phenyl-n-tert-butylnitrone has been researched along with Brain Ischemia in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 10 (29.41) | 18.2507 |
| 2000's | 19 (55.88) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Balogh, GT; Fischer, J; Gere, A; Kis-Varga, A; Könczöl, A; Vukics, K | 1 |
| Jiang, J; Liu, W; Sun, Y; Wang, L; Wang, Y; Xu, C; Yu, P; Zhang, Z | 1 |
| Bartolomé, B; Chioua, M; García, AG; Garrido, I; González-Lafuente, L; Ismaili, L; Marco-Contelles, J; Oset-Gasque, MJ; Revuelta, J; Samadi, A; Soriano, E; Tomassolli, I; Valderas, C; Villarroya, M | 1 |
| Chamorro, B; Chioua, M; Diez-Iriepa, D; Fernández, I; García-Vieira, D; Gonzàlez-Nieto, D; Hadjipavlou-Litina, D; Iriepa, I; López-Muñoz, F; Marco-Contelles, J; Martínez-Murillo, R; Merás-Sáiz, B; Oset-Gasque, MJ | 1 |
| Ataliotis, P; Fejes-Toth, G; Green, AR; Hainsworth, AH; Kind, CN; McCaig, C; Murray, JT; Naray-Fejes-Toth, A; Omar, AS; Pereira, AC; Shtaya, A; Yáñez-Muñoz, RJ | 1 |
| Ikeda, M; Kobayashi, C; Saito, K | 1 |
| Ahn, HN; Chan, PH; Chang, M; Narasimhan, P; Song, YS; Yang, J | 1 |
| Asanuma, T; Inanami, O; Ishibashi, H; Kon, Y; Konno, A; Kuwabara, M | 1 |
| Araki, T; Koshino, T; Nakai, A; Taniuchi, Y | 1 |
| Bruhn, T; Christensen, T; Diemer, NH | 1 |
| Medvedev, OS; Povarova, OV; Timoshin, AA | 1 |
| Brezová, V; Dobrota, D; Horecký, J; Kasparová, S; Liptaj, T; Mlynárik, V; Ulicná, O; Valko, M; Vancová, O | 1 |
| Farrokhnia, N; Lennmyr, F; Roos, MW; Terént, A | 1 |
| LaManna, JC; Puchowicz, MA; Sun, X; Xu, K | 2 |
| Barth, A; Barth, L; Newell, DW | 1 |
| Bates, TE; Hillered, L; Katsura, K; Kuroda, S; Siesjö, BK | 1 |
| Dewar, D; Irving, EA; McCulloch, J; Yatsushiro, K | 1 |
| Hallenbeck, JM; Martin, D; Nawashiro, H | 1 |
| Adachi, T; Arai, T; Endo, N; Ishii, H; Makino, K; Mori, H; Mori, K | 1 |
| Ericsson, A; Roos, MW | 1 |
| Chai, PJ; Jaggers, JJ; Langley, SM; Ungerleider, RM | 1 |
| Cronberg, T; Gidö, G; Wieloch, T | 1 |
| Asahi, K; Asahi, M; Lo, EH; Wang, X | 1 |
| Li, Q; Shuaib, A; Yang, Y | 1 |
| Fujibayashi, Y; Murata, T; Omata, N; Sadato, N; Wada, Y; Waki, A; Yonekura, Y; Yoshimoto, M | 1 |
| Araki, T; Asakura, H; Koshino, T; Nakai, A; Oya, A; Taniuchi, Y; Yokota, A | 1 |
| Hossmann, KA; Krep, H; Oschlies, U; Schwindt, W | 1 |
| Csiszar, K; He, QP; Li, PA; Nakamura, L | 1 |
| Barone, FC; Cheng, HY; Feuerstein, G; Gu, JL; Lysko, PG; Yue, TL | 1 |
| Agnati, LF; Grimaldi, R; Tomasi, A; Vannini, V; Zini, I | 1 |
| Clough-Helfman, C; Phillis, JW | 2 |
| Fujita, Y; Imaizumi, S; Suzuki, J; Tominaga, T; Uenohara, H; Yoshimoto, T | 1 |
34 other study(ies) available for phenyl-n-tert-butylnitrone and Brain Ischemia
| Article | Year |
|---|---|
Nitrone derivatives of trolox as neuroprotective agents.
Topics: Animals; Antioxidants; Arterial Occlusive Diseases; Brain Ischemia; Cerebrovascular Circulation; Chromans; Free Radical Scavengers; Hydroxyl Radical; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Mice; Neuroprotective Agents; Nitrogen Oxides; Structure-Activity Relationship | 2005 |
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
Topics: Animals; Antioxidants; Brain Ischemia; Fibrinolytic Agents; Nitrogen Oxides; Pyrazines; Rats; Stroke; Thrombolytic Therapy | 2008 |
Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.
