phenylacetic acid has been researched along with Neuroblastoma in 5 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the morphology of PA-treated medulloblastoma cells was not significantly altered, the D283 MED cells exhibited increased expression of neurofilament proteins and Hu antigen, indicative of differentiation along a neuronal pathway." | 1.29 | Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate. ( Johnson, R; Lieberman, FS; Manley, GT; Rosenblum, MK; Samid, D; Stockhammer, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stockhammer, G | 1 |
| Manley, GT | 1 |
| Johnson, R | 1 |
| Rosenblum, MK | 1 |
| Samid, D | 2 |
| Lieberman, FS | 1 |
| Sidell, N | 3 |
| Wada, R | 1 |
| Han, G | 1 |
| Chang, B | 2 |
| Shack, S | 1 |
| Moore, T | 1 |
| Cinatl, J | 2 |
| Mainke, M | 1 |
| Weissflog, A | 1 |
| Rabenau, H | 1 |
| Kornhuber, B | 1 |
| Doerr, HW | 1 |
| Yamashiro, JM | 1 |
| Wada, RK | 2 |
| Han, S | 1 |
5 other studies available for phenylacetic acid and Neuroblastoma
| Article | Year |
|---|---|
Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.
Topics: Animals; Astrocytoma; Cell Differentiation; Cell Division; Cell Line; DNA, Neoplasm; Dose-Response R | 1995 |
Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells.
Topics: Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Genes, myc; G | 1995 |
In vitro differentiation of human neuroblastoma cells induced by sodium phenylacetate.
Topics: Cell Differentiation; Cell Division; Cell Survival; Culture Media; DNA, Neoplasm; Humans; Neuroblast | 1993 |
Transcriptional upregulation of retinoic acid receptor beta (RAR beta) expression by phenylacetate in human neuroblastoma cells.
Topics: Antimetabolites, Antineoplastic; Binding Sites; Cell Differentiation; Chloramphenicol O-Acetyltransf | 1998 |
Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma.
Topics: Acetylcholinesterase; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Nucleus; Humans; L | 2001 |