phentolamine and Shock studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Shock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.

Research Excerpts

Excerpt	Relevance	Reference
"To observe the effect and mechanism of alpha-adrenergic receptor inhibitor phentolamine (PTL) in a rabbit model of acute pulmonary embolism (APE) combined with shock."	8.12	Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock. ( Gu, Y; Hu, L; Qiu, L; Wang, Y; Yu, D; Yu, Y, 2022)
"A case of pheochromocytoma with spontaneous remission after recovery from shock induced by the phentolamine test is presented."	7.67	Pheochromocytoma with remission following phentolamine-induced shock. ( Akaza, H; Asakage, H; Kawabe, K; Koiso, K; Mori, C; Niijima, T; Suzuki, T; Ueno, A, 1984)
"Comparison, in the dog, of the fibrinolytic response to adrenaline and histamine in presence of adrenergic blocking agents, suggests that adrenergic stimulation plays only a minor role in the mobilization of plasminogen activators during histamine shock."	7.65	Role of adrenergic stimulation in the fibrinolytic activation induced by histamine shock. ( Dosne, AM, 1975)
" The effects of vasoconstrictor drugs such as methoxamine, phenylephrine, and norepinephrine have been generally unfavorable in shock because of the inhibition of tissue perfusion which results from their use."	4.75	The role of vasoactive agents in shock therapy. ( Ogburn, P, 1976)
"To observe the effect and mechanism of alpha-adrenergic receptor inhibitor phentolamine (PTL) in a rabbit model of acute pulmonary embolism (APE) combined with shock."	4.12	Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock. ( Gu, Y; Hu, L; Qiu, L; Wang, Y; Yu, D; Yu, Y, 2022)
"The effects of phentolamine, KBIV24 and captopril on the mean arterial blood pressure of normal and treated (dehydration, hemorrhage) frogs were determined."	3.67	Blood pressure homeostasis in Rana catesbeiana under normal and hypovolemic conditions. ( Chiu, KW; Pang, PK; Sham, JS; Wong, VC, 1984)
"A case of pheochromocytoma with spontaneous remission after recovery from shock induced by the phentolamine test is presented."	3.67	Pheochromocytoma with remission following phentolamine-induced shock. ( Akaza, H; Asakage, H; Kawabe, K; Koiso, K; Mori, C; Niijima, T; Suzuki, T; Ueno, A, 1984)
"Comparison, in the dog, of the fibrinolytic response to adrenaline and histamine in presence of adrenergic blocking agents, suggests that adrenergic stimulation plays only a minor role in the mobilization of plasminogen activators during histamine shock."	3.65	Role of adrenergic stimulation in the fibrinolytic activation induced by histamine shock. ( Dosne, AM, 1975)
" The keys to successful therapy are time, antibiotics, vasopressors, cortisone and correction of acidosis."	3.64	SEPTIC SHOCK. ( LANSING, AM, 1963)
"Phentolamine treatment augmented the basal IRI, IRG and SLI concentrations."	1.26	The nervous control of rat somatostatin, glucagon and insulin secretions. ( Assan, R; Bobbioni, E; Kronheim, S; Marre, M; Miller, J; Sheppard, M, 1982)
"Pretreatment with phentolamine, an alpha-adrenergic blocker, increases the systemic arterial hypotension and shortens the survival time."	1.26	[Cardiovascular collapse after tracheal ligature in the rat]. ( Lagneaux, D; Lecomte, J; Remacle, R, 1980)
"Phentolamine has been advocated for several years as a beneficial agent for the treatment of shock."	1.26	Phentolamine. ( Gould, L; Reddy, CV, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (98.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.00)	2.80

