Page last updated: 2024-08-23

phenyl acetate and Alzheimer Disease

phenyl acetate has been researched along with Alzheimer Disease in 56 studies

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.79)18.7374
1990's4 (7.14)18.2507
2000's16 (28.57)29.6817
2010's26 (46.43)24.3611
2020's9 (16.07)2.80

Authors

AuthorsStudies
Datusalia, AK; Gaun, S; Manik, M; Singh, G; Singh, RK; Yadav, N1
Choi, JH; Choi, YS; Choi, YW; Ho, MJ; Joung, MY; Kang, MJ; Kim, MS; Lee, S; Park, HJ; Park, JS; Seo, JH; Song, WH1
Chen, S; Du, J; Gao, C; He, G; He, Y; Huang, P; Li, B; Tang, H; Zhang, P1
Dietlein, M; Dillen, K; Dronse, J; Fink, GR; Jacobs, HIL; Kracht, L; Kukolja, J; Langen, KJ; Nellessen, N; Neumaier, B; Onur, OA; Richter, N1
Ai, L; Bai, S; Cai, X; Di, Y; Fei, X; He, R; Lyu, J; Tong, Z; Yao, D; Yu, Y; Zhao, S1
Chen, W; Gong, T; Kong, Y; Li, H; Liu, J; Mao, S; Sun, J; Yu, J1
Cheng, Y; Hu, S; Li, H; Liu, J; Long, J; Peng, Y; Qin, C; Shi, L; Wang, C; Wang, Y; Xu, X; Zhang, S; Zhao, D1
Aigner, L; Hutter-Paier, B; Michael, J; Paiement, N; Poupardin, R; Reitsamer, H; Rieß, T; Unger, MS; Zerbe, H; Zirknitzer, J1
Caba, IC; Ştefănescu, R; Tamba, BI1
Bertolini, A; Bucciantini, M; Leri, M; Stefani, M1
Andreozzi, EM; Blower, PJ; Dunn, J; Sunassee, K; Szanda, I; Torres, JB; Walker-Samuel, S1
Baek, SJ; Heo, S; Jung, J; Kim, BC; Kim, DH; Kwon, H; Lee, S; Lee, YC; Park, HJ; Park, SJ; Ryu, JH; Yi, JH1
Beckers, N; Dietlein, M; Fink, GR; Kracht, L; Kukolja, J; Neumaier, B; Onur, OA; Richter, N; Tittgemeyer, M1
Fukushi, K; Higuchi, M; Hirano, S; Irie, T; Kuwabara, S; Ota, T; Sato, K; Shimada, H; Shinotoh, H; Suhara, T; Tanaka, N; Zhang, MR1
Avila, J; Cordero, JG; García-Escudero, R; García-Escudero, V; Gargini, R1
Bocti, C; Castellano, CA; Croteau, E; Cunnane, SC; Duchesne, S; Fortier, M; Fülöp, T; Lepage, M; Nugent, S; Richard, MA; Turcotte, ÉE; Whittingstall, K1
Jiang, B; Kong, Y; Luo, X1
Cho, M; Lee, Y; Qin, J1
Abbasov, ME; Alfonso, A; Alonso, E; Alvariño, R; Botana, LM; Chaheine, CM; Conner, ML; Romo, D1
Garcia, R; Hu, Z; Li, Q; Olariu, A; Pei, J; Saydoff, JA; Sheng, J; Sun, GY; von Borstel, R1
Cappa, SF; Florea, I; Garibotto, V; Marcone, A; Moresco, R; Panzacchi, A; Perani, D; Rinne, J; Tettamanti, M; Virta, JR1
Anumala, UR; Czech, C; Goetschy-Meyer, V; Gu, J; Herms, J; Heyny-von Haußen, R; Hilger, I; Hölzer, J; Kramer, T; Lo Monte, F; Mall, G; Schmidt, B; Schön, C1
