phentolamine has been researched along with Epilepsy in 6 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Excerpt | Relevance | Reference |
---|---|---|
"We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats." | 3.67 | Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (66.67) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kombian, SB | 1 |
Ananthalakshmi, KV | 1 |
Edafiogho, IO | 1 |
Johansson, B | 1 |
Nilsson, B | 1 |
Doba, N | 1 |
Beresford, HR | 1 |
Reis, DJ | 1 |
Hattori, Y | 2 |
Moriwaki, A | 2 |
Hayashi, Y | 1 |
Hori, Y | 2 |
Yasuhara, H | 1 |
Nicoletti, F | 1 |
Barbaccia, ML | 1 |
Iadarola, MJ | 1 |
Pozzi, O | 1 |
Laird, HE | 1 |
6 other studies available for phentolamine and Epilepsy
Article | Year |
---|---|
Norepinephrine and E139 interactions on epileptiform activity in the rat hippocampus in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cyclohexanes; Epilepsy; Hippocampus; Humans; | 2008 |
The pathophysiology of the blood-brain barrier dysfunction induced by severe hypercapnia and by epileptic brain activity.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Epilepsy; Homocysteine; Hypercapnia; Hype | 1977 |
Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in cat.
Topics: Adrenalectomy; Animals; Atropine; Blood Pressure; Cardiac Output; Cats; Electric Stimulation; Electr | 1975 |
Regional difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Electrocardiography; Epileps | 1990 |
Lateral difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Epilepsy; Ferrous Compounds; In Vitro Techniques; Male; Norepi | 1988 |
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam | 1986 |