Authors	Studies
Wang, Y	1
Qiu, L	1
Yu, D	1
Yu, Y	1
Hu, L	1
Gu, Y	1
TERRY, RB	1
TOBIN, JR	1
O'CONNOR, RB	1
CORMIER, M	2
VAN DEN DRIESSCHE, J	1
PARIGOT, C	1
TREBAUL, L	2
LE BARS, R	2
ZUCKER, G	1
EISINGER, RP	1
FLOCH, MH	1
SINGER, MM	1
LANSING, AM	1
AGRESS, CM	1
SCHAPOSNIK, F	1
VICK, JA	1
Ick, JA	1
Du Plessis, JM	1
Du Toit, HJ	1
Bull, AB	1
Rorke, MJ	1
Dietzman, RH	2
Manax, WG	1
Lillehei, RC	2
Marre, M	1
Bobbioni, E	1
Sheppard, M	1
Kronheim, S	1
Miller, J	1
Assan, R	1
Adams, HR	1
Sham, JS	1
Wong, VC	1
Chiu, KW	1
Pang, PK	1
Lagneaux, D	1
Remacle, R	1
Lecomte, J	1
Vincent, JL	1
Suzuki, T	1
Mori, C	1
Asakage, H	1
Akaza, H	1
Kawabe, K	1
Ueno, A	1
Koiso, K	1
Niijima, T	1
El-Etr, AA	1
Glisson, SN	1
Kuznik, BI	1
Tsybikov, NN	1
Lindsey, CA	1
Faloona, GR	1
Unger, RH	1
Dosne, AM	1
Ogburn, P	1
Gould, L	2
Reddy, CV	1
Berk, JL	1
Litton, A	1
Lewis, CM	1
Weil, MH	1
Faucon, G	1
Evreux, JC	1
Perrot, E	1
Bazaugour, R	1
Nelson, NC	1
Nelson, JL	1
Weldon, WE	1
Vela, AR	1
Huguenard, P	1
Alho, A	1
Aagaard, GN	1
Puri, PS	1
Bing, RJ	1
Motsay, GJ	1
Hardaway, RM	1
Müller, H	1
Stauch, M	1
Böszörményi, E	1
Farsang, C	1
Forland, M	1
Talley, RC	1
Zierott, G	1
Wilson, RF	1
Sarver, EJ	1
Rizzo, J	1
Shoemaker, WC	1
Brown, RS	1
Schröder, R	1
Delaney, JP	1
Paritzky, AZ	1
Bocian, J	2
Mazurowa, A	2
Musial, W	2
Rosiek, S	1
Bradley, EC	1
Cohn, JN	1

Article	Year
THERAPY OF CARDIOGENIC SHOCK. Progress in cardiovascular diseases, 1963, Volume: 6 Topics: Angiotensins; Cardiac Tamponade; Heart Aneurysm; Heart Diseases; Heart Failure; Humans; Hydromorphon	1963
Place of vasoactive agents in the treatment of acute circulatory failure. Resuscitation, 1984, Volume: 11, Issue:3-4 Topics: Cardiac Output; Depression, Chemical; Dobutamine; Dopamine; Fluid Therapy; Humans; Ketanserin; Nitro	1984
Alpha-adrenergic blocking agents. International anesthesiology clinics, 1978,Summer, Volume: 16, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Ergot	1978
The role of vasoactive agents in shock therapy. The Veterinary clinics of North America, 1976, Volume: 6, Issue:2 Topics: Animals; Chlorpromazine; Dog Diseases; Dogs; Dopamine; Isoproterenol; Methoxamine; Norepinephrine; P	1976