Akashiba, H; Asai, M; Ishikawa, N; Matsuoka, N; Mitani, Y; Ni, K; Nozawa, T; Okabe, M; Saita, K; Shitaka, Y; Uchino, H; Yamasaki, S; Yarimizu, J1
Dadashpour, S; Emami, S; Irannejad, H; Ozadali, K; Tuylu Kucukkilinc, T; Unsal Tan, O1
Aderibigbe, AO; Adewole, FA; Ajayi, AM; Eduviere, AT; Umukoro, S1
Bowen, ZD; Bryleva, EY; Chang, CCY; Chang, TY; Harris, BT; Kheirollah, A; Murphy, SR; Niu, Z; Shibuya, Y1
McGilvray, A1
Brown, RE; Roberts, AD; Roddick, KM; Schellinck, HM1
Chen, CL; Chen, PT; Chen, RP; Hu, CJ; Lin, LT; Lo, CH; Wang, SS1
Huang, SW; Liu, QB; Luo, SY; Peng, Y; Song, SJ; Sun, B; Wang, W; Wu, DL; Zhang, MY1
Dietlein, M; Fink, GR; Kracht, L; Kukolja, J; Michel, A; Neumaier, B; Onur, OA; Richter, N; Tittgemeyer, M1
Gibbs, ME; Gibbs, Z; Hertz, L1
Barren, C; Duller, S; Frosch, MP; Havas, D; Hutter-Paier, B; Huttunen, HJ; Kovacs, DM; Peach, C; Windisch, M; Xia, W1
Brorsson, AC; Göransson, AL; Kågedal, K; Nilsson, KP1
Choi, SJ; Heo, HJ; Jeong, HR; Jeong, JH; Jin, DE; Jo, YN; Shin, DH; Song, BG1
Akashiba, H; Matsuoka, N; Mitani, Y; Ni, K; Shitaka, Y; Yarimizu, J1
Järvenpää, T; Kaasinen, V; Kurki, T; Någren, K; Oikonen, V; Rinne, JO; Roivainen, A; Yu, M1
Koudinov, AR; Koudinova, NV1
Bauer, B; Heiss, WD; Herholz, K; Kalbe, E; Lenz, O; Schröder, H; Weisenbach, S; Zündorf, G1
Alkhalil, B; Alkhalil, C; Hahar, N; Lowenthal, DT; Zavros, G1
Mascalzi, MG; Raudino, F; Zagami, A1
Aotsuka, A; Arai, H; Fukushi, K; Irie, T; Iyo, M; Nagatsuka, S; Namba, H; Ota, T; Sato, K; Shinotoh, H; Shiraishi, T; Tanada, S; Tanaka, N1
Baumann, K; Haass, C; Narlawar, R; Pérez Revuelta, BI; Schmidt, B; Schubenel, R; Steiner, H1
Ge, H; Lin, C; Ma, L; Peng, W; Song, H; Wang, Z; Wen, H; Zhou, Y1
Atanassov, CL; Knödgen, B; Muller, CD; Rebel, G; Sarhan, S; Seiler, N1
Fukushi, K; Ikota, N; Irie, T; Iyo, M; Nagatsuka, S; Namba, H; Tamagami, H1
Gordon, SM; Regan, WM1
Ancill, RJ; Holliday, SG; Sheldon, LJ1
Feinberg, TE; Meckler, L; Miner, CR; Roane, DM; Rosenthal, RN; Scicutella, A1
Buffa, C; Dallocchio, C; Mazzarello, P1
Aotsuka, A; Fukushi, K; Irie, T; Iyo, M; Nagatsuka , S; Namba, H; Ota, T; Shinotoh, H; Tanada, S; Tanaka, N1
Bauer, B; Heiss, WD; Herholz, K; Lenz, O; Lercher, M; Wienhard, K1
Bauer, B; Heiss, WD; Herholz, K; Kracht, L; Lenz, MO; Mielke, R; Strotmann, T; Wienhard, K1
Antonello, RM; Cazzato, G; Moretti, R; Torre, P1
Aotsuka, A; Fukushi, K; Irie, T; Iyo, M; Nagatsuka Si, S; Namba, H; Ota, T; Shinotoh, H; Tanada, S; Tanaka, N1
Blair, JA; Cowburn, JD1

