phenylacetic acid has been researched along with Brain Neoplasms in 9 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of six patients with glioblastoma multiforme, whose steroid dosage has remained unchanged for the duration of therapy, has sustained functional improvement for more than 9 months." | 2.67 | A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer. ( Cooper, MR; Figg, WD; Headlee, DJ; McCall, NA; Samid, D; Sartor, AO; Thibault, A; Tompkins, AC; Venzon, DJ; Weinberger, MS, 1994) |
| " The steady state plasma concentrations of PA and phenylacetylglutamine were comparatively the same between the two dosing schedules." | 1.32 | A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report. ( Berger, MS; Chang, SM; Clifford Schold, S; Gilbert, M; Ian Robins, H; Kuhn, JG; Mehta, MP; Pollack, I; Prados, MD; Spence, AM, 2003) |
| "Rats with established brain tumors (n = 12) received continuous s." | 1.29 | Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. ( Myers, CE; Oldfield, EH; Oshiro, EM; Ram, Z; Samid, D; Shack, S; Tao-Cheng, JH; Thibault, A; Viola, JJ; Walbridge, S, 1994) |
| "Because primary brain tumors are highly reminiscent of the immature central nervous system, these neoplasms should be equally vulnerable." | 1.29 | Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. ( Hudgins, WR; Liu, L; Myers, CE; Oldfield, EH; Ram, Z; Samid, D; Shack, S; Walbridge, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (88.89) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, SM | 2 |
| Kuhn, JG | 2 |
| Ian Robins, H | 1 |
| Clifford Schold, S | 1 |
| Spence, AM | 2 |
| Berger, MS | 2 |
| Mehta, MP | 2 |
| Pollack, I | 2 |
| Gilbert, M | 2 |
| Prados, MD | 3 |
| Thibault, A | 3 |
| Cooper, MR | 1 |
| Figg, WD | 1 |
| Venzon, DJ | 1 |
| Sartor, AO | 1 |
| Tompkins, AC | 1 |
| Weinberger, MS | 1 |
| Headlee, DJ | 1 |
| McCall, NA | 1 |
| Samid, D | 5 |
| Ram, Z | 2 |
| Walbridge, S | 2 |
| Oshiro, EM | 1 |
| Viola, JJ | 1 |
| Tao-Cheng, JH | 1 |
| Shack, S | 3 |
| Myers, CE | 3 |
| Oldfield, EH | 2 |
| Hudgins, WR | 2 |
| Liu, L | 3 |
| Prasanna, P | 2 |
| Robins, HI | 1 |
| Schold, SC | 1 |
| Bozik, ME | 1 |
| Schiff, D | 1 |
| Rankin, C | 1 |
| Ozawa, T | 1 |
| Lu, RM | 1 |
| Hu, LJ | 1 |
| Lamborn, KR | 1 |
| Deen, DF | 1 |
| Smigel, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenylacetic acid and Brain Neoplasms
| Article | Year |
|---|---|
Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers.
Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Differentiation; Clinical Trials, Phas | 1997 |
2 trials available for phenylacetic acid and Brain Neoplasms
| Article | Year |
|---|---|
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Administration Schedule; Female; Glioblast | 1994 |
Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Neop | 1999 |
6 other studies available for phenylacetic acid and Brain Neoplasms
| Article | Year |
|---|---|
A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report.
Topics: Adult; Aged; Brain Neoplasms; Cohort Studies; Confidence Intervals; Drug Administration Schedule; Fe | 2003 |
Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate.
Topics: Animals; Brain Neoplasms; Cell Division; Drug Screening Assays, Antitumor; Gliosarcoma; Microscopy, | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 1996 |
Radiopotentiation of human brain tumor cells by sodium phenylacetate.
Topics: Brain Neoplasms; Cell Division; Cell Hypoxia; Cell Survival; Glioblastoma; Humans; Medulloblastoma; | 1999 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplas | 1992 |