MG	1
Akalestou, E; Alamshah, A; Amarsi, R; Amin, A; Bloom, SR; Cao, Y; Gonzalez-Abuin, N; Gray, GW; Johnson, R; Jomard, A; Kinsey-Jones, JS; Malik, Z; Moolla, A; Murphy, KG; Norton, M; Ramgulam, A; Saleh, K; Sargent, PR; Spreckley, E	1
Abudu, H; Ahemaiti, A; Aximujiang, K; Wu, G; Yunusi, K; Zhang, J	1
Bruinenberg, VM; de Blaauw, P; Heiner-Fokkema, MR; Kema, IP; van der Goot, E; van der Zee, EA; van Faassen, M; van Spronsen, FJ; van Vliet, D	1
Boulton, ME; Corson, TW; Fei, X; Kharwadkar, R; Lee, B; Meroueh, SO; Mitter, SK; Park, B; Qi, X; Seo, SY; Sheik Pran Babu, SP; Si, Y; Sulaiman, RS; Sun, W	1
Harding, CO; Martinez, A; Raber, J; Scherer, T; Thöny, B; Weber, S; Winn, SR; Ying, M	1
Borsch, J; Büttner, L; Danecka, MK; Eichinger, A; Gersting, SW; Möglich, T; Muntau, AC; Woidy, M	1
Bigini, N; Cabib, S; Carducci, C; Colamartino, M; Gabucci, C; Leuzzi, V; Magnani, M; Pascucci, T; Pierigè, F; Puglisi-Allegra, S; Rossi, L; Sasso, V; Valzania, A; Ventura, R; Viscomi, MT	1
Armirotti, A; Caci, E; Cavalli, A; Falchi, F; Ferrera, L; Giacomini, E; Goldoni, L; Mandrup Bertozzi, S; Pedemonte, N; Pesce, E; Ravazzolo, R; Sondo, E; Tomati, V	1
Ito, K; Izui, S; Kakuchi, Y; Kawano, M; Malissen, B; Malissen, M; Mizuguchi, K; Onoe, T; Suzuki, Y; Yamada, K; Yamagishi, M; Zuka, M	1
Kang, S; Kim, CE; Kim, K; Kleinman, HK; Ousler, GW; Sosne, G; Yang, J	1
Belanger, AM; Cheng, SH; Furgerson, M; Gefteas, E; Geller, S; Kloss, A; Przybylska, M; Yew, NS; Zhu, Y	1
Bao, A; Gao, W; Li, Q; Lu, HY; Sun, L; Turvey, SE; Wang, K; Wang, L; Wang, Y; Xiong, Y; Yang, H	1
Seagraves, NJ; Watson, JN	1
Cai, Y; Huang, Y; Jiang, X; Li, D; Li, X; Lin, Y; Liu, H; Liu, L; Liu, Z; Lu, X; Peng, M; Shao, Y; Su, X; Tan, T; Tang, YP; Xu, J; Zeng, C; Zhang, W	1
Cao, J; Chen, S; Liu, W; Luo, X; Qiao, Y; Sun, M; Wen, A; Yang, Z; Zhao, X	1
Abete, P; Aitoro, R; Avagliano, C; Berni Canani, R; Bianco, R; Bonaduce, D; Calignano, A; Ciccarelli, M; Fiordelisi, A; Ghigo, A; Guida, F; Hirsch, E; Iaccarino, G; Li, M; Mercurio, V; Napolitano, F; Paparo, L; Russo, M; Sala, V; Sorriento, D; Tocchetti, CG; Trinchese, G	1
Bruinenberg, VM; Counotte, DS; Kuhn, M; van der Goot, E; van der Zee, EA; van Spronsen, FJ; van Vliet, D	1
Han, XM; Lu, YN; Qin, YJ; Rang, Y; Wang, NX; Zhai, XJ; Zhang, XL; Zhu, Y	1
Bortoluzzi, VT; Brust, L; de Franceschi, ID; Preissler, T; Wannmacher, CMD	1
Grisch-Chan, HM; Harding, CO; Schwank, G; Thöny, B	1
Armstrong, SA; Austin, R; Breyfogle, LJ; Bruedigam, C; Ebert, BL; Heckl, D; Heidel, FH; Hill, GR; Kalaitzidis, D; Kuhn, CP; Lane, SW; Mullally, A; Poveromo, L; Purdon, A; Vu, T; Williams, DA	1
Anderson, KC; Chauhan, D; Lewensohn, R; Munshi, N; Paba-Prada, C; Ray, A; Richardson, P; Spira, J; Viktorsson, K	1
Cayabyab, FS; Gowribai, K; Walz, W	1
Gao, J; Gu, X; He, Y; Liang, L; Lu, L; Zhang, X	1
Andou, A; Dohi, T; Eda, H; Ejima, C; Kageyama, S; Miyazawa, T; Nakayama, A; Sugiura, T	1
du Jardin, KG; Jensen, JB; Pehrson, AL; Sanchez, C	1
de Souza, RA; Mangueira, NM; Pinheiro, AL; Santos, AP; Silveira, L; Villaverde, AB; Xavier, M	1
Arning, E; Bottiglieri, T; Gibson, KM; Vogel, KR; Wasek, BL	1
Bihani, G; Bodhankar, S; Dhaneshwar, S; Kusurkar, M	1
Abraham, S; Anikster, Y; Brenner, O; Harmelin, A; Pode-Shakked, B; Schwartz, G; Shemer-Meiri, L; Stettner, N	1
Budac, D; du Jardin, KG; Jensen, JB; Pehrson, AL; Sanchez, C; Smagin, G; Song, D	1
Bai, Y; Kang, J; Lian, GC; Liu, M; Wang, HL; Wang, HM; Wang, Y; Zhang, XH	1
Corbo, C; Daniele, A; Imperlini, E; Orrù, S; Salvatore, F	1
Chuah, MK; Harbottle, RP; Harding, CO; Schlegel, A; Thöny, B; VandenDriessche, T; Viecelli, HM; Wong, SP	1
Chen, IP; Dutra, EH; Reichenberger, EJ; Tadinada, A; Uribe, F; Utreja, A	1
Morilak, DA; Pehrson, AL; Sánchez, C; Wallace, A	1
Chen, G; Du, Z; Li, B; Li, Y; Sun, T; Wei, Y; Wu, T; Xie, X; Zhou, Y	1
Almand, EA; Mogen, AB; Rice, KC; Richardson, AR; Rivera, FE; Sapp, AM; Shaw, LN	1
Horling, K; Rune, GM; Santer, R; Schlegel, G; Schulz, S; Ullrich, K; Vierk, R	1
Go, YM; Jo, H; Jones, DP; Kang, DW; Kim, CW; Kumar, S; Orr, M; Quyyumi, AA; Uppal, K; Walker, DI	1
Braccini, T; Grandgirard, D; Koedel, U; Leib, SL; Oggioni, MR; Ricci, S; Salvatore, P; Wenzel, M	1
Dirnhofer, S; Duek, A; Grisouard, J; Hao-Shen, H; Kubovcakova, L; Shimizu, T; Skoda, RC	1
Azuma, H; Hirano, H; Ibuki, N; Inamoto, T; Kawabata, S; Kirihata, M; Kiyama, S; Kuroiwa, T; Minami, K; Miyatake, S; Nomi, H; Suzuki, M; Takahara, K; Takai, T; Yoshikawa, Y	1
Galba, J; Kovac, A; Michalicova, A; Novak, M; Parrak, V	1
Corrales, RM; de Paiva, CS; Krauss, AH; Pelegrino, FS; Pflugfelder, SC; Tukler-Henriksson, J	1
Carsten, CG; Chowdhury, A; Gerard, P; Gray, BH; Nahar-Gohad, P; Nosoudi, N; Sinha, A; Vyavahare, NR	1
Contreras-Ruiz, L; Krauss, AH; Masli, S; Mir, FA; Turpie, B	1
Bruinenberg, VM; de Blaauw, P; Heiner-Fokkema, MR; Kema, IP; Mazzola, PN; van Anholt, RD; van der Zee, EA; van Faassen, MH; van Spronsen, FJ; van Vliet, D	1
Harding, CO; Scherer, T; Thöny, B; Winn, SR	1
Biery, A; Dobrowolski, SF; Lyons-Weiler, J; Skvorak, K; Spridik, K; Vockley, J	1
Rune, GM; Santer, R; Schlegel, G; Scholz, R; Ullrich, K	1
Boulton, ME; Corson, TW; Kennedy, B; Lee, B; Merrigan, S; Qi, X; Quigley, J; Seo, SY; Sulaiman, RS	1
Cannizzaro, C; De Caro, V; Giannola, LI; Lavanco, G; Plescia, F; Sutera, FM	1
Morgan, B	1
Ackerman, HC; Alkaitis, MS	1
Bruinenberg, VM; de Blaauw, P; Heiner-Fokkema, MR; Kema, IP; Mazzola, PN; Pascucci, T; Puglisi-Allegra, S; van der Zee, EA; van Faassen, MH; van Spronsen, FJ; van Vliet, D	1
Singh, V	1
Arning, E; Bottiglieri, T; Gibson, KM; Vogel, KR	1
Borzì, RM; Fini, M; Giavaresi, G; Grigolo, B; Maglio, M; Olivotto, E; Politi, L; Scandurra, R; Scotto d'Abusco, A; Veronesi, F	1
Baba, N; Maeda, N; Sagara, Y; Shen, Y; Tsuda, M; Tsuru, E; Wang, F; Yamashita, T	1
Choudhary, AK; Lee, YY	1
Jahan, K; Pillai, KK; Vohora, D	1
Gatchel, JR; Lee, Y; Orr, HT; Samaco, RC; Thaller, C; Zoghbi, HY	1
Cabañero, D; Célérier, E; García-Nogales, P; Maldonado, R; Mata, M; Puig, MM; Roques, BP	1
Rosenberg, GA; Walker, EJ	2
Aromando, RF; Heber, EM; Itoiz, ME; Nigg, DW; Schwint, AE; Trivillin, VA	1
Kawashima, Y; Kudo, N; Shiba, S; Tamura, M	1
Altieri, S; Bakeine, GJ; Bertolotti, A; Bortolussi, S; Bruschi, P; Clerici, A; Di Salvo, M; Ferrari, C; Marchetti, A; Nano, R; Stella, S; Zonta, C	1
Andolina, D; Cabib, S; Conversi, D; Latagliata, C; Mela, IL; Pascucci, T; Puglisi-Allegra, S; Ventura, R	1
Cox, RA; Deyo, DJ; Hawkins, HK; Herndon, DN; Jacob, S; Traber, DL	1
Hashimoto, K; Inoue, T; Iwakura, Y; Izumi-Nakaseko, H; Kakuta, S; Kano, M; Katayama, N; Kiyama, Y; Manabe, T; Murphy, NP; Nakazawa, T; Sudo, K; Taniguchi, S; Tanimura, A; Tezuka, T; Umemori, H; Watabe, AM; Yamamoto, T; Yokoyama, K	1
Choi, JO; Jung, SC; Lee, MH; Park, HY; Park, JW	1
Cao, W; Glushakov, AV; Martynyuk, AE; Mecca, AP; Seubert, CN; Shah, HP; Shi, P; Sumners, C	1
George, SJ; Jackson, CL; Johnson, JL; White, SJ; Williams, H	1
Aigrot, MS; Belachew, S; Bours, V; Hong, P; Josse, C; Lubetzki, C; Marée, R; Schoemans, R; Wu, C	1
Danecka, MK; Domdey, KA; Eichinger, A; Fingerhut, R; Gersting, SW; Glossmann, H; Kemter, KF; Lagler, FB; Messing, DD; Muntau, AC; Roscher, AA; Staudigl, M; Zsifkovits, C	1
Feng, JB; Ge, SL; Gong, WH; Han, PH; Zhang, CX; Zhang, L; Zhang, SQ; Zhou, DC	1
Bhatnagar, S; Kumar, A	1
Danecka, MK; Eichinger, A; Fingerhut, R; Gersting, SW; Glossmann, H; Lagler, FB; Muntau, AC; Staudigl, M; Steinbacher, A; Zsifkovits, C	1
Chen, YZ; Jiang, CL; Jing, ZP; Li, M; Li, Z; Liu, L; Sheng, CQ; Wang, Y; Zhou, J; Zhou, JR	1
Kajioka, T; Kitahara, Y; Miura, K; Takeuchi, M; Yamagishi, S	1
Altieri, S; Bakeine, JG; Ballarini, F; Bortolussi, S; Bruschi, P; Cansolino, L; Clerici, A; Ferrari, C; Gadan, MA; Nano, R; Protti, N; Stella, S; Zonta, A; Zonta, C	1
Huang, D; Li, Y; Luo, L; Wang, Z; Wen, R; Xia, X	2
Blass, G; Israel, I; Reiners, C; Samnick, S	1
Asai, N; Hara, A; Hoshino, T; Ida-Eto, M; Jijiwa, M; Kato, M; Nakashima, T; Ohgami, N; Sakashita, N; Shimada, A; Sobue, G; Sone, M; Tabuchi, K; Takahashi, M; Tsuzuki, T; Yamamoto, M	1
Fornace, AJ; Gonzalez, FJ; Idle, JR; Krausz, KW; Manna, SK; Patterson, AD; Yang, Q	1
Aromando, RF; Garabalino, MA; Heber, EM; Itoiz, ME; Miller, M; Molinari, AJ; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Thorp, S; Trivillin, VA	1
Coelho, J; Cortes, MX; Dalazen, G; Dutra-Filho, CS; Jacques, CE; Mazzola, PN; Mescka, CP; Moraes, TB; Piccoli, B; Rosa, AP; Terra, M	1
Jiang, X; Liu, J; Peng, S; Wang, W; Wang, Y; Wu, G; Wu, J; Yang, Y; Zhao, M; Zheng, M	1
Aromando, RF; Garabalino, MA; Heber, EM; Itoiz, ME; Miller, M; Molinari, AJ; Monti Hughes, A; Nigg, DW; Pozzi, EC; Schwint, AE; Thorp, SI; Trivillin, VA	1
Ichinose, H; Kume, A; Mizukami, H; Ozawa, K; Sanechika, S; Sumi-Ichinose, C; Urabe, M; Yagi, H	1
Li, F; Liu, X; Lu, X; Xiong, Z; Zhang, S; Zheng, S	1
Hutchison, RE; Mohi, G; Yan, D	1
Chevessier, F; Girard, E; Krejci, E; McArdle, JJ; Mersdorf, U; Peter, C; Witzemann, V	1
Clayton, TA	1
Cerreto, M; Daniele, A; Mehdawy, B; Nisticò, R; Ombrone, D; Pastore, L; Ruoppolo, M; Salvatore, F; Usiello, A	1
Martinez, A; Sarkissian, CN; Scherer, T; Thöny, B; Ying, M	1
Caffrey, CR; Lantz, LD; Vermeire, JJ	1
McBride, KL; Seagraves, NJ	1
Chen, L; Dong, XC; Jones, DR; Liu, S; Shen, W; Tao, R; Wang, L; Wei, D; Yu, ZH; Zhang, S; Zhang, ZY	1
Gadek, TR; O'Neill, CA; Pearlman, E; Sun, Y; Zhang, R	1
Coelho, JG; Dalazen, GR; Dutra-Filho, CS; Jacques, CE; Moraes, TB; Rosa, AP; Terra, M	1
Aguiar, AS; Berthiau, AS; Caussanel, S; Chevarin, C; Farrington, DT; Hamon, M; Herrick-Davis, K; Lanfumey, L; Madjar, JJ; Martin, CB; Mongeau, R; Ramond, F	1
Andriolo, M; Calì, F; McDonald, JD; Mirisola, M; Puglisi-Allegra, S; Romano, V; Sarkissian, CN; Smith, CB	1
Espinar, A; Guerrero, JM; Marchante, C; Martinez-Cruz, F; Osuna, C; Pozo, D	1
Medeiros, DM; Yannicelli, S	1
Napoli, C	1
Anglard, P; Bonnafous, S; Chavey, C; Mari, B; Monthouel, MN; Tartare-Deckert, S; Van Obberghen, E	1
Buhr, HJ; Foitzik, T; Hines, OJ; Hotz, B; Hotz, HG; Reber, HA	1
Gellerich, FN; Neuhof, C; Trumbeckaite, S; Zierz, S	1
Cabib, S; Pascucci, T; Puglisi-Allegra, S; Romano, V; Ventura, R	1
Pfefferkorn, T; Rosenberg, GA	1
Dyer, CA; Joseph, B	1
Ezell, E; Jinga, W; Matalon, KM; Matalon, R; Quast, M; Surendran, S; Szucs, S; Tyring, S	1
Allen, GC; Brooke, SL; Day, JC; Heard, PJ; Oyedepo, AC; Patel, H	1
Lee, SR; Lo, EH; Tsuji, K	1
Abraham, WM; Andrade-Gordon, P; Carolyn Fisher, M; Damiano, BP; de Garavilla, L; Dyatkin, AB; Fisher, MC; He, W; Hlasta, DJ; Hoekstra, WJ; Hornby, PJ; Kimball, ES; Kinney, WA; Kontoyianni, M; Maryanoff, BE; Prouty, SM; Santulli, RJ	1
Kitahara, Y; Miura, K; Mori, Y; Tajima, N	1
Dennis, DM; Glushakov, AV; Kagiyama, T; Martynyuk, AE; Ozcan, MS; Phillips, MI; Roose, B; Seubert, CN; Sumners, C	1
Gropper, SS; Medeiros, DM; White, BD; Yannicelli, S	1
Arnold, LA; Egami, K; Hyland, K; Jinnah, HA; Kasim, S	1
Bentley, L; Browne, M; Cox, RD; Goldsworthy, M; Haynes, A; Hough, T; Hugill, A; Hunter, AJ; Mijat, V; Moir, L; Quarterman, J; Spurr, N; Toye, AA	1
Aleshin, AN; Matsuda, H; Miyamoto, Y; Ono, M; Ryugo, M; Sawa, Y	1
Jo, I; Jung, SC; Kang, S; Oh, HJ; Park, ES	1
Bajpai, LK; Baker, SP; Dennis, DM; Embury, JE; Glushakov, AV; Glushakova, O; Laipis, PJ; Martynyuk, AE; Otero, DH; Seubert, CN; Sumners, C; Varshney, M	1
Hellwig, D; Kirsch, CM; Menger, MD; Menges, M; Moellers, MO; Romeike, BF; Samnick, S; Schneider, G	1
Bozic, M; Budihna, MV; Cerne, M; Drevensek, G; Peternel, L; Stalc, A; Stegnar, M; Urleb, U; Zega, A	1
Achten, E; Bauwens, M; Cornelissen, B; Dierckx, RA; Kersemans, K; Kersemans, V; Mertens, J; Slegers, G	1
Battistini, B; Blouin, A; Daull, P; Jeng, AY; Nantel, F; Sirois, P	1
Beutler, B; Ding, L; Du, X; Gong, X; Horwitz, J; Huang, Q; Liu, H; McDonald, HW; Wang, M; Yates, JR	1
Alhonen, L; Christensen, R; Jakobsen, M; Jensen, TG; Wahlfors, J	1
Al-Dhalimy, M; Clark, H; Finegold, M; Grompe, M; Hamman, K; Harding, CO; Montini, E	1
Jiang, YB; Lin, XT; Sun, DY; Sun, X; Yan, WL	1
Jo, I; Jung, SC; Kang, S; Koo, SK; Lee, H; Oh, HJ; Park, JW; Rhee, H	1
Ashokkumar, N; Pari, L	1
Guerrero, JM; Martínez-Cruz, F; Osuna, C	1
Bacher, K; Cornelissen, B; De Spiegeleer, B; Dierckx, RA; Kersemans, K; Kersemans, V; Mertens, J; Slegers, G; Thierens, H	1
Alfón, J; Cortijo, J; Gómez, LA; Iranzo, A; Merlos, M; Montesinos, JL; Morcillo, EJ; Nabah, YN; Sanz, MJ	1
De Spiegeleer, B; Kersemans, V; Mertens, J; Slegers, G	1
Chung, JH; Kim, JM; Laipis, P; Lee, YJ; Oh, SP; Park, S; Park, YS; Peris, J; Yang, S	1
Almstead, NG; Baker, TR; Brown, KK; De, B; Heitmeyer, SA; Hookfin, EB; Hsieh, LC; Janusz, MJ; Natchus, MG; Patel, V; Peng, SX; Pikul, S; Taiwo, YO	1
Armstrong, C; Durkin, AJ; Osborne, DA; Rosemurgy, AS; Yeatman, TJ; Zervos, EE	1
Batistoni, D; Gonzalez, BN; Heber, EM; Itoiz, ME; Kreimann, EL; Nigg, DW; Rebagliati, RJ; Schwint, AE; Trivillin, VA	1
Fukui, K; Maruhashi, J; Tajima, N; Tojo, A; Uesato, N	1
Erkent, U; Ertunc, M; Guc, MO; Ilhan, M; Iskit, AB; Onur, R	1
Ali, SF; Charron, CE; Embury, JE; Laipis, PJ; Liu, B; Martynyuk, A; Rowland, NE; Zori, AG	1
Estrada, EY; Mobashery, S; Rosenberg, GA	1
Bilkei-Gorzo, A; Michel, K; Noble, F; Roques, BP; Zimmer, A	1
Carney, PR; Dennis, DM; Laipis, PJ; Martynyuk, AE; Norman, WM; Ucar, DA; Yang, DD	1
Blaumann, H; Bumaschny, E; Calzetta, O; Cardoso, JE; Heber, EM; Itoiz, ME; Longhino, J; Nigg, DW; Pozzi, E; Schwint, AE; Trivillin, VA	1
Libert, C; López-Otin, C; Shapiro, S; Van Laere, I; Van Lint, P; Van Roy, M; Wielockx, B; Wilson, C	1
Dagrosa, MA; Juvenal, GJ; Pisarev, MA	1
Castillo, L; Erez, A; Lee, B; Marini, JC	1
Andresen, JH; Escrig, R; Saugstad, OD; Solberg, R; Vento, M	1
Dong, F; Ren, J; Sreejayan, N; Yang, X	1
Kajioka, T; Kitahara, Y; Mine, T; Miura, K	1
Etzel, MR; Hull, AK; Liu, X; Ney, DM; van Calcar, SC	1
Cullen, DE; Doukas, J; Gilliland, DG; Gozo, M; Hood, JD; Kharas, MG; Ko, YD; Lee, BH; Leeman, DS; Levine, RL; Mak, CC; Martin, M; McDowell, EP; Moore, SA; Noronha, G; Okabe, R; Soll, RM; Tefferi, A; Wernig, G	1
Dwivedy, AK; Shah, SN	2
Chamove, AS	1
Johnson, RC; Shah, SN	1
Benevenga, NJ; Steele, RD	1
Lane, JD; Langenbeck, U; Neuhoff, V; Schöne, B	1
Lane, JD; Neuhoff, V	1
Lo, GS; Longenecker, JB	1
Berry, HK; Butcher, RE; Vorhees, CV	1
Lipovac, K; Zanić-Grubisić, T	1
Sancilio, LF; Sleevi, MC; Walsh, DA	1
Blumstein, L; Levitsky, DA; Strupp, BJ	1
Esmail, A; Fears, R; Ferres, H; Rush, WR; Walker, P	1
Ambrus, CM; Ambrus, JL; Anthone, S; Cooley, C; Horváth, C; Kalghatgi, K; Mirand, EA; Sharma, SD	1
Chakravarti, RN; Mitra, SK; Narasimharao, KL; Rani, VU; Sarkar, AK; Sidhu, GS	1
Huether, G; Neuhoff, V	1
Eller, AG; Hommes, FA; Taylor, EH	1
Huether, G; Kaus, R; Neuhoff, V	1
Burri, R; Herschkowitz, N; Reynolds, R	1
Ciaramitaro, V; Diamond, A; Djali, S; Donner, E; Robinson, MB	1
Bengtsson, F; Bergqvist, PB; Bosman, DK; Chamuleau, RA; Hjorth, S; Maas, MA; Vogels, BA	1
Bourget, L; Chang, TM; Lister, C	1
Bilaniuk, I; Moyse, J; O'Connor, MM; Slonim, AE; Teichberg, S; Zdanowicz, MM	1
Diamond, A	2
Bywaters, A; Coderre, JA; Hopewell, JW; Liu, HB; Micca, PL; Morris, GM; Nawrocky, MM	1
Cunha-Filho, JS; Milton, C; Sarkis, JJ; Schetinger, MR; Teixeira, MV; Wajner, M; Wannmacher, D; Wyse, AT	1
Asano, S; Hashimoto, E; Kira, Y; Nakaoka, T; Okabe, F; Sekine, I	1
Grecksch, G; Rüthrich, HL; Schmidt, R	1
Brown, PD; Crimmin, MJ; Fu, X; Hoffman, RM; Wang, X	1
Hommes, FA	1
Imamura, T; Isshiki, G; Nakajima, T; Oura, T; Sawada, Y; Shintaku, H	1
Dove, WF; McDonald, JD; Shedlovsky, A; Symula, D	1
Ido, T; Ishiwata, K; Kubota, K; Kubota, R; Tada, M; Yamada, S	1
Dove, WF; Shedlovsky, A; Symula, DJ	1
Dove, WF; Guillery, EN; Shedlovsky, A; Symula, DJ	1
Gubkina, HA; Kachur, VA; Lepekhin, EA; Ushakova, GA	1
Dyer, CA; Gailis, L; Kirby, ML; McDonald, JD	1
Bigatel, DA; Carey, DJ; Cizmeci-Smith, G; Elmore, JR; Franklin, DP; Youkey, JR	1
Blain, F; Chang, TM; Heft, R; Peevers, R; Sarkissian, CN; Scriver, CR; Shao, Z; Su, H	1
Das, A; McGuire, PG; McLamore, A; Song, W	1
Boulais, DM; McDonald, JD; Sarkissian, CN; Scriver, CR	1
Campbell, CA; Chapman, GA; Harrison, D; Moores, K; Stewart, BR; Strijbos, PJ	1
Daikhin, E; Dyer, CA; Jean-Guillaume, D; Kendler, A; Nguyen, LB; Shefer, S; Tint, GS; Yudkoff, M	1
Balkwill, FR; Dias, S; Holdsworth, H; Scott, KA	1
Alexander, B; Benjamin, IS; Li, X; Preston, JE; Segal, MB; Sherwood, R	1
Chapman, DF; Lapchak, PA; Zivin, JA	1
Haefele, MJ; McDonald, JD; White, G	1
Gretz, N; Kränzlin, B; Morente, N; Obermüller, N; Witzgall, R	1
Huszagh, VA; Infante, JP	1
Howard, RB; Johnston, MR; Mullen, JB; Pagura, ME	1
Attaix, D; Debiton, E; Knowles, AL; Madelmont, JC; Samuels, SE; Tilignac, T	1
Artese, L; di Mola, FF; Di Sebastiano, P; Innocenti, P; Mascetta, G; Pernthaler, H; Rossi, C	1
Duriez, M; Levy, BI; Mallat, Z; Silvestre, JS; Tamarat, R; Tedgui, A	1
Mao, L; Sun, K; Yu, S	1
Cho, S; McDonald, JD	1
Blaumann, H; Calzetta, O; Itoiz, ME; Kreimann, EL; Longhino, J; Schwint, AE	1
Batistoni, D; Dagrosa, A; Farías, S; Garavaglia, R; Itoiz, ME; Kreimann, EL; Schwint, AE	1
Anderson, RL; Bissell, MJ; Le Beyec, J	1
Bhagat, S; Che, M; Cher, ML; Fridman, R; Herzog, M; Mullins, C; Nemeth, JA; Shekarriz, B; Upadhyay, J; Yousif, R	1
Al-Dhalimy, M; Finegold, M; Grompe, M; Overturf, K	1
Calderon-Ramirez, L; Frösen, J; Häyry, P; Myllärniemi, M	1
Lo, EH; Sumii, T	1
Aykin-Burns, N; Ercal, N; Gurer-Orhan, H; McDonald, JD	1
Bruins, MJ; Deutz, NE; Lamers, WH; Soeters, PB	1
Banai, S; Fishbein, I; Gertz, SD; Golomb, G; Margolin, L; Perez, LS; Reich, R	1
Chamove, AS; Molinaro, TJ	1
Avins, L; Guroff, G; Kuwabara, T	1
Andersen, AE; Fales, HM; Guroff, G; Pisano, JJ; Rowe, VD	1
Antonas, KN; Coulson, WF	1
Brown, WJ; Copenhaver, JH; Gunter, R; Schalock, RL	1
Elias, JM; Feinstein, G; Janoff, A; Malemud, CJ	1
Delvalle, JA; Greengard, O	1
Dhondt, JL; Farriaux, JP	1
Biserte, G; Dautrevaux, M; Dhondt, JL; Farriaux, JP	1
Loo, YH; Scotto, J; Wisniewski, HM	1
Benavides, J; Gimenez, C; Mayor, F; Sanchez-Rubiales, M; Valdivieso, F	1
Chan, W; Kopple, JD; Siassi, F; Swendseid, ME; Tam, CF; Vyhmeister, I; Wang, M	1
Colmant, G	1
Fisher, JE; Hodgman, J; James, JH; Rosen, HM; Soeters, PB	1
Ambrus, CM; Ambrus, JL; Guthrie, R; Horvath, C; Kant, C; Mirand, E; Paul, T; Pedersen, H; Sharma, S	1
Berry, HK; Brunner, RL; Butcher, RE; McLean, MS; Vorhees, CV	1
Barthon, F; Charpentier, C; Domange, C; Laggoune, B; Lemonnier, A; Wolf, M	1
Borisy, GG; Rodriguez, JA	1
Del Valle, JA; Greengard, O; Yoss, MS	1
Cummings, MG; Fischer, JE; James, JH; Kean, JM; Soeters, PB	1
