phenyl-n-tert-butylnitrone and Brain Ischemia

phenyl-n-tert-butylnitrone has been researched along with Brain Ischemia in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's10 (29.41)18.2507
2000's19 (55.88)29.6817
2010's3 (8.82)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Balogh, GT; Fischer, J; Gere, A; Kis-Varga, A; Könczöl, A; Vukics, K1
Jiang, J; Liu, W; Sun, Y; Wang, L; Wang, Y; Xu, C; Yu, P; Zhang, Z1
Bartolomé, B; Chioua, M; García, AG; Garrido, I; González-Lafuente, L; Ismaili, L; Marco-Contelles, J; Oset-Gasque, MJ; Revuelta, J; Samadi, A; Soriano, E; Tomassolli, I; Valderas, C; Villarroya, M1
Chamorro, B; Chioua, M; Diez-Iriepa, D; Fernández, I; García-Vieira, D; Gonzàlez-Nieto, D; Hadjipavlou-Litina, D; Iriepa, I; López-Muñoz, F; Marco-Contelles, J; Martínez-Murillo, R; Merás-Sáiz, B; Oset-Gasque, MJ1
Ataliotis, P; Fejes-Toth, G; Green, AR; Hainsworth, AH; Kind, CN; McCaig, C; Murray, JT; Naray-Fejes-Toth, A; Omar, AS; Pereira, AC; Shtaya, A; Yáñez-Muñoz, RJ1
Ikeda, M; Kobayashi, C; Saito, K1
Ahn, HN; Chan, PH; Chang, M; Narasimhan, P; Song, YS; Yang, J1
Asanuma, T; Inanami, O; Ishibashi, H; Kon, Y; Konno, A; Kuwabara, M1
Araki, T; Koshino, T; Nakai, A; Taniuchi, Y1
Bruhn, T; Christensen, T; Diemer, NH1
Medvedev, OS; Povarova, OV; Timoshin, AA1
Brezová, V; Dobrota, D; Horecký, J; Kasparová, S; Liptaj, T; Mlynárik, V; Ulicná, O; Valko, M; Vancová, O1
Farrokhnia, N; Lennmyr, F; Roos, MW; Terént, A1
LaManna, JC; Puchowicz, MA; Sun, X; Xu, K2
Barth, A; Barth, L; Newell, DW1
Bates, TE; Hillered, L; Katsura, K; Kuroda, S; Siesjö, BK1
Dewar, D; Irving, EA; McCulloch, J; Yatsushiro, K1
Hallenbeck, JM; Martin, D; Nawashiro, H1
Adachi, T; Arai, T; Endo, N; Ishii, H; Makino, K; Mori, H; Mori, K1
Ericsson, A; Roos, MW1
Chai, PJ; Jaggers, JJ; Langley, SM; Ungerleider, RM1
Cronberg, T; Gidö, G; Wieloch, T1
Asahi, K; Asahi, M; Lo, EH; Wang, X1
Li, Q; Shuaib, A; Yang, Y1
Fujibayashi, Y; Murata, T; Omata, N; Sadato, N; Wada, Y; Waki, A; Yonekura, Y; Yoshimoto, M1
Araki, T; Asakura, H; Koshino, T; Nakai, A; Oya, A; Taniuchi, Y; Yokota, A1
Hossmann, KA; Krep, H; Oschlies, U; Schwindt, W1
Csiszar, K; He, QP; Li, PA; Nakamura, L1
Barone, FC; Cheng, HY; Feuerstein, G; Gu, JL; Lysko, PG; Yue, TL1
Agnati, LF; Grimaldi, R; Tomasi, A; Vannini, V; Zini, I1
Clough-Helfman, C; Phillis, JW2
Fujita, Y; Imaizumi, S; Suzuki, J; Tominaga, T; Uenohara, H; Yoshimoto, T1

