phenylalanine has been researched along with Alzheimer Disease in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.92) | 18.7374 |
| 1990's | 9 (17.65) | 18.2507 |
| 2000's | 11 (21.57) | 29.6817 |
| 2010's | 18 (35.29) | 24.3611 |
| 2020's | 11 (21.57) | 2.80 |
| Authors | Studies |
|---|---|
| Dube, T; Kour, A; Kumar, A; Panda, JJ | 1 |
| Cho, KM; Jo, JK; Kim, EJ; Kim, HW; Kim, JH; Kwon, SJ; Lee, G; Nguyen, CD; Park, SE; Seo, SH; Son, HS | 1 |
| Chang, CP; Chang, CW; Chen, YC; Li, SW; Liao, PC; Liu, YH; Ma, JT; Tan, TH | 1 |
| He, J; He, Y; Li, M; Liu, M; Sun, Z; Yang, J | 1 |
| Aggarwal, N; Chauhan, VS; Kour, A; Kumar, A; Panda, JJ; Sekhar Panda, H; Shukla, S; Tiwari, S; Tiwari, V | 1 |
| Bukharov, M; Hua, B; Huang, F; Kharlamova, A; Nazarova, A; Padnya, P; Petrov, K; Stoikov, I; Yusupov, G; Zelenikhin, P | 1 |
| Cho, SH; Choi, HK; Kim, JS; Kim, KK; Kim, MG; Koo, BS; Lee, YB; Liu, QF; Ryu, JE; Shin, SJ | 1 |
| Chang, S; Chu, X; Ding, J; Du, C; Feng, T; Ge, C; Geng, M; Gong, Y; Huang, X; Lian, W; Lin, F; Liu, J; Ruan, L; Sun, G; Wang, H; Wang, T; Wang, X; Xiao, S; Xie, Z; Yan, S; Yang, D; Yang, J; Zhang, G; Zhang, H; Zhang, J; Zhang, Q | 1 |
| Ambasta, RK; Gupta, R; Kumar, P | 1 |
| Haldar, D; Mondal, S; Nandi, SK; Podder, D; Roy Chowdhury, S | 1 |
| Liu, S; Liu, Z; Pi, Z; Song, F; Wang, A; Zheng, Z | 1 |
| Cao, Y; Liu, P; Ma, C; Qiu, WY; Wang, X; Wang, Z; Yang, Q; Yu, N | 1 |
| Genji, M; Hoshino, M; Matsuzaki, K; Yano, Y | 1 |
| Babiloni, C; Bastlund, JF; Bentivoglio, M; Bertini, G; Bordet, R; Christensen, DZ; Colavito, V; Del Percio, C; Dix, S; Drinkenburg, W; Fabene, PF; Ferri, R; Forloni, G; Frasca, A; Limatola, C; Lopez, S; Noe, FM; Pedersen, JT; Richardson, JC | 1 |
| Buell, AK; Dobson, CM; Gazit, E; Knowles, TPJ; Levin, A; Mason, TO; Michaels, TCT | 1 |
| Fuchs, D; Geisler, S; Leblhuber, F; Wissmann, P | 1 |
| Frölich, L; Hartmann, T; Hausner, L; Hentschel, F; Schmitt, HP; Tschäpe, JA | 1 |
| Soloway, AH; Soloway, PD; Warner, VD | 1 |
| Fuchs, D; Geisler, S; Leblhuber, F; Schütz, B; Steiner, K | 1 |
| Chan, AO; Chiu, PK; Chu, LW; Law, CY; Lee, SC; See, CH; Shea, YF; Yiu, KL | 1 |
| Han, W; Wu, YD; Xiong, H | 1 |
| Blesa, R; Clarimón, J; Coma, M; Ferrer, I; Gómez-Isla, T; Guardia-Laguarta, C; Lladó, A; Lleó, A; Molinuevo, JL; Pera, M; Sánchez-Valle, R | 1 |
| Fukumori, A; Gutsmiedl, A; Haass, C; Page, RM; Steiner, H; Winkler, E | 1 |
| Beattie, BL; Butler, R; Dwosh, E; Feldman, HH; Guimond, C; Hsiung, GY; Rogaeva, E; Sadovnick, AD; St George-Hyslop, P; Thong, UP | 1 |
| Chance, P; Church, A; Lillis, S; Morris, HR; Prescott, J; Rees, J; Williamson, K | 1 |
| Chen, YC; Chen, YR; Huang, HB; Lin, TH; Liu, HT; Lo, CJ; Shiao, MS; Su, CL; Wang, CC | 1 |
| Armstrong, AH; Chen, J; Hecht, MH; McKoy, AF | 1 |
| Capone, R; Jang, H; Kagan, BL; Kotler, SA; Lal, R; Nussinov, R | 1 |
