phentolamine has been researched along with Disease Models, Animal in 81 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 7.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "We performed this study to demonstrate the experimental procedure for inducing pulmonary edema by angiotensin II (AT II) in rats and to determine the mechanism of hemodynamic pulmonary edema." | 7.69 | Pulmonary edema induced by angiotensin II in rats. ( Mineshita, S; Miyazaki, M; Sanaka, M; Shimakura, K; Wang, L, 1995) |
| " However, the gastroprotective effect of chronic stress was not manifested and there was no aggravation of indomethacin-induced gastric ulceration, either." | 3.79 | Does chronic stress enhance the risk of diseases? ( Filaretova, L; Laszlo, F; Morozova, O; Morschl, E; Zelena, D, 2013) |
| "In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics following myocardial ischemia in the region of the descendent left coronary artery were studied in control animals and after the blockade of alpha-adrenoreceptors by phentolamine or N-cholinoreceptors of autonomic ganglia by hexamethonium." | 3.78 | [The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits]. ( Evlakhov, VI; Poiasov, IZ, 2012) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 3.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| " The study aimed to understand the quantity and location of alpha1-AR subtypes mRNA expression in control and hypoxia rats,and the effect of phentolamine in hypoxic pulmonary hypertension." | 3.72 | [The mRNA expression of alpha1-adrenergic receptor subtypes in the outer lung tissues of hypoxia pulmonary hypertension rats]. ( Han, L; Xiao, YY, 2004) |
| "We performed this study to demonstrate the experimental procedure for inducing pulmonary edema by angiotensin II (AT II) in rats and to determine the mechanism of hemodynamic pulmonary edema." | 3.69 | Pulmonary edema induced by angiotensin II in rats. ( Mineshita, S; Miyazaki, M; Sanaka, M; Shimakura, K; Wang, L, 1995) |
| "The recent use of vasodilators to improve ventricular function in acute myocardial infarction led us to investigate the effects of nitroglycerin, nitroprusside, and phentolamine on coronary collateral flow." | 3.65 | Comparison of nitroglycerin-, nitroprusside-, and phentolamine-induced changes in coronary collateral function in dogs. ( Capurro, NL; Epstein, SE; Kent, KM, 1977) |
| " Here we use these as case studies to emphasize the importance of informed drug target selection, the early evaluation of dose-response relationships in human studies, and the value of the deep phenotyping of patients in clinical studies to better understand inter-individual variation in patient response." | 2.53 | Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future. ( Attard, M; Ghataorhe, P; Lythgoe, MP; Rhodes, CJ; Wharton, J; Wilkins, MR, 2016) |
| "In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision." | 2.49 | Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma. ( Bartholomew, P; Elwell, M; Radi, Z; Vogel, WM, 2013) |
