Page last updated: 2024-11-06

phentolamine and Hypoglycemia

phentolamine has been researched along with Hypoglycemia in 53 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Research Excerpts

ExcerptRelevanceReference
"The role of the autonomic nervous system in the glucagon response to hypoglycemia has not been fully clarified."7.68Plasma glucagon and glucose recovery after hypoglycemia: the effect of total autonomic blockade. ( Christensen, NJ; Frandsen, H; Hilsted, J; Holst, JJ; Nielsen, SL, 1991)
"The effects of adrenergic blockers on the glucagon response to insulin hypoglycemia were investigated in diabetic (10-15 days poststreptozocin [STZ] injection) and age-matched control rats."7.67Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats. ( Patel, DG, 1984)
"Previous studies demonstrated that insulin-induced hypoglycemia enhances glicentin secretion in piglets and prompted us to investigate the response of glucagon-like immunoreactivity (GLI) to hypoglycemia in dogs."7.67Response of gut glucagon-like immunoreactivity to hypoglycemia in dogs. ( Koizumi, F; Naito, H; Ohneda, A; Ohneda, M; Sasaki, I; Toda, M, 1989)
"To further characterize mechanisms of glucose counterregulation in man, the effects of pharmacologically inducd deficiencies of glucagon, growth hormone, and catecholamines (alone and in combination) on recovery of plasma glucose from insulin-induced hypoglycemia and attendant changes in isotopically ([3-(3)H]glucose) determined glucose fluxes were studied in 13 normal subjects."7.66Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. ( Cryer, PE; Gerich, JE; Rizza, RA, 1979)
"In an attempt to ascertain whether the sympathetic nervous system modulates glucagon release in man during starvation and hypoglycemia, the influence of alpha and beta adrenergic blockade on glucagon responses was studied in young, healthy men subjected to fasting and insulin-induced hypoglycemia."7.65The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man. ( Dudl, RJ; Ensinck, JW; Palmer, JP; Walter, RM, 1974)
"The role of the autonomic nervous system in the glucagon response to hypoglycemia has not been fully clarified."3.68Plasma glucagon and glucose recovery after hypoglycemia: the effect of total autonomic blockade. ( Christensen, NJ; Frandsen, H; Hilsted, J; Holst, JJ; Nielsen, SL, 1991)
"To assess the role of catecholamines in the prevention of hypoglycemia during moderate exercise (approximately 60% peak O2 consumption for 60 min), normal humans were studied with combined alpha- and beta-adrenergic blockade and with adrenergic blockade while changes in insulin and glucagon were prevented with the islet clamp technique (somatostatin infusion with insulin and glucagon infused at fixed rates)."3.68Catecholamines in prevention of hypoglycemia during exercise in humans. ( Cryer, PE; Hirsch, IB; Holloszy, JO; Marker, JC; Parvin, CA; Smith, LJ, 1991)
"Arginine vasopressin, oxytocin and ACTH are released from the pituitary gland in response to acute hypoglycemia."3.68Effect of alpha-adrenergic blockade on pituitary hormonal responses to insulin-induced hypoglycemia in humans. ( Baylis, PH; Beastall, GH; Fisher, BM; Frier, BM; Gray, CE; Hepburn, DA; Morton, JJ; Thornton, S, 1991)
"The effects of intravenous infusion of the nonselective alpha-adrenergic antagonist phentolamine or of the selective alpha 2-adrenergic antagonist yohimbine on growth hormone (GH), prolactin (PRL) and cortisol secretion during insulin-induced hypoglycemia were studied in 11 healthy young men."3.67Role of alpha 1- and alpha 2-adrenergic receptors in the growth hormone and prolactin response to insulin-induced hypoglycemia in man. ( Tatár, P; Vigas, M, 1984)
"The effects of adrenergic blockers on the glucagon response to insulin hypoglycemia were investigated in diabetic (10-15 days poststreptozocin [STZ] injection) and age-matched control rats."3.67Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats. ( Patel, DG, 1984)
"To study possible adrenergic modulation of pituitary-adrenal responses to insulin-induced hypoglycemia and CRH we examined the effect of nonselective alpha-blockade (phentolamine) and nonselective beta-blockade (propranolol) on plasma ACTH, cortisol, and vasopressin (AVP) responses to hypoglycemia and CRH in five normal men."3.67Adrenergic modulation of adrenocorticotropin responses to insulin-induced hypoglycemia and corticotropin-releasing hormone. ( Demura, H; Nakagami, Y; Shizume, K; Suda, T; Sumitomo, T; Tomori, N; Tozawa, F; Ushiyama, T, 1989)
"Previous studies demonstrated that insulin-induced hypoglycemia enhances glicentin secretion in piglets and prompted us to investigate the response of glucagon-like immunoreactivity (GLI) to hypoglycemia in dogs."3.67Response of gut glucagon-like immunoreactivity to hypoglycemia in dogs. ( Koizumi, F; Naito, H; Ohneda, A; Ohneda, M; Sasaki, I; Toda, M, 1989)
"although epinephrine is not essential for prompt restoration of normoglycemia in normal man following insulin-induced hypoglycemia, it plays a major role in glucose counterregulation in diabetics who have an impaired glucagon secretion in response to hypoglycemia."3.66Important role of adrenergic mechanisms in acute glucose counterregulation following insulin-induced hypoglycemia in type I diabetes. Evidence for an effect mediated by beta-adrenoreceptors. ( Angeletti, G; Bolli, G; Brunetti, P; Cartechini, MG; Compagnucci, P; de Feo, P; Santeusanio, F, 1982)
"To further characterize mechanisms of glucose counterregulation in man, the effects of pharmacologically inducd deficiencies of glucagon, growth hormone, and catecholamines (alone and in combination) on recovery of plasma glucose from insulin-induced hypoglycemia and attendant changes in isotopically ([3-(3)H]glucose) determined glucose fluxes were studied in 13 normal subjects."3.66Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. ( Cryer, PE; Gerich, JE; Rizza, RA, 1979)
"In an attempt to ascertain whether the sympathetic nervous system modulates glucagon release in man during starvation and hypoglycemia, the influence of alpha and beta adrenergic blockade on glucagon responses was studied in young, healthy men subjected to fasting and insulin-induced hypoglycemia."3.65The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man. ( Dudl, RJ; Ensinck, JW; Palmer, JP; Walter, RM, 1974)
"Hypoglycemia was induced by a bolus of short-acting insulin (0."2.67Effects of adrenergic blockade on serum potassium changes in response to acute insulin-induced hypoglycemia in nondiabetic humans. ( Fisher, BM; Frier, BM; Hepburn, DA; Thomson, I, 1991)
"1."2.67Autonomic mechanisms underlying intraocular pressure changes during insulin-induced hypoglycaemia in normal human subjects: effects of pharmacological blockade. ( Barrie, T; Fisher, BM; Frier, BM; Hepburn, DA; Thomson, I, 1991)
"This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by anti-insulin serum."1.26An involvement of alpha-adrenergic stimulation in exercise-induced hypoglycemia. ( Hosokawa, T; Ui, M; Yajima, M, 1977)
"Phentolamine was infused throughout (0."1.25Effect of cerebral intraventricular insulin on pancreatic insulin secretion in the dog. ( Chen, M; Porte, D; Woods, SC, 1975)