| Chang, P; Dai, X; Jiang, Z; Liu, W; Sun, Y; Xu, K; Zhu, S | 1 |
| Govitrapong, P; Hernandez, JF; Htoo, HH; Jargaval, MR; Javagal, MR; Narasingapa, RB; Narasingappa, RB; Pullabhatla, S; Rao, JK; Vincent, B | 1 |
| Beher, D; Owens, AP; Shearman, MS; Wrigley, JD | 1 |
| Bianchi, G; Forti, P; Macini, P; Maioli, F; Mariani, E; Nativio, V; Ravaglia, G; Sacchetti, L; Talerico, T | 1 |
| Pogocki, D | 1 |
| Boyd-Kimball, D; Butterfield, DA; Mohmmad Abdul, H; Reed, T; Sultana, R | 1 |
| Abdel-Meguid, SS; Babine, RE; Jin, L; Navaneetham, D; Pandey, P; Strickler, JE; Walsh, PN | 1 |
| Armirotti, A; Borghi, R; Damonte, G; Gelati, M; Ghetti, B; Giordano, R; Monaco, S; Noviello, C; Piccini, A; Russo, C; Russo, R; Tabaton, M; Zambenedetti, P; Zanusso, G | 1 |
| Barcikowska, M; Filipek, S; Golan, MP; Jóźwiak, K; Lugiewicz, R; Maruszak, A; Pniewski, J; Styczyńska, M; Walecki, J; Zekanowski, C | 1 |
| Smith, I | 1 |
| Benson, MD; Farlow, M; Ghetti, B; Murrell, J; Roses, AD; Zeldenrust, SR | 1 |
| Capell, A; Citron, M; Haass, C; Selkoe, DJ; Teplow, DB | 1 |
| Citron, M; Johnston, J; Lannfelt, L; Miller, C; Schenk, D; Selkoe, DJ; Teplow, DB; Venizelos, N; Vigo-Pelfrey, C; Winblad, B | 1 |
| Haass, C; Hung, AY; Selkoe, DJ; Teplow, DB | 1 |
| Axelman, K; Cowburn, RF; Dahlkild, A; Engvall, B; Forsell, C; Froelich, S; Ingelson, M; Johansson, K; Johnston, JA; Lannfelt, L; Lilius, L; St George-Hyslop, PH; Vestling, M | 1 |
| Hooper, NM; Hussain, I; Karran, EH; Parvathy, S; Turner, AJ | 1 |
| El-Agnaf, OM; Fitzpatrick, G; Glass, WK; Guthrie, DJ; Irvine, GB | 1 |
| Beyreuther, K; Grimm, H; Lichtenthaler, SF; Masters, CL; Uljon, SN; Wang, R | 1 |
| Hooper, NM; Parkin, ET; Trew, AJ; Turner, AJ | 1 |
| Choe, H; Farzan, M; Leung, D; Schnitzler, CE; Vasilieva, N | 1 |
| Basile, AM; Capurso, A; Capurso, C; Capurso, S; Colacicco, AM; Cozza, S; D'Introno, A; Flora, R; Panza, F; Solfrizzi, V; Torres, F | 1 |
| Kuncl, RW; Martin, LJ; Rothstein, JD | 1 |
| Pardridge, WM | 1 |
3 review(s) available for phenylalanine and Alzheimer Disease
| Article | Year |
|---|---|
Mutation of the Phe20 residue in Alzheimer's amyloid beta-peptide might decrease its toxicity due to disruption of the Met35-cupric site electron transfer pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Copper; Electron Transport; Humans; Methionine; Models, Molecular; Mutation; Oxidation-Reduction; Peptide Fragments; Phenylalanine | 2004 |
The role of proteolysis in Alzheimer's disease.
Topics: ADAM Proteins; ADAM17 Protein; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biotinylation; Endopeptidases; Humans; Hydroxamic Acids; Membrane Lipids; Membrane Proteins; Metalloendopeptidases; Nerve Tissue Proteins; Phenylalanine; Presenilin-1; Presenilin-2; Protease Inhibitors; Rats; Thiophenes | 2000 |
New directions in blood-brain barrier research. Studies with isolated human brain capillaries.