Hunt, R; Mertin, J	1
Andersen, A	1
Frazer, A; Mendels, J	1
Kao, R; Morgan, HE; Rannels, DE	1
Hijikata-Okunomiya, A; Katsuura, Y; Okada, Y; Okamoto, S; Wanaka, K	1
Coderre, J; Fairchild, R; Hansrote, J; Packer, S; Perry, H; Saraf, S	1
Oparina, TI; Putilina, FE	1
Bespalova, MA; Chaeva, LS; Kliaich, K; Maksimova, SP; Mukhina, AP	1
Zuber, VL	1
Hatta, S; Honda, C; Ichihashi, M; Mishima, Y	1
Bode, VC; Dove, WF; McDonald, JD; Shedlovsky, A	1
Christensen, HN; de Cespedes, C; Lowler, K; Thoene, JG	1
Sze, PY	1
Chow, IZ; Inoue, A; Isshiki, G; Okano, Y; Oura, T	1
Boylan, J; Ellenbogen, R; Pueschel, SM	1
Cotton, RG	1
Bode, VC; McDonald, JD	1
Elliott, RB; Lewis, SA; Lyon, IC	1
Boylan, JM; Povar, ML; Pueschel, SM; Schrier, AM	1
Gerritsen, T; Siegel, FL	1
Chang, AY	1
Andersen, AE; Guroff, G	1
Masek, K; Rasková, H; Rotta, J	1
Brown, WJ; Gunter, R; Schalock, R	1
Copenhaver, JH; Schalock, RL	1
Carver, MJ; Copenhaver, JH; Schalock, RL	1
Tourian, A	1
Koprowski, H	1
Norton, AL; Pihlaja, DJ	1
Daftari, B; Fishman, MA; Prensky, AL	1
Andersen, AE; Guroff, G; Rowe, V	1
Seller, MJ	1
Adelman, LS; Bass, NH; Caley, DW; Mann, JD	1
Herron, WL; Riegel, BW	1
Brennan, E; Herron, WL; Riegel, BW; Rubin, ML	1
Shoma, N	1
Chamove, AS; Davenport, JW	1
Costantini, ML; Grümer, HD; Hetland, LB	1
Kozik, M	1
Haufe, F; Haufe, U; Lubs, H; Machill, G	1
Child, CG; Coon, WW; Iob, V; Mattson, WJ; Sloan, M; Turcotte, JG	1
Aoki, K; Siegel, FL	1
Mitoma, C; Pryor, GT	1
Bory, P; Jakubovic, A; Woolf, F; Woolf, LI	1
McKean, CM; Peterson, NA; Shah, SN	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1

Reviews

10 review(s) available for phenylalanine and Disease Models, Animal

Article	Year
State-of-the-Art 2019 on Gene Therapy for Phenylketonuria. Human gene therapy, 2019, Volume: 30, Issue:10 Topics: Animals; Biomarkers; Clinical Trials as Topic; Dependovirus; Disease Models, Animal; Gene Editing; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Liver; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Plasmids	2019
Neurophysiological symptoms and aspartame: What is the connection? Nutritional neuroscience, 2018, Volume: 21, Issue:5 Topics: Affect; Animals; Aspartame; Aspartic Acid; Brain; Cognitive Dysfunction; Disease Models, Animal; Dopamine; Free Radicals; Humans; Hydrocortisone; Migraine Disorders; Nervous System Diseases; Neurotransmitter Agents; Non-Nutritive Sweeteners; Norepinephrine; Oxidative Stress; Phenylalanine; Seizures; Serotonin; Sleep Initiation and Maintenance Disorders	2018
Boron neutron capture therapy in cancer: past, present and future. Arquivos brasileiros de endocrinologia e metabologia, 2007, Volume: 51, Issue:5 Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Deuteroporphyrins; Disease Models, Animal; Dogs; Humans; Mice; Mice, Nude; Phenylalanine; Radiation-Sensitizing Agents; Thyroid Neoplasms	2007
Adverse effects of excessive consumption of amino acids. Annual review of nutrition, 1984, Volume: 4 Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Animal; Ethionine; Fenclonine; Glycine; Growth Disorders; Histidine; Humans; Methionine; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pneumonia, Atypical Interstitial, of Cattle; Serine; Stereoisomerism; Sulfhydryl Compounds; Tissue Distribution; Tryptophan; Tyrosine; Vitamin A	1984
Progress in experimental phenylketonuria: a critical review. Neuroscience and biobehavioral reviews, 1981,Spring, Volume: 5, Issue:1 Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Energy Metabolism; Female; Fenclonine; Glutamates; Humans; Mice; Myelin Sheath; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Protein Biosynthesis; Pyridoxine; Serotonin	1981
Phenylalanine levels of 6-10 mg/dl may not be as benign as once thought. Acta paediatrica (Oslo, Norway : 1992). Supplement, 1994, Volume: 407 Topics: Animals; Case-Control Studies; Cerebral Cortex; Cognition Disorders; Contrast Sensitivity; Cross-Sectional Studies; Disease Models, Animal; Humans; Longitudinal Studies; Phenylalanine; Phenylketonurias; Rats	1994
Evidence for the importance of dopamine for prefrontal cortex functions early in life. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1996, Oct-29, Volume: 351, Issue:1346 Topics: Animals; Child, Preschool; Cognition; Disease Models, Animal; Dopamine; Humans; Infant; Inhibition, Psychological; Macaca; Neural Pathways; Phenylalanine; Phenylketonurias; Prefrontal Cortex; Spatial Behavior; Task Performance and Analysis; Tyrosine; Visual Pathways	1996
Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. Molecular genetics and metabolism, 2001, Volume: 72, Issue:3 Topics: Adult; Animals; Arachidonic Acid; Brain; Brain Diseases, Metabolic; Child; Disease Models, Animal; Docosahexaenoic Acids; Female; Humans; Infant; Infant, Newborn; Male; Mice; Mitochondria; Models, Biological; Phenylalanine; Phenylketonuria, Maternal; Phenylketonurias; Pregnancy	2001
Urinary phenylalanine metabolites in preweanling rats treated with p-chlorophenylalanine and phenylalanine. Nutrition reviews, 1975, Volume: 33, Issue:9 Topics: Animals; Disease Models, Animal; Fenclonine; Humans; Lactates; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Rats	1975
Pharmacological effects of phenylalanine on seizure susceptibility: an overview. Neurochemical research, 1989, Volume: 14, Issue:2 Topics: Animals; Aspartame; Dipeptides; Disease Models, Animal; Disease Susceptibility; Humans; Phenylalanine; Seizures	1989

Other Studies

318 other study(ies) available for phenylalanine and Disease Models, Animal

Article	Year
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy. Metabolic brain disease, 2021, Volume: 36, Issue:8 Topics: Animals; Brain; Disease Models, Animal; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Transcriptome	2021
Correlations of blood and brain biochemistry in phenylketonuria: Results from the Pah-enu2 PKU mouse. Molecular genetics and metabolism, 2021, Volume: 134, Issue:3 Topics: Amino Acids; Animals; Brain; Brain Chemistry; Disease Models, Animal; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Phenylalanine; Phenylketonurias	2021
Blood phenylalanine reduction reverses gene expression changes observed in a mouse model of phenylketonuria. Scientific reports, 2021, 11-24, Volume: 11, Issue:1 Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Down-Regulation; Gene Expression Profiling; Genetic Therapy; Liver; Male; Mice, Knockout; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylalanine Hydroxylase; Phenylketonurias; Proteome; Proteomics; Transcriptome	2021
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation. Cells, 2021, 12-02, Volume: 10, Issue:12 Topics: Animals; Apoptosis; Boron; Boron Neutron Capture Therapy; Brain; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Cranial Irradiation; Disease Models, Animal; Humans; Lymphoma; Methotrexate; Mice; Phenylalanine; Tissue Distribution	2021
The increasing importance of LNAA supplementation in phenylketonuria at higher plasma phenylalanine concentrations. Molecular genetics and metabolism, 2022, Volume: 135, Issue:1 Topics: Amino Acids, Neutral; Animals; Dietary Supplements; Disease Models, Animal; Humans; Mice; Phenylalanine; Phenylketonurias	2022
The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PloS one, 2022, Volume: 17, Issue:1 Topics: Amino Acids; Animals; Bone and Bones; Bone Density; Brain; Caseins; Dietary Supplements; Disease Models, Animal; Female; Maze Learning; Mice; Mice, Inbred C57BL; Peptide Fragments; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Serotonin; Tyrosine	2022
Modeling the cognitive effects of diet discontinuation in adults with phenylketonuria (PKU) using pegvaliase therapy in PAH-deficient mice. Molecular genetics and metabolism, 2022, Volume: 136, Issue:1 Topics: Adult; Animals; Cognition; Diet; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylalanine Hydroxylase; Phenylketonurias; Recombinant Proteins	2022
Oral administration of phenylalanine molecularly imprinted polymer (MIP) benefits PKU mouse model. Journal of inherited metabolic disease, 2022, Volume: 45, Issue:4 Topics: Administration, Oral; Animals; Disease Models, Animal; Mice; Molecularly Imprinted Polymers; Phenylalanine; Phenylketonurias	2022
An exercise-inducible metabolite that suppresses feeding and obesity. Nature, 2022, Volume: 606, Issue:7915 Topics: Adiposity; Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Energy Metabolism; Feeding Behavior; Glucose; Lactic Acid; Mice; Obesity; Phenylalanine; Physical Conditioning, Animal	2022
Evaluation of the Key Advantages between Two Modalities of Boronophenylalanine Administration for Clinical Boron Neutron Capture Therapy Using an Animal Model. Cells, 2022, 09-01, Volume: 11, Issue:17 Topics: Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Carcinoma, Squamous Cell; Disease Models, Animal; Humans; Mouth Neoplasms; Phenylalanine	2022
Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria. Journal of proteome research, 2022, Oct-07, Volume: 21, Issue:10 Topics: Animals; Arginine; Bile Acids and Salts; Bile Pigments; Disease Models, Animal; Hippurates; Histidine; Hormones; Humans; Malaria, Cerebral; Mice; Ornithine; Phenylalanine; Plasmodium berghei; Sphingolipids; Valine	2022
Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model. Molecules (Basel, Switzerland), 2022, Oct-05, Volume: 27, Issue:19 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Gastrointestinal Microbiome; Glutamic Acid; Glycerol; Hypoxanthines; Inosine; Mice; Oxalates; Phenylalanine; Pyrrolidonecarboxylic Acid; Xylose	2022
Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites. International journal of biological macromolecules, 2023, Dec-31, Volume: 253, Issue:Pt 7 Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Mice; Mice, Inbred C57BL; Phenylalanine; Polysaccharides	2023
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell research, 2019, Volume: 29, Issue:10 Topics: Alzheimer Disease; Amino Acids; Animals; Anti-Bacterial Agents; Bacteria; Clinical Trials, Phase III as Topic; Cognitive Dysfunction; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Humans; Isoleucine; Mannose; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Oligosaccharides; Phenylalanine; Th1 Cells	2019
Of mice and men: Plasma phenylalanine reduction in PKU corrects neurotransmitter pathways in the brain. Molecular genetics and metabolism, 2019, Volume: 128, Issue:4 Topics: Amino Acids; Animals; Biomarkers; Biosynthetic Pathways; Brain; Disease Models, Animal; Humans; Male; Mice; Mice, Knockout; Mutation; Neurotransmitter Agents; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylalanine Hydroxylase; Phenylketonurias; Recombinant Proteins; Treatment Outcome	2019
Poly(vinyl alcohol) boosting therapeutic potential of Science advances, 2020, Volume: 6, Issue:4 Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Energy Metabolism; Humans; Mass Spectrometry; Mice; Neoplasms; Phenylalanine; Polyvinyl Alcohol; Radiation-Sensitizing Agents; Signal Transduction; Tissue Distribution; Xenograft Model Antitumor Assays	2020
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma. Anticancer research, 2020, Volume: 40, Issue:4 Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease Models, Animal; Docosahexaenoic Acids; Fasting; Humans; Insulin; Isoleucine; Lactic Acid; Leucine; Metabolomics; Mice; Neoplasm Metastasis; Phenylalanine; Pyruvic Acid	2020
A novel Pah-exon1 deleted murine model of phenylalanine hydroxylase (PAH) deficiency. Molecular genetics and metabolism, 2020, Volume: 131, Issue:3 Topics: Animals; CRISPR-Cas Systems; Disease Models, Animal; Exons; Gene Editing; Genetic Vectors; Humans; Liver; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2020
A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing. JCI insight, 2020, 10-15, Volume: 5, Issue:20 Topics: Adolescent; Adult; Animals; CRISPR-Cas Systems; Diet; Disease Models, Animal; Gene Editing; Humans; Liver; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Swine	2020
Selective Detection of Nano-Sized Diagnostic Markers Using Au-ZnO Nanorod-Based Surface-Enhanced Raman Spectroscopy (SERS) in Ureteral Obstruction Models. International journal of nanomedicine, 2020, Volume: 15 Topics: Animals; Biomarkers; Collagen; Disease Models, Animal; Female; Fibrosis; Gold; Kidney; Kidney Diseases; Nanotubes; Phenylalanine; Rats, Sprague-Dawley; Spectrum Analysis, Raman; Ureteral Obstruction; Urinalysis; Zinc Oxide	2020
Repeat-dose animal toxicity studies and genotoxicity study with deactivated alkaline serine protease (DASP), a protein low in phenylalanine (PHE). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 146 Topics: Animals; Diet; Disease Models, Animal; Drug Administration Schedule; Escherichia coli; Female; Humans; Male; Mutagenicity Tests; Phenylalanine; Phenylketonurias; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Serine Endopeptidases	2020
Mesenchymal stem cell energy deficit and oxidative stress contribute to osteopenia in the Pah Molecular genetics and metabolism, 2021, Volume: 132, Issue:3 Topics: Alkaline Phosphatase; Animals; Bone Density; Bone Diseases, Metabolic; Cell Differentiation; Disease Models, Animal; Humans; Mesenchymal Stem Cells; Mice; Osteoblasts; Oxidative Stress; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Resveratrol	2021
Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models. EBioMedicine, 2021, Volume: 65 Topics: Animals; Atropine; Cricetinae; Disease Models, Animal; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Hydroxamic Acids; Lumican; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Morpholinos; Myopia; Phenylalanine; Sclera; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Zebrafish; Zebrafish Proteins	2021
Use of an adeno-associated virus serotype Anc80 to provide durable cure of phenylketonuria in a mouse model. Journal of inherited metabolic disease, 2021, Volume: 44, Issue:6 Topics: Animals; Cell Line; Dependovirus; Disease Models, Animal; DNA, Recombinant; Female; Genetic Therapy; Genetic Vectors; Hair Color; Humans; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C57BL; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Transduction, Genetic	2021
Mass spectrometry-based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats. Journal of separation science, 2021, Volume: 44, Issue:16 Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Disease Models, Animal; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Mass Spectrometry; Medicine, Chinese Traditional; Metabolomics; Nervous System; Panax; Phenylalanine; Plant Extracts; Rats; Reproducibility of Results; Schisandra; Tandem Mass Spectrometry; Tyrosine; Urinalysis	2021
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging. Circulation, 2021, 08-17, Volume: 144, Issue:7 Topics: Aging; Amino Acids; Animals; Biomarkers; Biopterins; Catalysis; Cellular Senescence; Disease Models, Animal; Disease Susceptibility; Heart Diseases; Humans; Liver; Male; Mice; Mice, Knockout; Models, Biological; Myocardium; Myocytes, Cardiac; Phenylalanine; Rats	2021
A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science (New York, N.Y.), 2021, 08-06, Volume: 373, Issue:6555 Topics: Acetylgalactosamine; Animals; Biopterins; Diet; Disease Models, Animal; Female; Hepatocytes; Humans; Liver; Male; Mice; Mice, Knockout; Nucleic Acid Conformation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Protein Binding; RNA, Long Noncoding	2021
A New View of Bone Loss in Phenylketonuria. Organogenesis, 2021, 10-02, Volume: 17, Issue:3-4 Topics: Animals; Bone Diseases, Metabolic; Disease Models, Animal; Humans; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2021
Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. Angewandte Chemie (International ed. in English), 2017, 06-12, Volume: 56, Issue:25 Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Heterografts; Hydroxylation; Kinetics; Liver Neoplasms; Mass Spectrometry; Mice; Mice, Nude; Phenylalanine; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry; Tyrosine	2017
Partial rescue of neuropathology in the murine model of PKU following administration of recombinant phenylalanine ammonia lyase (pegvaliase). Molecular genetics and metabolism, 2017, Volume: 122, Issue:1-2 Topics: Animals; Brain; Disease Models, Animal; Humans; Mice; Neurotransmitter Agents; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Recombinant Proteins; Tyrosine 3-Monooxygenase	2017
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats. Epilepsy research, 2017, Volume: 138 Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine; HEK293 Cells; Humans; Ligands; Male; Membrane Potentials; Microinjections; Neuroblastoma; Oocytes; Oxidopamine; Patch-Clamp Techniques; Phenylalanine; Rats; Rats, Wistar; Receptors, Glycine; Seizures; Strychnine; Transduction, Genetic; Xenopus laevis	2017
Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F). Current Alzheimer research, 2018, Volume: 15, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Arousal; Brain Mapping; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Fourier Analysis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phenylalanine; Valine	2018
Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis. American journal of physiology. Gastrointestinal and liver physiology, 2017, Nov-01, Volume: 313, Issue:5 Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterochromaffin Cells; Enterocolitis, Necrotizing; Enzyme Inhibitors; Inflammation; Intestinal Mucosa; Liver; Mice; Oxytocin; Phenylalanine; Pyrimidines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Signal Transduction; Tryptophan Hydroxylase	2017
l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents. International journal of obesity (2005), 2017, Volume: 41, Issue:11 Topics: Animals; Appetite Depressants; Appetite Regulation; Disease Models, Animal; Eating; Energy Metabolism; Gastrointestinal Hormones; Glucose Intolerance; Male; Mice; Mice, Inbred C57BL; Phenylalanine; Rats; Rats, Wistar; Receptors, Calcium-Sensing; Receptors, Gastrointestinal Hormone; Satiation	2017
[Metabonomic analysis of the urine from rat model with abnormal sapra syndrome]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2017, Oct-28, Volume: 42, Issue:10 Topics: Amino Acids; Animals; Citric Acid; Creatine; Disease Models, Animal; Energy Metabolism; Glutamine; Glycoproteins; Isoleucine; Leucine; Metabolomics; Phenylalanine; Rats; Rats, Wistar; Syndrome	2017
