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phentolamine and Seizures

phentolamine has been researched along with Seizures in 23 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice."7.69Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994)
"The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice."7.68The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993)
"The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice."7.67Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984)
"The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs."7.67Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984)
"After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter."5.26Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979)
" Identical observations are obtained when the hypertension is evoked by intravenous injection of phentolamine and by electrically induced seizures."4.75The blood-brain barrier to horseradish peroxidase under normal and experimental conditions. ( Westergaard, E, 1977)
"The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice."3.70Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999)
" The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice."3.69Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994)
"The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice."3.68The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993)
"The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice."3.67Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984)
"The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs."3.67Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984)
" Combining of xanthone with piperazine moiety resulted in obtaining of compounds with increased bioavailability after oral administration."1.39Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety. ( Bojarski, AJ; Gunia, A; Marona, H; Pytka, K; Satała, G; Siwek, A; Szkaradek, N; Szneler, E; Waszkielewicz, AM, 2013)
"However, the attenuation of severe seizures by a single PRA, PHEN, DZP, or PHB cotreatment was accompanied by a decrease in the brain COCA concentration."1.31Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity. ( Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y, 2000)
"Amygdaloid kindled seizures in the rat induce an abrupt elevation of blood pressure accompanied by a significant decrease in heart rate."1.30Kindled seizures activate both branches of the autonomic nervous system. ( Crawford, IL; Goodman, JH; Homan, RW, 1999)
"With 40 rabbits, the occurrence of convulsion at this dose level was 100%."1.29[Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits]. ( Cao, H; Xu, JH; Zheng, JH, 1993)
"Audiogenic seizure responses were unchanged after phentolamine (10--100 micrograms) but were reduced after prazosin (25--50 micrograms)."1.26Noradrenergic influences on sound-induced seizures. ( Anlezark, G; Horton, R; Meldrum, B, 1980)
"After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter."1.26Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979)
"Neither compound affects electrical seizures."1.25The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat. ( Jagiello-Wójtowicz, E; Kleinrok, Z; Sieklucka, M, 1975)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199015 (65.22)18.7374
1990's5 (21.74)18.2507
2000's2 (8.70)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Waszkielewicz, AM1
Gunia, A1
Szkaradek, N1
Pytka, K1
Siwek, A1
Satała, G1
Bojarski, AJ1
Szneler, E1
Marona, H1
REINS, DA1
HOLMES, DD1
HINSHAW, LB1
Oda, Y1
Funao, T1
Tanaka, K1
Asada, A1
Horton, R1
Anlezark, G1
Meldrum, B1
Wambebe, C1
Osuide, G1
Gamaniel, K1
Cunningham, JG1
Stephenson, RB1
Amabeoku, G1
Chandomba, R1
Xu, JH1
Cao, H1
Zheng, JH1
Amabeoku, GJ1
Altenburg, SP1
Farah, MB1
Goodman, JH1
Homan, RW1
Crawford, IL1
Hayase, T1
Yamamoto, Y1
Yamamoto, K1
Fukui, Y1
Oishi, R1
Suenaga, N1
Hidaka, T1
Fukuda, T1
Kuschinsky, W1
Wahl, M1
Sabelli, HC1
Diamond, BI1
May, J1
Havdala, HS1
Westergaard, E1
Chermat, R1
Lachapelle, F1
Baumann, N1
Simon, P1
Riffee, WH1
Gerald, MC1
Mannino, RA1
Wolf, HH1
Kleinrok, Z1
Jagiello-Wójtowicz, E1
Sieklucka, M1
Kuga, T1
Naito, J1
Yamamoto, I1
Otori, K1
Inoki, R1
Thiessen, PN1
Cook, DA1

Reviews

1 review available for phentolamine and Seizures

ArticleYear
The blood-brain barrier to horseradish peroxidase under normal and experimental conditions.
    Acta neuropathologica, 1977, Aug-31, Volume: 39, Issue:3

    Topics: Animals; Blood-Brain Barrier; Capillaries; Carotid Artery, Internal; Endothelium; Gerbillinae; Horse

1977

Other Studies

22 other studies available for phentolamine and Seizures

ArticleYear
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Administration, Oral; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Half-Lif