Topics: Alzheimer Disease; Aspartame; Blood-Brain Barrier; Capillaries; Cerebrovascular Circulation; Humans; Neurology; Peptides; Phenylalanine | 1988 |
48 other study(ies) available for phenylalanine and Alzheimer Disease
| Article | Year |
|---|---|
Anti-Amyloidogenic and Fibril-Disaggregating Potency of the Levodopa-Functionalized Gold Nanoroses as Exemplified in a Diphenylalanine-Based Amyloid Model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Gold; Humans; Levodopa; Peptide Fragments; Phenylalanine | 2022 |
Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Gastrointestinal Microbiome; Glutamic Acid; Glycerol; Hypoxanthines; Inosine; Mice; Oxalates; Phenylalanine; Pyrrolidonecarboxylic Acid; Xylose | 2022 |
Rat Hair Metabolomics Analysis Reveals Perturbations of Unsaturated Fatty Acid Biosynthesis, Phenylalanine, and Arachidonic Acid Metabolism Pathways Are Associated with Amyloid-β-Induced Cognitive Deficits.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonic Acid; Biomarkers; Cognition; Cognitive Dysfunction; Cortisone; Fatty Acids, Unsaturated; Hair; Metabolomics; Phenylalanine; Rats | 2023 |
Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer's Disease.
Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; D-Aspartic Acid; Humans; Neurodegenerative Diseases; Phenylalanine; Proline; Tandem Mass Spectrometry | 2023 |
Anti-amyloidogenic amphipathic arginine-dehydrophenylalanine spheres capped selenium nanoparticles as potent therapeutic moieties for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Dipeptides; Humans; Nanoparticles; Neuroblastoma; Peptide Fragments; Phenylalanine; Rats; Selenium; Streptozocin | 2023 |
Peptidomimetics based on ammonium decasubstituted pillar[5]arenes: Influence of the alpha-amino acid residue nature on cholinesterase inhibition.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Peptidomimetics; Phenylalanine; Structure-Activity Relationship; Tryptophan | 2023 |
Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Donepezil; Humans; Metabolome; Methionine; Mice; Mice, Inbred ICR; Neuroblastoma; Phenylalanine; Reactive Oxygen Species; Scopolamine Derivatives; Tyrosine | 2024 |
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.
Topics: Alzheimer Disease; Amino Acids; Animals; Anti-Bacterial Agents; Bacteria; Clinical Trials, Phase III as Topic; Cognitive Dysfunction; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Humans; Isoleucine; Mannose; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Oligosaccharides; Phenylalanine; Th1 Cells | 2019 |
Identification of novel class I and class IIb histone deacetylase inhibitor for Alzheimer's disease therapeutics.
Topics: Alzheimer Disease; Aspartic Acid; Databases, Chemical; Drug Evaluation, Preclinical; Glycine; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Machine Learning; Molecular Docking Simulation; Molecular Structure; Molecular Targeted Therapy; Phenylalanine; Protein Isoforms; Pyrimidines; Thermodynamics; Zinc | 2020 |
Acid-responsive fibrillation and urease-assisted defibrillation of phenylalanine: a transient supramolecular hydrogel.
Topics: Alzheimer Disease; Humans; Hydrogels; Phenylalanine; Proteins; Urease | 2020 |
Mass spectrometry-based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Disease Models, Animal; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Inflammation; Mass Spectrometry; Medicine, Chinese Traditional; Metabolomics; Nervous System; Panax; Phenylalanine; Plant Extracts; Rats; Reproducibility of Results; Schisandra; Tandem Mass Spectrometry; Tyrosine; Urinalysis | 2021 |
Phenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer's Disease Related Pathological Changes.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Brain; Female; Hippocampus; Humans; Male; Metabolomics; Phenylalanine; Up-Regulation | 2021 |
Aromaticity of Phenylalanine Residues Is Essential for Amyloid Formation by Alzheimer's Amyloid β-Peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Phenylalanine | 2017 |
Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F).
