phenylacetic acid has been researched along with Medulloblastoma in 3 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the morphology of PA-treated medulloblastoma cells was not significantly altered, the D283 MED cells exhibited increased expression of neurofilament proteins and Hu antigen, indicative of differentiation along a neuronal pathway." | 1.29 | Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate. ( Johnson, R; Lieberman, FS; Manley, GT; Rosenblum, MK; Samid, D; Stockhammer, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, XN | 1 |
| Parikh, S | 1 |
| Shu, Q | 1 |
| Jung, HL | 1 |
| Chow, CW | 1 |
| Perlaky, L | 1 |
| Leung, HC | 1 |
| Su, J | 1 |
| Blaney, S | 1 |
| Lau, CC | 1 |
| Stockhammer, G | 1 |
| Manley, GT | 1 |
| Johnson, R | 1 |
| Rosenblum, MK | 1 |
| Samid, D | 1 |
| Lieberman, FS | 1 |
| Ozawa, T | 1 |
| Lu, RM | 1 |
| Hu, LJ | 1 |
| Lamborn, KR | 1 |
| Prados, MD | 1 |
| Deen, DF | 1 |
3 other studies available for phenylacetic acid and Medulloblastoma
| Article | Year |
|---|---|
Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Differentia | 2004 |
Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate.
Topics: Animals; Astrocytoma; Cell Differentiation; Cell Division; Cell Line; DNA, Neoplasm; Dose-Response R | 1995 |
Radiopotentiation of human brain tumor cells by sodium phenylacetate.
Topics: Brain Neoplasms; Cell Division; Cell Hypoxia; Cell Survival; Glioblastoma; Humans; Medulloblastoma; | 1999 |