| "Following pulmonary embolism in animals with intact circulation in the control group and after the blockade of alpha-adrenoceptors the pulmonary artery pressure and pulmonary vascular resistance increased, but the pulmonary artery flow decreased to the same extent." | 1.43 | [THE PULMONARY HEMODYNAMICS FOLLOWING EXPERIMENTAL PULMONARY THROMBOEMBOLISM AND AFTER BLOCKADE OF THE ALPHA-ADRENOCEPTORS]. ( Evlakhov, VI; Poyassov, IZ; Shaidakov, EV, 2016) |
| "Cold allodynia [evaluated by immersing the tail into cold water (4 °C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i." | 1.40 | Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats. ( Bae, H; Kim, SK; Lee, DI; Lee, G; Lim, BS; Min, BI; Moon, HJ; Na, HS; Ye, MS, 2014) |
| "Epinephrine (EPI) contributes to hyperalgesia in inflammatory and stress conditions." | 1.37 | GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. ( Carbajal, AG; Dantzer, R; Eijkelkamp, N; Heijnen, CJ; Kavelaars, A; Kelley, KW; Schedlowski, M; Wang, H, 2011) |
| "When isosorbide dinitrate (ISDN, 1 mM) was applied during isometric measurement, 18." | 1.31 | The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil. ( Hirai, M; Iino, S; Kondo, T; Takeshita, K; Tanaka, T, 2002) |
| "Hemorrhage was induced in fasted anesthetized rats, and the reduction of blood pressure to 40 mm Hg for a duration of 30 minutes was accomplished by withdrawal or infusion of shed blood." | 1.31 | Regulation of liver and kidney glucose-6-phosphatase gene expression in hemorrhage and resuscitation. ( El-Maghrabi, MR; Henry, MC; Maitra, SR; Wang, S, 2000) |
| "The chronic allodynia-like behavior was stable for months without signs of remission and i." | 1.30 | Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury. ( Haegerstrand, A; Hao, JX; Hökfelt, T; Saydoff, J; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W, 1998) |
| "With 40 rabbits, the occurrence of convulsion at this dose level was 100%." | 1.29 | [Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits]. ( Cao, H; Xu, JH; Zheng, JH, 1993) |
| "To study the effects of airway obstruction (AWO) and arousal on coronary blood flow, mean arterial pressure (MAP), and heart rate, pigs were chronically instrumented with arterial catheters, Doppler flow probes on the left circumflex coronary artery, and electrodes for determination of sleep stages." | 1.29 | Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model. ( Bergau, DM; Garpestad, E; Kirby, DA; Pinto, JM; Weiss, JW, 1993) |
| "The chronic renal failure was induced by surgical ablation of 75% renal mass." | 1.28 | [Effects of alpha and beta receptor blockaders on urinary excretion of sodium and potassium in healthy rats and in those with chronic renal failure]. ( Jakubowski, Z; Manitius, A; Manitius, J, 1992) |
| "Petechiae were not seen below the diaphragm." | 1.27 | Norepinephrine-induced pulmonary petechiae in the rat: an experimental model with potential implications for sudden infant death syndrome. ( Catron, AC; Farber, JP; Krous, HF, 1984) |
| "When mannoheptulose was introduced 15 min after starting perfusion with 27 mM glucose, inhibition was apparent in non-diabetic rats, but not in STZ." | 1.27 | B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia. ( Grill, V; Ostenson, CG; Westberg, M, 1987) |
