phentolamine has been researched along with Pulmonary Hypertension in 35 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of phentolamine was studied in 5 patients with pulmonary hypertension, of whom 3 had primary pulmonary hypertension and 2 had secondary pulmonary hypertension after pulmonary embolism." | 7.66 | [Therapy of primary pulmonary hypertension with phentolamine]. ( Angehrn, W; Heinrich, U; Steinbrunn, W, 1983) |
| "Ethchlorvynol (10 mg/kg) causes transient pulmonary hypertension and an increased permeability pulmonary edema in sheep." | 7.66 | Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema. ( Fairman, RP; Falls, RK; Glauser, FL; Millen, JE, 1982) |
| " The study aimed to understand the quantity and location of alpha1-AR subtypes mRNA expression in control and hypoxia rats,and the effect of phentolamine in hypoxic pulmonary hypertension." | 3.72 | [The mRNA expression of alpha1-adrenergic receptor subtypes in the outer lung tissues of hypoxia pulmonary hypertension rats]. ( Han, L; Xiao, YY, 2004) |
| "The effect of phentolamine was studied in 5 patients with pulmonary hypertension, of whom 3 had primary pulmonary hypertension and 2 had secondary pulmonary hypertension after pulmonary embolism." | 3.66 | [Therapy of primary pulmonary hypertension with phentolamine]. ( Angehrn, W; Heinrich, U; Steinbrunn, W, 1983) |
| "Ethchlorvynol (10 mg/kg) causes transient pulmonary hypertension and an increased permeability pulmonary edema in sheep." | 3.66 | Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema. ( Fairman, RP; Falls, RK; Glauser, FL; Millen, JE, 1982) |
| " Here we use these as case studies to emphasize the importance of informed drug target selection, the early evaluation of dose-response relationships in human studies, and the value of the deep phenotyping of patients in clinical studies to better understand inter-individual variation in patient response." | 2.53 | Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future. ( Attard, M; Ghataorhe, P; Lythgoe, MP; Rhodes, CJ; Wharton, J; Wilkins, MR, 2016) |
| "Isosorbide dinitrate was the only drug that elicited any reduction in pulmonary artery pressure; pulmonary vascular resistance decreased modestly." | 1.26 | Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. ( Bambach, D; Fontana, ME; Hermiller, JB; Huss, P; Leier, CV; Magorien, RD; Thompson, MJ; Unverferth, DV, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (82.86) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lythgoe, MP | 1 |
| Rhodes, CJ | 1 |
| Ghataorhe, P | 1 |
| Attard, M | 1 |
| Wharton, J | 1 |
| Wilkins, MR | 1 |
| Leuchte, HH | 1 |
| Baezner, C | 1 |
| Baumgartner, RA | 1 |
| Bevec, D | 1 |
| Bacher, G | 1 |
| Neurohr, C | 1 |
| Behr, J | 1 |
| TAGUCHI, K | 1 |
| Xiao, YY | 1 |
| Han, L | 1 |
| Peter, RH | 2 |
| Rubin, L | 1 |
| Aminov, VN | 1 |
| Zamochnikova, NI | 1 |
| Niarchos, AP | 1 |
| Whitman, HH | 1 |
| Goldstein, JE | 1 |
| Laragh, JH | 1 |
| Pannarale, G | 2 |
| Gaspardone, A | 2 |
| Acconcia, MC | 2 |
| Valente, A | 2 |
| Heinrich, U | 1 |
| Angehrn, W | 1 |
| Steinbrunn, W | 1 |
| Rich, S | 1 |
| Martinez, J | 1 |
| Lam, W | 1 |
| Levy, PS | 1 |
| Rosen, KM | 1 |
| Fishman, AP | 1 |
| Pietra, GG | 1 |
| Sakharchuk, II | 1 |
| Bil'kevich, LT | 1 |
| Denisenko, GT | 1 |
| Sidorenko, ID | 1 |
| Shostka, IP | 1 |
| Hermiller, JB | 1 |
| Bambach, D | 1 |
| Thompson, MJ | 1 |
| Huss, P | 1 |
| Fontana, ME | 1 |
| Magorien, RD | 1 |
| Unverferth, DV | 1 |
| Leier, CV | 1 |
| Glauser, FL | 1 |
| Fairman, RP | 1 |
| Millen, JE | 1 |
| Falls, RK | 1 |
| Cohen, ML | 1 |
| Kronzon, I | 1 |
| Klinke, WP | 1 |
| Rubin, LJ | 1 |
| Elkayam, U | 1 |
| Barbieri, A | 1 |
| Zonta, F | 1 |
| Saracino, ML | 1 |
| Dondi, G | 1 |
| Frattini, P | 1 |
| Lucchelli, A | 1 |