Other Studies

34 other study(ies) available for phenyl-n-tert-butylnitrone and Brain Ischemia

ArticleYear
Nitrone derivatives of trolox as neuroprotective agents.
    Bioorganic & medicinal chemistry letters, 2005, Jun-15, Volume: 15, Issue:12

    Topics: Animals; Antioxidants; Arterial Occlusive Diseases; Brain Ischemia; Cerebrovascular Circulation; Chromans; Free Radical Scavengers; Hydroxyl Radical; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Mice; Neuroprotective Agents; Nitrogen Oxides; Structure-Activity Relationship

2005
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
    Bioorganic & medicinal chemistry, 2008, Oct-01, Volume: 16, Issue:19

    Topics: Animals; Antioxidants; Brain Ischemia; Fibrinolytic Agents; Nitrogen Oxides; Pyrazines; Rats; Stroke; Thrombolytic Therapy

2008
Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.
    Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2

    Topics: Antioxidants; Brain Ischemia; Cell Line, Tumor; Humans; Hydrogen Bonding; Hydroxyl Radical; Models, Theoretical; Nitrogen Oxides; Reactive Oxygen Species; Thermodynamics

2011
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
    Scientific reports, 2020, 08-25, Volume: 10, Issue:1

    Topics: Animals; Apoptosis; Brain Ischemia; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Glucose; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroblastoma; Neurons; Neuroprotection; Neuroprotective Agents; Nitrogen Oxides; Oligomycins; Oxygen; Rotenone

2020
Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6

    Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Immediate-Early Proteins; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Nitrogen Oxides; Protein Serine-Threonine Kinases; Rats; Stroke; Transcriptional Activation

2019
Effect of radical scavenger N-tert-butyl-alpha-phenylnitrone on stroke in a rat model using a telemetric system.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2008, Volume: 11, Issue:4

    Topics: Animals; Blood Pressure; Body Weight; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Heart Rate; Motor Activity; Rats; Rats, Inbred SHR; Stroke

2008
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
    Journal of neurochemistry, 2013, Volume: 124, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Complement C3; Cyclic N-Oxides; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Glucose; Hypoxia; L-Lactate Dehydrogenase; Male; Mice; Mice, Transgenic; Nervous System Diseases; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Up-Regulation

2013
Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping.
    Neuroscience letters, 2002, Sep-06, Volume: 329, Issue:3

    Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cyclic N-Oxides; Diffusion; Magnetic Resonance Imaging; Male; Malonates; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Spin Trapping; Water

2002
Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain.
    Gynecologic and obstetric investigation, 2003, Volume: 55, Issue:3

    Topics: Adenosine Diphosphate; Animals; Arteries; Asphyxia; Brain Ischemia; Constriction; Cyclic N-Oxides; Female; Fetal Diseases; Maternal-Fetal Exchange; Mitochondrial Diseases; Nitrogen Oxides; Oxygen Consumption; Pregnancy; Rats; Rats, Wistar; Uterus

2003
The free radical spin-trap alpha-PBN attenuates periinfarct depolarizations following permanent middle cerebral artery occlusion in rats without reducing infarct volume.
    Brain research, 2003, Nov-14, Volume: 990, Issue:1-2

    Topics: Animals; Body Temperature; Brain Ischemia; Cerebrovascular Circulation; Cortical Spreading Depression; Cyclic N-Oxides; Electrophysiology; Extracellular Space; Free Radical Scavengers; Free Radicals; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Nitrogen Oxides; Potassium Chloride; Rats; Rats, Wistar; Survival; Time Factors

2003
Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia.
    Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:6

    Topics: Animals; Brain Chemistry; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Free Radicals; Infarction, Middle Cerebral Artery; Kidney; Liver; Male; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Spin Labels

2003
Study of the oxidative stress in a rat model of chronic brain hypoperfusion.
    Neurochemistry international, 2005, Volume: 46, Issue:8