Large neutral amino acid supplementation as an alternative to the phenylalanine-restricted diet in adults with phenylketonuria: evidence from adult Pah-enu2 mice. The Journal of nutritional biochemistry, 2018, Volume: 53 Topics: Amino Acids, Neutral; Animals; Biogenic Monoamines; Brain; Dietary Supplements; Disease Models, Animal; Eating; Female; Male; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Phenylketonurias	2018
Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization. ACS chemical biology, 2018, 01-19, Volume: 13, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Binding Sites; Choroidal Neovascularization; Chromones; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Fatty Acids, Unsaturated; Humans; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Targeted Therapy; Phenylalanine; Protein Domains; Proteomics; Wet Macular Degeneration	2018
Blood phenylalanine reduction corrects CNS dopamine and serotonin deficiencies and partially improves behavioral performance in adult phenylketonuric mice. Molecular genetics and metabolism, 2018, Volume: 123, Issue:1 Topics: Animals; Central Nervous System Diseases; Cognitive Dysfunction; Disease Models, Animal; Dopamine; Humans; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Serotonin; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase	2018
Secondary BH4 deficiency links protein homeostasis to regulation of phenylalanine metabolism. Human molecular genetics, 2018, 05-15, Volume: 27, Issue:10 Topics: Animals; Biopterins; Disease Models, Animal; Humans; Inactivation, Metabolic; Kinetics; Liver; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Protein Folding; Proteostasis	2018
A new therapy prevents intellectual disability in mouse with phenylketonuria. Molecular genetics and metabolism, 2018, Volume: 124, Issue:1 Topics: Administration, Intravenous; Anabaena; Animals; Brain Chemistry; Disease Models, Animal; Drug Delivery Systems; Drug Evaluation, Preclinical; Erythrocytes; Female; Intellectual Disability; Male; Mice; Mice, Knockout; Motor Activity; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Recombinant Proteins	2018
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell chemical biology, 2018, 07-19, Volume: 25, Issue:7 Topics: Animals; Apoptosis; Benzamidines; Cell Proliferation; Cell Survival; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; Mice; Models, Molecular; Molecular Structure; Phenylalanine; Structure-Activity Relationship; Thiadiazoles; Ubiquitin-Protein Ligases	2018
LatY136F knock-in mouse model for human IgG4-related disease. PloS one, 2018, Volume: 13, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Adrenal Cortex Hormones; Animals; Disease Models, Animal; Gene Knock-In Techniques; Humans; Immunoglobulin G4-Related Disease; Kidney; Leukocytes, Mononuclear; Lung; Membrane Proteins; Mice; Mutation; Pancreas; Phenotype; Phenylalanine; Phosphoproteins; Salivary Glands; Tyrosine	2018
RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model. Scientific reports, 2018, Jul-12, Volume: 8, Issue:1 Topics: Animals; Conjunctiva; Cornea; Cyclosporine; Disease Models, Animal; Dry Eye Syndromes; Female; Goblet Cells; Humans; Inflammation Mediators; Lacrimal Apparatus; Male; Mice; Mice, Inbred NOD; Mucins; Ophthalmic Solutions; Phenylalanine; Polyphosphates; Prescription Drugs; Scopolamine; Sulfones; Tears; Thymosin; Treatment Outcome; Uracil Nucleotides	2018
Inhibiting neutral amino acid transport for the treatment of phenylketonuria. JCI insight, 2018, 07-26, Volume: 3, Issue:14 Topics: Amines; Amino Acid Transport Systems, Neutral; Amino Acids, Neutral; Animals; Astrocytes; Biological Transport; Brain; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Diseases, Inborn; Kidney Tubules, Proximal; Male; Memory, Short-Term; Mice; Mice, Knockout; Morpholinos; Oligonucleotides; Phenylalanine; Phenylketonurias; Renal Reabsorption	2018
Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury. Acta biomaterialia, 2019, Volume: 85 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Gold; Inflammation; Lipopolysaccharides; Metal Nanoparticles; Particle Size; Peptides; Phenylalanine	2019
RNA-Seq analysis in an avian model of maternal phenylketonuria. Molecular genetics and metabolism, 2019, Volume: 126, Issue:1 Topics: Animals; Chickens; Disease Models, Animal; Female; Heart Defects, Congenital; Metabolic Networks and Pathways; Phenotype; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Sequence Analysis, RNA; Transcriptome; Tretinoin; Zygote	2019
Gene Editing Successfully Corrects 2 Amino Acid Disorders: In 2 preclinical studies using CRISPR-mediated gene editing, phenylketonuria and hereditary tyrosinemia type 1 were corrected. American journal of medical genetics. Part A, 2019, Volume: 179, Issue:1 Topics: Amino Acids; Animals; CRISPR-Cas Systems; Disease Models, Animal; Gene Editing; Humans; Hydrolases; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine; Tyrosinemias	2019
A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments. Metabolism: clinical and experimental, 2019, Volume: 94 Topics: Animals; Biopterins; Brain; Disease Models, Animal; GTP Cyclohydrolase; Homozygote; Humans; Liver; Mice; Motor Disorders; Mutant Proteins; Mutation, Missense; Phenylalanine; Survival Rate	2019
Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis. Molecular medicine reports, 2019, Volume: 19, Issue:4 Topics: Animals; Behavior, Animal; Brain Ischemia; Chalcone; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation, Enzymologic; Mice; Mitochondria; Neurons; Neuroprotective Agents; Organelle Biogenesis; Oxidative Stress; PC12 Cells; Phenylalanine; Quinones; Rats; Reperfusion Injury; Treatment Outcome	2019
The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. European journal of heart failure, 2019, Volume: 21, Issue:4 Topics: Amides; Animals; Antibiotics, Antineoplastic; Apoptosis; Butyrates; Butyric Acid; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Echocardiography; Mice; Mice, Inbred C57BL; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Phenylalanine; Protective Agents; Treatment Outcome	2019
Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in phenylketonuria (PKU). PloS one, 2019, Volume: 14, Issue:3 Topics: Age Factors; Animals; Behavior, Animal; Brain; Disease Models, Animal; Female; Learning; Male; Memory; Mice; Mice, Knockout; Neurotransmitter Agents; Nutrients; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2019
Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats. Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174 Topics: Animals; Blood Chemical Analysis; Chromatography, Liquid; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Male; Neurotransmitter Agents; Phenylalanine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Urinalysis	2019
Creatine plus pyruvate supplementation prevents oxidative stress and phosphotransfer network disturbances in the brain of rats subjected to chemically-induced phenylketonuria. Metabolic brain disease, 2019, Volume: 34, Issue:6 Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Creatine; Disease Models, Animal; Energy Metabolism; Oxidative Stress; Phenylalanine; Phenylketonurias; Pyruvic Acid; Rats; Rats, Wistar; Reactive Oxygen Species	2019
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood, 2013, May-02, Volume: 121, Issue:18 Topics: Amino Acid Substitution; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Hematologic Neoplasms; Humans; Interferon-alpha; Janus Kinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutant Proteins; Neoplastic Stem Cells; Phenylalanine; Polycythemia Vera; Valine	2013
In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jun-01, Volume: 19, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Movement; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Humans; Melphalan; Mice; Multiple Myeloma; Neovascularization, Pathologic; Phenylalanine; Tumor Burden; Xenograft Model Antitumor Assays	2013
Involvement of matrix metalloproteinases-2 and -9 in the formation of a lacuna-like cerebral cavity. Journal of neuroscience research, 2013, Volume: 91, Issue:7 Topics: Analysis of Variance; Animals; CD11b Antigen; Disease Models, Animal; Ectodysplasins; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microglia; Minocycline; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Stroke; Stroke, Lacunar; Thiophenes; Time Factors	2013
NOX, the main regulator in oxidative stress in experimental models of phenylketonuria? Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:7-8 Topics: Animals; Disease Models, Animal; Glutathione; Mice; NADPH Oxidases; Oxidative Stress; Phenylalanine; Phenylketonurias; Superoxides	2013
Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. Journal of Crohn's & colitis, 2013, Volume: 7, Issue:11 Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Biopsy, Needle; Cell Adhesion Molecules; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Female; Immunohistochemistry; Integrin alpha4; Male; Mice; Mice, Inbred BALB C; Phenylalanine; Quinazolinones; Random Allocation; Reference Values	2013
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indazoles; Maze Learning; Memory Disorders; Memory, Short-Term; Phenylalanine; Piperazines; Protein Binding; Pyridines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Recognition, Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Sulfides; Time Factors; Tritium; Tropanes; Vortioxetine	2014
Raman spectroscopy detection of molecular changes associated with two experimental models of osteoarthritis in rats. Lasers in medical science, 2014, Volume: 29, Issue:2 Topics: Animals; Cartilage; Collagenases; Disease Models, Animal; Male; Motor Activity; Osteoarthritis; Osteoarthritis, Knee; Phenylalanine; Rats, Wistar; Spectrum Analysis, Raman; Tibia	2014
Characterization of 2-(methylamino)alkanoic acid capacity to restrict blood-brain phenylalanine transport in Pah enu2 mice: preliminary findings. Molecular genetics and metabolism, 2013, Volume: 110 Suppl Topics: Acids, Acyclic; Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Humans; Isoleucine; Large Neutral Amino Acid-Transporter 1; Methylation; Mice; Mice, Transgenic; Molecular Targeted Therapy; Organ Specificity; Phenylalanine; Phenylketonurias; Protein Conformation; Protein Folding; Valine	2013
Carrier-linked mutual prodrugs of biphenylacetic acid as a promising alternative to bioprecursor fenbufen: design, kinetics, and pharmacological studies. Inflammopharmacology, 2014, Volume: 22, Issue:4 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Liberation; Female; Glycine; Humans; Inflammation; Male; Pain; Phenylacetates; Phenylalanine; Phenylbutyrates; Prodrugs; Rats; Rats, Wistar	2014
Man made disease: clinical manifestations of low phenylalanine levels in an inadequately treated phenylketonuria patient and mouse study. Molecular genetics and metabolism, 2013, Volume: 110 Suppl Topics: Alopecia; Animals; Body Weight; Corneal Perforation; Diarrhea, Infantile; Disease Models, Animal; Failure to Thrive; Female; Humans; Infant; Infant Formula; Male; Mice; Phenylalanine; Phenylketonurias; Random Allocation; Tyrosine; Vitamin A Deficiency	2013
Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Exploratory Behavior; Female; Hippocampus; Maze Learning; Memory Disorders; Phenylalanine; Piperazines; Protein Binding; Rats; Rats, Long-Evans; Recognition, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin; Sulfides; Thiophenes; Vortioxetine	2014
4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation. International journal of molecular medicine, 2014, Volume: 33, Issue:2 Topics: Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fenclonine; Hypertension, Pulmonary; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Monocrotaline; Phenylalanine; Pneumonia; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha	2014
Altered brain protein expression profiles are associated with molecular neurological dysfunction in the PKU mouse model. Journal of neurochemistry, 2014, Volume: 129, Issue:6 Topics: Animals; Biomarkers; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Computational Biology; Computer Simulation; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Regulatory Networks; Mice; Nervous System Diseases; Phenylalanine; Phenylketonurias; Protein Biosynthesis; Tandem Mass Spectrometry	2014
Treatment of phenylketonuria using minicircle-based naked-DNA gene transfer to murine liver. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; Disease Models, Animal; DNA, Superhelical; Female; Genetic Therapy; Genetic Vectors; Liver; Male; Mice, Inbred C57BL; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Promoter Regions, Genetic	2014
Dental Anomalies Associated with Craniometaphyseal Dysplasia. Journal of dental research, 2014, Volume: 93, Issue:6 Topics: Acid Phosphatase; Animals; Bone Density; Bone Diseases, Developmental; Cephalometry; Cone-Beam Computed Tomography; Craniofacial Abnormalities; Disease Models, Animal; Gene Knock-In Techniques; Humans; Hyperostosis; Hypertelorism; Isoenzymes; Mandible; Maxilla; Mice; Mutation; Osteoclasts; Phenylalanine; Phosphate Transport Proteins; Sequence Deletion; Skull Base; Tartrate-Resistant Acid Phosphatase; Tooth Abnormalities; Tooth Movement Techniques; Vertical Dimension; X-Ray Microtomography	2014
Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:10 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Attention; Autoradiography; Body Weight; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Learning Disabilities; Male; Phenylalanine; Piperazines; Rats; Rats, Sprague-Dawley; Reversal Learning; Serotonin; Stress, Psychological; Sulfides; Vortioxetine	2014
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. Melanoma research, 2014, Volume: 24, Issue:4 Topics: Animals; Boron Compounds; Cell Line, Tumor; Disease Models, Animal; Heterografts; Humans; Melanoma, Amelanotic; Mice; Mice, Inbred BALB C; Mice, Nude; Phenylalanine; Skin Neoplasms	2014
Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus. PloS one, 2014, Volume: 9, Issue:9 Topics: Animals; Carotenoids; Disease Models, Animal; Female; Fluoresceins; Genes, Bacterial; Intracellular Space; Methicillin; Mice; Nitric Oxide; Nitric Oxide Synthase; Operon; Oxidative Stress; Phenotype; Phenylalanine; Pigmentation; Prephenate Dehydratase; Reactive Nitrogen Species; Sepsis; Staphylococcus aureus; Survival Analysis; Transcription, Genetic; Virulence	2014
Hippocampal synaptic connectivity in phenylketonuria. Human molecular genetics, 2015, Feb-15, Volume: 24, Issue:4 Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Neurons; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Synapses; Synaptic Transmission; Synaptosomal-Associated Protein 25	2015
Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE⁻/⁻ mice with partial carotid ligation. American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Jan-01, Volume: 308, Issue:1 Topics: Animals; Apolipoproteins E; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Chromatography, Liquid; Disease Models, Animal; Ligation; Male; Mass Spectrometry; Metabolomics; Methionine; Mice, Knockout; Phenylalanine; Phosphatidylcholines; Phosphatidylethanolamines; Regional Blood Flow; Sphingomyelins; Time Factors	2015
Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC infectious diseases, 2014, Dec-31, Volume: 14 Topics: Animals; Apoptosis; Blood-Brain Barrier; Cerebellum; Cerebral Hemorrhage; Chemokines; Cytokines; Dentate Gyrus; Disease Models, Animal; Female; Kaplan-Meier Estimate; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Meningitis, Meningococcal; Mice; Phenylalanine; Thiophenes	2014
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN. Blood, 2015, Mar-26, Volume: 125, Issue:13 Topics: Amino Acid Substitution; Animals; Bone Marrow; Bone Marrow Neoplasms; Disease Models, Animal; Disease Progression; Gene Deletion; Hematopoietic Stem Cells; Janus Kinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloproliferative Disorders; Phenylalanine; STAT3 Transcription Factor; Thrombocytosis; Valine	2015
The Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate Cancer Xenograft Model. PloS one, 2015, Volume: 10, Issue:9 Topics: Animals; Apoptosis; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Radiation; Humans; Male; Mice; Mice, Nude; Neutrons; Phenylalanine; Prostatic Neoplasms; Xenograft Model Antitumor Assays	2015
Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection. Journal of pharmaceutical and biomedical analysis, 2016, Jan-05, Volume: 117 Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Kynurenine; Phenylalanine; Rats; Rats, Inbred SHR; Rats, Transgenic; Tandem Mass Spectrometry; Tauopathies; Tryptophan; Tyrosine	2016
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Investigative ophthalmology & visual science, 2015, Volume: 56, Issue:10 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Biomarkers; Cell Adhesion; Cells, Cultured; Cornea; Dendritic Cells; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Integrin alpha Chains; Integrin alpha4; Integrin alpha4beta1; Leukocytes; Mice; Mice, Inbred C57BL; Organic Chemicals; Phenylalanine; Piperidines; Vascular Cell Adhesion Molecule-1	2015
Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles. Circulation research, 2015, Nov-06, Volume: 117, Issue:11 Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Chemistry, Pharmaceutical; Disease Models, Animal; Disease Progression; Drug Carriers; Elastin; Immunoconjugates; Macrophages; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Nanoparticles; Phenylalanine; Polyesters; Proteolysis; Rats, Sprague-Dawley; RAW 264.7 Cells; Thiophenes; Time Factors; Vascular Calcification	2015
Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin α4 antagonist GW559090. Experimental eye research, 2016, Volume: 143 Topics: Administration, Topical; Animals; Cell Count; Dexamethasone; Disease Models, Animal; Dry Eye Syndromes; Fluorescein; Glucocorticoids; Goblet Cells; Integrin alpha4beta1; Interleukin-1beta; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Ophthalmic Solutions; Phenylalanine; Piperidines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sjogren's Syndrome; Staining and Labeling; Thrombospondin 1	2016