| "[3H]Yohimbine binding sites were not significantly altered." | 1.27 | Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma. ( Hashimoto, K; Hoffman, BB; Honda, K; Tsujimoto, G, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (35.80) | 18.7374 |
| 1990's | 13 (16.05) | 18.2507 |
| 2000's | 16 (19.75) | 29.6817 |
| 2010's | 20 (24.69) | 24.3611 |
| 2020's | 3 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Nakatsuka, K | 1 |
| Matsuoka, Y | 1 |
| Kurita, M | 1 |
| Wang, R | 1 |
| Tsuboi, C | 1 |
| Sue, N | 1 |
| Kaku, R | 1 |
| Morimatsu, H | 1 |
| Katsuda, SI | 1 |
| Fujikura, Y | 1 |
| Horikoshi, Y | 1 |
| Hazama, A | 1 |
| Shimizu, T | 1 |
| Shirai, K | 1 |
| Evlakhov, VI | 3 |
| Poyassov, IZ | 2 |
| Shaidakov, EV | 1 |
| Ovsyannikov, VI | 1 |
| Argueta-Morales, IR | 1 |
| Munro, HM | 1 |
| Olsen, M | 1 |
| Ionan, C | 1 |
| Nguyen, M | 1 |
| Amin, S | 1 |
| Danker, S | 1 |
| Meador, LC | 1 |
| Decampli, WM | 1 |
| Radi, Z | 1 |
| Bartholomew, P | 1 |
| Elwell, M | 1 |
| Vogel, WM | 1 |
| Filaretova, L | 1 |
| Morozova, O | 1 |
| Laszlo, F | 1 |
| Morschl, E | 1 |
| Zelena, D | 1 |
| Moon, HJ | 1 |
| Lim, BS | 1 |
| Lee, DI | 1 |
| Ye, MS | 1 |
| Lee, G | 1 |
| Min, BI | 2 |
| Bae, H | 1 |
| Na, HS | 3 |
| Kim, SK | 2 |
| Jarillo-Luna, RA | 1 |
| Rivera-Aguilar, V | 1 |
| Pacheco-Yépez, J | 1 |
| Godínez-Victoria, M | 1 |
| Oros-Pantoja, R | 1 |
| Miliar-García, A | 1 |
| Campos-Rodríguez, R | 1 |
| Ogon, I | 1 |
| Takebayashi, T | 1 |
| Miyakawa, T | 1 |
| Iwase, T | 1 |
| Tanimoto, K | 1 |
| Terashima, Y | 1 |
| Jimbo, S | 1 |
| Kobayashi, T | 1 |
| Tohse, N | 1 |
| Yamashita, T | 1 |
| Lythgoe, MP | 1 |
| Rhodes, CJ | 1 |
| Ghataorhe, P | 1 |
| Attard, M | 1 |
| Wharton, J | 1 |
| Wilkins, MR | 1 |
| Zhang, S | 1 |
| Johnson, CM | 1 |
| Cui, N | 1 |
| Xing, H | 1 |
| Zhong, W | 1 |
| Wu, Y | 1 |
| Jiang, C | 1 |
| Yang, JH | 1 |
| Meng, XX | 1 |
| Xie, LS | 1 |
| Guo, Z | 1 |
| Kim, HY | 1 |
| Wang, J | 1 |
| Lee, I | 1 |
| Kim, HK | 1 |
| Chung, K | 2 |
| Chung, JM | 2 |
| Romana-Souza, B | 1 |
| Monte-Alto-Costa, A | 1 |
| Chen, HS | 1 |
| Qu, F | 1 |
| He, X | 1 |
| Wang, Y | 1 |
| Wen, WW | 1 |
| Wang, H | 1 |
| Heijnen, CJ | 1 |
| Eijkelkamp, N | 1 |
| Carbajal, AG | 1 |
| Schedlowski, M | 1 |
| Kelley, KW | 1 |
| Dantzer, R | 1 |
| Kavelaars, A | 1 |
| Wu, F | 1 |
| Beard, DA | 1 |
| Frisbee, JC | 3 |
| Chen, D | 1 |
| Xiong, Y | 1 |
| Wang, L | 2 |
| Lv, B | 1 |
| Lin, Y | 1 |
| Barchini, J | 1 |
| Tchachaghian, S | 1 |
| Shamaa, F | 1 |
| Jabbur, SJ | 1 |
| Meyerson, BA | 1 |
| Song, Z | 1 |
| Linderoth, B | 1 |
| Saadé, NE | 1 |
| Zhou, K | 1 |
| Kumar, U | 1 |
| Yuen, VG | 1 |
| McNeill, JH | 1 |
| Poiasov, IZ | 1 |
| Butcher, JT | 1 |
| Goodwill, AG | 1 |
| Stanley, SC | 1 |
| Tanaka, T | 1 |
| Iino, S | 1 |
| Takeshita, K | 1 |
| Kondo, T | 1 |
| Hirai, M | 1 |
| Talalaenko, AN | 1 |
| Pankrat'ev, DV | 1 |
| Goncharenko, NV | 1 |
| Shafik, A | 1 |
| Shafik, AA | 1 |
| El-Sibai, O | 1 |
| Ahmed, I | 1 |
| Fields, AM | 1 |
| Kaye, AD | 1 |
| Richards, TA | 1 |
| Ibrahim, IN | 1 |
| Heavner, JE | 1 |
| Dewitt, BJ | 1 |
| Bayer, EZ | 1 |
| Xiao, YY | 1 |
| Han, L | 1 |
| Kim, JH | 1 |
| Hwang, BG | 1 |
| Yoo, GY | 1 |
| Park, DS | 1 |
| Schumacher, AM | 1 |
| Zbilut, JP | 1 |