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199036 (67.92)18.7374
1990's15 (28.30)18.2507
2000's1 (1.89)29.6817
2010's1 (1.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ramanathan, R1
Cryer, PE6
Tatár, P1
Vigas, M1
Tse, TF1
Clutter, WE1
Shah, SD1
Bolli, G1
de Feo, P1
Compagnucci, P1
Cartechini, MG1
Angeletti, G1
Santeusanio, F1
Brunetti, P1
Patel, DG1
Hilsted, J3
Madsbad, S1
Sestoft, L1
Rizza, R1
Go, V1
Cryer, P2
Verdonk, C1
Gerich, J1
Filkins, JP2
Phaosawasdi, K1
Goppold, R1
Fisher, RS1
Towler, DA1
Havlin, CE1
Craft, S1
Bolinder, J1
Sjöberg, S1
Arner, P1
Bolli, GB1
Hoffman, RP2
Sinkey, CA2
Tsalikian, E1
Dopp, JM1
Phillips, BG1
Rizza, RA1
Gerich, JE1
Kaul, CL1
Talwalker, PK1
Grewal, RS1
Yajima, M1
Hosokawa, T1
Ui, M1
Clarke, WL1
Santiago, JV1
Thomas, L1
Ben-Galim, E1
Haymond, MW1
Chen, M1
Woods, SC1
Porte, D1
Fisher, BM7
Hepburn, DA7
Smith, JG2
Frier, BM7
Shearing, CH1
Ashby, JP1
Frandsen, H2
Holst, JJ1
Christensen, NJ2
Nielsen, SL2
Marker, JC1
Hirsch, IB1
Smith, LJ1
Parvin, CA1
Holloszy, JO1
Thomson, I2
Thornton, S1
Morton, JJ1
Baylis, PH1
Beastall, GH1
Gray, CE1
Barrie, T1
Gillen, G1
Dargie, HJ1
Hourani, H1
Lacy, DB1
Nammour, TM1
Abumrad, NN1
Morris, JA1
Tomori, N1
Suda, T1
Nakagami, Y1
Tozawa, F1
Sumitomo, T1
Ushiyama, T1
Demura, H1
Shizume, K1
Ohneda, A1
Sasaki, I1
Naito, H1
Toda, M1
Ohneda, M1
Koizumi, F1
Trovati, M1
Massucco, P1
Cavalot, F1
Anfossi, G1
Mularoni, E1
Busca, G1
Orecchia, C1
Emanuelli, G1
Bosquet, F1
Grimaldi, A1
Gürtler, H1
Müller, EE1
Walter, RM1
Dudl, RJ1
Palmer, JP1
Ensinck, JW1
Nakagawa, K1
Horiuchi, Y1
Mashimo, K1
Colwell, JA1
Wilber, JF1
Widström, A1
Cerasi, E2
Bressler, R1
Vargas-Cord, M1
Lebovitz, HE1
Imura, H1
Kato, Y1
Ikeda, M1
Morimoto, M1
Yawata, M1
Tzagournis, M2
Skillman, RG1
Winkelmann, W1
Oneda, A1
Werrbach, JH1
Gale, CC1
Goodner, CJ1
Conway, MJ1
Goldfine, ID1
Luft, R1
Malaisse, WJ1
Tinant, A1
Ooms, HA1
Franckson, RM1
Herrold, JN1
Korec, R2

