phenylacetic acid has been researched along with Glial Cell Tumors in 6 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine whether aromatic fatty acids are potential imaging agents for PPARalpha or tumors in general, [11C]phenylacetic acid (PAA) and [18F]fluorophenyl-acetic acid (FPAA) were synthesized and evaluated in EMT-6 tumor bearing mice and 9L-Glioma tumor bearing rats and compared to [11C]acetate." | 3.71 | Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids. ( Jonson, SD; Welch, MJ, 2002) |
| "Because primary brain tumors are highly reminiscent of the immature central nervous system, these neoplasms should be equally vulnerable." | 1.29 | Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. ( Hudgins, WR; Liu, L; Myers, CE; Oldfield, EH; Ram, Z; Samid, D; Shack, S; Walbridge, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samid, D | 2 |
| Ram, Z | 1 |
| Hudgins, WR | 1 |
| Shack, S | 1 |
| Liu, L | 2 |
| Walbridge, S | 1 |
| Oldfield, EH | 1 |
| Myers, CE | 1 |
| Prasanna, P | 1 |
| Thibault, A | 1 |
| Chang, SM | 1 |
| Kuhn, JG | 1 |
| Robins, HI | 1 |
| Schold, SC | 1 |
| Spence, AM | 1 |
| Berger, MS | 1 |
| Mehta, MP | 1 |
| Bozik, ME | 1 |
| Pollack, I | 1 |
| Schiff, D | 1 |
| Gilbert, M | 1 |
| Rankin, C | 1 |
| Prados, MD | 1 |
| Burzynski, SR | 1 |
| Jonson, SD | 1 |
| Welch, MJ | 1 |
| Tian, Y | 1 |
| Yang, C | 1 |
| Zhao, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phenylacetic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Neop | 1999 |
5 other studies available for phenylacetic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 1996 |
Efficacy of antineoplastons A10 and AS2-1.
Topics: Antineoplastic Agents; Benzeneacetamides; Clinical Trials as Topic; Dose-Response Relationship, Drug | 1999 |
Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids.
Topics: Acetates; Animals; Carbon Radioisotopes; Female; Fluorine Radioisotopes; Glioma; Kidney; Liver; Mamm | 2002 |
[Up regulation of phenylacetate to glioma homeobox gene expression].
Topics: Animals; Antimetabolites, Antineoplastic; Gene Expression Regulation, Neoplastic; Genes, Homeobox; G | 2002 |