Compounds > phentolamine
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phentolamine and Diabetes Mellitus

phentolamine has been researched along with Diabetes Mellitus in 38 studies

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"although epinephrine is not essential for prompt restoration of normoglycemia in normal man following insulin-induced hypoglycemia, it plays a major role in glucose counterregulation in diabetics who have an impaired glucagon secretion in response to hypoglycemia."3.66Important role of adrenergic mechanisms in acute glucose counterregulation following insulin-induced hypoglycemia in type I diabetes. Evidence for an effect mediated by beta-adrenoreceptors. ( Angeletti, G; Bolli, G; Brunetti, P; Cartechini, MG; Compagnucci, P; de Feo, P; Santeusanio, F, 1982)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199035 (92.11)18.7374
1990's1 (2.63)18.2507
2000's2 (5.26)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lane, BR1
Lane, BZ1
Ausmundson, SJ1
Butler, RS1
Zippe, CD1
Jones, JS1
Lakin, MM1
Cardwell, RJ1
Webb, RC1
Stryjek-Kamińska, D1
Giugliano, D1
Coppola, L1
Misso, L1
Tirelli, A1
Passariello, N1
D'Onofrio, F1
Cryer, PE1
Bolli, G1
de Feo, P1
Compagnucci, P1
Cartechini, MG1
Angeletti, G1
Santeusanio, F1
Brunetti, P1
Matthews, DR1
Lang, DA1
Burnett, MA1
Turner, RC1
Nakhooda, AF1
Sole, MJ1
Marliss, EB1
Krzymien, J1
Stepp, DW1
Frisbee, JC1
Galton, DJ1
Reckless, JP1
Clifton-Bligh, P1
Gilbert, CH1
Garber, AJ1
Karl, IE1
Kipnis, DM1
Jorgensen, KD1
Metz, SA2
Halter, JB3
Porte, D3
Robertson, RP3
Pecora, P1
Suraci, C1
Mileto, A1
Christensen, NJ1
Galbo, H1
Hansen, JF1
Hesse, B1
Richter, EA1
Trap-Jensen, J1
Tutwiler, GF1
Jaworski, TM1
Richards, JS1
Lloyd, LK1
Krotkiewski, M1
Górski, J1
Kuhn, CM1
Cochrane, C1
Feinglos, MN1
Surwit, RS1
Di Lollo, F1
Hagroo, AA1
Verma, NP1
Datta, P1
Ajmani, NK1
Vaishnava, H1
Iwatsuka, H1
Shino, A1
Taketomi, S1
Atkinson, JN1
Randle, PJ1
Burr, IM1
Balant, L1
Stauffacher, W1
Renold, AE1
Atkins, T1
Matty, AJ1
Persson, I1
Larsen, L1
Lundbaek, K1
Linde, J1
Deckert, T1
Means, BJ1
Lamy, PP1
Handwerger, S1
Roth, J1
Gorden, P1
Di Sant' Agnese, P1
Carpenter, DF1
Peter, G1
Tzagournis, M1
Skillman, RG1
McKechnie, JK1
Goldman, A1
Vinik, AI1
Oneda, A1
Sato, T1
Oikawa, A1
Maebashi, M1
Ito, H1
Kumagai, N1

Reviews

2 reviews available for phentolamine and Diabetes Mellitus

ArticleYear
[Growth hormone and carbohydrate metabolism].
    Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:8

    Topics: Acromegaly; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Dogs; Glucagon; Growth Hormone; Hum

1971
Sympathetic regulation of insulin secretion. Its relation to diabetes mellitus.
    Archives of internal medicine, 1969, Volume: 123, Issue:3

    Topics: Adolescent; Adult; Blood Glucose; Catecholamines; Diabetes Mellitus; Diabetic Ketoacidosis; Epinephr

1969

Trials

3 trials available for phentolamine and Diabetes Mellitus

ArticleYear
Observations on lipolysis in ketosis-resistant, growth-onset diabetes.
    Diabetes, 1974, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Body Height; Body Weight; Child; Climate; Clinical Trials as Topic

1974
Glucose intolerance mechanism after starvation.
    Metabolism: clinical and experimental, 1970, Volume: 19, Issue:2

    Topics: Adult; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Fatty Acids, Nonesterified; Gluco

1970
Acute metabolic studies with trasicor in diabetics.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Dec-06

    Topics: 1-Propanol; Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Epinephrine; Fa

1969

Other Studies

33 other studies available for phentolamine and Diabetes Mellitus

ArticleYear
Use of a visual analog scale to assess pain of injection with intracavernous injection therapy.
    The journal of sexual medicine, 2005, Volume: 2, Issue:3

    Topics: Adult; Aged; Alprostadil; Diabetes Mellitus; Drug Administration Routes; Humans; Injections; Male; M

2005
Diabetes and reactivity of isolated human saphenous vein.
    Clinical physiology (Oxford, England), 1984, Volume: 4, Issue:6

    Topics: Aged; Angiotensin II; Blood Vessels; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Hu

1984
[Effect of adrenergic alpha and beta receptor blockaders and the stimulation and blockade of muscarinic receptors in insulinemia and glycemia in healthy persons and patients with diabetes].
    Polskie Archiwum Medycyny Wewnetrznej, 1980, Volume: 64, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adult; Atropine; Blood Glucose; Depression, Chemical; Diabetes Mellitu