Reviews

2 review(s) available for phenyl acetate and Alzheimer Disease

ArticleYear
Targeted Delivery of Montelukast for the Treatment of Alzheimer's Disease.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:10

    Topics: Acetates; Alzheimer Disease; Cyclopropanes; Humans; Leukotrienes; Quinolines; Sulfides

2022
Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Acetates; Alzheimer Disease; Animals; Autophagy; Cyclopentane Monoterpenes; Humans; Pyrans; TOR Serine-Threonine Kinases

2018

Trials

5 trial(s) available for phenyl acetate and Alzheimer Disease

ArticleYear
Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease.
    Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:1

    Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Analysis of Variance; Brain; Carbon Radioisotopes; Cognition Disorders; Female; Hippocampus; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Neuropsychological Tests; Piperidines; Predictive Value of Tests; Reference Values; Tomography, Emission-Computed

2003
A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:3

    Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Female; Humans; Image Interpretation, Computer-Assisted; Iofetamine; Male; Middle Aged; Piperidines; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

2004
Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:3

    Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Arteries; Blood Specimen Collection; Brain; Carbon Radioisotopes; Humans; Middle Aged; Monte Carlo Method; Piperidines; Tomography, Emission-Computed

2001
Gabapentin as a possible treatment of behavioral alterations in Alzheimer disease (AD) patients.
    European journal of neurology, 2001, Volume: 8, Issue:5

    Topics: Acetates; Aged; Alzheimer Disease; Amines; Behavior; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Agonists; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male

2001
Kinetic analysis of [(11)C]MP4A using a high-radioactivity brain region that represents an integrated input function for measurement of cerebral acetylcholinesterase activity without arterial blood sampling.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:11

    Topics: Acetates; Acetylcholinesterase; Adult; Aged; Alzheimer Disease; Blood Specimen Collection; Brain; Carbon Radioisotopes; Computer Simulation; Humans; Kinetics; Least-Squares Analysis; Middle Aged; Models, Biological; Piperidines; Tomography, Emission-Computed

2001

Other Studies

49 other study(ies) available for phenyl acetate and Alzheimer Disease

ArticleYear
Design of Montelukast Nanocrystalline Suspension for Parenteral Prolonged Delivery.
    International journal of nanomedicine, 2022, Volume: 17

    Topics: Acetates; Alzheimer Disease; Animals; Cyclopropanes; Nanoparticles; Particle Size; Quinolines; Rats; Solubility; Sulfides; Suspensions

2022
Early changes of fecal short-chain fatty acid levels in patients with mild cognitive impairments.
    CNS neuroscience & therapeutics, 2023, Volume: 29, Issue:11

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Atrophy; Butyric Acid; Caproates; Cognitive Dysfunction; Fatty Acids, Volatile; Humans; Positron-Emission Tomography

2023
Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.
    NeuroImage. Clinical, 2019, Volume: 24

    Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals

2019
A rapid and non-invasive fluorescence method for quantifying coenzyme Q10 in blood and urine in clinical analysis.
    Journal of clinical laboratory analysis, 2020, Volume: 34, Issue:4

    Topics: Acetates; Aged; Alzheimer Disease; Chemistry, Clinical; Chromatography, High Pressure Liquid; Fluorescence; Humans; Limit of Detection; Spectrometry, Fluorescence; Temperature; Time Factors; Ubiquinone

2020
Anti-neuroinflammatory Effect of Short-Chain Fatty Acid Acetate against Alzheimer's Disease via Upregulating GPR41 and Inhibiting ERK/JNK/NF-κB.
    Journal of agricultural and food chemistry, 2020, Jul-08, Volume: 68, Issue:27

