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phentolamine and Epilepsy

phentolamine has been researched along with Epilepsy in 6 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats."3.67Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kombian, SB1
Ananthalakshmi, KV1
Edafiogho, IO1
Johansson, B1
Nilsson, B1
Doba, N1
Beresford, HR1
Reis, DJ1
Hattori, Y2
Moriwaki, A2
Hayashi, Y1
Hori, Y2
Yasuhara, H1
Nicoletti, F1
Barbaccia, ML1
Iadarola, MJ1
Pozzi, O1
Laird, HE1

Other Studies

6 other studies available for phentolamine and Epilepsy

ArticleYear
Norepinephrine and E139 interactions on epileptiform activity in the rat hippocampus in vitro.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2008, Volume: 17, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cyclohexanes; Epilepsy; Hippocampus; Humans;

2008
The pathophysiology of the blood-brain barrier dysfunction induced by severe hypercapnia and by epileptic brain activity.
    Acta neuropathologica, 1977, May-16, Volume: 38, Issue:2

    Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Epilepsy; Homocysteine; Hypercapnia; Hype

1977
Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in cat.
    Brain research, 1975, Jun-06, Volume: 90, Issue:1

    Topics: Adrenalectomy; Animals; Atropine; Blood Pressure; Cardiac Output; Cats; Electric Stimulation; Electr

1975
Regional difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
    Journal of neurochemistry, 1990, Volume: 54, Issue:2

    Topics: Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Electrocardiography; Epileps

1990
Lateral difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
    Brain research, 1988, Sep-27, Volume: 461, Issue:1

    Topics: Animals; Cerebral Cortex; Cyclic AMP; Epilepsy; Ferrous Compounds; In Vitro Techniques; Male; Norepi

1988
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam

1986