Page last updated: 2024-08-23

phenyl acetate and Hypertension, Pulmonary

phenyl acetate has been researched along with Hypertension, Pulmonary in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's10 (71.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Clozel, M; Gatfield, J; Gnerre, C; Hess, P; Iglarz, M; Menyhart, K; Monnier, L; Morrison, K; Nayler, O; Wanner, D1
Bruderer, S; Dingemanse, J; Hurst, N; Remenova, T1
Honorato Pérez, J1
Bruderer, S; Dingemanse, J; Hurst, N; Krause, A; Lott, D; Machacek, M1
Calderone, A; Daneault, C; Dupuis, J; Fen Shi, Y; Gagnon, L; Grouix, B; Laurin, P; Nguyen, QT; Nsaibia, MJ; Ruiz, M; Sirois, MG; Tardif, JC1
Knaapen, P; Lammertsma, AA; Lubberink, M; Raijmakers, P; Ruiter, G; van Campen, J; van der Laarse, WJ; Vonk Noordegraaf, A; Wong, YY1
Lang, IM; Skoro-Sajer, N1
Beanlands, RS; Fujii, S; Ito, YM; Kasai, K; Katoh, C; Manabe, O; Mielniczuk, L; Nishimura, M; Ohira, H; Oyama-Manabe, N; Sato, T; Tamaki, N; Tomiyama, Y; Tsujino, I; Yoshinaga, K1
Asaki, T; Clozel, M; Gatfield, J; Hamamoto, T; Kuwano, K; Morrison, K1
Adams, JW; Behan, DP; Blackburn, A; Boatman, PD; Chang, S; Chen, W; Chen, X; Gaidarov, I; Garrido Montalban, A; Gharbaoui, T; Kramer, B; Krishnan, A; Leakakos, T; Morgan, M; Pal, B; Ramirez, J; Sadeque, A; Sage, CR; Semple, G; Shakya, SR; Shi, Y; Shifrina, A; Shin, YJ; Shu, HH; Tran, TA; Tung, SF; Unett, DJ; Vallar, P; Zou, N1
Hashino, A; Kosugi, K; Kuwabara, K; Kuwano, K; Noda, K1
Clozel, M; Ernst, R; Haag, F; Kauser, K; Morrison, K; Studer, R1
Chen, X; Cheng, D; Fan, L; Guan, J; Su, Q; Xia, X1
Chen, XJ; Cheng, DY; Guan, J; Wang, H; Xia, XQ; Zhang, Y1

Reviews

3 review(s) available for phenyl acetate and Hypertension, Pulmonary

ArticleYear
Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension.
    Expert opinion on drug safety, 2017, Volume: 16, Issue:6

    Topics: Acetamides; Acetates; Administration, Oral; Adult; Animals; Antihypertensive Agents; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hypertension, Pulmonary; Pyrazines

2017
Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review.
    Expert review of clinical pharmacology, 2017, Volume: 10, Issue:7

    Topics: Acetamides; Acetates; Administration, Oral; Animals; Antihypertensive Agents; Drug Design; Humans; Hypertension, Pulmonary; Pyrazines; Receptors, Epoprostenol

2017
Selexipag for the treatment of pulmonary arterial hypertension.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:3

    Topics: Acetamides; Acetates; Administration, Oral; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Prostaglandins I; Pyrazines; Receptors, Prostaglandin; Signal Transduction

2014

Trials

1 trial(s) available for phenyl acetate and Hypertension, Pulmonary

ArticleYear
Population Modeling of Selexipag Pharmacokinetics and Clinical Response Parameters in Patients With Pulmonary Arterial Hypertension.
    CPT: pharmacometrics & systems pharmacology, 2017, Volume: 6, Issue:7

    Topics: Acetamides; Acetates; Adult; Antihypertensive Agents; Bilirubin; Double-Blind Method; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Leukocyte Count; Male; Models, Biological; Natriuretic Peptide, Brain; Peptide Fragments; Pyrazines; Treatment Outcome