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cognition; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Volatile; Humans; Male; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Neuroprotective Agents; NF-kappa B; Receptors, G-Protein-Coupled; Up-Regulation

2020
Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERβ-dependent Manner.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:3

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Catechols; Cognition; Disease Models, Animal; Encephalitis; Estrogen Receptor beta; Female; Hippocampus; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; Presenilin-1; Rats, Wistar

2021
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice.
    International journal of molecular sciences, 2021, Mar-09, Volume: 22, Issue:5

    Topics: Acetates; Alzheimer Disease; Animals; Brain; CD8-Positive T-Lymphocytes; Cognition; Cyclopropanes; Inflammation; Leukotriene Antagonists; Mice; Mice, Transgenic; Quinolines; Sulfides

2021
Observation of Intact and Proteolytically Cleaved Amyloid-Beta (1-40)-Oleuropein Noncovalent Complex at Neutral pH by Mass Spectrometry.
    Molecules (Basel, Switzerland), 2021, May-28, Volume: 26, Issue:11

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Bicarbonates; Binding Sites; Humans; Hydrogen-Ion Concentration; Iridoid Glucosides; Mass Spectrometry; Peptide Fragments; Peptide Hydrolases; Protein Binding; Proteolysis; Solvents; Spectrometry, Mass, Electrospray Ionization; Trypsin

2021
EVOO Polyphenols Relieve Synergistically Autophagy Dysregulation in a Cellular Model of Alzheimer's Disease.
    International journal of molecular sciences, 2021, Jul-05, Volume: 22, Issue:13

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Cell Line; Cyclopentane Monoterpenes; Diet, Mediterranean; Humans; Mitochondria; Models, Neurological; Nerve Degeneration; Neurons; Olive Oil; Peptide Fragments; Phenylethyl Alcohol; Polyphenols; Proteasome Endopeptidase Complex; Pyrans; Reactive Oxygen Species; Ubiquitin

2021
Studies of copper trafficking in a mouse model of Alzheimer's disease by positron emission tomography: comparison of
    Metallomics : integrated biometal science, 2017, 11-15, Volume: 9, Issue:11

    Topics: Acetates; Administration, Intravenous; Alzheimer Disease; Animals; Biological Transport; Brain; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Humans; Metabolic Clearance Rate; Mice, Transgenic; Organometallic Compounds; Positron-Emission Tomography; Thiosemicarbazones; Tissue Distribution

2017
Direct pharmacological Akt activation rescues Alzheimer's disease like memory impairments and aberrant synaptic plasticity.
    Neuropharmacology, 2018, Volume: 128

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Benzofurans; Benzopyrans; Disease Models, Animal; Enzyme Inhibitors; Evoked Potentials; Gene Expression Regulation; Hippocampus; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Oligopeptides; Oncogene Protein v-akt; Oxadiazoles; Peptide Fragments; Reaction Time; Recognition, Psychology

2018
Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer's disease.
    Brain : a journal of neurology, 2018, 03-01, Volume: 141, Issue:3

    Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cerebral Cortex; Cholinergic Agents; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Oxygen; Piperidines; Positron-Emission Tomography; Rivastigmine

2018
Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 62, Issue:4

    Topics: Acetates; Acetylcholinesterase; Age of Onset; Aged; Aging; Alzheimer Disease; Brain; Brain Mapping; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals

2018
Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 64, Issue:2

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbon; Energy Metabolism; Female; Fluorodeoxyglucose F18; Humans; Ketones; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Triglycerides

2018
Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model.
    Future microbiology, 2018, Volume: 13

    Topics: Acetates; Alzheimer Disease; Animals; Bacteria; Biodiversity; Disease Models, Animal; Drosophila; Gastrointestinal Microbiome; Metabolome; Phenotype; RNA, Ribosomal, 16S

