phenylacetic acid has been researched along with Melanoma in 3 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "By contrast, treatment of melanoma cells that were in a more advanced stage of maturation resulted in profound alterations in cell growth, morphology, and pigmentation consistent with terminal differentiation." | 1.29 | Differentiation of cultured human melanoma cells induced by the aromatic fatty acids phenylacetate and phenylbutyrate. ( Hudgins, WR; Liu, L; Samid, D; Shack, S; Stetler-Stevenson, WG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 2 |
| Hudgins, WR | 2 |
| Miller, AC | 1 |
| Chen, LC | 1 |
| Samid, D | 2 |
| Shack, S | 1 |
| Stetler-Stevenson, WG | 1 |
| Gervelas, C | 1 |
| Avramoglou, T | 1 |
| Crépin, M | 1 |
| Jozefonvicz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for phenylacetic acid and Melanoma
| Article | Year |
|---|---|
Transcriptional upregulation of TGF-alpha by phenylacetate and phenylbutyrate is associated with differentiation of human melanoma cells.
Topics: Antineoplastic Agents; Cell Differentiation; Culture Media; Gene Expression Regulation, Neoplastic; | 1995 |
Differentiation of cultured human melanoma cells induced by the aromatic fatty acids phenylacetate and phenylbutyrate.
Topics: Antineoplastic Agents; Carcinogenicity Tests; Cell Differentiation; Cell Division; Drug Synergism; F | 1994 |
Growth inhibition of human melanoma tumor cells by the combination of sodium phenylacetate (NaPA) and substituted dextrans and one NaPA-dextran conjugate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Survival; Dextrans; Dru | 2002 |