Large Neutral Amino Acid Supplementation Exerts Its Effect through Three Synergistic Mechanisms: Proof of Principle in Phenylketonuria Mice. PloS one, 2015, Volume: 10, Issue:12 Topics: Amino Acids, Neutral; Animals; Brain; Dietary Supplements; Disease Models, Animal; Dopamine; Female; Male; Mice; Neurocognitive Disorders; Phenylalanine; Phenylketonurias; Serotonin	2015
High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Molecular genetics and metabolism, 2016, Volume: 117, Issue:1 Topics: Administration, Oral; Animals; Biopterins; Brain; Disease Models, Animal; Dopamine; Genotype; Homovanillic Acid; Humans; Indoles; Mice; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Serotonin; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase	2016
DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAH(enu2) mouse model of phenylketonuria. Molecular genetics and metabolism, 2016, Volume: 119, Issue:1-2 Topics: Animals; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA Methylation; Gene Expression Regulation; Genomic Imprinting; Humans; Intercellular Signaling Peptides and Proteins; Iodide Peroxidase; Liver; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Promoter Regions, Genetic; RNA, Untranslated	2016
Phenylketonuria: Direct and indirect effects of phenylalanine. Experimental neurology, 2016, Volume: 281 Topics: Animals; Cells, Cultured; Cofilin 1; Dendrites; Disease Models, Animal; Embryo, Mammalian; Entorhinal Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mutation; N-Methylaspartate; Neurons; Phagocytosis; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; rac1 GTP-Binding Protein; Synapses	2016
A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy. Scientific reports, 2016, 05-05, Volume: 6 Topics: Angiogenesis Inhibitors; Animals; Antibodies, Neutralizing; Biological Assay; Choroid; Choroidal Neovascularization; Chromones; Disease Models, Animal; Drug Combinations; Drug Synergism; Female; Gene Expression; Humans; Intravitreal Injections; Larva; Mice; Mice, Inbred C57BL; Phenylalanine; Retina; Tissue Culture Techniques; Vascular Endothelial Growth Factor A; Zebrafish	2016
Effects of DA-Phen, a dopamine-aminoacidic conjugate, on alcohol intake and forced abstinence. Behavioural brain research, 2016, 09-01, Volume: 310 Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Anxiety; Central Nervous System Depressants; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agents; Drug-Seeking Behavior; Ethanol; Male; Phenylalanine; Rats, Wistar; Recurrence; Self Administration	2016
Drug development: A healthy pipeline. Nature, 2016, 05-19, Volume: 533, Issue:7603 Topics: Animals; Benzimidazoles; Benzofurans; Bile Acids and Salts; Carbolines; Colesevelam Hydrochloride; Colestipol; Disease Models, Animal; Enteric Nervous System; Female; Humans; Imidazoles; Indoles; Irritable Bowel Syndrome; Loperamide; Lubiprostone; Male; Mice; Natriuretic Peptides; Peptides; Phenylalanine; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Rifamycins; Rifaximin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Visceral Pain	2016
Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria. ACS infectious diseases, 2016, 11-11, Volume: 2, Issue:11 Topics: Animals; Aorta; Arginine; Biopterins; Brain; Disease Models, Animal; Humans; Malaria; Mice; Mice, Inbred C57BL; Nitric Oxide; Phenylalanine; Plasmodium berghei	2016
Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model. The American journal of clinical nutrition, 2016, Volume: 104, Issue:5 Topics: Amino Acids, Neutral; Animals; Brain; Diet; Dietary Supplements; Disease Models, Animal; Dopamine; Female; Male; Mice; Mice, Knockout; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Serotonin	2016
DCoH: A novel biomarker for diagnosing acute kidney injury. Medical hypotheses, 2016, Volume: 95 Topics: Acute Kidney Injury; Animals; Biomarkers; Cell Line; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Humans; Hydro-Lyases; Models, Theoretical; Phenylalanine; Prognosis	2016
Multicompartment analysis of protein-restricted phenylketonuric mice reveals amino acid imbalances in brain. Journal of inherited metabolic disease, 2017, Volume: 40, Issue:2 Topics: Amino Acids; Animals; Brain; Diet, Protein-Restricted; Disease Models, Animal; Mice; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2017
Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis. Osteoarthritis and cartilage, 2017, Volume: 25, Issue:4 Topics: ADAMTS5 Protein; Animals; Cartilage, Articular; Disease Models, Animal; Glucosamine; I-kappa B Kinase; Inflammation; Injections, Intra-Articular; Knee Joint; Male; Matrix Metalloproteinase 10; Matrix Metalloproteinase 13; Menisci, Tibial; Mice; Organ Size; Osteoarthritis, Knee; Phenylalanine	2017
CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem cell research & therapy, 2017, 02-07, Volume: 8, Issue:1 Topics: Animals; Animals, Newborn; Benzamides; Brain; Brain Injuries; Carotid Arteries; Cell Movement; Cell Proliferation; Cerebrovascular Disorders; Chemokine CCL11; Chemokines, CC; Disease Models, Animal; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred NOD; Mice, SCID; Neural Stem Cells; Phenylalanine; Primary Cell Culture; Receptors, CCR3	2017
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice. Fundamental & clinical pharmacology, 2017, Volume: 31, Issue:4 Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice; Neurotransmitter Agents; Phenylalanine; Psychomotor Agitation; Seizures; Serotonin; Valproic Acid	2017
miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nature neuroscience, 2008, Volume: 11, Issue:10 Topics: Animals; Ataxin-1; Ataxins; Cell Line, Transformed; Cerebellum; Disease Models, Animal; Gene Expression Regulation; Glutamine; Green Fluorescent Proteins; Humans; Mice; Mice, Transgenic; MicroRNAs; Nerve Tissue Proteins; Nuclear Proteins; Phenylalanine; Purkinje Cells; RNA, Small Interfering; Spinocerebellar Ataxias; Time Factors; Transfection; Trinucleotide Repeat Expansion	2008
The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain, 2009, Volume: 141, Issue:1-2 Topics: Analgesics; Animals; Disease Models, Animal; Disulfides; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Methyl Ethers; Mice; Pain Measurement; Pain Threshold; Pain, Postoperative; Phenylalanine; Piperidines; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Remifentanil; RNA, Messenger; Sevoflurane; Spinal Cord; Time Factors	2009
TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia. Experimental neurology, 2009, Volume: 216, Issue:1 Topics: ADAM Proteins; ADAM17 Protein; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; Phenylalanine; Receptors, Tumor Necrosis Factor, Type I; Reperfusion Injury; Thiophenes; Tissue Inhibitor of Metalloproteinase-3; Tumor Necrosis Factor-alpha	2009
Insight into the mechanisms underlying tumor response to boron neutron capture therapy in the hamster cheek pouch oral cancer model. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2009, Volume: 38, Issue:5 Topics: Animals; Apoptosis; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; DNA, Neoplasm; Drug Carriers; In Situ Nick-End Labeling; Mesocricetus; Mouth Neoplasms; Neoplasms, Experimental; Phenylalanine; Radiation Dosage; Radiation-Sensitizing Agents; Radiopharmaceuticals	2009
Pharmacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model for type 2 diabetes mellitus. Chirality, 2010, Volume: 22, Issue:1 Topics: Animals; Cyclohexanes; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Male; Nateglinide; Phenylalanine; Rats; Rats, Wistar; Stereoisomerism	2010
Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2009, Volume: 67, Issue:7-8 Suppl Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Disease Models, Animal; In Vitro Techniques; Lung Neoplasms; Phenylalanine; Radiation Tolerance; Radiation-Sensitizing Agents; Rats	2009
5-Hydroxytryptophan rescues serotonin response to stress in prefrontal cortex of hyperphenylalaninaemic mice. The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:8 Topics: 5-Hydroxytryptophan; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Diet, Reducing; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Mice; Microdialysis; Neuraminidase; Norepinephrine; Phenylalanine; Phenylketonurias; Prefrontal Cortex; Serotonin; Time Factors; Tryptophan Hydroxylase	2009
Mechanisms of toxic smoke inhalation and burn injury: role of neutral endopeptidase and vascular leakage in mice. Toxicology mechanisms and methods, 2009, Volume: 19, Issue:3 Topics: Animals; Burns; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neprilysin; Organophosphonates; Phenylalanine; Protease Inhibitors; Pulmonary Edema; Smoke Inhalation Injury	2009
Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:4 Topics: Animals; Caspase 3; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Ischemic Attack, Transient; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Phenylalanine; Thiophenes; Time Factors	2010
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. The EMBO journal, 2009, Dec-02, Volume: 28, Issue:23 Topics: Animals; Cell Line; Depression; Disease Models, Animal; Down-Regulation; Gene Knock-In Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenylalanine; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tyrosine	2009
Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid. Experimental & molecular medicine, 2010, Feb-28, Volume: 42, Issue:2 Topics: Animals; Brain Stem; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Liver; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 3; Organ Specificity; p38 Mitogen-Activated Protein Kinases; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Phenylpyruvic Acids; Prealbumin	2010
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit. British journal of pharmacology, 2009, Volume: 158, Issue:8 Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Endothelin-1; Gait Disorders, Neurologic; Glutamic Acid; Male; Pentylenetetrazole; Phenylalanine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Seizures; Stroke	2009
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovascular research, 2010, Jul-01, Volume: 87, Issue:1 Topics: Animals; Antigens, CD; Apolipoproteins E; Apoptosis; Atherosclerosis; Cadherins; Caspase 3; Cells, Cultured; Disease Models, Animal; Fas Ligand Protein; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenylalanine; Protease Inhibitors; Recombinant Proteins; Rupture; Thiophenes; Time Factors	2010
Oligodendrocyte development and myelinogenesis are not impaired by high concentrations of phenylalanine or its metabolites. Journal of inherited metabolic disease, 2010, Volume: 33, Issue:2 Topics: Animals; Cells, Cultured; Corpus Callosum; Disease Models, Animal; Lac Operon; Mice; Mice, Mutant Strains; Mice, Transgenic; Myelin Basic Protein; Myelin Sheath; Oligodendroglia; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Promoter Regions, Genetic; Rats; Rats, Wistar	2010
Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo. Human molecular genetics, 2010, May-15, Volume: 19, Issue:10 Topics: Amino Acid Substitution; Animals; Biopterins; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Humans; Hydroxylation; Kinetics; Mice; Molecular Chaperones; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Quaternary	2010
[Protective role of MMP-9 inhibitor batimastat in acute lung injury after cardiopulmonary bypass]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2010, Jan-01, Volume: 48, Issue:1 Topics: Acute Lung Injury; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Dogs; Lung; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phenylalanine; Postoperative Complications; Thiophenes	2010
Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice. The American journal of pathology, 2010, Volume: 177, Issue:1 Topics: Animals; Disease Models, Animal; Dystrophin; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Phenylalanine; Protease Inhibitors; Thiophenes; Transcription Factor AP-1	2010
New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Biochemical pharmacology, 2010, Nov-15, Volume: 80, Issue:10 Topics: Animals; Biopterins; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Heterozygote; Mice; Mice, Mutant Strains; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Treatment Outcome; Tyrosine	2010
A novel strategy for development of glucocorticoids through non-genomic mechanism. Cellular and molecular life sciences : CMLS, 2011, Volume: 68, Issue:8 Topics: Animals; Cell Line; Disease Models, Animal; Genome; Glucocorticoids; Guinea Pigs; Histamine; Humans; Hydrocortisone; Male; Mast Cells; Molecular Structure; Neutrophils; Peroxidase; Phenylalanine; Rats; Time Factors	2011
Combination therapy with nateglinide and telmisartan ameliorates insulin resistance in zucker Fatty rats by suppressing advanced glycation end product receptor axis. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2011, Volume: 43, Issue:3 Topics: Animals; Benzimidazoles; Benzoates; Cyclohexanes; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Glycation End Products, Advanced; Humans; Insulin Resistance; Liver; Male; Nateglinide; Phenylalanine; Rats; Rats, Zucker; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Telmisartan	2011
Boron uptake measurements in a rat model for Boron Neutron Capture Therapy of lung tumours. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2011, Volume: 69, Issue:2 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; Lung Neoplasms; Phenylalanine; Rats	2011
CCR3 and choroidal neovascularization. PloS one, 2011, Feb-15, Volume: 6, Issue:2 Topics: Animals; Antibodies, Neutralizing; Choroidal Neovascularization; Collagen; Disease Models, Animal; Drug Combinations; Laminin; Mice; Mice, Inbred BALB C; Models, Biological; Molecular Targeted Therapy; Naphthalenes; Phenylalanine; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptors, CCR3; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A	2011
Validation of an amino-acid-based radionuclide therapy plus external beam radiotherapy in heterotopic glioblastoma models. Nuclear medicine and biology, 2011, Volume: 38, Issue:4 Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Glioblastoma; Humans; Iodine Radioisotopes; Mice; Phenylalanine; Radiotherapy; Rats; Transplantation, Heterotopic	2011
Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiology of aging, 2012, Volume: 33, Issue:3 Topics: Animals; Disease Models, Animal; Genetic Carrier Screening; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mutation; Phenylalanine; Phosphorylation; Presbycusis; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ret; Spiral Ganglion; Tyrosine; Up-Regulation	2012
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. Journal of proteome research, 2011, Sep-02, Volume: 10, Issue:9 Topics: Alcohols; Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; Indoles; Lactates; Liver Diseases, Alcoholic; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Knockout; Phenylalanine; PPAR alpha; Principal Component Analysis; Taurine; Tryptophan	2011
Boron Neutron Capture Therapy (BNCT) in an oral precancer model: therapeutic benefits and potential toxicity of a double application of BNCT with a six-week interval. Oral oncology, 2011, Volume: 47, Issue:11 Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; DNA; Mouth Neoplasms; Mucositis; Phenylalanine; Precancerous Conditions; Radiation Injuries, Experimental; Treatment Outcome	2011
Regular exercise prevents oxidative stress in the brain of hyperphenylalaninemic rats. Metabolic brain disease, 2011, Volume: 26, Issue:4 Topics: Animals; Antioxidants; Brain Chemistry; Catalase; Disease Models, Animal; Glutathione Peroxidase; Glycogen; Muscle, Skeletal; Oxidative Stress; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2011
Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles: a group of urokinase inhibitors, their synthesis, and stereochemistry-dependent activity. ChemMedChem, 2011, Dec-09, Volume: 6, Issue:12 Topics: Animals; Antifibrinolytic Agents; Blood Proteins; Disease Models, Animal; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Indoles; Male; Mice; Mice, Inbred ICR; Phenylalanine; Rats; Rats, Wistar; Stereoisomerism; Thrombosis; Urokinase-Type Plasminogen Activator	2011
Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer. Radiation research, 2012, Volume: 177, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Blood Vessels; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Radiation; Mouth Neoplasms; Phenylalanine; Thalidomide; Treatment Outcome	2012
Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy. Neuroreport, 2012, Jan-04, Volume: 23, Issue:1 Topics: Animals; Brain; Catecholamines; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Liver; Mice; Mice, Transgenic; Neurotransmitter Agents; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Serotonin	2012
Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of ethnopharmacology, 2012, Jan-06, Volume: 139, Issue:1 Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Density; Bone Density Conservation Agents; Chromatography, Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Femur; Lysophosphatidylcholines; Metabolomics; Osteocalcin; Osteoporosis; Phenylalanine; Polypodiaceae; Prednisolone; Protein Carbonylation; Rats; Rats, Wistar; Rhizome; Tandem Mass Spectrometry; Tibia; Tryptophan	2012
Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood, 2012, Apr-12, Volume: 119, Issue:15 Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Gene Knock-In Techniques; Genes, Lethal; HEK293 Cells; Humans; Janus Kinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Phenylalanine; Polycythemia Vera; STAT5 Transcription Factor; Valine	2012
A new mouse model for the slow-channel congenital myasthenic syndrome induced by the AChR εL221F mutation. Neurobiology of disease, 2012, Volume: 45, Issue:3 Topics: Acetylcholinesterase; Aminophenols; Animals; Biophysics; Diaphragm; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Hand Strength; Humans; In Vitro Techniques; Isoleucine; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Miniature Postsynaptic Potentials; Motor Endplate; Mutagenesis; Myasthenic Syndromes, Congenital; Neurofilament Proteins; Neuromuscular Junction; Patch-Clamp Techniques; Phenylalanine; Receptors, Nicotinic; S100 Proteins; Synaptophysin; Time Factors	2012
