phentolamine has been researched along with Nerve Degeneration in 7 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of phentolamine on the neurogenic contractile response in vasa deferentia from rat and guinea pig was studied during Wallerian degeneration." | 3.67 | Intimacy of the neuroeffector junction and resistance to alpha-adrenoceptor-blockade of the neurogenic contractile response in vasa deferentia from guinea pig and rat. ( Hammarström, M; Sjöstrand, NO, 1984) |
| " Because PM had not been approved previously for submucosal administration, 2 Good Laboratory Practices (GLP) studies in dogs designed to investigate systemic toxicity and the local effects of single and repeated dosing of OraVerse on the inferior alveolar nerve and branches of the superior alveolar nerve and adjacent soft tissues after local administration were conducted." | 1.35 | Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse). ( Rutherford, B; Thake, D; Zeller, JR, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rutherford, B | 1 |
| Zeller, JR | 1 |
| Thake, D | 1 |
| Hammarström, M | 1 |
| Sjöstrand, NO | 1 |
| Stefano, FJ | 1 |
| Perec, CJ | 1 |
| Tumilasci, OR | 1 |
| Imura, H | 1 |
| Nakai, Y | 1 |
| Matsukura, S | 1 |
| Matsuyama, H | 1 |
| Wall, PD | 1 |
| Gutnick, M | 1 |
| Ceccarelli, B | 1 |
| Clementi, F | 1 |
| Mantegazza, P | 1 |
| Langer, SZ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma[NCT02838758] | Phase 1 | 10 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for phentolamine and Nerve Degeneration
| Article | Year |
|---|---|
Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse).
Topics: Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Cranial Nerve Diseases; Dogs; Hematocrit; | 2009 |
Intimacy of the neuroeffector junction and resistance to alpha-adrenoceptor-blockade of the neurogenic contractile response in vasa deferentia from guinea pig and rat.
Topics: Adrenergic alpha-Antagonists; Animals; Ganglia, Sympathetic; Guinea Pigs; Male; Muscle Contraction; | 1984 |
Changes in neuronal uptake and metabolism of, and sensitivity to, norepinephrine during the degeneration secretion in the rat submaxillary gland.
Topics: Animals; Autonomic Fibers, Postganglionic; Cocaine; Female; In Vitro Techniques; Nerve Degeneration; | 1974 |
Effect of intravenous infusion of L-DOPA on plasma growth hormone levels in man.
Topics: Adult; Aged; Anorexia Nervosa; Blood Glucose; Central Nervous System Diseases; Dihydroxyphenylalanin | 1973 |
Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Evoked Potentials; Isoproterenol; Nerve Degen | 1974 |
Adrenergic reinnervation of sommoth muscle of nictitating membrane by preganglionic sympathetic fibers.
Topics: Animals; Atropine; Autonomic Fibers, Preganglionic; Cats; Denervation; Electric Stimulation; Hexamet | 1972 |
The degeneration contraction of the nictitating membrane in the unanesthetized cat.
Topics: Animals; Cats; Denervation; Dibenzylchlorethamine; In Vitro Techniques; Muscle Contraction; Muscles; | 1966 |