2018
Ultrasensitive Detection of Amyloid-β Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles-Poly(3,4-ethylene dioxythiophene)-Poly(thiophene-3-acetic acid) Composite Electrode.
    Analytical chemistry, 2019, 09-03, Volume: 91, Issue:17

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Biosensing Techniques; Bridged Bicyclo Compounds, Heterocyclic; Electric Conductivity; Electrochemical Techniques; Electrodes; Gold; Metal Nanoparticles; Mice; Polymers; Prion Proteins; Thiophenes

2019
Gracilin A Derivatives Target Early Events in Alzheimer's Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress.
    ACS chemical neuroscience, 2019, 09-18, Volume: 10, Issue:9

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cytokines; Diterpenes; Furans; Humans; Inflammation; Lipopolysaccharides; Microglia; Neuroprotection; Neuroprotective Agents; Oxidative Stress

2019
Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:4

    Topics: Acetates; Alzheimer Disease; Animals; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Female; Gerbillinae; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Prodrugs; Stroke; Uridine

2013
Cholinergic activity correlates with reserve proxies in Alzheimer's disease.
    Neurobiology of aging, 2013, Volume: 34, Issue:11

    Topics: Acetates; Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Carbon Isotopes; Cognitive Dysfunction; Cognitive Reserve; Educational Status; Employment; Female; Fluorodeoxyglucose F18; Humans; Male; Mental Status Schedule; Middle Aged; Piperidines; Positron-Emission Tomography; Radiography; Statistics, Nonparametric; Tomography Scanners, X-Ray Computed

2013
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
    Bioorganic & medicinal chemistry, 2013, Sep-01, Volume: 21, Issue:17

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Line, Tumor; Cell Survival; Embryo, Nonmammalian; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Peptide Fragments; Rhodanine; tau Proteins; Zebrafish

2013
Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates.
    Neuropharmacology, 2014, Volume: 79

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Brain; Cell Line, Tumor; Cognition; Cyclohexylamines; Disease Models, Animal; Female; Humans; Macaca fascicularis; Male; Mice; Mice, Transgenic; Molecular Structure; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Notch

2014
Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors.
    Archiv der Pharmazie, 2015, Volume: 348, Issue:3

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Cyclooxygenase 2 Inhibitors; Drug Design; Molecular Docking Simulation; Molecular Structure; Permeability; Plaque, Amyloid; Protein Aggregation, Pathological; Protein Stability; Structure-Activity Relationship; Triazines

2015
Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice.
    Life sciences, 2015, Jul-01, Volume: 132

    Topics: Acetates; Alzheimer Disease; Analysis of Variance; Animals; Biomarkers; Brain; Catalase; Cholinesterase Inhibitors; Cyclopentanes; Male; Malondialdehyde; Maze Learning; Memory; Mice; Oxidative Stress; Oxylipins; Recognition, Psychology; Scopolamine; Superoxide Dismutase

2015
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
    Neurobiology of aging, 2015, Volume: 36, Issue:7

    Topics: Acetamides; Acetates; Acetyl-CoA C-Acetyltransferase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Benzimidazoles; Brain; Cells, Cultured; Cholesterol; Cholesterol Esters; Disease Models, Animal; Enzyme Inhibitors; Gene Knockdown Techniques; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Neurons; Peptide Fragments; Presenilin-1; Sulfonamides; Sulfonic Acids; tau Proteins

2015
Ageing: Restoration project.
    Nature, 2016, Mar-03, Volume: 531, Issue:7592

    Topics: Acetates; Aging; Alzheimer Disease; Animals; Anti-Asthmatic Agents; Cognition Disorders; Cyclopropanes; Estrogens; Female; Hippocampus; Humans; Inflammation Mediators; Leukotrienes; Macaca mulatta; Male; Mice; Neuronal Plasticity; Parkinson Disease; Plasma; Prefrontal Cortex; Quinolines; Rats; Rejuvenation; Sulfides; Synapses