What is the role of CCR3 in choroidal neovascularization? Advances in experimental medicine and biology, 2012, Volume: 723 Topics: Animals; Antibodies, Neutralizing; Biocompatible Materials; Choroidal Neovascularization; Collagen; Disease Models, Animal; Drug Combinations; Laminin; Macular Degeneration; Mice; Mice, Inbred BALB C; Naphthalenes; Phenylalanine; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptors, CCR3	2012
Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism. FEBS letters, 2012, Apr-05, Volume: 586, Issue:7 Topics: Animals; Autistic Disorder; Bacterial Proteins; Biomarkers; Chlorogenic Acid; Clostridium; Disease Models, Animal; Fungal Proteins; Glycine; Hippurates; Humans; Intestines; Phenylalanine; Phenylalanine Ammonia-Lyase; Rats; Stereoisomerism; Systems Biology; Tryptophan; Tyrosine; Yeasts	2012
Reversal of metabolic and neurological symptoms of phenylketonuric mice treated with a PAH containing helper-dependent adenoviral vector. Current gene therapy, 2012, Feb-01, Volume: 12, Issue:1 Topics: Adenoviridae; Animals; Disease Models, Animal; Electrophysiology; Genetic Therapy; Genetic Vectors; Humans; Learning Disabilities; Mice; N-Methylaspartate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pigmentation; Tyrosine	2012
The mechanism of BH4 -responsive hyperphenylalaninemia--as it occurs in the ENU1/2 genetic mouse model. Human mutation, 2012, Volume: 33, Issue:10 Topics: Animals; Biopterins; Disease Models, Animal; Female; Hydroxylation; Male; Mice; Mice, Mutant Strains; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2012
Cure of hookworm infection with a cysteine protease inhibitor. PLoS neglected tropical diseases, 2012, Volume: 6, Issue:7 Topics: Administration, Oral; Ancylostoma; Animals; Anthelmintics; Cricetinae; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Female; Hookworm Infections; Larva; Male; Mesocricetus; Phenylalanine; Piperazines; Sulfones; Survival Analysis; Tosyl Compounds; Treatment Outcome; Vinyl Compounds; Zygote	2012
Cardiac teratogenicity in mouse maternal phenylketonuria: defining phenotype parameters and genetic background influences. Molecular genetics and metabolism, 2012, Volume: 107, Issue:4 Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Female; Genetic Association Studies; Heart Defects, Congenital; Heart Valves; Humans; Male; Mice; Mice, Transgenic; Phenotype; Phenylalanine; Phenylketonuria, Maternal; Pregnancy	2012
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes. Journal of the American Chemical Society, 2012, Oct-31, Volume: 134, Issue:43 Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Obese; Models, Molecular; Molecular Structure; Phenylalanine; Protein Tyrosine Phosphatases, Non-Receptor	2012
Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2013, Volume: 29, Issue:4 Topics: Animals; CD11a Antigen; CD18 Antigens; Contact Lenses; Cornea; Corneal Stroma; Disease Models, Animal; Eye Infections, Bacterial; Inflammation; Lymphocyte Function-Associated Antigen-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neutrophil Infiltration; Phenylalanine; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections; Staphylococcus aureus; Sulfones	2013
Role of catalase and superoxide dismutase activities on oxidative stress in the brain of a phenylketonuria animal model and the effect of lipoic acid. Cellular and molecular neurobiology, 2013, Volume: 33, Issue:2 Topics: Animals; Brain; Catalase; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Female; Lipid Peroxidation; Male; Oxidative Stress; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid	2013
RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice. Molecular psychiatry, 2013, Volume: 18, Issue:6 Topics: Aggression; Animals; Anxiety; Bioluminescence Resonance Energy Transfer Techniques; Brain; Defense Mechanisms; Disease Models, Animal; Gene Expression Regulation; Glycine; HEK293 Cells; Humans; Hydroxyindoleacetic Acid; Interpersonal Relations; Mice; Mice, Inbred C57BL; Mutation; Phenylalanine; Protein Binding; Protein Isoforms; Receptor, Serotonin, 5-HT2C; RNA Editing; RNA Precursors; RNA Splicing; RNA, Messenger; Transfection; Ultrasonics; Valine	2013
The phenylketonuria mouse model: a meeting review. Molecular genetics and metabolism, 2002, Volume: 76, Issue:4 Topics: Animals; Disease Models, Animal; Genetic Therapy; Mice; Neurochemistry; Phenylalanine; Phenylketonurias	2002
Oxidative stress induced by phenylketonuria in the rat: Prevention by melatonin, vitamin E, and vitamin C. Journal of neuroscience research, 2002, Aug-15, Volume: 69, Issue:4 Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Brain; Cerebellum; Disease Models, Animal; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Lipid Peroxidation; Melatonin; Nervous System Malformations; Neurons; Oxidative Stress; Phenylalanine; Phenylketonurias; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Vitamin E	2002
Elevated plasma phenylalanine concentrations may adversely affect bone status of phenylketonuric mice. Journal of inherited metabolic disease, 2002, Volume: 25, Issue:5 Topics: Animals; Biomarkers; Bone Density; Bone Resorption; Diet; Disease Models, Animal; Femoral Fractures; Femur; Fractures, Bone; Male; Mice; Organ Size; Osteocalcin; Phenylalanine; Phenylketonurias; Weight Gain	2002
MMP inhibition and the development of cerebrovascular atherosclerosis: The road ahead. Stroke, 2002, Volume: 33, Issue:12 Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Female; Glycine; Hemodynamics; Humans; Hydroxamic Acids; Infarction, Middle Cerebral Artery; Intracranial Arteriosclerosis; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Phenylalanine; Thiophenes; Treatment Outcome	2002
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. The Journal of biological chemistry, 2003, Apr-04, Volume: 278, Issue:14 Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3	2003
Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2003, Volume: 7, Issue:2 Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Chi-Square Distribution; Disease Models, Animal; Drug Therapy, Combination; Endothelial Growth Factors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Matrix Metalloproteinases; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenylalanine; Probability; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria. Biochemical pharmacology, 2003, Mar-01, Volume: 65, Issue:5 Topics: Animals; Calpain; Disease Models, Animal; Enzyme Inhibitors; In Vitro Techniques; Mitochondria, Heart; Phenylalanine; Rabbits; Reperfusion Injury	2003
The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria. Behavior genetics, 2003, Volume: 33, Issue:3 Topics: Animals; Disease Models, Animal; Emotions; Exploratory Behavior; Genotype; Heterozygote; Homozygote; Humans; Intellectual Disability; Maze Learning; Mice; Mice, Inbred Strains; Phenylalanine; Phenylketonurias; Space Perception	2003
Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke, 2003, Volume: 34, Issue:8 Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Wistar; Recombinant Proteins; Reperfusion; Sucrose; Survival Rate; Thiophenes; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Water	2003
Relationship between myelin production and dopamine synthesis in the PKU mouse brain. Journal of neurochemistry, 2003, Volume: 86, Issue:3 Topics: Animals; Blotting, Western; Brain; Brain Chemistry; Corpus Striatum; Disease Models, Animal; Dopamine; Food, Formulated; Frontal Lobe; Male; Mice; Mice, Mutant Strains; Myelin Basic Protein; Myelin Sheath; Neurofilament Proteins; Phenylalanine; Phenylketonurias; Phosphorylation; Tyrosine; Tyrosine 3-Monooxygenase	2003
Future role of large neutral amino acids in transport of phenylalanine into the brain. Pediatrics, 2003, Volume: 112, Issue:6 Pt 2 Topics: Amino Acids, Neutral; Animals; Biological Transport; Blood-Brain Barrier; Brain; Disease Models, Animal; Energy Metabolism; Mice; Mice, Mutant Strains; Phenylalanine; Phenylketonurias	2003
Analysis of boron-10 in soft tissue by dynamic secondary ion mass spectrometry. Journal of microscopy, 2004, Volume: 213, Issue:1 Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain; Brain Neoplasms; Disease Models, Animal; Glioblastoma; Gliosarcoma; Humans; Isotopes; Mice; Phenylalanine; Rats; Spectrometry, Mass, Secondary Ion; Tumor Cells, Cultured	2004
Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-21, Volume: 24, Issue:3 Topics: Animals; Dipeptides; Disease Models, Animal; Disease Progression; Hippocampus; Immunohistochemistry; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Phenylalanine; Protease Inhibitors; Thiophenes	2004
Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists. Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3 Topics: Amino Acids; Animals; Antibodies, Monoclonal; Antigens, Helminth; Ascaris; Asthma; Aza Compounds; Bronchi; Disease Models, Animal; Hypersensitivity; Integrin alpha4beta1; Integrins; Molecular Conformation; Molecular Structure; Phenylalanine; Sheep; Structure-Activity Relationship; Sulfonamides	2004
Comparison of voglibose and nateglinide for their acute effects on insulin secretion and free fatty acid levels in OLETF rat portal blood after sucrose loading. Endocrine, 2004, Volume: 23, Issue:1 Topics: Animals; Area Under Curve; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, Nonesterified; Hypoglycemic Agents; Inositol; Insulin; Insulin Secretion; Male; Nateglinide; Phenylalanine; Portal Vein; Postprandial Period; Rats; Rats, Inbred OLETF; Secretory Rate; Sucrose	2004
Neuroprotective action of halogenated derivatives of L-phenylalanine. Stroke, 2004, Volume: 35, Issue:5 Topics: Animals; Disease Models, Animal; In Vitro Techniques; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stroke; Synaptic Transmission; Tyrosine	2004
Plasma phenylalanine concentrations are associated with hepatic iron content in a murine model for phenylketonuria. Molecular genetics and metabolism, 2004, Volume: 82, Issue:1 Topics: Animals; Copper; Dietary Proteins; Disease Models, Animal; Feces; Intestinal Mucosa; Intestines; Iron; Liver; Male; Mice; Organ Size; Phenylalanine; Phenylketonurias; Zinc	2004
Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Journal of inherited metabolic disease, 2004, Volume: 27, Issue:2 Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Tyrosine	2004
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes, 2004, Volume: 53, Issue:6 Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chromosome Mapping; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Glucokinase; Glucose; Glucose Intolerance; Heterozygote; Homozygote; Isoleucine; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenylalanine; Phosphorylation; Thymine	2004
Pharmacologic preconditioning of JTE-607, a novel cytokine inhibitor, attenuates ischemia-reperfusion injury in the myocardium. The Journal of thoracic and cardiovascular surgery, 2004, Volume: 127, Issue:6 Topics: Animals; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Phenylalanine; Piperazines; Probability; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Survival Rate	2004
Long-term enzymatic and phenotypic correction in the phenylketonuria mouse model by adeno-associated virus vector-mediated gene transfer. Pediatric research, 2004, Volume: 56, Issue:2 Topics: Animals; Cell Line; Dependovirus; Diet Therapy; Disease Models, Animal; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hair Color; Humans; Liver; Male; Mice; Mice, Knockout; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2004
Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 2 Topics: Animals; Blotting, Western; Brain; Cells, Cultured; Chromatography, Liquid; Disease Models, Animal; Humans; Mass Spectrometry; Mice; Patch-Clamp Techniques; Phenylalanine; Phenylketonurias; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2005
Radioiodinated phenylalanine derivatives to image pancreatic cancer: a comparative study with [18F]fluoro-2-deoxy-D-glucose in human pancreatic carcinoma xenografts and in inflammation models. Nuclear medicine and biology, 2005, Volume: 32, Issue:2 Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Inflammation; Iodine Radioisotopes; Metabolic Clearance Rate; Mice; Mice, SCID; Organ Specificity; Pancreatic Neoplasms; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Transplantation, Heterologous	2005
Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models. Thrombosis and haemostasis, 2005, Volume: 93, Issue:3 Topics: Administration, Oral; Animals; Anticoagulants; Arginine; Blood Coagulation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fibrinolytic Agents; Injections, Subcutaneous; Male; Nadroparin; Phenylalanine; Pipecolic Acids; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombophilia; Vena Cava, Inferior; Venous Thrombosis	2005
In vivo characterization of 123/125I-2-iodo-L-phenylalanine in an R1M rhabdomyosarcoma athymic mouse model as a potential tumor tracer for SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:3 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Feasibility Studies; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Mice; Mice, Nude; Organ Specificity; Phenylalanine; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyosarcoma; Tissue Distribution	2005
Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aspartic Acid Endopeptidases; Benzazepines; Benzofurans; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin-Converting Enzymes; Heart Rate; Hypertension; Infusions, Intra-Arterial; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Phenylalanine; Rats; Rats, Inbred SHR; Time Factors	2004
Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26 Topics: alpha-Crystallins; Angiography; Animals; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Crystallins; Disease Models, Animal; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Ethylnitrosourea; Fluorescein; gamma-Crystallins; Genetic Linkage; Homozygote; Immunohistochemistry; Isoleucine; Lens, Crystalline; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Mutation, Missense; Phenotype; Phenylalanine; Protein Binding; Recombinant Proteins; Retinal Vessels; Sequence Analysis, DNA; Ultraviolet Rays	2005
Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin. Experimental dermatology, 2005, Volume: 14, Issue:7 Topics: Animals; Base Sequence; Disease Models, Animal; DNA, Complementary; Gene Expression; Genetic Engineering; Genetic Therapy; GTP Cyclohydrolase; Humans; Keratin-14; Keratins; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Promoter Regions, Genetic; Protein Precursors; Skin	2005
Low therapeutic threshold for hepatocyte replacement in murine phenylketonuria. Molecular therapy : the journal of the American Society of Gene Therapy, 2005, Volume: 12, Issue:2 Topics: Animals; Disease Models, Animal; Hepatocytes; Liver; Mice; Mice, Mutant Strains; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2005
L-[1-13C] phenylalanine breath test results reflect the activity of phenylalanine hydroxylase in carbon tetrachloride acute injured rat liver. Life sciences, 2006, Jan-18, Volume: 78, Issue:8 Topics: Acute Disease; Animals; Breath Tests; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Rats; Rats, Sprague-Dawley	2006
Reversal of gene expression profile in the phenylketonuria mouse model after adeno-associated virus vector-mediated gene therapy. Molecular genetics and metabolism, 2005, Volume: 86 Suppl 1 Topics: Animals; Dependovirus; Disease Models, Animal; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Mice; Mice, Mutant Strains; Oligonucleotide Array Sequence Analysis; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Transgenes; Up-Regulation	2005
Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats. Fundamental & clinical pharmacology, 2005, Volume: 19, Issue:5 Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glutathione; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Lipids; Liver; Male; Metformin; Phenylalanine; Rats; Rats, Wistar; Streptozocin; Thiobarbituric Acid Reactive Substances	2005
Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C. Neuroscience letters, 2006, Jan-09, Volume: 392, Issue:1-2 Topics: Aldehydes; Animals; Animals, Newborn; Ascorbic Acid; Disease Models, Animal; Drug Interactions; Female; Male; Malondialdehyde; Melatonin; Mitochondrial Diseases; Phenethylamines; Phenylalanine; Phenylketonurias; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Time Factors; Vitamin A	2006
In vivo evaluation and dosimetry of 123I-2-iodo-D-phenylalanine, a new potential tumor-specific tracer for SPECT, in an R1M rhabdomyosarcoma athymic mouse model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:12 Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Cluster Analysis; Disease Models, Animal; Evaluation Studies as Topic; Humans; Image Processing, Computer-Assisted; Inflammation; Iodine Radioisotopes; Kinetics; Male; Mice; Mice, Nude; Phenylalanine; Radiation Dosage; Radiometry; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyosarcoma; Time Factors; Tomography, Emission-Computed, Single-Photon	2005
A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. British journal of pharmacology, 2006, Volume: 147, Issue:6 Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Regulation; Integrin alpha4beta1; Integrins; Interleukin-4; Interleukin-5; Leukocyte Rolling; Leukocytes; Lung; Male; Mesenteric Veins; Ovalbumin; Phenylalanine; Pneumonia; Rats; Rats, Inbred BN; RNA, Messenger; Serotonin	2006
Influence of sedation and data acquisition method on tracer uptake in animal models: [123I]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice. Nuclear medicine and biology, 2006, Volume: 33, Issue:1 Topics: Animals; Artifacts; Cell Line, Tumor; Disease Models, Animal; Hypnotics and Sedatives; Image Interpretation, Computer-Assisted; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Mice; Mice, Nude; Organ Specificity; Pentobarbital; Phenylalanine; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Rhabdomyosarcoma; Sensitivity and Specificity; Tissue Distribution	2006
