phentolamine has been researched along with Spinal Cord Injuries in 35 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 66 spinal cord injury patients with erectile dysfunction entered a protocol of penile intracavernous pharmacotherapy with papaverine hydrochloride (30 mg." | 5.06 | Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal cord injury. ( Cameron, JS; Dykstra, DD; Lange, PH; Reinberg, Y; Sidi, AA, 1987) |
| " We studied patients with spinal cord injuries during spinal shock and found that the urethral pressure profile had a normal configuration, the peak profile pressure increased with bladder filling and phentolamine (10 mg." | 5.04 | Urethral pressure profile during the spinal shock stage in man: a preliminary report. ( Awad, SA; Bryniak, SR; Downie, JW; Twiddy, DA, 1977) |
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| "Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction." | 3.69 | Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction. ( Chao, R; Clowers, DE, 1994) |
| " In the current study, we evaluated 40 SCI patients and 116 patients with vascular based impotence who had been followed for a minimum of 1 month while utilising intracavernous injections of phentolamine and papaverine." | 3.67 | Intracavernous pharmacotherapy for management of erectile dysfunction in spinal cord injury. ( Lloyd, LK; Richards, JS, 1989) |
| "We report on our results with the intracavernous injection and self-injection of papaverine-phentolamine in a group of spinal cord injury patients with erectile impotence." | 3.67 | Intracavernous injection of vasoactive drugs, an alternative for treating impotence in spinal cord injury patients. ( Claessens, H; de Meyer, JM; de Sy, WA; Wyndaele, JJ, 1986) |
| "Autonomic dysreflexia is a hypertensive episode in spinal cord-injured individuals induced by exaggerated sympathetic activity and thought to be alpha-adrenergic mediated." | 2.75 | Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals. ( Danser, AH; Deinum, J; Geurts, AC; Groothuis, JT; Hopman, MT; Pickkers, P; Rongen, GA; Smits, P, 2010) |
| " A decline in mean arterial pressure was observed in both groups with increasing dosage of phentolamine." | 1.32 | Preserved alpha-adrenergic tone in the leg vascular bed of spinal cord-injured individuals. ( Hopman, MT; Kooijman, M; Rongen, GA; Smits, P, 2003) |
| "The chronic allodynia-like behavior was stable for months without signs of remission and i." | 1.30 | Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury. ( Haegerstrand, A; Hao, JX; Hökfelt, T; Saydoff, J; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (45.71) | 18.7374 |
| 1990's | 9 (25.71) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kooijman, M | 2 |
| Rongen, GA | 3 |
| Smits, P | 3 |
| van Kuppevelt, HJ | 1 |
| Hopman, MT | 3 |
| Groothuis, JT | 1 |
| Deinum, J | 1 |
| Pickkers, P | 1 |
| Danser, AH | 1 |
| Geurts, AC | 1 |
| Sharma, HS | 1 |
| Winkler, T | 1 |
| Shafik, A | 1 |
| Shafik, AA | 1 |
| El-Sibai, O | 1 |
| Ahmed, I | 1 |
| Miao, FJ | 1 |
| Green, P | 1 |
| Benowitz, N | 1 |
| Levine, JD | 1 |
| Reitz, A | 2 |
| Schmid, DM | 2 |
| Curt, A | 2 |
| Knapp, PA | 2 |
| Schurch, B | 2 |
| Mittmann, N | 1 |
| Craven, BC | 1 |
| Gordon, M | 1 |
| MacMillan, DH | 1 |
| Hassouna, M | 1 |
| Raynard, W | 1 |
| Kaiser, A | 1 |
| Lanctôt, LK | 1 |
| Tarride, JE | 1 |
| Erickson, RP | 1 |
| Thomas, DG | 1 |
| Philp, NH | 1 |
| McDermott, TE | 1 |
| Rickwood, AM | 1 |
| Rossier, AB | 3 |
| Fam, BA | 2 |
| Lee, IY | 1 |
| Sarkarati, M | 1 |
| Evans, DA | 1 |
| Koyanagi, T | 1 |
| Arikado, K | 1 |
| Takamatsu, T | 1 |
| Tsuji, I | 1 |
| Karol, JB | 1 |
| Anderson, RU | 1 |
| Chao, R | 1 |
| Clowers, DE | 1 |
| Watanabe, T | 1 |
| Chancellor, MB | 1 |
| Rivas, DA | 1 |
| Hirsch, IH | 1 |
| Bennett, CJ | 1 |
| Finocchiaro, MV | 1 |
| Razi, S | 1 |
| Bennett, JK | 1 |
| Green, BG | 1 |
| Foote, JE | 1 |
| Killorian, RW | 1 |
| Juma, S | 1 |
| Linsenmeyer, TA | 2 |
| Lloyd, K | 1 |
| Kontani, H | 1 |
| Hayashi, K | 1 |
| Yu, W | 1 |
| Hao, JX | 1 |
| Xu, XJ | 1 |
| Saydoff, J | 1 |
