phenyl-n-tert-butylnitrone has been researched along with Aging in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (64.29) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hohaus, C; Johnson, AA; Krystel, I; Meisel, HJ; Naaldijk, Y; Stolzing, A | 1 |
| LaManna, JC; Puchowicz, MA; Sun, X; Xu, K | 3 |
| Bailey, DM; Henry, RR; James, PE; Mathieu-Costello, O; McCord, JM; McEneny, J; Pietri, S; Richardson, RS; Young, IS | 1 |
| Bickford, PC; Kaufmann, JA; Taglialatela, G | 2 |
| Astle, CM; Floyd, RA; Flurkey, K; Harrison, DE; Hensley, KL; Javors, MA; Leeuwenburgh, C; Miller, RA; Nadon, NL; Nelson, JF; Ongini, E; Strong, R; Warner, HR | 1 |
| Edamatsu, R; Mori, A; Packer, L | 1 |
| Cao, G; Cutler, RC; Joseph, JA | 1 |
| Cao, G; Cutler, RG | 2 |
| Carney, JM; Floyd, RA | 1 |
| Bickford, PC; Gould, TJ | 1 |
| Cutler, RC; Joseph, JA | 1 |
| Dubey, A; Forster, MJ; Sohal, RS | 1 |
| Arendash, GW; Crandall, BM; Socci, DJ | 1 |
| Cutler, R; Denisova, N; Erat, S; Joseph, JA; Strain, J; Villalobos-Molina, R | 1 |
| Arendash, GW; Crandall, BM; Sack, CA; Socci, DJ | 1 |
| Asanuma, T; Inukai, N; Kasai, N; Kon, Y; Kuwabara, M; Miyoshi, I; Ohshima, H; Sato, F; Watanabe, T; Yamashita, T | 1 |
| Fisher, D; Jimenez, ND; Joseph, JA; Strain, JG | 1 |
| Brundin, P; Emgârd, M; Karlsson, J; Rosenblad, C | 1 |
| Ames, BN; Hagen, TM; Wehr, CM | 1 |
| Aksenov, M; Aksenova, M; Allen, K; Butterfield, DA; Carney, J; Hall, N; Hensley, K; Howard, B; Koppal, T; Subramaniam, R; Yatin, S | 1 |
| Fonnum, F; Lock, EA; Rustad, A; Sturgess, NC | 1 |
| Kotake, Y | 1 |
| Floyd, RA; Forster, MJ; Hensley, K; Kelleher-Andersson, JA; Wood, PL | 1 |
| Carney, JM; Cheng, MS; Floyd, RA; Landum, RW; Oliver, CN; Starke-Reed, PE; Wu, JF | 1 |
4 review(s) available for phenyl-n-tert-butylnitrone and Aging
| Article | Year |
|---|---|
The role of oxidative stress in signal transduction changes and cell loss in senescence.
Topics: Aging; Animals; Antioxidants; Brain; Brain Diseases; Cyclic N-Oxides; Free Radicals; Humans; Hydroxyl Radical; Kainic Acid; Neurons; Nitrogen Oxides; Oxidative Stress; Signal Transduction; Spin Labels | 1994 |
Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.
Topics: Adult; Aging; Animals; Antioxidants; Brain; Cerebrovascular Disorders; Cyclic N-Oxides; DNA, Mitochondrial; Free Radicals; Humans; Mice; Mitochondria; Nitrogen Oxides; Oxidative Stress; Protein Conformation; Proteins; Reactive Oxygen Species; RNA, Messenger; Vitamin E | 1998 |
Pharmacologic properties of phenyl N-tert-butylnitrone.
Topics: Aging; Animals; Cyclic N-Oxides; Cytokines; Disease Models, Animal; Humans; In Vitro Techniques; Molecular Structure; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Nitrogen Oxides; Reperfusion Injury; Spin Trapping | 1999 |
Nitrones, their value as therapeutics and probes to understand aging.
Topics: Aging; Animals; Benzene Derivatives; Cyclic N-Oxides; Free Radical Scavengers; Humans; Neuroprotective Agents; Nitrogen Oxides; Signal Transduction; Spin Labels; Spin Trapping | 2002 |
1 trial(s) available for phenyl-n-tert-butylnitrone and Aging
| Article | Year |
|---|---|
Sedentary aging increases resting and exercise-induced intramuscular free radical formation.