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Propranolol as a Treatment for Impaired Awareness of Hypoglycemia in Type 1 Diabetes[NCT03161964]Phase 22 participants (Actual)Interventional2017-10-19Terminated (stopped due to Statistical power could not be achieved due to low enrollment.)
Restoration of Hypoglycemia Awareness With Metoclopramide[NCT03970720]Phase 236 participants (Anticipated)Interventional2019-05-28Recruiting
A Randomized, Placebo-controlled, Double-blinded Cross-over Study of the Pharmacologic Action of a GPR119 Agonist on Glucagon Counter-regulation During Insulin-induced Hypoglycemia in Type 1 Diabetes Mellitus[NCT04432090]Phase 267 participants (Actual)Interventional2021-04-21Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for phentolamine and Hypoglycemia

ArticleYear
[Blood glucose counter-regulation].
    Annales de medecine interne, 1985, Volume: 136, Issue:2

    Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Fatty Acids; Glu

1985
Nervous control of growth hormone secretion.
    Neuroendocrinology, 1973, Volume: 11, Issue:6

    Topics: Amines; Animals; Brain; Brain Diseases; Central Nervous System; Dopamine; Electric Stimulation; Feed

1973
Control of growth hormone secretion.
    Saishin igaku. Modern medicine, 1968, May-10, Volume: 23, Issue:5

    Topics: Age Factors; Amino Acids; Animals; Growth Hormone; Humans; Hypoglycemia; Hypothalamus; Phentolamine;

1968
[Growth hormone and carbohydrate metabolism].
    Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:8

    Topics: Acromegaly; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Dogs; Glucagon; Growth Hormone; Hum

1971

Trials

5 trials available for phentolamine and Hypoglycemia

ArticleYear
Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects.
    Diabetes, 2002, Volume: 51, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Arteries; Blood Flow Velocity; Blo