    Topics: Animals; Ascorbic Acid; Brain; Brain Ischemia; Chronic Disease; Creatine Kinase; Cyclic N-Oxides; Dementia; Disease Models, Animal; Energy Metabolism; Free Radicals; Hydroxyl Radical; Male; Mitochondria; Molecular Conformation; Nitrogen Oxides; Oxidative Phosphorylation; Oxidative Stress; Rats; Rats, Wistar; Spin Trapping

2005
Experimental treatment for focal hyperglycemic ischemic brain injury in the rat.
    Experimental brain research, 2005, Volume: 167, Issue:2

    Topics: Animals; Blood Glucose; Body Temperature; Brain Ischemia; Butadienes; Carbon Dioxide; Cyclic N-Oxides; Enzyme Inhibitors; Hyperglycemia; Male; Neurologic Examination; Neuroprotective Agents; Nitriles; Nitrogen Oxides; Oxygen; Pyrimidines; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Time Factors

2005
Increased sensitivity to transient global ischemia in aging rat brain.
    Advances in experimental medicine and biology, 2007, Volume: 599

    Topics: Aging; Aldehydes; Animals; Antioxidants; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Hypoxia; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred F344; Survival Rate

2007
Mitochondrial dysfunction in aging rat brain following transient global ischemia.
    Advances in experimental medicine and biology, 2008, Volume: 614

    Topics: Aging; Aldehydes; Animals; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Hypoxia; Male; Mitochondria; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred F344; Time Factors

2008
Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures.
    Experimental neurology, 1996, Volume: 141, Issue:2

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Free Radical Scavengers; Hippocampus; Nitrogen Oxides; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1996
Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.
    Neurobiology of disease, 1996, Volume: 3, Issue:2

    Topics: Adenosine Diphosphate; Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cyclic N-Oxides; Energy Metabolism; Free Radical Scavengers; Male; Mitochondria; Neuroprotective Agents; Nitrogen Oxides; Oxygen Consumption; Rats; Rats, Wistar; Reperfusion Injury; Spin Labels

1996
Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: involvement of free radicals.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:6

    Topics: Animals; Brain Ischemia; Caudate Nucleus; Cerebral Cortex; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Free Radicals; Immunohistochemistry; Male; Microtubule-Associated Proteins; Nitrogen Oxides; Oligodendroglia; Quinoxalines; Rats; Rats, Inbred F344; Spin Labels; tau Proteins

1997
Neuroprotective effects of TNF binding protein in focal cerebral ischemia.
    Brain research, 1997, Dec-19, Volume: 778, Issue:2

    Topics: Animals; Arterial Occlusive Diseases; Biotin; Brain Ischemia; Cerebral Infarction; Cyclic N-Oxides; Deoxyuracil Nucleotides; DNA Fragmentation; Free Radical Scavengers; Interleukin 1 Receptor Antagonist Protein; Male; Mice; Mice, Inbred BALB C; Neurons; Neuroprotective Agents; Nitrogen Oxides; Phosphopyruvate Hydratase; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sialoglycoproteins; Staining and Labeling; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha

1997
Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.
    Neuroscience letters, 1998, Jan-30, Volume: 241, Issue:2-3

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Gerbillinae; Male; Neurons; Neuroprotective Agents; Nitrogen Oxides; Pteridines; Pterins; Spin Labels; Xanthine Oxidase

1998
N-tert-butyl-alpha-phenylnitrone reduces the number of microinfarctions in the rabbit brain cortex.
    Experimental brain research, 1999, Volume: 124, Issue:2

    Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Cyclic N-Oxides; Female; Intracranial Embolism and Thrombosis; Magnetic Resonance Imaging; Male; Microcirculation; Nitrogen Oxides; Rabbits

1999
The free radical spin trap alpha-phenyl-tert-butyl nitrone attenuates the cerebral response to deep hypothermic ischemia.
    The Journal of thoracic and cardiovascular surgery, 2000, Volume: 119, Issue:2

    Topics: Animals; Animals, Newborn; Blood Flow Velocity; Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Cyclic N-Oxides; Free Radical Scavengers; Hypothermia, Induced; Nitrogen Oxides; Oxygen Consumption; Random Allocation; Spin Labels; Swine