A murine model for human sepiapterin-reductase deficiency. American journal of human genetics, 2006, Volume: 78, Issue:4 Topics: Alcohol Oxidoreductases; Animals; Base Sequence; Biopterins; Catecholamines; Disease Models, Animal; DNA Primers; Growth; Humans; Immunohistochemistry; Locomotion; Metabolism, Inborn Errors; Mice; Mice, Knockout; Phenotype; Phenylalanine; Serotonin	2006
Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:2 Topics: Amino Acids; Animals; Carboxylic Acids; Cartilage; Disease Models, Animal; Humans; Hydroxamic Acids; Iodoacetates; Knee Joint; Male; Matrix Metalloproteinase Inhibitors; Molecular Structure; Osteoarthritis; Phenylalanine; Plasma; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones	2006
EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma. The Journal of surgical research, 2006, Volume: 135, Issue:1 Topics: Adenocarcinoma; Animals; Cell Division; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenylalanine; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Survival Rate; Thiophenes	2006
Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): chemical analyses in the hamster cheek pouch oral cancer model. Archives of oral biology, 2006, Volume: 51, Issue:10 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Borohydrides; Boron Compounds; Boron Neutron Capture Therapy; Cheek; Cricetinae; Disease Models, Animal; Mesocricetus; Mouth Mucosa; Mouth Neoplasms; Phenylalanine; Precancerous Conditions	2006
JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Experimental hematology, 2006, Volume: 34, Issue:10 Topics: Animals; Autocrine Communication; Cell Proliferation; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Interleukin-8; Leukemia, Myeloid, Acute; Leukocyte Common Antigens; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Paracrine Communication; Phenylalanine; Piperazines; Transplantation, Heterologous	2006
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels. Vascular pharmacology, 2007, Volume: 46, Issue:2 Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Carbamates; Cyclohexanes; Disease Models, Animal; Drug Interactions; Endotoxemia; Glyburide; Heart Atria; Heart Conduction System; Lipopolysaccharides; Male; Myocardial Ischemia; Nateglinide; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Tetraethylammonium; Time Factors; Ventricular Fibrillation; Ventricular Premature Complexes	2007
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice. Brain research, 2007, Jan-05, Volume: 1127, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Biogenic Monoamines; Corpus Striatum; Dependovirus; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Male; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Neural Pathways; Neurodegenerative Diseases; Neuroglia; Neurons; Oxidative Stress; Phenylalanine; Phenylketonurias; Substantia Nigra; Treatment Outcome	2007
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents. Brain research, 2007, Feb-16, Volume: 1133, Issue:1 Topics: Animals; Benzyl Compounds; Blood-Brain Barrier; Dexamethasone; Dimethyl Sulfoxide; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Encephalitis; Endothelial Cells; Enzyme Inhibitors; Genetic Variation; Heterocyclic Compounds, 1-Ring; Inflammation Mediators; Lipopolysaccharides; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Pentoxifylline; Phenylalanine; Rats; Rats, Inbred WKY; Solvents; Species Specificity; Succinates; Sulfones; Thiophenes	2007
Preproenkephalin knockout mice show no depression-related phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:11 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Hindlimb Suspension; Immobility Response, Tonic; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nialamide; Phenotype; Phenylalanine; Protein Precursors; Swimming; Vocalization, Animal	2007
Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels. Epilepsia, 2007, Volume: 48, Issue:6 Topics: Acoustic Stimulation; Age Factors; Animals; Circadian Rhythm; Disease Models, Animal; Epilepsy; Epilepsy, Reflex; Female; Food, Formulated; Genetic Predisposition to Disease; Mice; Mice, Mutant Strains; Phenylalanine; Phenylketonurias	2007
Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: towards a novel therapy for liver metastases. International journal of radiation biology, 2007, Volume: 83, Issue:10 Topics: Animals; Body Weight; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; DNA; Dose-Response Relationship, Radiation; Hepatocytes; Humans; Kidney; Liver; Liver Neoplasms; Liver Regeneration; Male; Organ Size; Phenylalanine; Radiotherapy Dosage; Rats; Rats, Wistar	2007
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice. Molecular cancer therapeutics, 2007, Volume: 6, Issue:9 Topics: Animals; Antiviral Agents; Disease Models, Animal; Interferon-gamma; Matrix Metalloproteinase 12; Matrix Metalloproteinase 7; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tumor Necrosis Factor-alpha	2007
Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6 Topics: Alanine; Ammonia; Animals; Arginine; Citrulline; Disease Models, Animal; Female; Glycine; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Mice, Mutant Strains; Models, Biological; Mutation; Nitric Oxide; Ornithine; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenotype; Phenylalanine; Urea	2007
Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation. Pediatric research, 2007, Volume: 62, Issue:5 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Animals, Newborn; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Female; Hypoxia; Male; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Phenylalanine; Reactive Oxygen Species; Respiration, Artificial; Swine; Tandem Mass Spectrometry; Time Factors; Tyrosine	2007
Chromium (D-phenylalanine)3 improves obesity-induced cardiac contractile defect in ob/ob mice. Obesity (Silver Spring, Md.), 2007, Volume: 15, Issue:11 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Homeodomain Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Myocardial Contraction; Myocytes, Cardiac; Obesity; Organometallic Compounds; Oxidative Stress; Phenylalanine; Picolinic Acids; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Thinness	2007
Nateglinide prevents fatty liver through up-regulation of lipid oxidation pathway in Goto-Kakizaki rats on a high-fat diet. Metabolism: clinical and experimental, 2008, Volume: 57, Issue:1 Topics: Animals; Blood Glucose; Cyclohexanes; Dietary Fats; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hypoglycemic Agents; Insulin; Male; Nateglinide; Phenylalanine; Rats; Rats, Inbred Strains; Rats, Wistar; Triglycerides	2008
Dietary glycomacropeptide supports growth and reduces the concentrations of phenylalanine in plasma and brain in a murine model of phenylketonuria. The Journal of nutrition, 2008, Volume: 138, Issue:2 Topics: Animals; Body Weight; Brain; Diet; Dietary Supplements; Disease Models, Animal; Feeding Behavior; Female; Glycopeptides; Male; Mice; Phenylalanine; Phenylketonurias	2008
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer cell, 2008, Volume: 13, Issue:4 Topics: Amino Acid Substitution; Animals; Bone Marrow Transplantation; Cell Line, Tumor; Colony-Forming Units Assay; Disease Models, Animal; Endpoint Determination; Flow Cytometry; Hematopoietic System; Humans; Janus Kinase 2; Mice; Mice, Inbred C57BL; Phenylalanine; Polycythemia Vera; Protein Kinase Inhibitors; Pyrrolidines; Signal Transduction; Sulfonamides; Survival Rate; Treatment Outcome; Valine	2008
Effect of hyperphenylalaninemia on Na+ + K+-ATPase in rat brain. Experimental neurology, 1981, Volume: 74, Issue:3 Topics: Adenosine Triphosphatases; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Disease Models, Animal; Enzyme Activation; Fenclonine; Kinetics; Mitochondria; Ouabain; Phenylalanine; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Synaptosomes	1981
Analysis of learning in retarded monkeys. Journal of mental deficiency research, 1984, Volume: 28 (Pt 1) Topics: Animals; Attention; Concept Formation; Discrimination, Psychological; Disease Models, Animal; Female; Fenclonine; Humans; Learning; Macaca mulatta; Phenylalanine; Phenylketonurias; Pregnancy; Reinforcement, Psychology; Retention, Psychology	1984
Effect of hyperphenylalaninemia induced during suckling on brain DNA metabolism in rat pups. Neurochemical research, 1984, Volume: 9, Issue:4 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Cell Division; Disease Models, Animal; DNA; DNA Replication; Fenclonine; Kinetics; Phenylalanine; Rats; Rats, Inbred Strains	1984
Effect of hyperphenylalaninemia on polyphosphoinositides content of rat brain. Experientia, 1982, Dec-15, Volume: 38, Issue:12 Topics: Animals; Brain; Disease Models, Animal; Fenclonine; Humans; Kinetics; Phenylalanine; Phenylketonurias; Phosphatidylinositols; Phospholipids; Rats; Rats, Inbred Strains	1982
Characterization of experimental phenylketonuria. Augmentation of hyperphenylalaninemia with alpha-methylphenylalanine and p-chlorophenylalanine. Biochimica et biophysica acta, 1980, Jan-17, Volume: 627, Issue:2 Topics: Age Factors; Amino Acids; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Disease Models, Animal; Fenclonine; Humans; Learning; Myelin Proteins; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Rats	1980
Phenylketonuria: clinical and experimental considerations revealed by the use of animal models. Die Naturwissenschaften, 1980, Volume: 67, Issue:5 Topics: Animals; Brain; Cerebellum; Disease Models, Animal; Fenclonine; Humans; Male; Neurons; Phenylalanine; Phenylketonurias; Rats	1980
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth. The American journal of clinical nutrition, 1981, Volume: 34, Issue:4 Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine	1981
Disturbances of amino acid transport in rats with experimental hyperphenylalaninaemia. Journal of inherited metabolic disease, 1981, Volume: 4, Issue:2 Topics: Amino Acids; Animals; Cerebral Cortex; Disease Models, Animal; Fenclonine; Glycine; Humans; Leucine; Liver; Phenylalanine; Phenylketonurias; Rats; Tryptophan	1981
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives. Journal of medicinal chemistry, 1984, Volume: 27, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry; Disease Models, Animal; Indicators and Reagents; Indomethacin; Phenylalanine; Pleurisy; Rats; Structure-Activity Relationship	1984
PKU, learning, and models of mental retardation. Developmental psychobiology, 1984, Volume: 17, Issue:2 Topics: Animals; Body Weight; Disease Models, Animal; Humans; Intellectual Disability; Learning; Phenylalanine; Phenylketonurias; Psychological Tests; Rats	1984
Hyperalphalipoproteinaemic activity of BRL 26314--II. Inhibition of atherosclerosis in rabbits. Biochemical pharmacology, 1984, Jan-15, Volume: 33, Issue:2 Topics: Animals; Arteriosclerosis; Cholesterol; Disease Models, Animal; Hyperlipoproteinemias; Lipoproteins, HDL; Male; Phenylalanine; Rabbits	1984
In vivo safety of hollow fiber enzyme-reactors with immobilized phenylalanine ammonia-lyase in a large animal model for phenylketonuria. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:3 Topics: Ammonia-Lyases; Animals; Blood Cells; Blood Urea Nitrogen; Disease Models, Animal; Dogs; Enzymes, Immobilized; Female; Humans; Macaca; Male; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Time Factors; Tyrosine	1983
Morphological and functional changes in the gut after massive small bowel resection and colon interposition in rhesus monkeys. Digestion, 1984, Volume: 29, Issue:1 Topics: Adaptation, Physiological; Alanine; Animals; Colon; Disease Models, Animal; Glucose; Hyperplasia; Hypertrophy; Intestine, Small; Macaca mulatta; Malabsorption Syndromes; Nucleic Acids; Phenylalanine; Short Bowel Syndrome	1984
Use of alpha-methylphenylalanine for studies of brain development in experimental phenylketonuria. Journal of inherited metabolic disease, 1981, Volume: 4, Issue:2 Topics: Animals; Brain; Cell Division; Cell Survival; Cerebellum; Disease Models, Animal; Humans; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats	1981
Turnover of the fast components of myelin and myelin proteins in experimental hyperphenylalaninaemia. Relevance to termination of dietary treatment in human phenylketonuria. Journal of inherited metabolic disease, 1982, Volume: 5, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Half-Life; Humans; Lysine; Myelin Proteins; Myelin Sheath; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains	1982
Brain development in experimental hyperphenylalaninaemia: myelination. Neuropediatrics, 1982, Volume: 13, Issue:4 Topics: Animals; Brain; Disease Models, Animal; Humans; Microscopy, Electron; Myelin Sheath; Nerve Fibers, Myelinated; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains; Spinal Cord	1982
Retarded development of neurons and oligodendroglia in rat forebrain produced by hyperphenylalaninemia results in permanent deficits in myelin despite long recovery periods. Experimental neurology, 1993, Volume: 124, Issue:2 Topics: Animals; Animals, Newborn; Axons; Corpus Callosum; Disease Models, Animal; Female; Male; Molecular Weight; Myelin Basic Protein; Myelin Sheath; Neurofilament Proteins; Neurons; Oligodendroglia; Phenylalanine; Phenylketonurias; Prosencephalon; Rats; Rats, Sprague-Dawley	1993
An animal model of early-treated PKU. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:5 Pt 2 Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Fetus; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains; Time Factors	1994
Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. Journal of neurochemistry, 1995, Volume: 64, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Amino Acids; Ammonia; Animals; Biogenic Monoamines; Body Weight; Cerebral Cortex; Chronic Disease; Dialysis; Disease Models, Animal; Dopamine; Extracellular Space; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Norepinephrine; Phenylalanine; Rats; Rats, Wistar; Serotonin; Tryptophan; Tyrosine	1995
A new theory of enterorecirculation of amino acids and its use for depleting unwanted amino acids using oral enzyme-artificial cells, as in removing phenylalanine in phenylketonuria. Artificial cells, blood substitutes, and immobilization biotechnology, 1995, Volume: 23, Issue:1 Topics: Amino Acids; Animals; Body Weight; Diet, Protein-Restricted; Disease Models, Animal; Dosage Forms; Drug Compounding; Intestinal Mucosa; Intestinal Secretions; Intestines; Male; Models, Biological; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Rats; Rats, Sprague-Dawley; Time Factors	1995
High protein diet has beneficial effects in murine muscular dystrophy. The Journal of nutrition, 1995, Volume: 125, Issue:5 Topics: Animals; Dietary Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methylhistidines; Mice; Mice, Mutant Strains; Muscle Proteins; Muscle, Skeletal; Muscular Dystrophy, Animal; Phenylalanine; Time Factors	1995
Response of the central nervous system to boron neutron capture irradiation: evaluation using rat spinal cord model. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1994, Volume: 32, Issue:3 Topics: Absorption; Animals; Blood-Brain Barrier; Borohydrides; Boron; Boron Compounds; Boron Neutron Capture Therapy; Disease Models, Animal; Dose-Response Relationship, Radiation; Isotopes; Linear Energy Transfer; Male; Phenylalanine; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Rats, Inbred F344; Relative Biological Effectiveness; Spinal Cord; Spinal Cord Diseases; Sulfhydryl Compounds	1994
Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex. Neurochemical research, 1994, Volume: 19, Issue:9 Topics: Animals; Apyrase; Cerebral Cortex; Disease Models, Animal; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Wistar; Synaptosomes	1994
Effect of long-term cyclic mechanical load on protein synthesis and morphological changes in cultured myocardial cells from neonatal rat. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:2 Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Cardiomegaly; Cell Size; Cells, Cultured; Disease Models, Animal; Heart; Microscopy; Microscopy, Electron; Myocardium; Phenylalanine; Physical Stimulation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Thymidine; Time Factors; Tritium	1994
Phe1-substituted beta-casomorphin-5 analogues with analgesic activity. Peptides, 1994, Volume: 15, Issue:3 Topics: Amino Acid Sequence; Analgesics; Animals; Disease Models, Animal; Drug Tolerance; Endorphins; Male; Molecular Sequence Data; Morphine; Pain; Peptide Fragments; Phenylalanine; Rats; Rats, Wistar; Vocalization, Animal	1994
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer research, 1994, Sep-01, Volume: 54, Issue:17 Topics: Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Humans; Male; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Thiophenes; Transplantation, Heterologous	1994
The effect of hyperphenylalaninaemia on the muscarinic acetylcholine receptor in the HPH-5 mouse brain. Journal of inherited metabolic disease, 1993, Volume: 16, Issue:6 Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; Metabolism, Inborn Errors; Mice; Mice, Mutant Strains; Phenylalanine; Phenylalanine Hydroxylase; Protein Binding; Quinuclidinyl Benzilate; Receptors, Dopamine D1; Receptors, Muscarinic	1993
Experimental research on a new treatment for maternal phenylketonuria(PKU). Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Biopterins; Brain; Disease Models, Animal; Female; Fetus; Guinea Pigs; Infusions, Intravenous; Liver; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Tyrosine	1993
Mouse models of human phenylketonuria. Genetics, 1993, Volume: 134, Issue:4 Topics: Animals; Blotting, Western; Cross Reactions; Diet; Disease Models, Animal; Genotype; Humans; Mice; Mutagenesis; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	1993
Cellular accumulation of 18F-labelled boronophenylalanine depending on DNA synthesis and melanin incorporation: a double-tracer microautoradiographic study of B16 melanomas in vivo. British journal of cancer, 1993, Volume: 67, Issue:4 Topics: Animals; Autoradiography; Boron Compounds; Boron Neutron Capture Therapy; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorine Radioisotopes; Male; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasm Transplantation; Phenylalanine; Pigmentation; Radionuclide Imaging	1993