| Santagostino, M | 1 |
| D'Agostino, G | 1 |
| Maestri, MO | 1 |
| Zonta, A | 1 |
| Ruskin, JN | 1 |
| Hutter, AM | 1 |
| Froom, P | 1 |
| Ortiz, C | 1 |
| Kirschbaum, M | 1 |
| Maranhao, V | 1 |
| Paine, E | 1 |
| Gooch, AS | 1 |
| Ugriumova, MO | 1 |
| Shirai, M | 1 |
| Ninomiya, I | 1 |
| Sada, K | 1 |
| Phlippoteau, C | 1 |
| Brenot, F | 1 |
| Blétry, O | 1 |
| Simmonneau, G | 1 |
| Duroux, P | 1 |
| Renard, M | 1 |
| Verhoeven, A | 1 |
| Liebens, I | 1 |
| Bernard, R | 1 |
| Lebreton, P | 1 |
| Lognone, T | 1 |
| Zerr, C | 1 |
| Fauchon, G | 1 |
| Khayat, A | 1 |
| Domenighetti, G | 1 |
| Leuenberger, P | 1 |
| Perret, C | 2 |
| Degenring, FH | 1 |
| Gardaz, JP | 1 |
| Reynaert, M | 1 |
| Grimbert, F | 1 |
| Enrico, JF | 1 |
| Rhodes, EL | 1 |
| O'Rourke, PT | 1 |
| Lee, R | 1 |
| Straker, J | 1 |
| Kirsh, MM | 1 |
| Mielke, H | 1 |
| Seiler, KU | 1 |
| Stumpf, U | 1 |
| Wassermann, O | 1 |
| Horzela, T | 1 |
| Dubiel, JP | 1 |
| Dubiel, JS | 1 |
| Pyzik, Z | 1 |
| Szczeklik, J | 1 |
| Yoshida, Y | 1 |
6 reviews available for phentolamine and Pulmonary Hypertension
| Article | Year |
|---|---|
Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.
Topics: Animals; Biomarkers; Clinical Studies as Topic; Disease Models, Animal; Dose-Response Relationship, | 2016 |
The pharmacologic control of the pulmonary circulation in pulmonary hypertension.
Topics: Acetylcholine; Adult; Aminophylline; Calcium Channel Blockers; Diazoxide; Female; Humans; Hydralazin | 1984 |
[Early pulmonary hypertension: current therapeutic prospectives].
Topics: Calcium Channel Blockers; Captopril; Diazoxide; Diltiazem; Humans; Hydralazine; Hypertension, Pulmon | 1982 |
Primary pulmonary hypertension.
Topics: Acetylcholine; Aminorex; Diet; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Isoproterenol; | 1980 |
[Use of phentolamine in the treatment of cardiovascular diseases (literature review)].
Topics: Animals; Blood Pressure; Cardiomyopathies; Coronary Circulation; Coronary Disease; Heart Valve Disea | 1981 |
[Anorexic preparations and primary pulmonary hypertension].
Topics: Aminorex; Animals; Anticoagulants; Appetite Depressants; Blood Pressure; Dogs; Female; Fibrinolytic | 1976 |
29 other studies available for phentolamine and Pulmonary Hypertension
| Article | Year |
|---|---|
Inhalation of vasoactive intestinal peptide in pulmonary hypertension.
Topics: Adult; Aerosols; Aged; Blood Pressure; Drug Combinations; Female; Heart Failure; Heart Ventricles; H | 2008 |
[PULMONARY HYPERTENSION: ITS CONCEPT AND SURGICAL MANIFESTATIONS. 3].
Topics: Classification; Humans; Hypertension; Hypertension, Pulmonary; Lung; Pharmacology; Phentolamine | 1965 |
[The mRNA expression of alpha1-adrenergic receptor subtypes in the outer lung tissues of hypoxia pulmonary hypertension rats].
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; In | 2004 |
[Effect of the alpha-adrenoblockader fentolamin on the indices of central and peripheral hemodynamics and myocardial contractile function in patients with chronic circulatory failure].
Topics: Coronary Disease; Drug Evaluation; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Mic | 1984 |
Hemodynamic effects of captopril in pulmonary hypertension of collagen vascular disease.
Topics: Adult; Aged; Blood Pressure; Captopril; Collagen Diseases; Female; Hemodynamics; Humans; Hypertensio | 1982 |
[Therapy of primary pulmonary hypertension with phentolamine].
Topics: Adult; Aged; Cardiac Output; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phentolamin | 1983 |
Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response.
Topics: Adult; Blood Pressure; Cardiac Catheterization; Cardiac Output; Diazoxide; Female; Humans; Hydralazi | 1983 |
[Primary pulmonary hypertension: current therapeutic prospectives].
