phenylacetic acid has been researched along with Glioma in 6 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine whether aromatic fatty acids are potential imaging agents for PPARalpha or tumors in general, [11C]phenylacetic acid (PAA) and [18F]fluorophenyl-acetic acid (FPAA) were synthesized and evaluated in EMT-6 tumor bearing mice and 9L-Glioma tumor bearing rats and compared to [11C]acetate." | 3.71 | Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids. ( Jonson, SD; Welch, MJ, 2002) |
| "Because primary brain tumors are highly reminiscent of the immature central nervous system, these neoplasms should be equally vulnerable." | 1.29 | Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. ( Hudgins, WR; Liu, L; Myers, CE; Oldfield, EH; Ram, Z; Samid, D; Shack, S; Walbridge, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samid, D | 2 |
| Ram, Z | 1 |
| Hudgins, WR | 1 |
| Shack, S | 1 |
| Liu, L | 2 |
| Walbridge, S | 1 |
| Oldfield, EH | 1 |
| Myers, CE | 1 |
| Prasanna, P | 1 |
| Thibault, A | 1 |
| Chang, SM | 1 |
| Kuhn, JG | 1 |
| Robins, HI | 1 |
| Schold, SC | 1 |
| Spence, AM | 1 |
| Berger, MS | 1 |
| Mehta, MP | 1 |
| Bozik, ME | 1 |
| Pollack, I | 1 |
| Schiff, D | 1 |
| Gilbert, M | 1 |
| Rankin, C | 1 |
| Prados, MD | 1 |
| Burzynski, SR | 1 |
| Jonson, SD | 1 |
| Welch, MJ | 1 |
| Tian, Y | 1 |
| Yang, C | 1 |
| Zhao, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phenylacetic acid and Glioma
| Article | Year |
|---|---|
Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Neop | 1999 |
5 other studies available for phenylacetic acid and Glioma
| Article | Year |
|---|---|
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 1996 |
Efficacy of antineoplastons A10 and AS2-1.
Topics: Antineoplastic Agents; Benzeneacetamides; Clinical Trials as Topic; Dose-Response Relationship, Drug | 1999 |
Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids.
Topics: Acetates; Animals; Carbon Radioisotopes; Female; Fluorine Radioisotopes; Glioma; Kidney; Liver; Mamm | 2002 |
[Up regulation of phenylacetate to glioma homeobox gene expression].
Topics: Animals; Antimetabolites, Antineoplastic; Gene Expression Regulation, Neoplastic; Genes, Homeobox; G | 2002 |