Genetic mapping of hph2, a mutation affecting amino acid transport in the mouse. Mammalian genome : official journal of the International Mammalian Genome Society, 1997, Volume: 8, Issue:2 Topics: Animals; Biological Transport; Chromosome Mapping; Crosses, Genetic; Disease Models, Animal; Hartnup Disease; Humans; Mice; Mice, Inbred C57BL; Mutation; Phenylalanine	1997
A candidate mouse model for Hartnup disorder deficient in neutral amino acid transport. Mammalian genome : official journal of the International Mammalian Genome Society, 1997, Volume: 8, Issue:2 Topics: Animals; Biological Transport; Blood Glucose; Disease Models, Animal; Glycosuria; Hartnup Disease; Humans; Kidney; Mice; Phenylalanine	1997
Effect of experimental hyperphenylalaninemia on the postnatal rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1997, Volume: 15, Issue:1 Topics: Animals; Cerebellum; Disease Models, Animal; Extracellular Matrix; Glial Fibrillary Acidic Protein; Hyaluronic Acid; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Phenylalanine; Phenylketonurias; Rats; Rats, Wistar; Telencephalon	1997
Cardiovascular defects among the progeny of mouse phenylketonuria females. Pediatric research, 1997, Volume: 42, Issue:1 Topics: Animals; Blood Vessels; Diet; Disease Models, Animal; Female; Genotype; Heart Defects, Congenital; Humans; Maternal-Fetal Exchange; Mice; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications	1997
The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. Journal of vascular surgery, 1999, Volume: 29, Issue:1 Topics: Animals; Antibodies, Monoclonal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Male; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rats; Rats, Wistar; Thiophenes	1999
A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase. Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-02, Volume: 96, Issue:5 Topics: Animals; Basidiomycota; Cloning, Molecular; Disease Models, Animal; Escherichia coli; Ethylnitrosourea; Humans; Injections, Intraperitoneal; Mice; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias; Recombinant Proteins	1999
Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor. Archives of ophthalmology (Chicago, Ill. : 1960), 1999, Volume: 117, Issue:4 Topics: Animals; Animals, Newborn; Collagenases; Disease Models, Animal; Gelatinases; Injections, Intraperitoneal; Ischemia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Phenylalanine; Protease Inhibitors; Retina; Retinal Neovascularization; Retinal Vessels; Thiophenes; Urokinase-Type Plasminogen Activator	1999
A heteroallelic mutant mouse model: A new orthologue for human hyperphenylalaninemia. Molecular genetics and metabolism, 2000, Volume: 69, Issue:3 Topics: Alleles; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Female; Genotype; Humans; Liver; Male; Mental Disorders; Mice; Mutation; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias	2000
Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15 Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Chemokine CX3CL1; Chemokines, CX3C; Chemotaxis; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Endothelium, Vascular; Glutamic Acid; Infarction, Middle Cerebral Artery; Interleukin-1; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Microglia; Monocytes; Neurons; Phenylalanine; Protease Inhibitors; Rats; RNA, Messenger; Thiophenes; Transfection; Tumor Necrosis Factor-alpha	2000
Is there a relationship between 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and forebrain pathology in the PKU mouse? Journal of neuroscience research, 2000, Sep-01, Volume: 61, Issue:5 Topics: Alkyl and Aryl Transferases; Animals; Brain Chemistry; Cell Count; Cell Line; Cholesterol; Demyelinating Diseases; Disease Models, Animal; Farnesyltranstransferase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microsomes; Myelin Basic Protein; Oligodendroglia; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Prosencephalon; Rhombencephalon	2000
Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model. British journal of cancer, 2000, Volume: 83, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Female; Interleukin-12; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Phenylalanine; Protease Inhibitors; Thiophenes	2000
A quantitative evaluation of the permeability of the blood brain barrier of portacaval shunted rats. Metabolic brain disease, 2000, Volume: 15, Issue:2 Topics: Acetates; Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Disease Models, Animal; Glutamic Acid; Hepatic Encephalopathy; Male; Mannitol; Permeability; Phenylalanine; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Tritium	2000
Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke, 2000, Volume: 31, Issue:12 Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Fibrinolytic Agents; Humans; Intracranial Embolism; Metalloendopeptidases; Phenylalanine; Protease Inhibitors; Rabbits; Stroke; Thiophenes; Thromboembolism; Tissue Plasminogen Activator	2000
Characterization of the mouse phenylalanine hydroxylase mutation Pah(enu3). Molecular genetics and metabolism, 2001, Volume: 72, Issue:1 Topics: Alleles; Animals; Base Sequence; Disease Models, Animal; DNA Mutational Analysis; DNA, Complementary; Exons; Frameshift Mutation; Gene Deletion; Humans; Introns; Male; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis; Mutation; Mutation, Missense; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; RNA Splice Sites; RNA, Messenger; Sequence Homology, Nucleic Acid	2001
A possible role for metalloproteinases in renal cyst development. American journal of physiology. Renal physiology, 2001, Volume: 280, Issue:3 Topics: Animals; Disease Models, Animal; Kidney; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Phenylalanine; Polycystic Kidney, Autosomal Dominant; Protease Inhibitors; Rats; Rats, Inbred Strains; RNA, Messenger; Thiophenes; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta; Transforming Growth Factor beta2	2001
Validation of an orthotopic model of human lung cancer with regional and systemic metastases. The Annals of thoracic surgery, 2001, Volume: 71, Issue:4 Topics: Analysis of Variance; Animals; Antineoplastic Agents; Carcinoma, Large Cell; Cisplatin; Disease Models, Animal; Doxorubicin; Humans; Lung Neoplasms; Male; Mitomycin; Neoplasm Invasiveness; Neoplasm Transplantation; Phenylalanine; Rats; Rats, Nude; Survival Rate; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays	2001
Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:1 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cachexia; Colonic Neoplasms; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Muscle Proteins; Muscle, Skeletal; Nitrosourea Compounds; Organ Size; Phenylalanine	2001
Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis. Digestion, 2001, Volume: 63, Issue:4 Topics: Animals; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Hematoxylin; Intestinal Mucosa; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peroxidase; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiophenes; Trinitrobenzenesulfonic Acid	2001
Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesis. Circulation research, 2001, Aug-03, Volume: 89, Issue:3 Topics: Angiography; Animals; Blood Flow Velocity; Capillaries; Disease Models, Animal; Endothelial Growth Factors; Enzyme Activation; Femoral Artery; Fibroblast Growth Factor 2; Hindlimb; Interleukin-10; Ischemia; Laser-Doppler Flowmetry; Lymphokines; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Phenylalanine; Platelet Endothelial Cell Adhesion Molecule-1; Protease Inhibitors; Thiophenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2001, Volume: 36, Issue:4 Topics: Animals; Carcinoma, Adenoid Cystic; Disease Models, Animal; Female; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phenylalanine; Protease Inhibitors; Salivary Gland Diseases; Thiophenes	2001
Effect of maternal blood phenylalanine level on mouse maternal phenylketonuria offspring. Molecular genetics and metabolism, 2001, Volume: 74, Issue:4 Topics: Abortion, Spontaneous; Animals; Disease Models, Animal; Embryonic and Fetal Development; Female; Fetal Diseases; Humans; Male; Mice; Phenylalanine; Phenylketonuria, Maternal; Pregnancy; Tyrosine	2001
Boron neutron capture therapy for the treatment of oral cancer in the hamster cheek pouch model. Cancer research, 2001, Dec-15, Volume: 61, Issue:24 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Boron Compounds; Boron Neutron Capture Therapy; Carcinogens; Cheek; Cricetinae; Disease Models, Animal; Mesocricetus; Mouth Neoplasms; Phenylalanine; Precancerous Conditions; Radiation-Sensitizing Agents	2001
The hamster cheek pouch as a model of oral cancer for boron neutron capture therapy studies: selective delivery of boron by boronophenylalanine. Cancer research, 2001, Dec-15, Volume: 61, Issue:24 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Carcinogens; Cheek; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Mesocricetus; Mouth Neoplasms; Phenylalanine; Radiation-Sensitizing Agents; Tissue Distribution	2001
Prostate cancer in bone: importance of context for inhibition of matrix metalloproteinases. Journal of the National Cancer Institute, 2002, Jan-02, Volume: 94, Issue:1 Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Disease Models, Animal; Humans; Male; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Phenylalanine; Prostatic Neoplasms; Thiophenes	2002
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. Journal of the National Cancer Institute, 2002, Jan-02, Volume: 94, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Bone Remodeling; Bone Transplantation; Calcium; Disease Models, Animal; Fetal Tissue Transplantation; Humans; Immunohistochemistry; In Situ Hybridization; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, SCID; Neoplasm Metastasis; Oligonucleotide Probes; Osteoclasts; Phenylalanine; Prostatic Neoplasms; RNA, Messenger; Thiophenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2002
Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I. Molecular genetics and metabolism, 2002, Volume: 75, Issue:1 Topics: Animals; Cyclohexanones; Diet; Disease Models, Animal; Enzyme Inhibitors; Hydrolases; Mice; Mice, Knockout; Nitrobenzoates; Phenylalanine; Tyrosine; Tyrosinemias	2002
Quantitation of cell migration in a rat carotid artery balloon injury model. Indications for a perivascular origin of the neointimal cells. Cardiovascular drugs and therapy, 2001, Volume: 15, Issue:5 Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Count; Cell Division; Cell Movement; Cyclophosphamide; Disease Models, Animal; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phenylalanine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiophenes; Tunica Intima	2001
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke, 2002, Volume: 33, Issue:3 Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Intracranial Embolism; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Rats; Rats, Inbred SHR; Sodium, Dietary; Survival Rate; Thiophenes; Thrombolytic Therapy; Tissue Plasminogen Activator	2002
Oxidative stress in a phenylketonuria animal model. Free radical biology & medicine, 2002, May-01, Volume: 32, Issue:9 Topics: Animals; Brain; Catalase; Chromatography, High Pressure Liquid; Disease Models, Animal; Erythrocytes; Glucosephosphate Dehydrogenase; Glutathione; Hydrogen Peroxide; Lipid Peroxidation; Malondialdehyde; Mice; Mice, Knockout; NADP; Oxidation-Reduction; Oxidative Stress; Oxygen; Phenylalanine; Phenylketonurias	2002
L-arginine supplementation in pigs decreases liver protein turnover and increases hindquarter protein turnover both during and after endotoxemia. The American journal of clinical nutrition, 2002, Volume: 75, Issue:6 Topics: Acute-Phase Proteins; Animals; Arginine; Blood Gas Analysis; Dietary Supplements; Disease Models, Animal; Endotoxemia; Enteral Nutrition; Female; Hindlimb; Isomerism; Kidney; Liver; Muscle, Skeletal; Phenylalanine; Proteins; Random Allocation; Sepsis; Swine; Viscera	2002
Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade. Atherosclerosis, 2002, Volume: 163, Issue:2 Topics: Angioplasty, Balloon; Animals; Arteries; Cell Movement; Constriction, Pathologic; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hydroxamic Acids; Hyperplasia; Male; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Oligopeptides; Phenylalanine; Rats; Receptors, Vitronectin; Thiophenes; Tunica Intima	2002
Monkey retardate learning analysis. Journal of mental deficiency research, 1978, Volume: 22, Issue:1 Topics: Age Factors; Animals; Choice Behavior; Conditioning, Operant; Diet; Discrimination Learning; Disease Models, Animal; Frontal Lobe; Haplorhini; Humans; Inhibition, Psychological; Intellectual Disability; Macaca mulatta; Phenylalanine; Phenylketonurias	1978
Ultrastructural changes in rat optic nerve associated with hyperphenylalaninemia induced by para-chlorophenylalanine and phenylalanine. Journal of neuropathology and experimental neurology, 1975, Volume: 34, Issue:2 Topics: Animals; Astrocytes; Axons; Cytoplasm; Disease Models, Animal; Endoplasmic Reticulum; Fenclonine; Golgi Apparatus; Humans; Microscopy, Electron; Myelin Sheath; Nerve Degeneration; Oligodendroglia; Optic Nerve; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred F344; Sodium Chloride	1975
Urinary metabolites of phenylalanine in the preweanling rat treated with p-chlorophenylalanine and phenylalanine. Biochemical medicine, 1975, Volume: 12, Issue:2 Topics: Animals; Chromatography; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fenclonine; Hippurates; Humans; Lactation; Male; Molecular Conformation; Phenylacetates; Phenylalanine; Phenylketonurias; Pregnancy; Rats	1975
Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninaemia. Journal of neurochemistry, 1975, Volume: 25, Issue:3 Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Female; Fenclonine; Glycine; Humans; Leucine; Lysine; Male; Nerve Tissue Proteins; Phenylalanine; Phenylketonurias; Rats	1975
Model phenylketonuria (PKU) in the albino rat: behaviroal, biochemical, and neuroanatomical effects. Journal of comparative and physiological psychology, 1975, Volume: 89, Issue:6 Topics: Animals; Axons; Body Weight; Disease Models, Animal; Emotions; Fenclonine; Humans; Learning; Liver; Motor Activity; Myelin Sheath; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Social Behavior; Tryptophan	1975
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue. The Journal of clinical investigation, 1976, Volume: 57, Issue:3 Topics: alpha 1-Antitrypsin; Animals; Cartilage, Articular; Chymotrypsin; Cytoplasmic Granules; Disease Models, Animal; Enzyme Inhibitors; Glycosaminoglycans; Humans; Immune Sera; Joint Diseases; Kinetics; Leukocytes; Oligopeptides; Pancreatic Elastase; Peptide Hydrolases; Phenylalanine; Proteoglycans; Rabbits; Sulfur Radioisotopes	1976
The regulation of phenylalanine hydroxylase in rat tissues in vivo. The maintenance of high plasma phenylalanine concentrations in suckling rats: a model for phenylketonuria. The Biochemical journal, 1976, Mar-15, Volume: 154, Issue:3 Topics: Animals; Brain; Disease Models, Animal; Fenclonine; Humans; Kidney; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine	1976
Study of blood aminoacids in experimental hyperphenylalaninemia. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1977, Volume: 27, Issue:2 Topics: Amino Acids; Animals; Disease Models, Animal; Fenclonine; Humans; Male; Phenylalanine; Phenylketonurias; Rats; Sulfamethoxazole; Trimethoprim	1977
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole. Biochimie, 1977, Volume: 59, Issue:8-9 Topics: Animals; Disease Models, Animal; Drug Combinations; Fenclonine; Humans; Kidney; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Sulfamethoxazole; Trimethoprim; Tyrosine	1977
Myelin deficiency in experimental phenylketonuria: contribution of the aromatic acid metabolites of phenylalanine. Advances in experimental medicine and biology, 1978, Volume: 100 Topics: Animals; Brain; Disease Models, Animal; Female; Fenclonine; Humans; Male; Membrane Lipids; Myelin Proteins; Myelin Sheath; Phenylacetates; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Rats	1978
Experimental phenylketonuria: metabolic studies in rat liver. Molecular and cellular biochemistry, 1977, May-31, Volume: 16, Issue:1 Topics: Animals; Disease Models, Animal; Fasting; Female; Fenclonine; Fructosephosphates; Gluconeogenesis; Glucose; Glucosephosphates; Humans; Hydroxybutyrate Dehydrogenase; Ketone Bodies; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; NAD; Phenylalanine; Phenylketonurias; Rats; Stereoisomerism	1977
Amino acid metabolism in the chronically uremic rat. Clinical nephrology, 1975, Volume: 3, Issue:6 Topics: Amine Oxidase (Copper-Containing); Amines; Amino Acids; Animals; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Chronic Disease; Citrulline; Dietary Proteins; Disease Models, Animal; Hydroxyindoleacetic Acid; Kidney; Liver; Monoamine Oxidase; Multienzyme Complexes; Muscles; Myocardium; Ornithine Carbamoyltransferase; Phenylalanine; Phenylalanine Hydroxylase; Rats; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Uremia	1975
[Phenylalanine-influenced retinal changes in the newborn rat (author's transl)]. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1977, Jun-28, Volume: 202, Issue:4 Topics: Animals; Animals, Newborn; Disease Models, Animal; Ganglia; Humans; Phenylalanine; Phenylketonurias; Rats; Retina; Retinal Diseases	1977
Influences of exogenous intake and nitrogen balance on plasma and brain aromatic amino acid concentrations. Metabolism: clinical and experimental, 1978, Volume: 27, Issue:4 Topics: Amino Acids; Animals; Disease Models, Animal; Female; Liver Diseases; Nitrogen; Octopamine; Parenteral Nutrition; Phenylalanine; Portacaval Shunt, Surgical; Rats; Tryptophan; Tyrosine	1978
Phenylalanine depletion for the management of phenylketonuria: use of enzyme reactors with immobilized enzymes. Science (New York, N.Y.), 1978, Sep-01, Volume: 201, Issue:4358 Topics: Ammonia-Lyases; Animals; Disease Models, Animal; Dogs; Enzymes, Immobilized; Extracorporeal Circulation; Humans; Phenylalanine; Phenylalanine Ammonia-Lyase; Phenylketonurias	1978
