phenylacetic acid and Atherosclerosis studies

phenylacetic acid and Atherosclerosis

phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.

Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Research Excerpts

Excerpt	Relevance	Reference
" Quinoline 16 showed good oral bioavailability and in vivo efficacy in a LDLr knockout mouse model for lesions."	1.33	Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis. ( Azam, F; Basso, M; Bonn, T; Chen, L; Clerin, V; Collini, M; Enroth, C; Farnegardh, M; Feingold, I; Goos-Nilsson, A; Halpern, A; Hu, B; Huselton, C; Keith, J; Liu, QY; Miller, C; Nambi, P; Quinet, E; Resmini, C; Savio, D; Singhaus, R; Unwalla, R; Wilhelmsson, A; Wrobel, J, 2006)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

2 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Hu, B	2
Collini, M	1
Unwalla, R	2
Miller, C	1
Singhaus, R	2
Quinet, E	2
Savio, D	2
Halpern, A	2
Basso, M	2
Keith, J	2
Clerin, V	2
Chen, L	2
Resmini, C	1
Liu, QY	2
Feingold, I	2
Huselton, C	2
Azam, F	2
Farnegardh, M	1
Enroth, C	1
Bonn, T	1
Goos-Nilsson, A	2
Wilhelmsson, A	2
Nambi, P	2
Wrobel, J	2
Jetter, J	1
Kaufman, D	1
Bernotas, R	1

Studies

Hu, B

Collini, M

Unwalla, R

Miller, C

Singhaus, R

Quinet, E

Savio, D

Halpern, A

Basso, M

Keith, J

Clerin, V

Chen, L

Resmini, C

Liu, QY

Feingold, I

Huselton, C

Azam, F

Farnegardh, M

Enroth, C

Bonn, T

Goos-Nilsson, A

Wilhelmsson, A

Nambi, P

Wrobel, J

Jetter, J

Kaufman, D

Bernotas, R

Other Studies

2 other studies available for phenylacetic acid and Atherosclerosis

Article	Year
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis. Journal of medicinal chemistry, 2006, Oct-19, Volume: 49, Issue:21 Topics: Animals; Anticholesteremic Agents; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding	2006
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10 Topics: Animals; Apolipoproteins E; Atherosclerosis; Carboxylic Acids; CHO Cells; Chromatography, High Press	2007

Article

Year

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.

Journal of medicinal chemistry, 2006, Oct-19, Volume: 49, Issue:21

Topics: Animals; Anticholesteremic Agents; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding

2006

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.

Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

Topics: Animals; Apolipoproteins E; Atherosclerosis; Carboxylic Acids; CHO Cells; Chromatography, High Press

2007