2017

Other Studies

10 other study(ies) available for phenyl acetate and Hypertension, Pulmonary

ArticleYear
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low
    The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1

    Topics: Acetamides; Acetates; Animals; beta-Arrestins; Cell Proliferation; CHO Cells; Contractile Proteins; Cricetinae; Cricetulus; Cyclic AMP; Epoprostenol; Extracellular Matrix; Humans; Hypertension, Pulmonary; Iloprost; Male; Muscle Contraction; Muscle Relaxation; Pyrazines; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Epoprostenol

2017
PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure.
    Cardiovascular research, 2020, 01-01, Volume: 116, Issue:1

    Topics: Acetates; Animals; Cells, Cultured; Disease Models, Animal; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Heart Failure; Heart Ventricles; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Interleukin-6; Lung; Male; Phosphorylation; Pulmonary Fibrosis; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction; Transforming Growth Factor beta; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling

2020
11C-Acetate clearance as an index of oxygen consumption of the right myocardium in idiopathic pulmonary arterial hypertension: a validation study using 15O-labeled tracers and PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:8

    Topics: Acetates; Adult; Aged; Blood Pressure; Carbon; Female; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Myocardium; Oxygen; Oxygen Radioisotopes; Positron-Emission Tomography; Pulmonary Artery; Radioactive Tracers

2013
Attenuated right ventricular energetics evaluated using ¹¹C-acetate PET in patients with pulmonary hypertension.
    European journal of nuclear medicine and molecular imaging, 2014, Volume: 41, Issue:6

    Topics: Acetates; Adult; Aged; Carbon; Case-Control Studies; Female; Heart Ventricles; Humans; Hypertension, Pulmonary; Male; Middle Aged; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Stroke Volume; Ventricular Function, Right

2014
Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
    Journal of medicinal chemistry, 2015, Sep-24, Volume: 58, Issue:18

    Topics: Acetamides; Acetates; Administration, Oral; Animals; CHO Cells; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cricetulus; Dogs; Double-Blind Method; Haplorhini; Humans; Hypertension, Pulmonary; Myocytes, Smooth Muscle; Platelet Aggregation Inhibitors; Pulmonary Artery; Pyrazines; Randomized Controlled Trials as Topic; Rats; Receptors, Epoprostenol; Structure-Activity Relationship

2015
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
    Journal of medicinal chemistry, 2017, 02-09, Volume: 60, Issue:3

    Topics: Acetates; Administration, Oral; Animals; Biological Availability; Carbamates; Drug Discovery; Hypertension, Pulmonary; Rats; Receptors, Prostaglandin; Structure-Activity Relationship

2017
A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 326, Issue:3

    Topics: Acetamides; Acetates; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; In Vitro Techniques; Male; Prodrugs; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Vasodilation

2008
Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:3

    Topics: Acetamides; Acetates; Alprostadil; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Hypertension, Pulmonary; In Vitro Techniques; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Receptors, Epoprostenol; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2012
[Preventive effects of montelukast on hypoxic pulmonary hypertension in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2003, Volume: 34, Issue:3

    Topics: Acetates; Animals; Cyclopropanes; Hypertension, Pulmonary; Hypoxia; Leukotriene Antagonists; Leukotriene C4; Male; Membrane Proteins; Quinolines; Random Allocation; Rats; Rats, Wistar; Receptors, Leukotriene; Sulfides

2003
[Preventive effects of montelukast on the collagen expression of pulmonary arterioles in rats with chronic hypoxia].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005, Volume: 36, Issue:2

    Topics: Acetates; Animals; Arterioles; Collagen Type I; Cyclopropanes; Hypertension, Pulmonary; Hypoxia; Leukotriene Antagonists; Male; Pulmonary Artery; Quinolines; Random Allocation; Rats; Rats, Wistar; Sulfides

2005