phenylahistin and Carcinoma--Lewis-Lung

phenylahistin has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for phenylahistin and Carcinoma--Lewis-Lung

Article	Year
Antitumor activity of phenylahistin in vitro and in vivo. Bioscience, biotechnology, and biochemistry, 1999, Volume: 63, Issue:6 Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo. Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Lewis Lung; Cell Cycle; Diketopiperazines; Leukemia P388; Male; Mice; Piperazines; Stereoisomerism; Tumor Cells, Cultured	1999

Article

Year

Antitumor activity of phenylahistin in vitro and in vivo.

Bioscience, biotechnology, and biochemistry, 1999, Volume: 63, Issue:6

Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.

Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Lewis Lung; Cell Cycle; Diketopiperazines; Leukemia P388; Male; Mice; Piperazines; Stereoisomerism; Tumor Cells, Cultured

1999