phentolamine has been researched along with Liver Dysfunction in 2 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One potential mechanism by which phentolamine may diminish the bromobenzene-induced hepatotoxicity is by a direct or indirect interference with the metabolism of bromobenzene to toxic metabolites." | 1.27 | Antagonism of bromobenzene-induced hepatotoxicity by phentolamine: evidence for a metabolism-independent intervention. ( Gandy, J; Harbison, RD; Hinson, JA; James, RC; Kerger, BD; Roberts, SM, 1988) |
| "5 ml/kg dosage of bromobenzene." | 1.27 | Antagonism of bromobenzene-induced hepatotoxicity by the alpha-adrenergic blocking agents, phentolamine and idazoxan. ( Bucci, TJ; Gandy, J; Harbison, RD; James, RC; Kerger, BD; Roberts, SM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kerger, BD | 2 |
| Roberts, SM | 2 |
| Hinson, JA | 1 |
| Gandy, J | 2 |
| Harbison, RD | 2 |
| James, RC | 2 |
| Bucci, TJ | 1 |
2 other studies available for phentolamine and Liver Dysfunction
| Article | Year |
|---|---|
Antagonism of bromobenzene-induced hepatotoxicity by phentolamine: evidence for a metabolism-independent intervention.
Topics: Adrenergic alpha-Antagonists; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced L | 1988 |
Antagonism of bromobenzene-induced hepatotoxicity by the alpha-adrenergic blocking agents, phentolamine and idazoxan.
Topics: Adrenergic alpha-Antagonists; Alanine Transaminase; Animals; Bromobenzenes; Chemical and Drug Induce | 1988 |