2000
The effect of alpha-phenyl-tert-butyl nitrone (PBN) on free radical formation in transient focal ischaemia measured by microdialysis and 3,4-dihydroxybenzoate formation.
    Acta physiologica Scandinavica, 2000, Volume: 168, Issue:2

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; In Vitro Techniques; Male; Microdialysis; Nitrogen Oxides; Parabens; Rats; Rats, Wistar; Salicylic Acid

2000
Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Cyclic N-Oxides; Drug Therapy, Combination; Free Radicals; Hypertension; Intracranial Embolism; Male; Nitrogen Oxides; Plasminogen Activators; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion Injury; Spin Trapping; Tissue Plasminogen Activator

2000
Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia.
    Experimental neurology, 2000, Volume: 163, Issue:1

    Topics: Animals; Benzenesulfonates; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedule; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Male; Neurologic Examination; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Recovery of Function; Thrombin

2000
Neurotoxicity after hypoxia/during ischemia due to glutamate with/without free radicals as revealed by dynamic changes in glucose metabolism.
    Brain research, 2000, May-26, Volume: 865, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Dizocilpine Maleate; Fluorodeoxyglucose F18; Glucose; Glutamic Acid; Hypothermia; Hypoxia, Brain; Male; Neuroprotective Agents; Nitrogen Oxides; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley

2000
Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria.
    American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:4

    Topics: Adenosine Diphosphate; Animals; Arteries; Brain; Brain Ischemia; Cyclic N-Oxides; Female; Fetal Diseases; Gestational Age; Ischemia; Mitochondria; Nitrogen Oxides; Oxygen Consumption; Pregnancy; Rats; Rats, Wistar; Spin Labels; Uterus

2001
Electron microscopic investigation of rat brain after brief cardiac arrest.
    Acta neuropathologica, 2001, Volume: 101, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Capillaries; Cardiovascular Physiological Phenomena; Cell Nucleus; Cell Size; Chromatin; Cyclic N-Oxides; Heart Arrest; Microscopy, Electron; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Nitrogen Oxides; Nuclear Envelope; Organelles; Rats

2001
Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury.
    Free radical biology & medicine, 2001, Nov-15, Volume: 31, Issue:10

    Topics: Animals; Brain Ischemia; Caspase 3; Caspase Inhibitors; Cyclic N-Oxides; Disease Models, Animal; Male; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Spin Trapping; Survival Rate

2001
Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons.
    Brain research, 1992, Mar-06, Volume: 574, Issue:1-2

    Topics: Animals; Brain Edema; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebellum; Cyclic N-Oxides; Excitatory Amino Acid Antagonists; Gerbillinae; Glutamic Acid; Hippocampus; Neurons; Nitrogen Oxides; Prosencephalon; Rats

1992
Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis.
    Neuroscience letters, 1992, Apr-27, Volume: 138, Issue:2

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dialysis; Free Radicals; Nitrogen Oxides; Pyridines; Rats; Rats, Inbred Strains; Reperfusion; Spin Labels; Thiobarbiturates

1992
The free radical trapping agent N-tert.-butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils.
    Free radical research communications, 1991, Volume: 15, Issue:3

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Free Radicals; Gerbillinae; Motor Activity; Nitrogen Oxides; Reperfusion Injury; Spin Labels; Temperature

1991
Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).
    Neuroscience letters, 1990, Aug-24, Volume: 116, Issue:3

    Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Gerbillinae; Hippocampus; Male; Motor Activity; Nitrogen Oxides; Reperfusion Injury; Spin Labels

1990
Initiation and propagation of lipid peroxidation in cerebral infarction models. Experimental studies.
    Neurological research, 1986, Volume: 8, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Energy Metabolism; Free Radicals; Hypoxia, Brain; Lipid Peroxides; Luminescent Measurements; Male; Nitrogen Oxides; Rats; Rats, Inbred Strains

1986