| Webber, CL | 1 |
| Schwertz, DW | 1 |
| Piano, MR | 1 |
| Zhang, YM | 1 |
| Wei, EQ | 1 |
| Hu, X | 1 |
| Xu, M | 1 |
| Shi, Y | 1 |
| Zhang, JF | 1 |
| Petkov, O | 1 |
| Krous, HF | 1 |
| Catron, AC | 1 |
| Farber, JP | 1 |
| Pals, DT | 1 |
| Orley, J | 1 |
| Henry, PD | 1 |
| Yokoyama, M | 2 |
| Shimakura, K | 1 |
| Sanaka, M | 1 |
| Mineshita, S | 1 |
| Miyazaki, M | 1 |
| Caldwell, FT | 1 |
| Graves, DB | 1 |
| Wallace, BH | 1 |
| Xu, JH | 1 |
| Cao, H | 1 |
| Zheng, JH | 1 |
| Kim, SH | 1 |
| Kwangsup, S | 1 |
| Jin, MC | 1 |
| Pinto, JM | 1 |
| Garpestad, E | 1 |
| Weiss, JW | 1 |
| Bergau, DM | 1 |
| Kirby, DA | 1 |
| Wu, WJ | 1 |
| Pruett, SB | 1 |
| Duarte, CG | 1 |
| Zhang, J | 1 |
| Ellis, S | 1 |
| Yu, W | 1 |
| Hao, JX | 1 |
| Xu, XJ | 1 |
| Saydoff, J | 1 |
| Haegerstrand, A | 1 |
| Hökfelt, T | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Kosofsky, BE | 1 |
| Wilkins, AS | 1 |
| Rise, IR | 1 |
| Kirkeby, OJ | 1 |
| Furuichi, S | 1 |
| Endo, S | 1 |
| Haji, A | 1 |
| Takeda, R | 1 |
| Nisijima, M | 1 |
| Takaku, A | 1 |
| Maitra, SR | 1 |
| Wang, S | 1 |
| El-Maghrabi, MR | 1 |
| Henry, MC | 1 |
| Park, SK | 1 |
| Matsui, A | 1 |
| Ishihara, H | 1 |
| Suzuki, A | 1 |
| Hashiba, E | 1 |
| Fukushi, T | 1 |
| Matsuki, A | 1 |
| Ye, S | 1 |
| Mozayeni, P | 1 |
| Gamburd, M | 1 |
| Zhong, H | 1 |
| Campese, VM | 1 |
| Burns, MJ | 1 |
| Dickson, EW | 1 |
| Sivilotti, ML | 1 |
| Cuenoud, H | 1 |
| Dill, RE | 1 |
| Dorris, RL | 1 |
| Phillips-Thonnard, I | 1 |
| Borison, RL | 1 |
| Diamond, BI | 1 |
| Capurro, NL | 1 |
| Kent, KM | 1 |
| Epstein, SE | 1 |
| Ramanathan, KB | 1 |
| Bodenheimer, MM | 1 |
| Banka, VS | 1 |
| Raina, S | 1 |
| Helfant, RH | 1 |
| Takeuchi, K | 1 |
| Okabe, S | 1 |
| Takagi, K | 1 |
| Nagai, H | 1 |
| Noda, S | 1 |
| Mabe, H | 1 |
| Perhach, JL | 1 |
| Ferguson, HC | 1 |
| McKinney, GR | 1 |
| Nathan, MA | 1 |
| Reis, DJ | 1 |
| Manitius, J | 1 |
| Jakubowski, Z | 1 |
| Manitius, A | 1 |
| Bouchot, O | 1 |
| Bondil, P | 1 |
| Navratil, H | 1 |
| Grill, V | 1 |
| Westberg, M | 1 |
| Ostenson, CG | 1 |
| Radic, A | 1 |
| Simic, M | 1 |
| Tasic, M | 1 |
| Zivojnovic, S | 1 |
| Sakamoto, S | 1 |
| Fukuzaki, H | 1 |
| Tsujimoto, G | 1 |
| Honda, K | 1 |
| Hoffman, BB | 1 |
| Hashimoto, K | 1 |
| Bekemeier, H | 1 |
| Hirschelmann, R | 1 |
| Giessler, AJ | 1 |
| Iwatsuka, H | 1 |
| Shino, A | 1 |
| Taketomi, S | 1 |
| Sjoerdsma, A | 2 |
| Baum, D | 1 |
| Porte, D | 1 |
| Gorodinskaia, VIa | 1 |
| Flamm, ES | 1 |
| Yasargil, MG | 1 |
| Ransohoff, J | 1 |
| Stepanek, J | 1 |
| Brunner, E | 1 |
| Wall, PD | 1 |
| Gutnick, M | 1 |
| Echlin, FA | 1 |
| Cryer, PE | 1 |
| Herman, CM | 1 |
| Sode, J | 1 |
| Coran, AG | 1 |
| Horwitz, D | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Shropshire, AT | 1 |
| Rowles, G | 1 |
| Varner, LL | 1 |
| Clineschmidt, BV | 1 |
| Geller, RG | 1 |
| Govier, WC | 1 |
| Sicuteri, F | 1 |
| Del Bianco, PL | 1 |
| Del Bene, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma[NCT02838758] | Phase 1 | 10 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for phentolamine and Disease Models, Animal
| Article | Year |
|---|---|
Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.