Article	Year
Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock. European journal of medical research, 2022, Nov-08, Volume: 27, Issue:1 Topics: Animals; Hominidae; Phentolamine; Pulmonary Embolism; Rabbits; Receptors, Adrenergic, alpha; Shock	2022
Intravenous phentolamine for phaeochromocytoma and adrenaline shock. British medical journal, 1958, Sep-27, Volume: 2, Issue:5099 Topics: Convulsive Therapy; Epinephrine; Humans; Phentolamine; Pheochromocytoma; Shock; Sympatholytics	1958
[Effect of various adrenolytics (regitine, reserpine, yohimbine) on changes in the formed elements of the blood following pentylenetetrazole shock]. Archives internationales de pharmacodynamie et de therapie, 1960, Aug-01, Volume: 127 Topics: Adrenergic Antagonists; Blood Cells; Convulsive Therapy; Humans; Pentylenetetrazole; Phentolamine; R	1960
Treatment of shock and prevention of ischemic necrosis with levarterenol-phentolamine mixtures. Circulation, 1960, Volume: 22 Topics: Biomedical Research; Convulsive Therapy; Norepinephrine; Phentolamine; Shock; Sympatholytics	1960
[Aspects of the pentetrazole crisis after reserpine, yohimbine or regitine]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1960, Volume: 154 Topics: Convulsive Therapy; Pentylenetetrazole; Phentolamine; Reserpine; Shock; Sympatholytics; Yohimbine	1960
SEPTIC SHOCK. Canadian Medical Association journal, 1963, Sep-21, Volume: 89 Topics: Acidosis; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibiotics, Antitubercular; Anuria; Bicar	1963
[SHOCK IN OBSTETRICS]. El Dia medico, 1964, Mar-26, Volume: 36 Topics: Abortion, Induced; Abortion, Spontaneous; Abruptio Placentae; Anti-Bacterial Agents; Blood Transfusi	1964
TRIGGER MECHANISM OF ENDOTOXIN SHOCK. The American journal of physiology, 1964, Volume: 206 Topics: Atropine; Blood; Blood Platelets; Cerebrospinal Fluid; Dextrans; Diphenhydramine; Dogs; Endotoxins;	1964
BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDOTOXIN SHOCK. The American journal of physiology, 1965, Volume: 209 Topics: Adrenalectomy; Biological Assay; Blood Pressure; Blood Pressure Determination; Diphenhydramine; Dogs	1965
The role of isoprenaline in the therapy of shock. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1967, May-27, Volume: 41, Issue:21 Topics: Adult; Blood Volume Determination; Cardiac Output; Female; Humans; Isoproterenol; Male; Middle Aged;	1967
Shock: mechanisms and therapy. Canadian Anaesthetists' Society journal, 1967, Volume: 14, Issue:4 Topics: Animals; Chlorpromazine; Digitalis Glycosides; Dogs; Endotoxins; Epinephrine; Equipment and Supplies	1967
The nervous control of rat somatostatin, glucagon and insulin secretions. Diabete & metabolisme, 1982, Volume: 8, Issue:3 Topics: Animals; Blood Pressure; Electric Stimulation; Glucagon; Insulin; Insulin Secretion; Liver Circulati	1982
Pharmacologic problems in circulation research: alpha adrenergic blocking drugs. Circulatory shock, 1983, Volume: 10, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Humans; Nerve Endings; Norepinephrine; Phentolamine; Prazosin	1983
Blood pressure homeostasis in Rana catesbeiana under normal and hypovolemic conditions. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:2 Topics: Animals; Blood Pressure; Captopril; Catecholamines; Dehydration; Hemorrhage; Homeostasis; Phentolami	1984
[Cardiovascular collapse after tracheal ligature in the rat]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1980, Volume: 174, Issue:2 Topics: Animals; Asphyxia; Ligation; Phentolamine; Rats; Receptors, Adrenergic, alpha; Shock; Trachea	1980
Pheochromocytoma with remission following phentolamine-induced shock. Urology, 1984, Volume: 23, Issue:6 Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Necrosis; Phentolamine; Pheochromocytoma; Remission,	1984
[Neurohumoral mechanism of the regulation of the blood and lymph coagulation process in heterologous blood transfusion shock]. Problemy gematologii i perelivaniia krovi, 1979, Volume: 24, Issue:2 Topics: Animals; Atropine; Blood Coagulation; Dogs; Humans; Lymph; Neurotransmitter Agents; Phentolamine; Pr	1979
PLasma glucagon levels during rapid exsanguination with and without adrenergic blockade. Diabetes, 1975, Volume: 24, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Dogs; Glucagon; Hemorrhage; Hypotension; Insuli	1975
Role of adrenergic stimulation in the fibrinolytic activation induced by histamine shock. Pathologie-biologie, 1975, Volume: 23 suppl Topics: Animals; Dogs; Epinephrine; Fibrinolysis; Histamine; Phentolamine; Plasminogen Activators; Propranol	1975
Phentolamine. American heart journal, 1976, Volume: 92, Issue:3 Topics: Angina Pectoris; Animals; Aortic Stenosis, Subvalvular; Arrhythmias, Cardiac; Asthma; Dogs; Heart Co	1976
Use of vasoactive drugs in the treatment of shock. The Surgical clinics of North America, 1975, Volume: 55, Issue:3 Topics: Adrenal Cortex Hormones; Blood Pressure; Calcium; Cardiac Output; Catecholamines; Digitalis Glycosid	1975
Microvascular effects of vasoactive agents in shock. The British journal of surgery, 1968, Volume: 55, Issue:10 Topics: Aged; Angiotensin II; Animals; Arteries; Blood; Blood Vessels; Cheek; Cricetinae; Epinephrine; Femal	1968
Hemodynamic spectrum of vasopressor and vasodilator drugs. JAMA, 1969, May-26, Volume: 208, Issue:8 Topics: Angiotensin II; Animals; Blood Pressure; Dogs; Epinephrine; Heart Rate; Hemodynamics; Isoproterenol;	1969
