phentolamine has been researched along with Seizures in 23 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice." | 7.69 | Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994) |
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 7.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice." | 7.67 | Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984) |
| "The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs." | 7.67 | Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984) |
| "After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter." | 5.26 | Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979) |
| " Identical observations are obtained when the hypertension is evoked by intravenous injection of phentolamine and by electrically induced seizures." | 4.75 | The blood-brain barrier to horseradish peroxidase under normal and experimental conditions. ( Westergaard, E, 1977) |
| "The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice." | 3.70 | Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999) |
| " The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice." | 3.69 | Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994) |
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 3.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "The effects of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on tonic seizures elicited by strychnine were investigated in mice." | 3.67 | Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice. ( Gamaniel, K; Osuide, G; Wambebe, C, 1984) |
| "The goal of this study was to test the hypothesis that phentolamine and propranolol premedication would affect tonus differently than clonus in pentylenetetrazol (PTZ)-induced tonic-clonic seizures in dogs." | 3.67 | Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs. ( Cunningham, JG; Stephenson, RB, 1984) |
| " Combining of xanthone with piperazine moiety resulted in obtaining of compounds with increased bioavailability after oral administration." | 1.39 | Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety. ( Bojarski, AJ; Gunia, A; Marona, H; Pytka, K; Satała, G; Siwek, A; Szkaradek, N; Szneler, E; Waszkielewicz, AM, 2013) |
| "However, the attenuation of severe seizures by a single PRA, PHEN, DZP, or PHB cotreatment was accompanied by a decrease in the brain COCA concentration." | 1.31 | Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity. ( Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y, 2000) |
| "Amygdaloid kindled seizures in the rat induce an abrupt elevation of blood pressure accompanied by a significant decrease in heart rate." | 1.30 | Kindled seizures activate both branches of the autonomic nervous system. ( Crawford, IL; Goodman, JH; Homan, RW, 1999) |
| "With 40 rabbits, the occurrence of convulsion at this dose level was 100%." | 1.29 | [Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits]. ( Cao, H; Xu, JH; Zheng, JH, 1993) |
| "Audiogenic seizure responses were unchanged after phentolamine (10--100 micrograms) but were reduced after prazosin (25--50 micrograms)." | 1.26 | Noradrenergic influences on sound-induced seizures. ( Anlezark, G; Horton, R; Meldrum, B, 1980) |
| "After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter." | 1.26 | Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats. ( Kuschinsky, W; Wahl, M, 1979) |
| "Neither compound affects electrical seizures." | 1.25 | The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat. ( Jagiello-Wójtowicz, E; Kleinrok, Z; Sieklucka, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (65.22) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia, A | 1 |
| Szkaradek, N | 1 |
| Pytka, K | 1 |
| Siwek, A | 1 |
| Satała, G | 1 |
| Bojarski, AJ | 1 |
| Szneler, E | 1 |
| Marona, H | 1 |
| REINS, DA | 1 |
| HOLMES, DD | 1 |
| HINSHAW, LB | 1 |
| Oda, Y | 1 |
| Funao, T | 1 |
| Tanaka, K | 1 |
| Asada, A | 1 |
| Horton, R | 1 |
| Anlezark, G | 1 |
| Meldrum, B | 1 |
| Wambebe, C | 1 |
| Osuide, G | 1 |
| Gamaniel, K | 1 |
| Cunningham, JG | 1 |
| Stephenson, RB | 1 |
| Amabeoku, G | 1 |
| Chandomba, R | 1 |
| Xu, JH | 1 |
| Cao, H | 1 |
| Zheng, JH | 1 |
| Amabeoku, GJ | 1 |
| Altenburg, SP | 1 |
| Farah, MB | 1 |
| Goodman, JH | 1 |
| Homan, RW | 1 |
| Crawford, IL | 1 |
| Hayase, T | 1 |
| Yamamoto, Y | 1 |
| Yamamoto, K | 1 |
| Fukui, Y | 1 |
| Oishi, R | 1 |
| Suenaga, N | 1 |
| Hidaka, T | 1 |
| Fukuda, T | 1 |
| Kuschinsky, W | 1 |
| Wahl, M | 1 |
| Sabelli, HC | 1 |
| Diamond, BI | 1 |
| May, J | 1 |
| Havdala, HS | 1 |
| Westergaard, E | 1 |
| Chermat, R | 1 |
| Lachapelle, F | 1 |
| Baumann, N | 1 |
| Simon, P | 1 |
| Riffee, WH | 1 |
| Gerald, MC | 1 |
| Mannino, RA | 1 |
| Wolf, HH | 1 |
| Kleinrok, Z | 1 |
| Jagiello-Wójtowicz, E | 1 |
| Sieklucka, M | 1 |
| Kuga, T | 1 |
| Naito, J | 1 |
| Yamamoto, I | 1 |
| Otori, K | 1 |
| Inoki, R | 1 |
| Thiessen, PN | 1 |
| Cook, DA | 1 |
1 review available for phentolamine and Seizures
| Article | Year |
|---|---|
The blood-brain barrier to horseradish peroxidase under normal and experimental conditions.