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Arousal; Brain Mapping; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Fourier Analysis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phenylalanine; Valine | 2018 |
Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Dipeptides; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Phenylalanine; Thermodynamics | 2017 |
Immune activation in patients with Alzheimer's disease is associated with high serum phenylalanine concentrations.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Neuropsychological Tests; Phenylalanine; Psychiatric Status Rating Scales; Single-Blind Method; Statistics, Nonparametric; Tyrosine | 2013 |
Clinical characterization of a presenilin 1 mutation (F177S) in a family with very early-onset Alzheimer's disease in the third decade of life.
Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Brain Waves; Cognition Disorders; Electroencephalography; Family Health; Female; Genetic Predisposition to Disease; Humans; Male; Mental Status Schedule; Middle Aged; Mutation; Peptide Fragments; Phenylalanine; Positron-Emission Tomography; Presenilin-1; Radiography; Serine | 2014 |
Possible chemical initiators of cognitive dysfunction in phenylketonuria, Parkinson's disease and Alzheimer's disease.
Topics: Alzheimer Disease; Catechols; Cognition Disorders; Humans; Metabolic Networks and Pathways; Methionine; Models, Biological; Molecular Structure; Oxidative Stress; Parkinson Disease; Phenylalanine; Phenylketonurias; Tyrosine | 2013 |
Elevated fecal calprotectin in patients with Alzheimer's dementia indicates leaky gut.
Topics: Aged; Alzheimer Disease; Feces; Female; Humans; Leukocyte L1 Antigen Complex; Male; Phenylalanine; Tryptophan; Tyrosine | 2015 |
Novel presenilin 1 mutation (p.F386I) in a Chinese family with early-onset Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Asian People; Codon; Female; Genes, Dominant; Genetic Association Studies; Heterozygote; Humans; Isoleucine; Male; Middle Aged; Mutation, Missense; Phenylalanine; Presenilin-1 | 2017 |
In silico study on the effect of F19T mutation on amyloid-beta peptide (10-35).
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Computer Simulation; Drug Stability; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Mutation; Peptide Fragments; Phenylalanine; Static Electricity; Threonine | 2008 |
Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.
Topics: Adult; Age of Onset; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Enzyme-Linked Immunosorbent Assay; Humans; Isoleucine; Male; Mutation; Neurologic Examination; Phenylalanine; Transfection | 2010 |
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
Topics: Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell-Free System; Humans; Immunoassay; Models, Biological; Mutation; Peptide Hydrolases; Peptides; Phenylalanine; Protein Binding | 2010 |
A novel PS1 gene mutation in a large Aboriginal kindred.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Canada; Family Health; Female; Genome-Wide Association Study; Humans; Leucine; Male; Middle Aged; Mutation; Neuropsychological Tests; Phenylalanine; Presenilin-1 | 2010 |
A novel presenilin 1 mutation, I202F occurring at a previously predicted pathogenic site causing autosomal dominant Alzheimer's disease.
Topics: Alzheimer Disease; Female; Humans; Isoleucine; Male; Middle Aged; Mutation; Phenylalanine; Predictive Value of Tests; Presenilin-1 | 2011 |
Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cell Survival; Humans; Leucine; Mutation; Neurons; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Peptide Fragments; Phenylalanine; Protein Conformation; Rats; Urea | 2011 |
Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amino Acids, Aromatic; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Leucine; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Phenylalanine; Protein Processing, Post-Translational | 2011 |
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Crystallography, X-Ray; Cysteine; DNA Mutational Analysis; Humans; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Peptide Fragments; Phenylalanine; Point Mutation; Proline | 2012 |
Aβ-40 Y10F increases βfibrils formation but attenuates the neurotoxicity of amyloid-β peptide.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cells, Cultured; Humans; Hydrogen Peroxide; Neurons; Peptide Fragments; Phenylalanine; Protein Aggregation, Pathological; Protein Folding; Protein Structure, Secondary; Rats, Sprague-Dawley; Tyrosine | 2012 |
Activation of α-secretase by curcumin-aminoacid conjugates.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Curcumin; Enzyme Activation; HEK293 Cells; Humans; Isoleucine; Membrane Proteins; Phenylalanine; Valine | 2012 |
Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antibodies, Monoclonal; Antibody Specificity; Aspartic Acid Endopeptidases; Cell Line; Culture Media, Conditioned; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Fluorobenzenes; Humans; Kidney; Mass Spectrometry; Metalloendopeptidases; Molecular Sequence Data; Neuroblastoma; Pentanoic Acids; Peptide Fragments; Peptides; Phenylalanine; Recombinant Proteins; Thiophenes; Transfection | 2002 |
Plasma amino acid concentrations in healthy and cognitively impaired oldest-old individuals: associations with anthropometric parameters of body composition and functional disability.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Analysis of Variance; Body Composition; Body Mass Index; Case-Control Studies; Chi-Square Distribution; Creatinine; Disabled Persons; Female; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Phenylalanine; Tyrosine | 2002 |
Role of phenylalanine 20 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Animals; Cell Culture Techniques; Copper; Female; Mitochondria; Molecular Sequence Data; Neurons; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Phenylalanine; Point Mutation; Pregnancy; Rats; Time Factors | 2004 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Disulfides; DNA Mutational Analysis; Dose-Response Relationship, Drug; Factor XIa; Humans; Inhibitory Concentration 50; Kinetics; Lysine; Models, Molecular; Models, Statistical; Mutation; Partial Thromboplastin Time; Phenylalanine; Plasmids; Point Mutation; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin; Time Factors; Vesicular Transport Proteins | 2005 |
Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brain; DNA Mutational Analysis; Humans; Male; Mutation; Peptide Fragments; Phenotype; Phenylalanine; Presenilin-1; Serine | 2007 |
Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene.