2002
Effects of adrenergic blockade on serum potassium changes in response to acute insulin-induced hypoglycemia in nondiabetic humans.
    Diabetes care, 1991, Volume: 14, Issue:7

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Adult; Epinephrine; Hu

1991
Autonomic mechanisms underlying intraocular pressure changes during insulin-induced hypoglycaemia in normal human subjects: effects of pharmacological blockade.
    Clinical science (London, England : 1979), 1991, Volume: 80, Issue:4

    Topics: Adult; Atropine; Autonomic Nervous System; Epinephrine; Humans; Hypoglycemia; Insulin; Intraocular P

1991
Plasma volume changes during hypoglycaemia: the effect of autonomic blockade.
    European journal of clinical investigation, 1991, Volume: 21, Issue:1

    Topics: Adult; Atropine; Autonomic Nervous System; Hematocrit; Humans; Hypoglycemia; Insulin; Male; Phentola

1991
Glucose intolerance mechanism after starvation.
    Metabolism: clinical and experimental, 1970, Volume: 19, Issue:2

    Topics: Adult; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Fatty Acids, Nonesterified; Gluco

1970

Other Studies

44 other studies available for phentolamine and Hypoglycemia

ArticleYear
Adrenergic mediation of hypoglycemia-associated autonomic failure.
    Diabetes, 2011, Volume: 60, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Analysis of Variance; Atropine; Au

2011
Role of alpha 1- and alpha 2-adrenergic receptors in the growth hormone and prolactin response to insulin-induced hypoglycemia in man.
    Neuroendocrinology, 1984, Volume: 39, Issue:3

    Topics: Adult; Blood Pressure; Growth Hormone; Heart Rate; Humans; Hypoglycemia; Insulin; Male; Phentolamine

1984
Hypoglycemic glucose counterregulation in patients with insulin-dependent diabetes mellitus.
    The Journal of laboratory and clinical medicine, 1982, Volume: 99, Issue:4

    Topics: Adrenalectomy; Blood Glucose; Diabetes Mellitus; Glucagon; Growth Hormone; Homeostasis; Humans; Hypo

1982
Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans.
    The American journal of physiology, 1984, Volume: 247, Issue:2 Pt 1

    Topics: Adrenalectomy; Blood Glucose; Epinephrine; Glucagon; Growth Hormone; Humans; Hyperglycemia; Hypoglyc

1984
Important role of adrenergic mechanisms in acute glucose counterregulation following insulin-induced hypoglycemia in type I diabetes. Evidence for an effect mediated by beta-adrenoreceptors.
    Diabetes, 1982, Volume: 31, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Growth Hormone;

1982
Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats.
    Diabetes, 1984, Volume: 33, Issue:12

    Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Insulin; Male; Phento

1984
Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects.
    Clinical physiology (Oxford, England), 1982, Volume: 2, Issue:4

    Topics: Adult; Ankle; Blood Circulation; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropathies; He

1982
Stimulation of human pancreatic polypeptide secretion by hypoglycemia is independent of adrenergic mechanisms.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 55, Issue:6

    Topics: Adult; Female; Humans; Hypoglycemia; Insulin; Male; Pancreatic Polypeptide; Phentolamine; Propranolo

1982
Effect of phentolamine on insulin levels and insulin responsiveness in endotoxicosis.
    Advances in shock research, 1982, Volume: 7

    Topics: Animals; Blood Glucose; Endotoxins; Glucose; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Ins

1982
Pyloric pressure response to insulin-induced hypoglycemia in humans.
    The American journal of physiology, 1981, Volume: 241, Issue:4

    Topics: Atropine; Blood Glucose; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epinephrine; G

1981
Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms.
    Diabetes, 1993, Volume: 42, Issue:12

    Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Atropine; Autonomic Nervous System; Awareness; Blood Glucose;

1993
Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM.
    Diabetologia, 1996, Volume: 39, Issue:7

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Analysis of Varian

1996
Importance of catecholamines in defense against insulin hypoglycemia in humans.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Glucose; Glycerol; Heparin; Homeos

1998
Effect of local sympathetic blockade on forearm blood flow and glucose uptake during hypoglycemia.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:12

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Autonomic Nerve Block; Blood Gluco

1999
Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia.
    The Journal of clinical investigation, 1979, Volume: 64, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Blood Glucose; Catecholamines; Dru

