phenylacetic acid has been researched along with Benign Neoplasms, Brain in 9 studies
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of six patients with glioblastoma multiforme, whose steroid dosage has remained unchanged for the duration of therapy, has sustained functional improvement for more than 9 months." | 2.67 | A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer. ( Cooper, MR; Figg, WD; Headlee, DJ; McCall, NA; Samid, D; Sartor, AO; Thibault, A; Tompkins, AC; Venzon, DJ; Weinberger, MS, 1994) |
| " The steady state plasma concentrations of PA and phenylacetylglutamine were comparatively the same between the two dosing schedules." | 1.32 | A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report. ( Berger, MS; Chang, SM; Clifford Schold, S; Gilbert, M; Ian Robins, H; Kuhn, JG; Mehta, MP; Pollack, I; Prados, MD; Spence, AM, 2003) |
| "Rats with established brain tumors (n = 12) received continuous s." | 1.29 | Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. ( Myers, CE; Oldfield, EH; Oshiro, EM; Ram, Z; Samid, D; Shack, S; Tao-Cheng, JH; Thibault, A; Viola, JJ; Walbridge, S, 1994) |
| "Because primary brain tumors are highly reminiscent of the immature central nervous system, these neoplasms should be equally vulnerable." | 1.29 | Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. ( Hudgins, WR; Liu, L; Myers, CE; Oldfield, EH; Ram, Z; Samid, D; Shack, S; Walbridge, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (88.89) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, SM | 2 |
| Kuhn, JG | 2 |
| Ian Robins, H | 1 |
| Clifford Schold, S | 1 |
| Spence, AM | 2 |
| Berger, MS | 2 |
| Mehta, MP | 2 |
| Pollack, I | 2 |
| Gilbert, M | 2 |
| Prados, MD | 3 |
| Thibault, A | 3 |
| Cooper, MR | 1 |
| Figg, WD | 1 |
| Venzon, DJ | 1 |
| Sartor, AO | 1 |
| Tompkins, AC | 1 |
| Weinberger, MS | 1 |
| Headlee, DJ | 1 |
| McCall, NA | 1 |
| Samid, D | 5 |
| Ram, Z | 2 |
| Walbridge, S | 2 |
| Oshiro, EM | 1 |
| Viola, JJ | 1 |
| Tao-Cheng, JH | 1 |
| Shack, S | 3 |
| Myers, CE | 3 |
| Oldfield, EH | 2 |
| Hudgins, WR | 2 |
| Liu, L | 3 |
| Prasanna, P | 2 |
| Robins, HI | 1 |
| Schold, SC | 1 |
| Bozik, ME | 1 |
| Schiff, D | 1 |
| Rankin, C | 1 |
| Ozawa, T | 1 |
| Lu, RM | 1 |
| Hu, LJ | 1 |
| Lamborn, KR | 1 |
| Deen, DF | 1 |
| Smigel, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Progressive or Recurrent CNS Malignancy[NCT00006450] | Phase 2 | 120 participants | Interventional | 2000-11-30 | Completed | ||
| Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy[NCT00001565] | Phase 1 | 35 participants | Interventional | 1996-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenylacetic acid and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Phenylacetate and phenylbutyrate as novel, nontoxic differentiation inducers.
Topics: Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Differentiation; Clinical Trials, Phas | 1997 |
2 trials available for phenylacetic acid and Benign Neoplasms, Brain
| Article | Year |
|---|---|
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Administration Schedule; Female; Glioblast | 1994 |
Phase II study of phenylacetate in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Neop | 1999 |
6 other studies available for phenylacetic acid and Benign Neoplasms, Brain
| Article | Year |
|---|---|
A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report.
Topics: Adult; Aged; Brain Neoplasms; Cohort Studies; Confidence Intervals; Drug Administration Schedule; Fe | 2003 |
Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate.
Topics: Animals; Brain Neoplasms; Cell Division; Drug Screening Assays, Antitumor; Gliosarcoma; Microscopy, | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.
Topics: Animals; Brain; Brain Neoplasms; Female; Glioma; Humans; Mevalonic Acid; Mice; Mice, Nude; Phenylace | 1994 |
Lipid metabolism as a target for brain cancer therapy: synergistic activity of lovastatin and sodium phenylacetate against human glioma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 1996 |
Radiopotentiation of human brain tumor cells by sodium phenylacetate.
Topics: Brain Neoplasms; Cell Division; Cell Hypoxia; Cell Survival; Glioblastoma; Humans; Medulloblastoma; | 1999 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplas | 1992 |