Topics: Animals; Benzazepines; Carcinogenicity Tests; Disease Models, Animal; Humans; Hydromorphone; Lipoma; | 2013 |
Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.
Topics: Animals; Biomarkers; Clinical Studies as Topic; Disease Models, Animal; Dose-Response Relationship, | 2016 |
[A year in male impotence].
Topics: Age Factors; Alprostadil; Animals; Castration; Clinical Trials as Topic; Disease Models, Animal; Dog | 1991 |
[Combined effect of beta-adrenoblockaders with other pharmacologic agents (review of the literature)].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia, Inhalation; Angina Pectoris; | 1971 |
Current concepts in the etiology and treatment of vasospasm.
Topics: Animals; Brain Edema; Cerebral Angiography; Cerebral Arteries; Cerebrovascular Circulation; Disease | 1968 |
1 trial available for phentolamine and Disease Models, Animal
| Article | Year |
|---|---|
Catecholamines in hypertension.
Topics: Animals; Catecholamines; Clinical Trials as Topic; Disease Models, Animal; Ganglionic Blockers; Huma | 1970 |
75 other studies available for phentolamine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Disease Models, Animal; Neuralgia; Phentolamine; R | 2022 |
Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits.
Topics: Animals; Antihypertensive Agents; Aorta; Atenolol; Blood Flow Velocity; Blood Pressure Determination | 2021 |
[THE PULMONARY HEMODYNAMICS FOLLOWING EXPERIMENTAL PULMONARY THROMBOEMBOLISM AND AFTER BLOCKADE OF THE ALPHA-ADRENOCEPTORS].
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Blood Pressure; Cardiac Output; Disease | 2016 |
Pulmonary Microcirculation in Experimental Model of Pulmonary Thromboembolism under Conditions of α-Adrenoceptor Blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Capillary Permeability; Disease Models, Anima | 2019 |
Effects of phentolamine infusion during selective cerebral perfusion in neonatal piglets.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Apoptosis; Brain; Cardiac Surgical Procedur | 2013 |
Does chronic stress enhance the risk of diseases?
Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chr | 2013 |
Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; beta-Endorphin; Cold Temperature; Disease M | 2014 |
Nasal IgA secretion in a murine model of acute stress. The possible role of catecholamines.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Catecholamines; Corticosterone; | 2015 |
Attenuation of pain behaviour by local administration of alpha-2 adrenoceptor antagonists to dorsal root ganglia in a rat radiculopathy model.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2016 |
An optogenetic mouse model of rett syndrome targeting on catecholaminergic neurons.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dopamine beta-Hydr | 2016 |
Acute myocardial ischemia up-regulates substance P in the retina of rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Male; My | 2008 |
Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism.
Topics: Acupuncture Points; Adrenergic alpha-Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; | 2009 |
Simultaneous blockade of alpha and beta adrenoceptors impairs cutaneous wound healing in rats.
Topics: Administration, Cutaneous; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cell | 2010 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Enzyme I | 2011 |
Computational analyses of intravascular tracer washout reveal altered capillary-level flow distributions in obese Zucker rats.
Topics: Albumins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillaries; Computer Simulation; Cyclic | 2011 |
Characteristics of emodin on modulating the contractility of jejunal smooth muscle.
Topics: Animals; Atropine; Constipation; Diarrhea; Diphenhydramine; Disease Models, Animal; Dose-Response Re | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
The effects of phentolamine on fructose-fed rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Disease Models | 2012 |
[The adrenergic mechanisms are involved in the pulmonary hemodynamics changes following experimental myocardial ischemia in rabbits].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Coronary Vessels; Disease Mod | 2012 |
Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease?