2016
Sex and Genotype Differences in Odor Detection in the 3×Tg-AD and 5XFAD Mouse Models of Alzheimer's Disease at 6 Months of Age.
    Chemical senses, 2016, Volume: 41, Issue:5

    Topics: Acetates; Alzheimer Disease; Animals; Behavior, Animal; Discriminant Analysis; Disease Models, Animal; Female; Genotype; Male; Mice; Mice, Transgenic; Sex Factors; Smell

2016
Design of Peptide Substrate for Sensitively and Specifically Detecting Two Aβ-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Acetates; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Cell Line, Tumor; Chromones; Humans; Insulysin; Neprilysin; Peptide Fragments; Peptidyl-Dipeptidase A; Proteolysis; Spectrometry, Fluorescence; Substrate Specificity

2016
The effect of ethyl acetate extract from persimmon leaves on Alzheimer's disease and its underlying mechanism.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Jun-15, Volume: 23, Issue:7

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Diospyros; Glutathione Peroxidase; Hippocampus; Male; Malondialdehyde; MAP Kinase Signaling System; Maze Learning; Microinjections; Peptide Fragments; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Solvents; Superoxide Dismutase

2016
White matter lesions and the cholinergic deficit in aging and mild cognitive impairment.
    Neurobiology of aging, 2017, Volume: 53

    Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Male; Memory; Middle Aged; Neuropsychological Tests; Piperidines; Positron-Emission Tomography; White Matter

2017
Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease.
    Journal of neurochemistry, 2009, Volume: 109 Suppl 1

    Topics: 3-Hydroxybutyric Acid; Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocytes; Caprylates; Chickens; Citric Acid Cycle; Discrimination Learning; Glucose; Hypoglycemic Agents; Insulin; Ketone Bodies; Lactic Acid; Memory Disorders; Oxidation-Reduction; Peptide Fragments; Reinforcement, Psychology

2009
The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.
    Journal of neuropathology and experimental neurology, 2010, Volume: 69, Issue:8

    Topics: Acetamides; Acetates; Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Brain; Cholesterol; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gliosis; Humans; Image Processing, Computer-Assisted; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Presenilin-1; Pyridines; Sterol O-Acyltransferase; Sulfonamides; Sulfonic Acids

2010
Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants.
    Biochemical and biophysical research communications, 2012, Apr-20, Volume: 420, Issue:4

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Cell Line; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Peptide Fragments; Thiophenes

2012
Antiamnesic effects of ethyl acetate fraction from chestnut (Castanea crenata var. dulcis) inner skin on Aβ(25-35)-induced cognitive deficits in mice.
    Journal of medicinal food, 2012, Volume: 15, Issue:12

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Catechin; Cell Survival; Chromatography, High Pressure Liquid; Cognition Disorders; Fagaceae; Fluoresceins; Gallic Acid; Hydrogen Peroxide; L-Lactate Dehydrogenase; Learning; Male; Memory; Mice; Mice, Inbred ICR; Neurons; Oxidative Stress; PC12 Cells; Plant Extracts; Rats; Reactive Oxygen Species

2012
Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools.
    Journal of neurochemistry, 2013, Volume: 125, Issue:3

    Topics: Acetates; Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antibodies; Chromatography, Liquid; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hippocampus; Humans; Mass Spectrometry; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Piperidines

2013
Cholesterol, synaptic function and Alzheimer's disease.
    Pharmacopsychiatry, 2003, Volume: 36 Suppl 2

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cholesterol; Disease Models, Animal; Electric Stimulation; Humans; Immunohistochemistry; In Vitro Techniques; Learning Disabilities; Long-Term Potentiation; Memory Disorders; Nerve Degeneration; Neurodegenerative Diseases; Rats; Rats, Wistar; Risk Factors; Synapses; Synaptic Transmission; Tritium

