phenylacetic acid has been researched along with Kidney Failure, Chronic in 7 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenylacetic acid (PAA) is a recently described uremic toxin that inhibits inducible nitric oxide synthase expression and plasma membrane calcium ATPase and may therefore also be involved in remodeling of arteries." | 1.34 | Phenylacetic acid and arterial vascular properties in patients with chronic kidney disease stage 5 on hemodialysis therapy. ( Haass, W; Henning, L; Jankowski, J; Jankowski, V; Scholze, A; Suvd-Erdene, S; Tepel, M; Wittstock, A; Zidek, W, 2007) |
| "Paraoxonase is an esterase that hydrolyzes organophosphate compounds." | 1.30 | Decrease of serum paraoxonase activity in chronic renal failure. ( Charmes, JP; Dantoine, TF; Debord, J; Lachatre, G; Leroux-Robert, C; Marquet, P; Merle, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henning, BF | 1 |
| Holzhausen, H | 1 |
| Tepel, M | 3 |
| Morita, M | 1 |
| Yano, S | 2 |
| Yamaguchi, T | 2 |
| Yamauchi, M | 2 |
| Sugimoto, T | 2 |
| Jankowski, J | 3 |
| van der Giet, M | 2 |
| Jankowski, V | 3 |
| Schmidt, S | 2 |
| Hemeier, M | 1 |
| Mahn, B | 1 |
| Giebing, G | 1 |
| Tolle, M | 1 |
| Luftmann, H | 1 |
| Schluter, H | 1 |
| Zidek, W | 3 |
| Scholze, A | 1 |
| Henning, L | 1 |
| Haass, W | 1 |
| Wittstock, A | 1 |
| Suvd-Erdene, S | 1 |
| Kanazawa, I | 1 |
| Ogawa, N | 1 |
| Hayashi, K | 1 |
| Westhoff, TH | 1 |
| Krauser, P | 1 |
| Ignatius, R | 1 |
| Dantoine, TF | 1 |
| Debord, J | 1 |
| Charmes, JP | 1 |
| Merle, L | 1 |
| Marquet, P | 1 |
| Lachatre, G | 1 |
| Leroux-Robert, C | 1 |
7 other studies available for phenylacetic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Continuous reduction of plasma paraoxonase activity with increasing dialysis vintage in hemodialysis patients.
Topics: Analysis of Variance; Aryldialkylphosphatase; Cross-Sectional Studies; Esterases; Female; Humans; Ki | 2010 |
Phenylacetic acid stimulates reactive oxygen species generation and tumor necrosis factor-α secretion in vascular endothelial cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aorta; Cells, Cultured; Deoxyguanosine; Dose-Response Relationship, Dru | 2011 |
Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression.
Topics: Adult; Aged; Animals; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Re | 2003 |
Phenylacetic acid and arterial vascular properties in patients with chronic kidney disease stage 5 on hemodialysis therapy.
Topics: Aged; Arteries; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Phenylacetates; | 2007 |
The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure.
Topics: 3T3 Cells; Animals; Bone and Bones; Calcification, Physiologic; Cell Differentiation; Cell Division; | 2007 |
The uraemic toxin phenylacetic acid impairs macrophage function.
Topics: Adult; Animals; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Kidney Failure, Chron | 2008 |
Decrease of serum paraoxonase activity in chronic renal failure.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arteriosclerosis; Aryldialkylphosphatase; Esterases; Fem | 1998 |