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Arterioles; Bridged Bicyclo Compounds, Heterocy | 2013 |
The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil.
Topics: Adrenergic alpha-Antagonists; Amlodipine; Angioplasty, Balloon, Coronary; Animals; Aorta, Thoracic; | 2002 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Role of sympathetic innervation in the defecation mechanism: a novel concept of its function.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anal Canal; Animals; Catheterization; Def | 2003 |
Pulmonary vascular responses to ma huang extract.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Dru | 2003 |
[The mRNA expression of alpha1-adrenergic receptor subtypes in the outer lung tissues of hypoxia pulmonary hypertension rats].
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; In | 2004 |
Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Volume; Disease Models, Animal; Dose-Re | 2006 |
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
Detection of cardiac variability in the isolated rat heart.
Topics: Acetylcholine; Animals; Atenolol; Atropine; Autonomic Nervous System; Cholinergic Agents; Disease Mo | 2006 |
Administration of angiotensin II in the paraventricular nucleus protects gastric mucosa from ischemia-reperfusion injury.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Disease M | 2008 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
Norepinephrine-induced pulmonary petechiae in the rat: an experimental model with potential implications for sudden infant death syndrome.
Topics: Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Haloperidol; Humans; Lung Diseases; | 1984 |
A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chlorisondamine; Disease Models, Animal; Hypotensi | 1983 |
Supersensitivity of atherosclerotic rabbit aorta to ergonovine. Mediation by a serotonergic mechanism.
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Diet, Atherogenic; Disease Models, Animal; Ergonovine | 1980 |
Pulmonary edema induced by angiotensin II in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; D | 1995 |
Effect of alpha adrenergic blockade on thermoregulation in adrenal demedullated burned rats.
Topics: Adrenal Medulla; Analysis of Variance; Animals; Body Temperature Regulation; Burns; Calorimetry; Col | 1995 |
[Intracerebral-ventricular injection of 4-aminopyridine induced convulsion in rabbits].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Disease Models, Animal; Female; Haloperidol; Injections, | 1993 |
Effects of sympathectomy on a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Guanethidine; Hot Temperature; Male; Pain; Pain Measurement; Periph | 1993 |
Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model.
Topics: Airway Obstruction; Animals; Arousal; Blood Pressure; Coronary Circulation; Disease Models, Animal; | 1993 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
Effects of radiocontrast and endothelin administration on systolic blood pressure and renal damage in male spontaneously hypertensive and Wistar Kyoto rats with phentolamine-induced adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Contrast Media; Diatrizoate; Diatrizoate Megl | 1998 |
Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury.
Topics: Animals; Behavior, Animal; Cattle; Cell Transplantation; Chromaffin Cells; Cold Temperature; Disease | 1998 |
A mouse model of transplacental cocaine exposure. Clinical implications for exposed infants and children.
Topics: Animals; Association Learning; Brain; Child; Cocaine; Conditioning, Classical; Disease Models, Anima | 1998 |
Effect of alpha-adrenergic blockade on the cerebrovascular response to increased intracranial pressure after hemorrhage.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cerebral Cortex; Cerebral Hemorrhage; Cerebro | 1998 |
Related changes in sympathetic activity, cerebral blood flow and intracranial pressure, and effect of an alpha-blocker in experimental subarachnoid haemorrhage.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Blood Transfusion; Cats; Cerebrovascula | 1999 |
Regulation of liver and kidney glucose-6-phosphatase gene expression in hemorrhage and resuscitation.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Northern; Disease Models, Animal; Gene Expre | 2000 |
Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy.
Topics: Adrenergic alpha-Antagonists; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Therapy, | 2000 |
Glucose dilution can detect fluid redistribution following phentolamine infusion in dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Volume Determination; Disease Models, An | 2000 |
Interleukin-1beta and neurogenic control of blood pressure in normal rats and rats with chronic renal failure.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antibodies; Blood Pressure; Creatinine; Disea | 2000 |
Phentolamine reduces myocardial injury and mortality in a rat model of phenylpropanolamine poisoning.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Heart Vent | 2001 |
A pharmacologic model of Huntington's chorea.