Topics: Antioxidants; Brain Ischemia; Cell Line, Tumor; Humans; Hydrogen Bonding; Hydroxyl Radical; Models, Theoretical; Nitrogen Oxides; Reactive Oxygen Species; Thermodynamics | 2011 |
Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Glucose; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroblastoma; Neurons; Neuroprotection; Neuroprotective Agents; Nitrogen Oxides; Oligomycins; Oxygen; Rotenone | 2020 |
Induction of the cell survival kinase Sgk1: A possible novel mechanism for α-phenyl-N-tert-butyl nitrone in experimental stroke.
Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Immediate-Early Proteins; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Nitrogen Oxides; Protein Serine-Threonine Kinases; Rats; Stroke; Transcriptional Activation | 2019 |
Effect of radical scavenger N-tert-butyl-alpha-phenylnitrone on stroke in a rat model using a telemetric system.
Topics: Animals; Blood Pressure; Body Weight; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Heart Rate; Motor Activity; Rats; Rats, Inbred SHR; Stroke | 2008 |
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
Topics: Animals; Brain; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Complement C3; Cyclic N-Oxides; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Glucose; Hypoxia; L-Lactate Dehydrogenase; Male; Mice; Mice, Transgenic; Nervous System Diseases; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Up-Regulation | 2013 |
Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cyclic N-Oxides; Diffusion; Magnetic Resonance Imaging; Male; Malonates; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Spin Trapping; Water | 2002 |
Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain.
Topics: Adenosine Diphosphate; Animals; Arteries; Asphyxia; Brain Ischemia; Constriction; Cyclic N-Oxides; Female; Fetal Diseases; Maternal-Fetal Exchange; Mitochondrial Diseases; Nitrogen Oxides; Oxygen Consumption; Pregnancy; Rats; Rats, Wistar; Uterus | 2003 |
The free radical spin-trap alpha-PBN attenuates periinfarct depolarizations following permanent middle cerebral artery occlusion in rats without reducing infarct volume.
Topics: Animals; Body Temperature; Brain Ischemia; Cerebrovascular Circulation; Cortical Spreading Depression; Cyclic N-Oxides; Electrophysiology; Extracellular Space; Free Radical Scavengers; Free Radicals; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Nitrogen Oxides; Potassium Chloride; Rats; Rats, Wistar; Survival; Time Factors | 2003 |
Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Free Radicals; Infarction, Middle Cerebral Artery; Kidney; Liver; Male; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Spin Labels | 2003 |
Study of the oxidative stress in a rat model of chronic brain hypoperfusion.
Topics: Animals; Ascorbic Acid; Brain; Brain Ischemia; Chronic Disease; Creatine Kinase; Cyclic N-Oxides; Dementia; Disease Models, Animal; Energy Metabolism; Free Radicals; Hydroxyl Radical; Male; Mitochondria; Molecular Conformation; Nitrogen Oxides; Oxidative Phosphorylation; Oxidative Stress; Rats; Rats, Wistar; Spin Trapping | 2005 |
Experimental treatment for focal hyperglycemic ischemic brain injury in the rat.
Topics: Animals; Blood Glucose; Body Temperature; Brain Ischemia; Butadienes; Carbon Dioxide; Cyclic N-Oxides; Enzyme Inhibitors; Hyperglycemia; Male; Neurologic Examination; Neuroprotective Agents; Nitriles; Nitrogen Oxides; Oxygen; Pyrimidines; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Time Factors | 2005 |
Increased sensitivity to transient global ischemia in aging rat brain.
Topics: Aging; Aldehydes; Animals; Antioxidants; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Hypoxia; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred F344; Survival Rate | 2007 |
Mitochondrial dysfunction in aging rat brain following transient global ischemia.
Topics: Aging; Aldehydes; Animals; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Hypoxia; Male; Mitochondria; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred F344; Time Factors | 2008 |
Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Free Radical Scavengers; Hippocampus; Nitrogen Oxides; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.
Topics: Adenosine Diphosphate; Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cyclic N-Oxides; Energy Metabolism; Free Radical Scavengers; Male; Mitochondria; Neuroprotective Agents; Nitrogen Oxides; Oxygen Consumption; Rats; Rats, Wistar; Reperfusion Injury; Spin Labels | 1996 |
Rapid alteration of tau in oligodendrocytes after focal ischemic injury in the rat: involvement of free radicals.
Topics: Animals; Brain Ischemia; Caudate Nucleus; Cerebral Cortex; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Free Radicals; Immunohistochemistry; Male; Microtubule-Associated Proteins; Nitrogen Oxides; Oligodendroglia; Quinoxalines; Rats; Rats, Inbred F344; Spin Labels; tau Proteins | 1997 |
Neuroprotective effects of TNF binding protein in focal cerebral ischemia.
