phenylahistin has been researched along with Carcinoma--Lewis-Lung* in 1 studies
1 other study(ies) available for phenylahistin and Carcinoma--Lewis-Lung
Article | Year |
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Antitumor activity of phenylahistin in vitro and in vivo.
Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo. Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Lewis Lung; Cell Cycle; Diketopiperazines; Leukemia P388; Male; Mice; Piperazines; Stereoisomerism; Tumor Cells, Cultured | 1999 |