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phentolamine and Myocardial Ischemia

phentolamine has been researched along with Myocardial Ischemia in 15 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).

Research Excerpts

ExcerptRelevanceReference
"In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics following 60 s myocardial ischemia in the region of the descendent left coronary artery were studied in control animals and after the blockade of α-adrenoreceptors by phentolamine or β-adrenoreceptors by propranolol."3.81[Pulmonary hemodynamics following experimental myocardial ischemia after the blockade of adrenergic receptors]. ( Evlakhov, VI; Poiasov, IZ, 2015)
"In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics following myocardial ischemia in the region of the descendent left coronary artery were studied in control animals and after the blockade of alpha-adrenoreceptors by phentolamine or N-cholinoreceptors of autonomic ganglia by hexamethonium."3.78[The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits]. ( Evlakhov, VI; Poiasov, IZ, 2012)
"Following pulmonary embolism in animals with intact circulation in the control group and after the blockade of alpha-adrenoceptors the pulmonary artery pressure and pulmonary vascular resistance increased, but the pulmonary artery flow decreased to the same extent."1.43[THE PULMONARY HEMODYNAMICS FOLLOWING EXPERIMENTAL PULMONARY THROMBOEMBOLISM AND AFTER BLOCKADE OF THE ALPHA-ADRENOCEPTORS]. ( Evlakhov, VI; Poyassov, IZ; Shaidakov, EV, 2016)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (53.33)18.2507
2000's4 (26.67)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Evlakhov, VI3
Poyassov, IZ1
Shaidakov, EV1
Poiasov, IZ2
Yang, JH1
Meng, XX1
Xie, LS1
Guo, Z1
Shamloul, R1
Ghanem, HM1
Salem, A1
Elnashaar, A1
Elnaggar, W1
Darwish, H1
Mousa, AA1
Nemcsik, J1
Kordás, K1
Egresits, J1
László, F1
László, FA1
Pávó, I1
Morschl, E1
Mizuyama, K1
Sato, S1
Okubo, N1
Naito, H1
Node, K1
Kitakaze, M1
Kosaka, H1
Komamura, K1
Minamino, T1
Tada, M1
Inoue, M1
Hori, M1
Kamada, T1
Liu, J1
Han, Z1
Cao, Q1
Chen, S1
Tweedie, D1
Henderson, C1
Kane, K1
Koley, J1
Basak, AK1
Das, M1
Sinha, S1
Koley, B1
Kern, MJ1
Egert, S1
Nguyen, N1
Schwaiger, M1
Finegan, BA1
Gandhi, M1
Clanachan, AS1
Rozen, MP1
Aniukhovskiĭ, EP1
Staĭnberg, SF1

Other Studies

15 other studies available for phentolamine and Myocardial Ischemia

ArticleYear
[THE PULMONARY HEMODYNAMICS FOLLOWING EXPERIMENTAL PULMONARY THROMBOEMBOLISM AND AFTER BLOCKADE OF THE ALPHA-ADRENOCEPTORS].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:7

    Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Blood Pressure; Cardiac Output; Disease

2016
[Pulmonary hemodynamics following experimental myocardial ischemia after the blockade of adrenergic receptors].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2015, Volume: 101, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output;

2015
Acute myocardial ischemia up-regulates substance P in the retina of rats.
    Neuroscience letters, 2008, Oct-10, Volume: 443, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Male; My

2008
[The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Coronary Vessels; Disease Mod

2012
Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction.
    International journal of impotence research, 2004, Volume: 16, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adult; Coronary Disease; Echocardiography, Stress; Humans; Impotence,

2004
Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Angina Pectoris; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Blood Pre

2004
Spinal anesthesia attenuates myocardial ischemia during coronary artery spasm induced by intraaortic methacholine in rats.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia, Sp

1995
Roles of alpha 1-adrenoceptor activity in the release of nitric oxide during ischemia of the canine heart.
    Biochemical and biophysical research communications, 1995, Jul-26, Volume: 212, Issue:3

    Topics: Animals; Arginine; Dogs; Hemodynamics; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Este

1995
[Influence of thoracic spinal subarachnoid microinjection of phentolamine on the effect of electroacupuncture].
    Zhen ci yan jiu = Acupuncture research, 1994, Volume: 19, Issue:2

    Topics: Animals; Electroacupuncture; Female; Injections, Spinal; Male; Microinjections; Myocardial Ischemia;

1994
Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.
    European journal of pharmacology, 1993, Aug-24, Volume: 240, Issue:2-3

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; Gl

1993
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessel

1997
Appreciating alpha-adrenergic receptors and their role in ischemic left ventricular dysfunction.
    Circulation, 1999, Feb-02, Volume: 99, Issue:4

    Topics: Adrenergic alpha-Antagonists; Coronary Circulation; Humans; Myocardial Ischemia; Phentolamine; Piper

1999
Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart.
    Circulation research, 1999, Jun-25, Volume: 84, Issue:12

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A

1999
Phentolamine prevents the adverse effects of adenosine on glycolysis and mechanical function in isolated working rat hearts subjected to antecedent ischemia.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:6

    Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Glycolysis; Heart; In Vitro Techniques; Male; Myoc

2000
[Modulation of heart rhythm by alpha-1 adrenoreceptors].
    Kardiologiia, 1992, Volume: 32, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Clonidine; Dioxanes; Dogs; Electrocardiography; Heart Rate; Myocardia

1992