[Risks of secondary circulatory failure at the time of excessive perfusion with vasoconstrictor agents]. European journal of toxicology, 1970, Volume: 3, Issue:3 Topics: Angiotensin II; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Dogs; Epinephrine; Female; H	1970
Mechanisms of change in thoracic duct lymph flow during hypotensive states. Annals of surgery, 1970, Volume: 171, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspirin; Capillary Permeability;	1970
[Adrenergic receptor drugs in treatment of shock]. Laval medical, 1971, Volume: 42, Issue:7 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Catecholamines; C	1971
Effects of vasoactive drugs on lysosomal stability in vitro. Biochemical pharmacology, 1973, Oct-15, Volume: 22, Issue:20 Topics: Acid Phosphatase; Adrenergic alpha-Antagonists; Animals; Cell Fractionation; Cell Membrane; Cell Sur	1973
Editorial: Drug spotlight on shock. Annals of internal medicine, 1974, Volume: 81, Issue:3 Topics: Acid-Base Equilibrium; Blood Pressure; Central Venous Pressure; Dopamine; Humans; Hypoxia; Norepinep	1974
[Drugs in shock treatment]. Der Internist, 1971, Volume: 12, Issue:3 Topics: Adrenal Cortex Hormones; Cardiac Output; Chlorpromazine; Digitalis Glycosides; Humans; Isoproterenol	1971
The problem of acute severe trauma and shock. Surgery, gynecology & obstetrics, 1971, Volume: 133, Issue:5 Topics: Accidents; Adolescent; Aircraft; Ambulances; Arteries; Blood Pressure; Cardiac Output; Central Venou	1971
[A blood pressure-controlled infusion machine: technical construction and testing upon experimental animals]. Zeitschrift fur Biologie, 1969, Volume: 116, Issue:4 Topics: Animals; Blood Pressure; Epinephrine; Humans; Infusions, Parenteral; Pharmacology; Phentolamine; Rab	1969
[Treatment of cardiogenic shock by combined noradrenaline-regitin infusion (preliminary report)]. Orvosi hetilap, 1970, Mar-22, Volume: 111, Issue:12 Topics: Adult; Aged; Drug Synergism; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Myocardial In	1970
Treatment of renal abnormalities accompanying shock. Postgraduate medicine, 1970, Volume: 48, Issue:3 Topics: Blood Flow Velocity; Dexamethasone; Glomerular Filtration Rate; Humans; Isoproterenol; Kidney Concen	1970
Vasopressors and other drugs used in shock. British medical journal, 1970, Sep-26, Volume: 3, Issue:5725 Topics: Blood Volume; Cardiac Output; Central Venous Pressure; Dopamine; Humans; Infusions, Parenteral; Isop	1970
[Volume substitution and vasoactive pharmaca in the treatment of shock]. Deutsche medizinische Wochenschrift (1946), 1970, Nov-27, Volume: 95, Issue:48 Topics: Bronchodilator Agents; Dextrans; Diuresis; Gelatin; Hematocrit; Humans; Infusions, Parenteral; Metap	1970
Hemodynamic changes, treatment, and prognosis in clinical shock. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 102, Issue:1 Topics: Blood Pressure; Cardiac Output; Heart; Hemodynamics; Humans; Liver Cirrhosis; Phenoxybenzamine; Phen	1971
The dilemma of vasopressors and vasodilators in the therapy of shock. Surgery, gynecology & obstetrics, 1971, Volume: 132, Issue:1 Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Chlorpromazine; Heart Rate; Hemodynamics; H	1971
[Basic principles of shock therapy]. Deutsche medizinische Wochenschrift (1946), 1971, Jan-22, Volume: 96, Issue:4 Topics: Blood Transfusion; Digitalis Glycosides; Dopamine; Glucagon; Humans; Isoproterenol; Metaproterenol;	1971
Necrosis of a pheochromocytoma with shock. The New England journal of medicine, 1969, Jun-19, Volume: 280, Issue:25 Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Female; Humans; Hypertension; Hypotension; Necrosis;	1969
Attempted therapeutic application of agents acting on alpha and beta adrenerging receptors in experimental cardiac shock. Polish medical journal, 1969, Volume: 8, Issue:2 Topics: Animals; Cardiomyopathies; Catecholamines; Cats; Electrocardiography; Epinephrine; Ergotamine; Femal	1969
Investigations on the effect of certain agents stimulating or blocking alpha and beta adrenergic receptors on the course of histamine shock in animals. Polish medical journal, 1969, Volume: 8, Issue:2 Topics: Animals; Dogs; Epinephrine; Ergotamine; Histamine; Mephentermine; Norepinephrine; Phentolamine; Prop	1969
Treatment of shock associated with myocardial infarction. The Medical letter on drugs and therapeutics, 1969, Apr-04, Volume: 11, Issue:7 Topics: Albumins; Arrhythmias, Cardiac; Dextrans; Digitalis Glycosides; Dopamine; Heart-Lung Machine; Humans	1969
Appraisal and reappraisal of cardiac therapy. Edited by Arthur C. DeGraff, Alan F. Lyon, and Julian Frieden. Phentolamine. American heart journal, 1969, Volume: 78, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Bronchodilator Agents; Dogs; Heart Diseases; Hemodynamics; Phentolami	1969
Results with phentolamine (Regitine) in the treatment of selected patients with shock. California medicine, 1965, Volume: 103, Issue:5 Topics: Blood Circulation; Humans; Phentolamine; Shock	1965
Paroxysmal hypertension and hypovolemia. The New England journal of medicine, 1966, Sep-22, Volume: 275, Issue:12 Topics: Adult; Antihypertensive Agents; Blood Volume; Cold Temperature; Histamine; Humans; Hypertension; Mal	1966

phentolamine and Shock

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