1979
Adrenergic blockade and glucoregulation in endotoxin shock.
    Circulatory shock, 1979, Volume: 6, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Gluconeogenesis;

1979
Effect of chemical sympathectomy, adrenalectomy and adrenergic alpha- and beta-blocking agents on the development of hyperglycemia induced by streptozotocin in the rat.
    Experientia, 1976, Aug-15, Volume: 32, Issue:8

    Topics: Adrenalectomy; Animals; Female; Hydroxydopamines; Hyperglycemia; Hypoglycemia; Oxprenolol; Phentolam

1976
An involvement of alpha-adrenergic stimulation in exercise-induced hypoglycemia.
    European journal of pharmacology, 1977, Mar-07, Volume: 42, Issue:1

    Topics: Animals; Blood Glucose; Catecholamines; Fatty Acids, Nonesterified; Gluconeogenesis; Glucose; Glycog

1977
Adrenergic mechanisms in recovery from hypoglycemia in man: adrenergic blockade.
    The American journal of physiology, 1979, Volume: 236, Issue:2

    Topics: Adult; Alanine; Epinephrine; Glucagon; Glucose; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia

1979
Effect of cerebral intraventricular insulin on pancreatic insulin secretion in the dog.
    Diabetes, 1975, Volume: 24, Issue:10

    Topics: Animals; Cerebral Ventricles; Dogs; Glucose; Hypoglycemia; Injections, Intraventricular; Insulin; In

1975
Responses of peripheral blood cells to acute insulin-induced hypoglycaemia in humans: effect of alpha-adrenergic blockade.
    Hormone and metabolic research. Supplement series, 1992, Volume: 26

    Topics: Acute Disease; Adult; Erythrocyte Count; Erythrocytes; Granulocytes; Humans; Hypoglycemia; Insulin;

1992
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans.
    The Journal of clinical endocrinology and metabolism, 1992, Volume: 74, Issue:6

    Topics: Adult; Blood Glucose; Calcium; Epinephrine; Humans; Hypoglycemia; Insulin; Insulin, Regular, Pork; K

1992
Plasma glucagon and glucose recovery after hypoglycemia: the effect of total autonomic blockade.
    Acta endocrinologica, 1991, Volume: 125, Issue:5

    Topics: Adult; Analysis of Variance; Atropine; Autonomic Nervous System; Blood Glucose; Cyclic AMP; Epinephr

1991
Catecholamines in prevention of hypoglycemia during exercise in humans.
    The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 1

    Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Blood Pressure; C-Peptide; Epinephrine; Fatty Acids, No

1991
Effect of alpha-adrenergic blockade on pituitary hormonal responses to insulin-induced hypoglycemia in humans.
    Acta endocrinologica, 1991, Volume: 125, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Adult; Arginine Vasopressin; Humans; Hypo

1991
Cardiac responses to acute insulin-induced hypoglycemia in humans.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 2

    Topics: Acute Disease; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Atropine; Blood Glu

1990
The effect of alpha-adrenergic blockade on responses of peripheral blood cells to acute insulin-induced hypoglycaemia in humans.
    European journal of clinical investigation, 1990, Volume: 20, Issue:1

    Topics: Adult; Blood Cells; Blood Glucose; Erythrocyte Count; Humans; Hypoglycemia; Insulin; Leukocyte Count

1990
Differential effects of alpha and beta adrenergic blockade on glucose and lactate metabolism during acute stress.
    The Journal of trauma, 1990, Volume: 30, Issue:9

    Topics: Animals; Blood Glucose; Dogs; Female; Glucose; Hemodynamics; Hypoglycemia; Insulin; Lactates; Liver;

1990
Adrenergic modulation of adrenocorticotropin responses to insulin-induced hypoglycemia and corticotropin-releasing hormone.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:1

    Topics: Adrenocorticotropic Hormone; Blood Glucose; Corticotropin-Releasing Hormone; Female; Hemodynamics; H

1989
Response of gut glucagon-like immunoreactivity to hypoglycemia in dogs.
    The American journal of physiology, 1989, Volume: 256, Issue:3 Pt 1