Topics: Adult; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Models, Molecular; Mutation; Phenylalanine; Presenilin-1; Serine; Time Factors | 2007 |
Significantly lower mean plasma total biopterin in 18 patients with senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Creatinine; Humans; Phenylalanine; Pteridines | 1984 |
RFLP analysis for APP 717 mutations associated with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Base Sequence; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Mutational Analysis; Electrophoresis, Agar Gel; Humans; Molecular Sequence Data; Phenylalanine; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Valine | 1993 |
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Cell Line; Cell Membrane; Cells, Cultured; DNA, Complementary; Fibroblasts; Humans; Kidney; Kinetics; Macrolides; Methionine; Molecular Sequence Data; Mutation; Phenylalanine; Protein Processing, Post-Translational; Proton-Translocating ATPases; Recombinant Proteins; Reference Values; Skin; Sulfur Radioisotopes; Sulfuric Acid Esters; Sweden; Transfection; Vacuoles; Valine | 1995 |
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cells, Cultured; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Genotype; Humans; Kidney; Methionine; Phenylalanine; Point Mutation; Skin; Sulfur Radioisotopes; Sweden; Tritium | 1994 |
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Base Sequence; Cells, Cultured; Chromosome Mapping; Humans; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Phenylalanine; Protein Processing, Post-Translational; Transfection | 1994 |
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease.
Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Genetic Testing; Humans; Leucine; Membrane Proteins; Phenylalanine; Point Mutation; Polymorphism, Single-Stranded Conformational; Presenilin-1; Presenilin-2; Sequence Analysis, DNA | 1997 |
Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Drug Screening Assays, Antitumor; Endopeptidases; Enzyme Inhibitors; Humans; Hydroxamic Acids; Metalloendopeptidases; Microvilli; Neuroblastoma; Peptidyl-Dipeptidase A; Phenylalanine; Swine; Tetrazolium Salts; Thiophenes; Tumor Cells, Cultured; Zinc | 1998 |
Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Abeta peptide [Abeta(25-35)].
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Circular Dichroism; Eledoisin; Magnetic Resonance Spectroscopy; Neurokinin B; Norleucine; Peptide Fragments; Phenylalanine; Rats; Substance P; Tachykinins | 1998 |
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Binding Sites; COS Cells; Endopeptidases; Humans; Mutagenesis, Site-Directed; Phenylalanine; Substrate Specificity | 1999 |
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Arginine; Aspartic Acid Endopeptidases; Binding Sites; Cell Line; Cloning, Molecular; Endopeptidases; Gene Expression Profiling; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutation, Missense; Nervous System; Netherlands; Peptide Fragments; Phenylalanine; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Sweden | 2000 |
F175S change and a novel polymorphism in presenilin-1 gene in late-onset familial Alzheimer's disease.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Humans; Male; Membrane Proteins; Middle Aged; Mutation, Missense; Pedigree; Phenylalanine; Polymerase Chain Reaction; Presenilin-1; Serine | 2002 |
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis.
Topics: Aged; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biological Transport; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; In Vitro Techniques; Male; Middle Aged; Motor Cortex; Phenylalanine; Somatosensory Cortex; Spinal Cord; Synaptosomes; Visual Cortex | 1992 |