Topics: Calcium Channel Blockers; Diazoxide; Heart Rate; Humans; Hydralazine; Hypertension, Pulmonary; Isopr | 1982 |
Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension.
Topics: Adolescent; Adult; Aspirin; Diazoxide; Dipyridamole; Female; Hemodynamics; Humans; Hydralazine; Hype | 1982 |
Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema.
Topics: Animals; Blood Pressure; Diphenhydramine; Ethchlorvynol; Hypertension, Pulmonary; Indomethacin; Phen | 1982 |
Adverse hemodynamic effects of phentolamine in primary pulmonary hypertension.
Topics: Adult; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Phentolamine; Vascular Resistanc | 1981 |
Treatment for primary pulmonary hypertension.
Topics: Diazoxide; Humans; Hypertension, Pulmonary; Isoproterenol; Oxygen Inhalation Therapy; Phentolamine | 1980 |
Primary pulmonary hypertension: new approaches to therapy.
Topics: Diazoxide; Female; Humans; Hydralazine; Hypertension, Pulmonary; Phentolamine; Pregnancy | 1980 |
Vasodilator therapy in primary pulmonary hypertension.
Topics: Adult; Diazoxide; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Isoproterenol; | 1981 |
Evaluation of the reperfusion syndrome after liver ischemia in the rat.
Topics: Animals; Dopamine; Epinephrine; Hypertension, Pulmonary; Ischemia; Liver; Male; Norepinephrine; Phen | 1996 |
Primary pulmonary hypertension treated with oral phentolamine.
Topics: Administration, Oral; Adult; Blood Pressure; Cardiac Output; Heart Rate; Humans; Hypertension, Pulmo | 1979 |
Primary pulmonary hypertension and oral phentolamine.
Topics: Blood Pressure; Humans; Hypertension, Pulmonary; Phentolamine; Physical Exertion | 1979 |
Phentolamine for primary pulmonary hypertension.
Topics: Adult; Female; Humans; Hypertension, Pulmonary; Hypotension, Orthostatic; Phentolamine; Tachycardia | 1979 |
Constrictor response of small pulmonary arteries to acute pulmonary hypertension during left atrial pressure elevation.
Topics: Angiography; Animals; Atrial Function; Blood Flow Velocity; Blood Pressure; Cats; Heart Atria; Hyper | 1991 |
[Vasodilator agents in pulmonary artery hypertension of systemic scleroderma].
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Epoprostenol; Female; Humans; Hydralazine; Hypertension | 1990 |
Blood gas and hemodynamic changes induced by the treatment of pulmonary congestion with vasodilators in the acute phase of myocardial infarction.
Topics: Adult; Aged; Carbon Dioxide; Female; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; I | 1986 |
[Complications of surgical treatment of interventricular communications in the infant].
Topics: Dobutamine; Drug Therapy, Combination; Extracorporeal Circulation; Female; Heart Septal Defects, Ven | 1986 |
[Hemodynamic and respiratory effects of phentolamine in pulmonary hypertension secondary to chronic obstructive syndrome].
Topics: Aged; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Middl | 1985 |
[The therapeutic modification of the primary vascular form of chronic cor pulmonale and of continuing pulmonary hypertension after commissurotomy for mitral stenosis. A comparison with control of the pulmonary artery pressure].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adult; Blood Pressure; Cardiac Output; Cardi | 1970 |
[Phentolamine in the treatment of left heart failure in the acute stage of myocardial infarct. Hemodynamic study; preliminary results].
Topics: Blood Pressure; Heart Failure; Heart Rate; Humans; Hypertension, Pulmonary; Myocardial Infarction; P | 1974 |
The effect of levarterenol and phentolamine on the hypertensive pulmonary vasculature.
Topics: Animals; Blood Pressure; Cardiac Output; Cattle; Hypertension, Pulmonary; Norepinephrine; Phentolami | 1973 |
[Relation between serotonin metabolism and pulmonary hypertension in rats following administration of various anorectic drugs].
Topics: Amines; Amphetamine; Animals; Appetite Depressants; Chlorphentermine; Hypertension, Pulmonary; Male; | 1973 |
The effects of regitine haemodynamics of pulmonary circulation in pulmonary hypertension in man.
Topics: Adult; Angiocardiography; Blood Pressure; Cardiac Catheterization; Cardiac Output; Female; Heart Rat | 1974 |
Studies on the pathologic physiology of pulmonary hypertension in mitral valvular disease. 1. The role of sympathetic nervous system on the increment of pulmonary vascular resistance.
Topics: Adolescent; Adult; Blood Pressure; Blood Volume; Cardiac Output; Catecholamines; Epinephrine; Female | 1969 |