2013
ACUTE AND CHRONIC EFFECTS OF THE INSECTICIDE ENDRIN ON RENAL FUNCTION AND RENAL HEMODYNAMICS.
    Canadian journal of physiology and pharmacology, 1964, Volume: 42

    Topics: Adrenalectomy; Animals; Blood Circulation; Bradycardia; Creatine; Creatinine; Dogs; Endrin; Glomerul

1964
Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:3

    Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Brain

2004
Noradrenergic influences on sound-induced seizures.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:2

    Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Drug Interac

1980
Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice.
    General pharmacology, 1984, Volume: 15, Issue:3

    Topics: Animals; Apomorphine; Droxidopa; Levodopa; Mice; Phentolamine; Propranolol; Seizures; Serine; Strych

1984
Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs.
    American journal of veterinary research, 1984, Volume: 45, Issue:4

    Topics: Animals; Dog Diseases; Dogs; Female; Humans; Male; Muscle Contraction; Muscle Tonus; Pentylenetetraz

1984
Strychnine-induced seizures in mice: the role of noradrenaline.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipram

1994
[Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:11

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Disease Models, Animal; Female; Haloperidol; Injections,

1993
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
    Experientia, 1993, Oct-15, Volume: 49, Issue:10

    Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Dr

1993
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
    Pharmacology & toxicology, 1999, Volume: 84, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe

1999
Kindled seizures activate both branches of the autonomic nervous system.
    Epilepsy research, 1999, Volume: 34, Issue:2-3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nervous Syst

1999
Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:1

    Topics: Animals; Anticonvulsants; Cardiovascular Agents; Cocaine; Diazepam; Enalapril; Ethanol; Male; Mice;

2000
The role of alpha-adrenoceptors in the regulation of pentylenetetrazol convulsions in mice.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:10

    Topics: Animals; Clonidine; Hydroxydopamines; Male; Mice; Pentylenetetrazole; Phentolamine; Receptors, Adren

1979
Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats.
    Pflugers Archiv : European journal of physiology, 1979, Volume: 382, Issue:1

    Topics: Acid-Base Equilibrium; Animals; Arteries; Bicuculline; Cats; Chloralose; Dose-Response Relationship,

1979
Differential interactions of phenobarbital and pentobarbital with beta-adrenergic mechanisms in vitro and in vivo.
    Experimental neurology, 1977, Volume: 54, Issue:3

    Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Cyclic AMP; Dose-Response Relationship, Dru

1977
Anticonvulsant effect of yohimbine in quaking mice: antagonism by clonidine and prazosine.
    Life sciences, 1979, Oct-22, Volume: 25, Issue:17

    Topics: Animals; Anticonvulsants; Clonidine; Male; Mice; Mice, Quaking; Phentolamine; Prazosin; Quinazolines

1979
Effects of amphetamine isomers and CNS catecholaminergic blockers on seizures in mice.
    Neuropharmacology, 1976, Volume: 15, Issue:11

    Topics: Amphetamine; Animals; Catecholamines; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship,

1976
Morphine's proconvulsant action: importance of endogenous norepinephrine.
    Life sciences, 1975, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Dopamine; Male; Methyltyrosines; Mice

1975
The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat.
    Polish journal of pharmacology and pharmacy, 1975, Volume: 27, Issue:Suppl

    Topics: Animals; Body Temperature; Brain; Dextroamphetamine; Electroshock; Exploratory Behavior; Humans; Mal

1975
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrolinone hydrochloride (doxapram). 1. The action on the central nervous system].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Amides; Animals; Atropine; Blood Pressure; Central Nervous System; Central Nervous System Stimulants

1973
Pharmacological studies on antagonists against nicotine-induced convulsions and death.
    Japanese journal of pharmacology, 1966, Volume: 16, Issue:4

    Topics: Animals; Anticonvulsants; Chlorpromazine; Drug Antagonism; Female; Ganglionic Blockers; Hexamethoniu

1966
The properties of 3,4-methylenedioxyamphetamine (MDA). II. Studies of acute toxicity in the mouse and protection by various agents.
    Clinical toxicology, 1973, Volume: 6, Issue:2

    Topics: Amphetamine; Animals; Dioxoles; Lethal Dose 50; Mice; Mice, Inbred Strains; Phenobarbital; Phentolam

1973