Beneficial effect of isoleucine on fetal brain development in induced phenylketonuria. Brain research, 1978, Oct-06, Volume: 154, Issue:1 Topics: Amino Acids; Animals; Body Weight; Brain; Disease Models, Animal; Female; Humans; Isoleucine; Organ Size; Phenylalanine; Phenylketonurias; Pregnancy; Rats	1978
[Comparative effects of different inhibitors of phenylalanine hydroxylase and dihydropteridine reductase. In vivo and in vitro study in rats]. Archives francaises de pediatrie, 1978, Volume: 35, Issue:10 Suppl Topics: Animals; Dihydropteridine Reductase; Disease Models, Animal; Humans; Liver; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine	1978
Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin. Science (New York, N.Y.), 1979, Oct-26, Volume: 206, Issue:4417 Topics: Amino Acid Sequence; Animals; Brain; Cytoplasm; Disease Models, Animal; Humans; Microtubules; Phenylalanine; Phenylketonurias; Protein Binding; Rats; Tubulin; Tyrosine	1979
Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats. Science (New York, N.Y.), 1976, Jun-04, Volume: 192, Issue:4243 Topics: Amino Acids; Animals; Animals, Newborn; Disease Models, Animal; Humans; Liver; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats	1976
Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat. Journal of neurochemistry, 1976, Volume: 27, Issue:2 Topics: Animals; Brain; Disease Models, Animal; Fatty Acids; Histidine; Hydroxyindoleacetic Acid; Hypothalamus; Isoleucine; Leucine; Liver Cirrhosis; Phenylalanine; Portacaval Shunt, Surgical; Rats; Serotonin; Tryptophan; Tyrosine; Valine	1976
Hyperphenylalaninaemia and experimental allergic encephalomyelitis. Journal of the neurological sciences, 1976, Volume: 29, Issue:2-4 Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids, Unsaturated; Female; Male; Multiple Sclerosis; Myelin Sheath; Phenylalanine; Rats	1976
Maternal hyperphenylalaninemia: an experimental model in rats. Developmental psychobiology, 1976, Volume: 9, Issue:2 Topics: Animals; Animals, Newborn; Birth Weight; Brain Chemistry; Disease Models, Animal; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Phenylalanine; Phenylketonurias; Placenta; Pregnancy; Pregnancy Complications; Rats; Rats, Inbred F344; Time Factors	1976
Reduced central serotonergic activity in mania: implications for the relationship between depression and mania. The British journal of psychiatry : the journal of mental science, 1975, Volume: 126 Topics: Bipolar Disorder; Brain; Depression; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Hypnotics and Sedatives; Imipramine; Lithium; Methysergide; Monoamine Oxidase Inhibitors; Phenylalanine; Probenecid; Serotonin; Tryptophan	1975
Effects of anoxia and ischemia on protein synthesis in perfused rat hearts. Circulation research, 1976, Volume: 38, Issue:5 Suppl 1 Topics: Aerobiosis; Anaerobiosis; Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Hypoxia; Lactates; Male; Muscle Proteins; Myocardium; Perfusion; Phenylalanine; Phosphocreatine; Purine Nucleotides; Rats	1976
A finding of highly selective synthetic inhibitor of plasma kallikrein; its action to bradykinin generation, intrinsic coagulation and experimental DIC. Agents and actions. Supplements, 1992, Volume: 38 ( Pt 1) Topics: Animals; Blood Coagulation; Bradykinin; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Fibrinogen; Humans; In Vitro Techniques; Kallikreins; Kaolin; Kinetics; Mice; Partial Thromboplastin Time; Phenylalanine; Rats; Tranexamic Acid	1992
Boron neutron capture therapy of anterior chamber melanoma with p-boronophenylalanine. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:2 Topics: Administration, Oral; Animals; Anterior Chamber; Autoradiography; Boron; Boron Compounds; Disease Models, Animal; Eye Neoplasms; Isotopes; Melanoma, Experimental; Neutrons; Phenylalanine; Rabbits; Radiation-Sensitizing Agents	1992
[The activity of NADP-dependent dehydrogenases in the brain of growing animals with demyelinating exposures]. Nervnaia sistema, 1991, Volume: 30 Topics: Animals; Brain; Chronic Disease; Cytoplasm; Demyelinating Diseases; Disease Models, Animal; Growth; Hypervitaminosis A; NADPH Dehydrogenase; Phenylalanine; Rats	1991
[The characteristics of the brain cerebrosides, sulfocerebrosides and gangliosides in experimental demyelination and cerebrolysin administration]. Nervnaia sistema, 1991, Volume: 30 Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cerebrosides; Chronic Disease; Demyelinating Diseases; Disease Models, Animal; Gangliosides; Phenylalanine; Rats	1991
[The effect of cerebrolysin on the metabolism of brain phospholipids in growing animals with experimental demyelination]. Nervnaia sistema, 1991, Volume: 30 Topics: Amino Acids; Animals; Brain; Brain Chemistry; Chromatography, Thin Layer; Demyelinating Diseases; Disease Models, Animal; Growth; Phenylalanine; Phospholipids; Rats	1991
In situ detection of cutaneous melanoma by prompt gamma-ray spectrometry using melanoma-seeking 10B-dopa analogue. Journal of dermatological science, 1990, Volume: 1, Issue:1 Topics: Aged; Animals; Boron; Boron Compounds; Cricetinae; Disease Models, Animal; Female; Humans; Isotopes; Male; Melanoma; Mesocricetus; Phenylalanine; Skin Neoplasms; Spectrometry, Gamma; Time Factors	1990
The use of N-ethyl-N-nitrosourea to produce mouse models for human phenylketonuria and hyperphenylalaninemia. Progress in clinical and biological research, 1990, Volume: 340C Topics: Amino Acid Metabolism, Inborn Errors; Animals; Crosses, Genetic; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Male; Mice; Mice, Mutant Strains; Mutation; Phenotype; Phenylalanine; Phenylketonurias	1990
Evidence for inhibition of exodus of small neutral amino acids from non-brain tissues in hyperphenylalaninaemic rats. Journal of inherited metabolic disease, 1989, Volume: 12, Issue:2 Topics: Amino Acids; Animals; Biological Transport; Brain; Disease Models, Animal; Liver; Male; Muscles; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains	1989
Effects of phenylalanine loading on protein synthesis in the fetal heart and brain of rat: an experimental approach to maternal phenylketonuria. Journal of inherited metabolic disease, 1986, Volume: 9, Issue:1 Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Female; Fenclonine; Fetal Heart; Fetus; Leucine; Maternal-Fetal Exchange; Phenylalanine; Phenylketonurias; Polyribosomes; Pregnancy; Protein Biosynthesis; Rats; Rats, Inbred Strains; Urea	1986
Studies on experimentally induced hyperphenylalaninemia. Journal of mental deficiency research, 1988, Volume: 32 ( Pt 4) Topics: Animals; Disease Models, Animal; Drug Combinations; Female; Fenclonine; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Inbred Strains; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
A model for hyperphenylalaninaemia due to tetrahydrobiopterin deficiency. Journal of inherited metabolic disease, 1986, Volume: 9, Issue:1 Topics: Animals; Biopterins; Brain; Catecholamines; Disease Models, Animal; Dose-Response Relationship, Drug; Hypoxanthines; Liver; Mice; Mice, Inbred BALB C; Phenylalanine; Pteridines	1986
Hyperphenylalaninemia in the hph-1 mouse mutant. Pediatric research, 1988, Volume: 23, Issue:1 Topics: Aminohydrolases; Animals; Biopterins; Disease Models, Animal; GTP Cyclohydrolase; Half-Life; Male; Metabolic Clearance Rate; Mice; Mice, Mutant Strains; Phenylalanine; Tyrosine	1988
Outcome of pregnancy in the rat with mild hyperphenylalaninaemia and hypertyrosinaemia: implications for the management of "human maternal PKU". Journal of inherited metabolic disease, 1985, Volume: 8, Issue:3 Topics: Animals; Brain Diseases; Discrimination, Psychological; Disease Models, Animal; Female; Motor Activity; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Space Perception; Tyrosine	1985
Biological and behavioural assessments of young rhesus monkeys after intrauterine exposure to high phenylalanine concentrations. Journal of mental deficiency research, 1985, Volume: 29 ( Pt 3) Topics: Animals; Disease Models, Animal; Female; Learning; Macaca mulatta; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications	1985
The use of animal models for the study of aminoacidopathies. Monographs in human genetics, 1972, Volume: 6 Topics: Age Factors; Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Damage, Chronic; Cricetinae; Disease Models, Animal; Enzyme Precursors; Haplorhini; In Vitro Techniques; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylpyruvic Acids; Rats	1972
Hepatic and renal protein synthesis in normal, diabetic and ketotic Chinese hamsters. Diabetologia, 1974, Volume: 10 Suppl Topics: Amino Acids; Animals; Carbon Radioisotopes; Cricetinae; Diabetes Mellitus; Diabetic Ketoacidosis; Disease Models, Animal; In Vitro Techniques; Kidney; Liver; Phenylalanine; Proteins; Ribosomes	1974
Enduring behavioral changes in rats with experimental phenylketonuria. Proceedings of the National Academy of Sciences of the United States of America, 1972, Volume: 69, Issue:4 Topics: Aggression; Animals; Appetitive Behavior; Avoidance Learning; Behavior, Animal; Brain; Defecation; Disease Models, Animal; Female; Fenclonine; Humans; Liver; Male; Motor Activity; Organ Size; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Inbred Strains	1972
On the mechanism of fever caused by the mucopeptide of group A streptococcus. Naunyn-Schmiedeberg's archives of pharmacology, 1972, Volume: 274, Issue:2 Topics: Animals; Bacterial Proteins; Brain; Disease Models, Animal; Fenclonine; Fever; Injections, Intravenous; Injections, Spinal; Mucoproteins; Norepinephrine; Phenylalanine; Premedication; Rabbits; Reserpine; Serotonin; Streptococcus; Streptococcus pyogenes; Tyrosine	1972
Cataractogenesis in infant rats with model phenylketonuria. Perceptual and motor skills, 1972, Volume: 35, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Cataract; Disease Models, Animal; Female; Fenclonine; Humans; Light; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Rats, Inbred Strains	1972
Behavioral effects of experimental maternal hyperphenylalaninemia. Developmental psychobiology, 1973, Volume: 6, Issue:6 Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; Female; Fenclonine; Fetus; Gestational Age; Humans; Maternal-Fetal Exchange; Motor Activity; Phenylalanine; Phenylketonurias; Pregnancy; Rats; Reinforcement Schedule; Social Behavior	1973
Experimental maternal hyperphenylalaninemia: biochemical effects and offspring development. Developmental psychobiology, 1974, Volume: 7, Issue:2 Topics: Aggression; Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Disease Models, Animal; Embryonic and Fetal Development; Female; Fenclonine; Growth; Humans; Maternal Behavior; Maternal-Fetal Exchange; Organ Size; Phenylalanine; Phenylketonurias; Pregnancy; Rats	1974
Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase. Voprosy biokhimii mozga, 1973, Volume: 8 Topics: Animals; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Inhibitors; Fenclonine; Guinea Pigs; Humans; Kinetics; Liver; Mice; Molecular Biology; Mutation; Organ Culture Techniques; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Temperature	1973
Chronic viral neuropathies: models for study and food for thought. International archives of allergy and applied immunology, 1969, Volume: 36 Topics: Animals; Antiviral Agents; Cattle; Chick Embryo; Cricetinae; Cytarabine; Cytomegalovirus; Dactinomycin; Deoxyuridine; Disease Models, Animal; DNA, Viral; Encephalitis Viruses; Friend murine leukemia virus; Humans; Imidazoles; Interferons; Mice; Mitomycins; Nervous System Diseases; Parainfluenza Virus 1, Human; Phenylalanine; Prions; Respirovirus; RNA Viruses; RNA, Viral; Vesicular stomatitis Indiana virus; Viral Interference; Virus Diseases	1969
Experimental disciform serous retinal detachment. II. Autoradiography of photoreceptor protein metabolism. Archives of ophthalmology (Chicago, Ill. : 1960), 1974, Volume: 91, Issue:6 Topics: Animals; Autoradiography; Disease Models, Animal; Eye Proteins; Female; Hyaluronoglucosaminidase; Leucine; Male; Microbial Collagenase; Phenylalanine; Photoreceptor Cells; Rabbits; Retinal Detachment; Time Factors; Tritium	1974
Recovery of rat brain from a brief hyperphenylalaninemic insult early in development. Brain research, 1974, Jun-14, Volume: 73, Issue:1 Topics: Age Factors; Animals; Body Weight; Brain; Disease Models, Animal; DNA; Growth Disorders; Humans; Lipid Metabolism; Nerve Tissue Proteins; Organ Size; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains; RNA	1974
The enduring behavioral changes in rats with experimental phenylketonuria. Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:1 Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Brain; Cataract; Cerebellum; Conditioning, Operant; Disease Models, Animal; Female; Humans; Learning Disabilities; Male; Motor Activity; Myelin Sheath; Organ Size; Phenylalanine; Phenylketonurias; Rats; Time Factors	1974
Some observations on the blood levels of phenylalanine in dilute mice and a comparison between human phenylketonuria and the disease of mice homozygous for the dilute lethal gene. Clinical genetics, 1972, Volume: 3, Issue:6 Topics: Age Factors; Animals; Chromosome Aberrations; Chromosome Disorders; Disease Models, Animal; Drug Tolerance; Female; Genes, Lethal; Homozygote; Humans; Male; Metabolic Clearance Rate; Mice; Phenylalanine; Phenylketonurias; Sex Factors; Time Factors	1972
Neuronal lesions in the cerebellum following the administration of excess phenylalanine to neonatal rats. Journal of neuropathology and experimental neurology, 1973, Volume: 32, Issue:3 Topics: Animals; Animals, Newborn; Axons; Cerebellum; Cytoplasm; Cytoplasmic Granules; Disease Models, Animal; Female; Humans; Liver; Myelin Sheath; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Purkinje Cells; Rats; Tyrosine	1973
Vitamin A deficiency-induced "rod thinning" to permanently decrease the production of rod outer segment material. Investigative ophthalmology, 1974, Volume: 13, Issue:1 Topics: Animals; Autoradiography; Diet; Disease Models, Animal; Electroretinography; Epithelium; Eye Proteins; Follow-Up Studies; Isoleucine; Phenylalanine; Photoreceptor Cells; Rats; Retina; Retinal Diseases; Tritium; Vitamin A; Vitamin A Deficiency	1974
Retinal dystrophy in the pigmented rat. Investigative ophthalmology, 1974, Volume: 13, Issue:2 Topics: Animals; Autoradiography; Disease Models, Animal; Epithelium; Fundus Oculi; Humans; Leucine; Ophthalmoscopy; Phagocytosis; Phenylalanine; Photoreceptor Cells; Rats; Rats, Inbred Strains; Retinal Degeneration; Retinitis Pigmentosa; Time Factors; Tritium	1974
[Experimental hyperphenylalanaemic animals and cystathionine contents in brain tissues]. Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1970, Volume: 32, Issue:4 Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Brain Chemistry; Diet; Dipeptides; Disease Models, Animal; Haplorhini; Hydro-Lyases; L-Serine Dehydratase; Male; Metabolic Diseases; Mixed Function Oxygenases; Phenylacetates; Phenylalanine; Phenylpyruvic Acids; Rats; Swine; Tyrosine	1970
Differential reinforcement of latency (DRL) in phenylketonuric monkeys. Developmental psychobiology, 1970, Volume: 2, Issue:4 Topics: Animals; Conditioning, Operant; Diet; Disease Models, Animal; Feeding Behavior; Female; Frustration; Haplorhini; Humans; Macaca; Phenylalanine; Phenylketonurias; Pregnancy; Reaction Time; Reinforcement, Psychology; Reward	1970
L-benzylalanine as a model amino acid for the study of accumulation diseases. Clinical chemistry, 1971, Volume: 17, Issue:2 Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Humans; Male; Phenylalanine; Phenylbutyrates; Phenylketonurias; Rats	1971
Degenerative changes of neurocytes in the light of autoradiographic investigations. Pathologia Europaea, 1971, Volume: 6, Issue:2 Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Models, Animal; Female; Glycine; Leucine; Male; Nerve Degeneration; Nerve Tissue Proteins; Nervous System Diseases; Neurons; Nucleoproteins; Phenylalanine; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Sciatic Nerve; Thymidine; Tritium	1971
[Behavior of serum amino acids in rats with experimentally produced hyperphenylalaninemia]. Acta biologica et medica Germanica, 1971, Volume: 26, Issue:5 Topics: Alanine; Amino Acids; Animals; Disease Models, Animal; Glutamates; Phenylalanine; Proline; Rats; Threonine	1971
Alterations of individual free amino acids in brain during acute hepatic coma. Surgery, gynecology & obstetrics, 1970, Volume: 130, Issue:2 Topics: Amino Acids; Animals; Brain Chemistry; Cerebral Cortex; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Histidine; Liver; Models, Biological; Nitrogen; Phenylalanine; Tryptophan; Tyrosine; Water	1970
Hyperphenylalaninemia: disaggregation of brain polyribosomes in young rats. Science (New York, N.Y.), 1970, Apr-03, Volume: 168, Issue:3927 Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Cell-Free System; Centrifugation, Density Gradient; Disease Models, Animal; Humans; Injections, Intraperitoneal; Phenylalanine; Phenylketonurias; Protein Biosynthesis; Rats; Ribosomes	1970
Use of p-chlorophenylalanine to induce a phenylketonuric-like condition in rats. Neuropharmacology, 1970, Volume: 9, Issue:3 Topics: Animals; Body Weight; Brain; Disease Models, Animal; Female; Humans; Intellectual Disability; Learning; Mixed Function Oxygenases; Norepinephrine; Phenylalanine; Phenylketonurias; Pregnancy; Rats; Serotonin; Swimming	1970
Metabolism of phenylalanine in mice homozygous for the gene 'dilute lethal'. The Biochemical journal, 1970, Volume: 119, Issue:5 Topics: Animals; Disease Models, Animal; Female; Genes, Lethal; Homozygote; Humans; Liver; Male; Mice; Mixed Function Oxygenases; Nervous System Diseases; Organ Size; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids	1970
Cerebral lipid metabolism in experimental hyperphenylalaninaemia: incorporation of 14C-labelled glucose into total lipids. Journal of neurochemistry, 1970, Volume: 17, Issue:2 Topics: Animals; Animals, Newborn; Brain; Carbon Isotopes; Disease Models, Animal; Glucose; Humans; In Vitro Techniques; Lipids; Phenylacetates; Phenylalanine; Phenylketonurias; Phenylpyruvic Acids; Rats; Tyrosine	1970
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020