| Haegerstrand, A | 1 |
| Hökfelt, T | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Uchida, S | 1 |
| Kagitani, F | 1 |
| Suzuki, A | 1 |
| Aikawa, Y | 1 |
| Andersen, JT | 1 |
| Bradley, WE | 1 |
| Awad, SA | 2 |
| Bryniak, SR | 1 |
| Downie, JW | 2 |
| Twiddy, DA | 1 |
| Tulloch, AG | 2 |
| Parkinson, J | 1 |
| Sunder, GS | 1 |
| Parsons, KF | 1 |
| Gibbon, NO | 1 |
| Yalla, SB | 1 |
| Gabilondo, FB | 1 |
| Di Benedetto, M | 1 |
| Gittes, RF | 1 |
| Padma-Nathan, H | 1 |
| Kanellos, A | 1 |
| Jaworski, TM | 1 |
| Richards, JS | 2 |
| Lloyd, LK | 2 |
| Bodner, DR | 2 |
| Leffler, B | 1 |
| Frost, F | 1 |
| Earle, CM | 1 |
| Keogh, EJ | 1 |
| Ker, JK | 1 |
| Cherry, DJ | 1 |
| Lord, DJ | 1 |
| Sidi, AA | 1 |
| Cameron, JS | 1 |
| Dykstra, DD | 1 |
| Reinberg, Y | 1 |
| Lange, PH | 1 |
| Lindan, R | 1 |
| Leffler, E | 1 |
| Kursh, ED | 1 |
| Resnick, MI | 1 |
| Wyndaele, JJ | 1 |
| de Meyer, JM | 1 |
| de Sy, WA | 1 |
| Claessens, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Mecamylamine for Autonomic Dysreflexia Prophylaxis[NCT03914677] | Phase 4 | 5 participants (Anticipated) | Interventional | 2019-06-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phentolamine and Spinal Cord Injuries
| Article | Year |
|---|---|
Autonomic hyperreflexia: pathophysiology and medical management.
Topics: Anesthesia, Spinal; Catecholamines; Diazoxide; Humans; Hydralazine; Neurotransmitter Agents; Nitropr | 1980 |
The management of erectile dysfunction following spinal cord injury.
Topics: Alprostadil; Autonomic Nervous System; Erectile Dysfunction; Follow-Up Studies; Humans; Male; Penile | 1992 |
Evaluation and treatment of erectile dysfunction following spinal cord injury: a review.
Topics: Equipment Design; Humans; Injections; Male; Papaverine; Penile Erection; Penile Prosthesis; Penis; P | 1991 |
4 trials available for phentolamine and Spinal Cord Injuries
| Article | Year |
|---|---|
Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin II; Autonomic Dysreflexia; Autonomic Nervous | 2010 |
Afferent fibers of the pudendal nerve modulate sympathetic neurons controlling the bladder neck.
Topics: Adrenergic Fibers; Adult; Electric Stimulation; Humans; Male; Muscle Contraction; Nerve Fibers; Neur | 2003 |
Urethral pressure profile during the spinal shock stage in man: a preliminary report.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Phentolamine; Spinal Cord Injuri | 1977 |
Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal cord injury.
Topics: Adult; Clinical Trials as Topic; Drug Combinations; Erectile Dysfunction; Follow-Up Studies; Humans; | 1987 |
28 other studies available for phentolamine and Spinal Cord Injuries
| Article | Year |
|---|---|
The role of the alpha-adrenergic receptor in the leg vasoconstrictor response to orthostatic stress.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Heart Rate; Humans; Leg; Male; Middle Aged; Phe | 2009 |
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Role of sympathetic innervation in the defecation mechanism: a novel concept of its function.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anal Canal; Animals; Catheterization; Def | 2003 |
Vagal modulation of spinal nicotine-induced inhibition of the inflammatory response mediated by descending antinociceptive controls.
Topics: Adrenergic alpha-Antagonists; Animals; Bradykinin; Capillary Permeability; Dose-Response Relationshi | 2003 |
Autonomic dysreflexia in response to pudendal nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Autonomic Dysreflexia; Blood Pressure; Electric Stimulation; Heart Rat | 2003 |
Preserved alpha-adrenergic tone in the leg vascular bed of spinal cord-injured individuals.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Blood Pressure; Cold Temperature; | 2003 |
Erectile dysfunction in spinal cord injury: a cost-utility analysis.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Alprostadil; Cost-Benefit Analysis; Drug Costs; Erectile | 2005 |
The use of urodynamic studies to assess the effect of pharmacological agents with particular references to alpha-adrenergic blockade.