Topics: Animals; Carbachol; Catheterization; Clozapine; Corpus Striatum; Disease Models, Animal; Dyskinesia, | 1976 |
A new animal model for schizophrenia: interactions with adrenergic mechanisms.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Ditiocarb; Drug Antagonism; Dr | 1978 |
Comparison of nitroglycerin-, nitroprusside-, and phentolamine-induced changes in coronary collateral function in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Ferricyanides; Heart; K | 1977 |
Contrasting effects of nitroprusside and phentolamine in experimental myocardial infarction.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Ferricyanides; Heart; Heart Rate; Myocardial | 1977 |
A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis.
Topics: Amylopectin; Animals; Atropine; Bicarbonates; Chlorpromazine; Disease Models, Animal; Gastric Mucosa | 1976 |
Experimental cerebral vasospasm. Part 2: effects of vasoactive drugs and sympathectomy on early and late spasm.
Topics: Animals; Circle of Willis; Disease Models, Animal; Dogs; Ischemic Attack, Transient; Isoxsuprine; Me | 1975 |
Evaluation of antihypertensive agents in the stress-induced hypertensive rat.
Topics: Animals; Antihypertensive Agents; Chlorisondamine; Disease Models, Animal; Drug Evaluation, Preclini | 1975 |
Fulminating arterial hypertension with pulmonary edema from release of adrenomedullary catecholamines after lesions of the anterior hypothalamus in the rat.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Blood Pressure; Body Temperature; Cardiac Output; Catechola | 1975 |
[Effects of alpha and beta receptor blockaders on urinary excretion of sodium and potassium in healthy rats and in those with chronic renal failure].
Topics: Animals; Disease Models, Animal; Glomerular Filtration Rate; Kidney Failure, Chronic; Models, Biolog | 1992 |
B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Diabetes Melli | 1987 |
[An experimental study of the effect of stimulation and blockage of the adrenergic system on the evolution of shock lung in dogs restored to normovolemia].
Topics: Animals; Blood Volume; Disease Models, Animal; Dogs; Female; Lung; Male; Norepinephrine; Phentolamin | 1989 |
Regulation of coronary blood flow by counteraction of coronary vascular alpha and beta adrenergic activation during experimental pliable coronary stenosis.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; | 1986 |
Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma.
Topics: Angiotensins; Animals; Blood Pressure; Cell Membrane; Disease Models, Animal; Dopamine; Heart Rate; | 1987 |
Carrageenin-induced thrombosis in rats and mice: a model for testing antithrombotic substances?
Topics: Animals; Carrageenan; Cyproheptadine; Dibenzylchlorethamine; Disease Models, Animal; Dose-Response R | 1985 |
Streptozotocin resistance of the genetically diabetic KK mouse.
Topics: Animals; Blood Glucose; Depression, Chemical; Diabetes Complications; Diabetes Mellitus; Disease Mod | 1974 |
Alpha-adrenergic inhibition of immunoreactive insulin release during deep hypothermia.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Blood Pressure; B | 1971 |
Alteration of experimental cerebral vasospasm by adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Blood Flow Velocity; Blood Pressure; Cats; Di | 1972 |
Effect of pretreatment with phentolamine on experimentally induced Euler-Liljestrand reflex.
Topics: Acid-Base Equilibrium; Animals; Arteries; Carbon Dioxide; Cardiac Catheterization; Cardiac Output; D | 1974 |
Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Evoked Potentials; Isoproterenol; Nerve Degen | 1974 |
Immunochemical and physiologic insulin lack during lethal E. coli septicemia in the subhuman primate.
Topics: Animals; Antigens; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Haplorhini | 1971 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |
Reactivity to norepinephrine and nature of the alpha adrenergic receptor in vascular smooth muscle of a genetically hypertensive rat.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Hypertension; Muscle Contraction; Muscle, Smooth; | 1970 |
Migraine-headache and essential arterial hypertension. A clinical pharmacological approach with the false transmitter metaraminol.
Topics: Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Headache; | 1970 |