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phentolamine and Hirschsprung Disease

phentolamine has been researched along with Hirschsprung Disease in 4 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.

Research Excerpts

ExcerptRelevanceReference
" Excitatory junction potentials were accompanied by muscle contraction and abolished by atropine or tetrodotoxin."3.67Electrophysiological and pharmacological study on innervation of the aganglionic colon in Hirschsprung's disease of human and murine model. ( Okamoto, E; Okasora, T, 1986)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matsufuji, H1
Okasora, T1
Okamoto, E1
Nirasawa, Y1
Yokoyama, J1
Ikawa, H1
Morikawa, Y1
Katsumata, K1
Wood, JD1
Brann, LR1

Other Studies

4 other studies available for phentolamine and Hirschsprung Disease

ArticleYear
[Responses of muscle strips from the internal anal sphincter in Hirschsprung's disease to drugs and electrical field stimulation].
    Nihon Heikatsukin Gakkai zasshi, 1990, Volume: 26, Issue:4

    Topics: Anal Canal; Animals; Child, Preschool; Dogs; Electric Stimulation; Female; Hirschsprung Disease; Hum

1990
Electrophysiological and pharmacological study on innervation of the aganglionic colon in Hirschsprung's disease of human and murine model.
    Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1986, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Animals; Atropine; Child; Child, Preschool; Colon; Culture Techniques; Electric S

1986
Hirschsprung's disease: catecholamine content, alpha-adrenoceptors, and the effect of electrical stimulation in aganglionic colon.
    Journal of pediatric surgery, 1986, Volume: 21, Issue:2

    Topics: Atropine; Catecholamines; Chromatography, High Pressure Liquid; Colon; Dopamine; Electric Stimulatio

1986
Pharmacological analysis of rebound excitation in large intestine of piebald mouse model for Hirschsprung's disease.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:7

    Topics: Animals; Atropine; Dimethylphenylpiperazinium Iodide; Guanethidine; Hirschsprung Disease; Indomethac

1986