Topics: Animals; Arterial Occlusive Diseases; Biotin; Brain Ischemia; Cerebral Infarction; Cyclic N-Oxides; Deoxyuracil Nucleotides; DNA Fragmentation; Free Radical Scavengers; Interleukin 1 Receptor Antagonist Protein; Male; Mice; Mice, Inbred BALB C; Neurons; Neuroprotective Agents; Nitrogen Oxides; Phosphopyruvate Hydratase; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sialoglycoproteins; Staining and Labeling; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 1997 |
Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Gerbillinae; Male; Neurons; Neuroprotective Agents; Nitrogen Oxides; Pteridines; Pterins; Spin Labels; Xanthine Oxidase | 1998 |
N-tert-butyl-alpha-phenylnitrone reduces the number of microinfarctions in the rabbit brain cortex.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Cyclic N-Oxides; Female; Intracranial Embolism and Thrombosis; Magnetic Resonance Imaging; Male; Microcirculation; Nitrogen Oxides; Rabbits | 1999 |
The free radical spin trap alpha-phenyl-tert-butyl nitrone attenuates the cerebral response to deep hypothermic ischemia.
Topics: Animals; Animals, Newborn; Blood Flow Velocity; Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; Cyclic N-Oxides; Free Radical Scavengers; Hypothermia, Induced; Nitrogen Oxides; Oxygen Consumption; Random Allocation; Spin Labels; Swine | 2000 |
The effect of alpha-phenyl-tert-butyl nitrone (PBN) on free radical formation in transient focal ischaemia measured by microdialysis and 3,4-dihydroxybenzoate formation.
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; In Vitro Techniques; Male; Microdialysis; Nitrogen Oxides; Parabens; Rats; Rats, Wistar; Salicylic Acid | 2000 |
Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Cyclic N-Oxides; Drug Therapy, Combination; Free Radicals; Hypertension; Intracranial Embolism; Male; Nitrogen Oxides; Plasminogen Activators; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion Injury; Spin Trapping; Tissue Plasminogen Activator | 2000 |
Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia.
Topics: Animals; Benzenesulfonates; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Drug Administration Schedule; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Male; Neurologic Examination; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Recovery of Function; Thrombin | 2000 |
Neurotoxicity after hypoxia/during ischemia due to glutamate with/without free radicals as revealed by dynamic changes in glucose metabolism.
Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Dizocilpine Maleate; Fluorodeoxyglucose F18; Glucose; Glutamic Acid; Hypothermia; Hypoxia, Brain; Male; Neuroprotective Agents; Nitrogen Oxides; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley | 2000 |
Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria.
Topics: Adenosine Diphosphate; Animals; Arteries; Brain; Brain Ischemia; Cyclic N-Oxides; Female; Fetal Diseases; Gestational Age; Ischemia; Mitochondria; Nitrogen Oxides; Oxygen Consumption; Pregnancy; Rats; Rats, Wistar; Spin Labels; Uterus | 2001 |
Electron microscopic investigation of rat brain after brief cardiac arrest.
Topics: Animals; Brain; Brain Ischemia; Capillaries; Cardiovascular Physiological Phenomena; Cell Nucleus; Cell Size; Chromatin; Cyclic N-Oxides; Heart Arrest; Microscopy, Electron; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Nitrogen Oxides; Nuclear Envelope; Organelles; Rats | 2001 |
Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury.
Topics: Animals; Brain Ischemia; Caspase 3; Caspase Inhibitors; Cyclic N-Oxides; Disease Models, Animal; Male; Neuroprotective Agents; Nitrogen Oxides; Rats; Rats, Wistar; Spin Trapping; Survival Rate | 2001 |
Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons.
Topics: Animals; Brain Edema; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebellum; Cyclic N-Oxides; Excitatory Amino Acid Antagonists; Gerbillinae; Glutamic Acid; Hippocampus; Neurons; Nitrogen Oxides; Prosencephalon; Rats | 1992 |
Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis.
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Dialysis; Free Radicals; Nitrogen Oxides; Pyridines; Rats; Rats, Inbred Strains; Reperfusion; Spin Labels; Thiobarbiturates | 1992 |
The free radical trapping agent N-tert.-butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils.
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Free Radicals; Gerbillinae; Motor Activity; Nitrogen Oxides; Reperfusion Injury; Spin Labels; Temperature | 1991 |
Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).
Topics: Animals; Brain Ischemia; Cyclic N-Oxides; Gerbillinae; Hippocampus; Male; Motor Activity; Nitrogen Oxides; Reperfusion Injury; Spin Labels | 1990 |
Initiation and propagation of lipid peroxidation in cerebral infarction models. Experimental studies.
Topics: Animals; Brain; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Energy Metabolism; Free Radicals; Hypoxia, Brain; Lipid Peroxides; Luminescent Measurements; Male; Nitrogen Oxides; Rats; Rats, Inbred Strains | 1986 |