2003
In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease.
    NeuroImage, 2004, Volume: 21, Issue:1

    Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Amygdala; Basal Nucleus of Meynert; Blood Glucose; Carbon Radioisotopes; Cerebral Cortex; Cholinergic Fibers; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed

2004
Can gabapentin be a safe alternative to hormonal therapy in the treatment of inappropriate sexual behavior in demented patients?
    International urology and nephrology, 2003, Volume: 35, Issue:2

    Topics: Acetates; Aged; Alzheimer Disease; Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hormones; Humans; Male; Sexual Behavior; Sexual Dysfunctions, Psychological

2003
Gabapentin and behavioral disorders in severe Alzheimer disease.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:4

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Cyclohexanecarboxylic Acids; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Male

2004
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.
    Bioorganic & medicinal chemistry letters, 2007, Jan-01, Volume: 17, Issue:1

    Topics: Acetates; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Humans

2007
Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.
    Bioorganic & medicinal chemistry letters, 2007, Apr-15, Volume: 17, Issue:8

    Topics: Acetates; Alzheimer Disease; Benzaldehydes; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Structure-Activity Relationship

2007
Effect of ammonia on endocytosis, cytokine production and lysosomal enzyme activity of a microglial cell line.
    Research in immunology, 1994, Volume: 145, Issue:4

    Topics: Acetates; Acid Phosphatase; Alzheimer Disease; Ammonia; Animals; beta-Glucosidase; Cathepsin D; Cell Line; Cytokines; Endocytosis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Interleukin-1; Interleukin-6; Lysosomes; Mice; Microglia; Phagocytosis; Tumor Necrosis Factor-alpha

1994
Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:4

    Topics: Acetates; Acetylcholinesterase; Alzheimer Disease; Amphetamines; Animals; Brain; Carbon Radioisotopes; Iodine Radioisotopes; Iofetamine; Male; Piperidines; Propionates; Rats; Rats, Wistar; Sensitivity and Specificity; Tomography, Emission-Computed

1996
Gabapentin for behavioral agitation in Alzheimer's disease.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1

    Topics: Acetates; Aged; Alzheimer Disease; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Haloperidol; Humans; Psychomotor Agitation; Treatment Outcome

1997
Gabapentin in geriatric psychiatry patients.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:4

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Dementia; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male

1998
Treatment of dementia-associated agitation with gabapentin.
    The Journal of neuropsychiatry and clinical neurosciences, 2000,Winter, Volume: 12, Issue:1

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dementia, Multi-Infarct; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Mental Status Schedule; Neurologic Examination; Psychomotor Agitation

2000
Combination of donepezil and gabapentin for behavioral disorders in Alzheimer's disease.
    The Journal of clinical psychiatry, 2000, Volume: 61, Issue:1

    Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Donepezil; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Male; Mental Disorders; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome

2000
PET measurement of cerebral acetylcholine esterase activity without blood sampling.
    European journal of nuclear medicine, 2001, Volume: 28, Issue:4

    Topics: Acetates; Acetylcholinesterase; Aged; Algorithms; Alzheimer Disease; Basal Ganglia; Brain; Female; Humans; Lewy Body Disease; Male; Middle Aged; Piperidines; Radiopharmaceuticals; Tomography, Emission-Computed

2001
In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:12

    Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Brain; Brain Stem; Carbon Radioisotopes; Cerebellum; Cerebrovascular Circulation; Corpus Striatum; Female; Glucose; Humans; Lewy Body Disease; Male; Mental Status Schedule; Middle Aged; Piperidines; Reference Values; Regression Analysis; Thalamus; Tomography, Emission-Computed

2000
Aluminium chelator (transferrin) reverses biochemical deficiency in Alzheimer brain preparations.
    Lancet (London, England), 1989, Jan-14, Volume: 1, Issue:8629

    Topics: Acetates; Alzheimer Disease; Biopterins; Brain; Chelating Agents; Humans; Transferrin

1989