Topics: Adult; Age Factors; Aged; Aging; Antioxidants; Ascorbic Acid; beta Carotene; Biomarkers; Biopsy; Carotenoids; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Exercise; Free Radicals; Humans; Lipid Peroxidation; Lycopene; Male; Mitochondria, Muscle; Muscle Contraction; Oxidative Stress; Quadriceps Muscle; Rest; Sedentary Behavior; Time Factors; Ubiquinone; Vitamin A; Young Adult | 2010 |
23 other study(ies) available for phenyl-n-tert-butylnitrone and Aging
| Article | Year |
|---|---|
Protective effects of alpha phenyl-tert-butyl nitrone and ascorbic acid in human adipose derived mesenchymal stem cells from differently aged donors.
Topics: Adipose Tissue; Adult; Aging; Ascorbic Acid; Cyclic N-Oxides; DNA Damage; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Middle Aged; Nitrogen Oxides; Ultraviolet Rays; Young Adult | 2016 |
Decreased brainstem function following cardiac arrest and resuscitation in aged rat.
Topics: Aging; Animals; Antioxidants; Brain Stem; Brain Stem Infarctions; Cell Respiration; Cyclic N-Oxides; Disease Models, Animal; Heart Arrest; Hippocampus; Male; Mitochondria; Nerve Degeneration; Oxidative Stress; Rats; Rats, Inbred F344; Recovery of Function; Reperfusion Injury; Respiratory Insufficiency; Resuscitation; Treatment Outcome | 2010 |
Free radical-dependent changes in constitutive Nuclear factor kappa B in the aged hippocampus.
Topics: Active Transport, Cell Nucleus; Aging; Animals; Cell Nucleus; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Hippocampus; Nerve Degeneration; Neuroprotective Agents; NF-kappa B; Nitrogen Oxides; Oxidative Stress; Rats; Rats, Inbred F344 | 2002 |
An Aging Interventions Testing Program: study design and interim report.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cyclic N-Oxides; Drug Evaluation, Preclinical; Female; Flurbiprofen; Male; Masoprocol; Mice; Research Design; Survival Analysis | 2007 |
Increased sensitivity to transient global ischemia in aging rat brain.
Topics: Aging; Aldehydes; Animals; Antioxidants; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Hypoxia; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred F344; Survival Rate | 2007 |
Mitochondrial dysfunction in aging rat brain following transient global ischemia.
Topics: Aging; Aldehydes; Animals; Brain Ischemia; Cross-Linking Reagents; Cyclic N-Oxides; Hypoxia; Male; Mitochondria; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Rats; Rats, Inbred F344; Time Factors | 2008 |
The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse.
Topics: Aging; Animals; Cyclic N-Oxides; Female; Free Radical Scavengers; Free Radicals; Injections, Intraperitoneal; Male; Mice; Nitrogen Oxides; Sex Characteristics; Spin Labels; Survival Analysis | 1995 |
In vivo or in vitro administration of the nitrone spin-trapping compound, n-tert-butyl-alpha-phenylnitrone, (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity.
Topics: Aging; Animals; Cyclic N-Oxides; Dopamine; Muscarinic Agonists; Neostriatum; Nitrogen Oxides; Oxidative Stress; Oxotremorine; Potassium; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spin Labels | 1995 |
Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine.
Topics: Aging; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Gerbillinae; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Nerve Tissue Proteins; Nitrogen Oxides; Nucleic Acids; Oxidation-Reduction; Phenylhydrazines; Proteins; Rats; Rats, Inbred F344; Spin Labels; Streptomycin | 1995 |
Protein oxidation and aging. II. Difficulties in measuring alkaline protease activity in tissues using the fluorescamine procedure.
Topics: Aging; Amino Acid Sequence; Animals; Cyclic N-Oxides; Endopeptidases; Fluorescamine; Fluorescent Dyes; Gerbillinae; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Sequence Data; Nitrogen Oxides; Oligopeptides; Oxidation-Reduction; Proteins; Rats; Rats, Inbred F344; Spin Labels; Substrate Specificity | 1995 |
Brain antioxidant activity of spin traps in Mongolian gerbils.