Topics: Animals; Blood-Brain Barrier; Capillaries; Carotid Artery, Internal; Endothelium; Gerbillinae; Horse | 1977 |
22 other studies available for phentolamine and Seizures
| Article | Year |
|---|---|
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.
Topics: Administration, Oral; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroshock; Half-Lif | 2013 |
ACUTE AND CHRONIC EFFECTS OF THE INSECTICIDE ENDRIN ON RENAL FUNCTION AND RENAL HEMODYNAMICS.
Topics: Adrenalectomy; Animals; Blood Circulation; Bradycardia; Creatine; Creatinine; Dogs; Endrin; Glomerul | 1964 |
Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.
Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Brain | 2004 |
Noradrenergic influences on sound-induced seizures.
Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Drug Interac | 1980 |
Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice.
Topics: Animals; Apomorphine; Droxidopa; Levodopa; Mice; Phentolamine; Propranolol; Seizures; Serine; Strych | 1984 |
Influence of phentolamine and propranolol on the length of tonus and clonus in pentylenetetrazol-induced seizures in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Humans; Male; Muscle Contraction; Muscle Tonus; Pentylenetetraz | 1984 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipram | 1994 |
[Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Disease Models, Animal; Female; Haloperidol; Injections, | 1993 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Dr | 1993 |
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe | 1999 |
Kindled seizures activate both branches of the autonomic nervous system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nervous Syst | 1999 |
Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity.
Topics: Animals; Anticonvulsants; Cardiovascular Agents; Cocaine; Diazepam; Enalapril; Ethanol; Male; Mice; | 2000 |
The role of alpha-adrenoceptors in the regulation of pentylenetetrazol convulsions in mice.
Topics: Animals; Clonidine; Hydroxydopamines; Male; Mice; Pentylenetetrazole; Phentolamine; Receptors, Adren | 1979 |
Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats.
Topics: Acid-Base Equilibrium; Animals; Arteries; Bicuculline; Cats; Chloralose; Dose-Response Relationship, | 1979 |
Differential interactions of phenobarbital and pentobarbital with beta-adrenergic mechanisms in vitro and in vivo.
Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Cyclic AMP; Dose-Response Relationship, Dru | 1977 |
Anticonvulsant effect of yohimbine in quaking mice: antagonism by clonidine and prazosine.
Topics: Animals; Anticonvulsants; Clonidine; Male; Mice; Mice, Quaking; Phentolamine; Prazosin; Quinazolines | 1979 |
Effects of amphetamine isomers and CNS catecholaminergic blockers on seizures in mice.
Topics: Amphetamine; Animals; Catecholamines; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, | 1976 |
Morphine's proconvulsant action: importance of endogenous norepinephrine.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Dopamine; Male; Methyltyrosines; Mice | 1975 |
The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat.
Topics: Animals; Body Temperature; Brain; Dextroamphetamine; Electroshock; Exploratory Behavior; Humans; Mal | 1975 |
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrolinone hydrochloride (doxapram). 1. The action on the central nervous system].
Topics: Amides; Animals; Atropine; Blood Pressure; Central Nervous System; Central Nervous System Stimulants | 1973 |
Pharmacological studies on antagonists against nicotine-induced convulsions and death.
Topics: Animals; Anticonvulsants; Chlorpromazine; Drug Antagonism; Female; Ganglionic Blockers; Hexamethoniu | 1966 |
The properties of 3,4-methylenedioxyamphetamine (MDA). II. Studies of acute toxicity in the mouse and protection by various agents.
Topics: Amphetamine; Animals; Dioxoles; Lethal Dose 50; Mice; Mice, Inbred Strains; Phenobarbital; Phentolam | 1973 |