Topics: Humans; Infusions, Parenteral; Male; Muscle Contraction; Phentolamine; Spinal Cord Injuries; Urinary | 1984 |
The respective contribution of smooth and striated components in the urethral pressure profile of the spinal cord injured. A neuropharmacological and urodynamic study.
Topics: Anal Canal; Electromyography; Humans; Male; Nerve Block; Phentolamine; Rectum; Spinal Cord Injuries; | 1983 |
Relevance of sympathetic dyssynergia in the region of external urethral sphincter: possible mechanism of voiding dysfunction in the absence of (somatic) sphincter dyssynergia.
Topics: Humans; Male; Muscle, Smooth; Phentolamine; Posture; Pressure; Reflex, Abnormal; Spinal Cord Injurie | 1982 |
Neuropharmacologic evaluation in spinal cord injury patients using membrane catheter cystosphincterometry.
Topics: Bethanechol Compounds; Catheterization; Drug Evaluation; Humans; Male; Muscle Contraction; Phentolam | 1980 |
Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction.
Topics: Adult; Alprostadil; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Drug Monitoring; Drug Syne | 1994 |
Epidemiology of current treatment for sexual dysfunction in spinal cord injured men in the USA model spinal cord injury centers.
Topics: Adolescent; Adult; Aged; Alprostadil; Humans; Impotence, Vasculogenic; Male; Middle Aged; Papaverine | 1996 |
Urinary bladder response to hypogastric nerve stimulation after bilateral resection of the pelvic nerve or spinal cord injury in rats.
Topics: Animals; Atropine; Chronic Disease; Electric Stimulation; Hexamethonium; Hypogastric Plexus; Nicotin | 1997 |
Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury.
Topics: Animals; Behavior, Animal; Cattle; Cell Transplantation; Chromaffin Cells; Cold Temperature; Disease | 1998 |
Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats.
Topics: Acetylcholine; Acupuncture Therapy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Affer | 2000 |
Urethral pressure profilometry: assessment of urethral function by combined intraurethral pressure and electromyographic recording.
Topics: Carbon Dioxide; Electromyography; Female; Humans; Male; Muscle, Smooth; Phentolamine; Pressure; Pros | 1977 |
The action of neuropharmacologic agents on the bladder and urethra during experimental spinal shock.
Topics: Animals; Bethanechol Compounds; Dogs; Female; Isoproterenol; Male; Phentolamine; Phenylephrine; Pres | 1977 |
The spinal cord-injured patient. Autonomic hyperreflexia.
Topics: Humans; Hypertension; Phenoxybenzamine; Phentolamine; Spinal Cord Injuries; Urinary Bladder; Vasomot | 1977 |
Outflow obstruction in neuropathic bladder dysfunction: the neuropathic urethra.
Topics: Adolescent; Adult; Aged; Electromyography; Female; Humans; Male; Middle Aged; Muscle, Smooth; Phento | 1978 |
Functional contribution of autonomic innervation to urethral striated sphincter: studies with parasympathomimetic, parasympatholytic and alpha-adrenergic blocking agents in spinal cord injury and control male subjects.
Topics: Adolescent; Bethanechol Compounds; Humans; Male; Middle Aged; Muscle, Smooth; Parasympathetic Nervou | 1977 |
Sympathetic dyssynergia in the region of the external sphincter: a possible source of lower urinary tract obstruction.
Topics: Humans; Male; Nervous System Diseases; Phenoxybenzamine; Phentolamine; Radiography; Spinal Cord Inju | 1977 |
Retrospective review of sexual and marital satisfaction of spinal cord injury and diabetic males post penile injection or implant.
Topics: Adult; Diabetes Mellitus; Drug Therapy, Combination; Humans; Injections; Male; Marriage; Middle Aged | 1992 |
The role of intracavernous injection of vasoactive medications for the restoration of erection in spinal cord injured males: a three year follow up.
Topics: Adult; Aged; Erectile Dysfunction; Female; Humans; Injections; Male; Middle Aged; Papaverine; Penile | 1992 |
The role of intracavernosal vasoactive agents to overcome impotence due to spinal cord injury.
Topics: Adult; Alprostadil; Blood Pressure; Erectile Dysfunction; Humans; Injections; Male; Middle Aged; Pap | 1992 |
Intracavernous pharmacotherapy for management of erectile dysfunction in spinal cord injury.
Topics: Adult; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Middle Aged; Papaverine | 1989 |
The application of intracavernous injection of vasoactive medications for erection in men with spinal cord injury.
Topics: Adult; Drug Combinations; Erectile Dysfunction; Humans; Male; Middle Aged; Papaverine; Penile Erecti | 1987 |
Intracavernous injection of vasoactive drugs, an alternative for treating impotence in spinal cord injury patients.
Topics: Drug Combinations; Erectile Dysfunction; Humans; Injections; Male; Papaverine; Penis; Phentolamine; | 1986 |