Topics: Aging; Animals; Antioxidants; Brain; Cyclic N-Oxides; Gerbillinae; Male; Maze Learning; Nitrogen Oxides | 1994 |
The effects of chronic treatment with N-tert-butyl-alpha-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats.
Topics: Aging; Animals; Cerebellum; Cyclic N-Oxides; gamma-Aminobutyric Acid; Isoproterenol; Male; Membrane Potentials; Nitrogen Oxides; Norepinephrine; Purkinje Cells; Rats; Rats, Inbred F344; Reference Values; Spin Labels | 1994 |
Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span.
Topics: Aging; Aldehydes; Animals; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclic N-Oxides; Gerbillinae; Heart; Houseflies; Ketones; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nitrogen Oxides; Oxidative Stress; Proteins; Species Specificity; Spin Labels | 1995 |
Chronic antioxidant treatment improves the cognitive performance of aged rats.
Topics: Aging; Animals; Antioxidants; Behavior, Animal; Cognition; Cyclic N-Oxides; Lipid Peroxidation; Male; Motor Activity; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Spin Labels; Time Factors; Vitamin E | 1995 |
Age differences in sensitivity to H2O2- or NO-induced reductions in K(+)-evoked dopamine release from superfused striatal slices: reversals by PBN or Trolox.
Topics: Aging; Animals; Antioxidants; Chromans; Cyclic N-Oxides; Dopamine; Free Radicals; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Lipid Peroxidation; Nitric Oxide; Nitrogen Oxides; Nitroprusside; Potassium; Rats; Rats, Inbred F344; Visual Cortex | 1996 |
Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats.
Topics: Aging; Analysis of Variance; Animals; Antioxidants; Cognition; Conditioning, Psychological; Cyclic N-Oxides; Free Radical Scavengers; Male; Maze Learning; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Spin Labels; Survival Analysis | 1996 |
The effects of alpha-phenyl-tert-butyl nitrone (PBN) on copper-induced rat fulminant hepatitis with jaundice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Copper; Cyclic N-Oxides; Deoxyguanosine; DNA; Jaundice; Lipid Peroxidation; Liver; Nitrogen Oxides; Rats; Rats, Mutant Strains; Spin Labels; Thiobarbituric Acid Reactive Substances; Weight Loss | 1996 |
Oxidant injury in PC12 cells--a possible model of calcium "dysregulation" in aging: I. Selectivity of protection against oxidative stress.
Topics: Aging; Animals; Antioxidants; Calcium; Cell Survival; Chromans; Cyclic N-Oxides; Dose-Response Relationship, Drug; Hydrogen Peroxide; Kinetics; Models, Neurological; Nifedipine; Nitrogen Oxides; Oxidative Stress; PC12 Cells; Rats; Time Factors | 1997 |
Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons.
Topics: Aging; Animals; Cell Survival; Cell Transplantation; Cells, Cultured; Cyclic N-Oxides; Dopamine; Female; Fetal Tissue Transplantation; Graft Survival; Mesencephalon; Neurons; Nitrogen Oxides; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Spin Labels; Substantia Nigra | 1998 |
Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone.
Topics: Acetylcarnitine; Aging; Animals; Cells, Cultured; Cyclic N-Oxides; Dietary Supplements; Fluoresceins; Injections, Intraperitoneal; Liver; Male; Mitochondria, Liver; Nitrogen Oxides; Oxidants; Oxygen Consumption; Rats; Rats, Inbred F344 | 1998 |
Neurotoxic effect of L-2-chloropropionic acid on primary cultures of rat cerebellar granule cells.
Topics: Aging; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebellum; Cyclic N-Oxides; Cytoplasmic Granules; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Hydrocarbons, Chlorinated; Neurons; Neurotoxins; Nitrogen Oxides; Propionates; Rats; Vitamin E | 2000 |
Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.
Topics: Aging; Animals; Blotting, Western; Central Nervous System; Cerebellum; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Immunohistochemistry; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tyrosine; Up-Regulation | 2001 |
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.
Topics: Aging; Animals; Behavior, Animal; Brain; Cyclic N-Oxides; Free Radicals; Gerbillinae; Glutamate-Ammonia Ligase; Male; Memory; Metalloendopeptidases; Nerve Tissue Proteins; Nitrogen Oxides; Oxidation-Reduction; Spin Labels | 1991 |