phenylacetic acid has been researched along with Invasiveness, Neoplasm in 5 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the highly invasive breast cancer cell line MDA-MB-231, we demonstrated that an 18-hour incubation with NaPa strongly inhibits the cell invasiveness through Matrigel (86% inhibition at 20 mM of NaPa)." | 1.31 | Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules. ( Crépin, M; Legrand, E; Paysant, J; Soria, C; Thibout, D; Vasse, M, 2001) |
| "By contrast, treatment of melanoma cells that were in a more advanced stage of maturation resulted in profound alterations in cell growth, morphology, and pigmentation consistent with terminal differentiation." | 1.29 | Differentiation of cultured human melanoma cells induced by the aromatic fatty acids phenylacetate and phenylbutyrate. ( Hudgins, WR; Liu, L; Samid, D; Shack, S; Stetler-Stevenson, WG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 2 |
| Shack, S | 3 |
| Stetler-Stevenson, WG | 1 |
| Hudgins, WR | 1 |
| Samid, D | 4 |
| Myers, CE | 1 |
| Prasanna, P | 2 |
| Thibault, A | 1 |
| Wilson, VL | 1 |
| Vasse, M | 1 |
| Thibout, D | 1 |
| Paysant, J | 1 |
| Legrand, E | 1 |
| Soria, C | 1 |
| Crépin, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for phenylacetic acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Differentiation of cultured human melanoma cells induced by the aromatic fatty acids phenylacetate and phenylbutyrate.
Topics: Antineoplastic Agents; Carcinogenicity Tests; Cell Differentiation; Cell Division; Drug Synergism; F | 1994 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.
Topics: Animals; Cell Division; Cell Survival; DNA Replication; Female; Glutamine; HLA-A3 Antigen; Humans; M | 1993 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 1996 |
Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine-induced carcinogenesis.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Azacitidine; Carcinogens; Cell Division; Cell Transform | 1995 |
Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion Molecules; Humans; Neoplasm Invasiveness; Phe | 2001 |