    Topics: Acetylcholine; Animals; Atropine; Blood Glucose; Deoxyglucose; Dogs; Epinephrine; Glucagon; Hypoglyc

1989
Alpha-adrenergic blockade with phentolamine increases the response of the renin-angiotensin-aldosterone system to insulin-induced hypoglycaemia in man.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:5

    Topics: Adult; Aldosterone; Angiotensin I; Blood Glucose; Humans; Hypoglycemia; Insulin; Male; Phentolamine;

1989
Effects of metyrapone and a combined alpha- and beta-adrenergic blockade on plasma glucose recovery from insulin-induced hypoglycaemia in pigs.
    Experimental and clinical endocrinology, 1986, Volume: 87, Issue:3

    Topics: Adrenal Cortex Hormones; Animals; Blood Glucose; Catecholamines; Female; Hypoglycemia; Insulin; Male

1986
The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man.
    The Journal of clinical investigation, 1974, Volume: 54, Issue:5

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Antigens; Blood Glucos

1974
Further studies on the relation between growth hormone and corticotrophin secretion in insulin-induced hypoglycemia.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 32, Issue:2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Blood Glucose; Dexamethasone; Growth Hormone; Humans

1971
Studies of insulin and growth hormone secretion in a subject with hepatoma and gypoglycemia.
    Diabetes, 1971, Volume: 20, Issue:9

    Topics: Adipose Tissue; Adult; Animals; Arginine; Blood Glucose; Carcinoma, Hepatocellular; Dexamethasone; F

1971
On the action of tolbutamide in normal man. I. Role of adrenergic mechanisms in tolbutamide-induced insulin release during normoglycaemia and induced hypoglycaemia.
    Acta endocrinologica, 1973, Volume: 72, Issue:3

    Topics: Adult; Blood Glucose; Catecholamines; Depression, Chemical; Feedback; Female; Humans; Hypoglycemia;

1973
Tranylcypromine: a potent insulin secretagogue and hypoglycemic agent.
    Diabetes, 1968, Volume: 17, Issue:10

    Topics: Animals; Blood Glucose; Epinephrine; Gluconeogenesis; Hypoglycemia; In Vitro Techniques; Insulin; In

1968
[Diagnosis and immediate therapy of the endocrine crisis].
    Der Internist, 1970, Volume: 11, Issue:2

    Topics: Adrenal Insufficiency; Diabetic Coma; Emergencies; Endocrine System Diseases; Glucose; Humans; Hydro

1970
Effects of autonomic blocking agents on growth hormone, insulin, free fatty acids and glucose in baboons.
    Endocrinology, 1970, Volume: 86, Issue:1

    Topics: Animals; Blood Glucose; Fatty Acids, Nonesterified; Ganglia, Autonomic; Growth Hormone; Haplorhini;

1970
Glucagon stimulation of insulin release in man: inhibition during hypoglycemia.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 35, Issue:2

    Topics: Blood Glucose; Catecholamines; Depression, Chemical; Glucagon; Humans; Hypoglycemia; Insulin; Insuli

1972
Metabolic effects of -guanidinobutyramide. I. In vivo study in anesthetized dogs.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1969, Volume: 1, Issue:6

    Topics: Amides; Anesthesia, Intravenous; Animals; Antigens; Blood Glucose; Blood Pressure; Blood Urea Nitrog

1969
The role of starvation, hypoglycemia, and adrenergic blockade on growth hormone secretion in obesity.
    Journal of surgical oncology, 1970, Volume: 2, Issue:3

    Topics: Adult; Catecholamines; Fasting; Female; Growth Hormone; Humans; Hypoglycemia; Injections, Intravenou

1970
[Post-insulin hypoglycemic pulmonary edema in rats].
    Casopis lekaru ceskych, 1968, May-31, Volume: 107, Issue:22

    Topics: Animals; Female; Hypoglycemia; Insulin; Male; Phenoxybenzamine; Phentolamine; Pulmonary Edema; Rats

1968
[The protective and noxious effect of catecholamines during postinsulin hypoglycemia in rats].
    Journal de physiologie, 1968, Volume: 60 Suppl 2

    Topics: Adrenal Medulla; Animals; Cardiovascular System; Catecholamines; Ergotamine; Fasting; Female; Hypogl

1968