1980
Further studies on the significance of circulating platelet aggregates induced by somatostatin in man.
    Metabolism: clinical and experimental, 1981, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Dose-Response Relationship, Drug; Fe

1981
Hypoglycemic glucose counterregulation in patients with insulin-dependent diabetes mellitus.
    The Journal of laboratory and clinical medicine, 1982, Volume: 99, Issue:4

    Topics: Adrenalectomy; Blood Glucose; Diabetes Mellitus; Glucagon; Growth Hormone; Homeostasis; Humans; Hypo

1982
Important role of adrenergic mechanisms in acute glucose counterregulation following insulin-induced hypoglycemia in type I diabetes. Evidence for an effect mediated by beta-adrenoreceptors.
    Diabetes, 1982, Volume: 31, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Growth Hormone;

1982
Control of pulsatile insulin secretion in man.
    Diabetologia, 1983, Volume: 24, Issue:4

    Topics: Adult; Aged; Atropine; Blood Glucose; Diabetes Mellitus; Female; Glucose; Humans; Insulin; Insulin S

1983
Adrenergic regulation of glucagon and insulin secretion during immobilization stress in normal and spontaneously diabetic BB rats.
    The American journal of physiology, 1981, Volume: 240, Issue:4

    Topics: Adrenal Glands; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Female; Glucagon;

1981
[Adrenergic blockade and vascular blood flow in diabetes].
    Polskie Archiwum Medycyny Wewnetrznej, 1980, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Blood Circulation; Diabetes Mellitus; Diabetic Angiopathies; Foot; Humans; Ischem

1980
Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:3

    Topics: Angiotensin II; Animals; Arteries; Arterioles; Blood Pressure; Diabetes Mellitus; Endothelins; Heart

2002
The control of fatty acid metabolism in adult diabetes.
    The Proceedings of the Nutrition Society, 1975, Volume: 34, Issue:3

    Topics: Adipose Tissue; Adult; Cyclic AMP; Diabetes Mellitus; Drug Synergism; Epinephrine; Fatty Acids; Glyc

1975
Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.
    The Journal of biological chemistry, 1976, Feb-10, Volume: 251, Issue:3

    Topics: Alanine; Animals; Bucladesine; Cortisone; Diabetes Mellitus; Epinephrine; Glucagon; Glutamine; In Vi

1976
The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo (b) furan-7-carboxamido)-ethyl)-benzenesulphonyl]-N'-cyclohexylurea (NOVO CS 476). II. Pharmacological studies on the mechanism of action.
    Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:2

    Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus; Dogs; Drug Evaluation, Preclinical;

1977
Suppression of plasma catecholamines and flushing by clonidine in man.
    The Journal of clinical endocrinology and metabolism, 1978, Volume: 46, Issue:1

    Topics: Adenoma, Islet Cell; Adult; Blood Pressure; Catecholamines; Clonidine; Diabetes Mellitus; Face; Fema

1978
Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus.
    The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:5

    Topics: Adult; Aged; Diabetes Mellitus; Epinephrine; Female; Galactose; Glucose Tolerance Test; Humans; Insu

1979
[Effect of adrenergic block on the glycosuria of diabetes mellitus].
    Bollettino della Societa italiana di biologia sperimentale, 1978, Jul-15, Volume: 54, Issue:13

    Topics: Adult; Aged; Diabetes Mellitus; Female; Glycosuria; Humans; Middle Aged; Phentolamine; Propranolol

1978
Catecholamines and exercise.
    Diabetes, 1979, Volume: 28 Suppl 1

    Topics: Animals; Blood Glucose; Catecholamines; Diabetes Mellitus; Glycogen; Heart Rate; Humans; Insulin; Li

1979
In vitro lipolytic effect of bovine pituitary diabetogenic protein.
    Biochimica et biophysica acta, 1975, Sep-08, Volume: 404, Issue:1

    Topics: Animals; Biological Assay; Cattle; Cycloheximide; Diabetes Mellitus; Dogs; Epinephrine; Fatty Acids,

1975
A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus.
    The Journal of clinical investigation, 1976, Volume: 57, Issue:3

    Topics: Autonomic Agents; Catecholamines; Diabetes Mellitus; Glucose; Humans; Insulin; Insulin Secretion; Ph

1976
Retrospective review of sexual and marital satisfaction of spinal cord injury and diabetic males post penile injection or implant.
    Urology, 1992, Volume: 40, Issue:2

    Topics: Adult; Diabetes Mellitus; Drug Therapy, Combination; Humans; Injections; Male; Marriage; Middle Aged

1992
Effect of muscular exercise on plasma C-peptide and insulin in obese non-diabetics and diabetics, type II.
    Clinical physiology (Oxford, England), 1986, Volume: 6, Issue:6

    Topics: Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Mid

1986
Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3

    Topics: Adrenergic Fibers; Animals; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Epin

1987
[On hyperosmolar diabetic coma].
    Recenti progressi in medicina, 1973, Volume: 55, Issue:5

    Topics: Aprotinin; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans; Insulin; Osmolar Concent

1973
Streptozotocin resistance of the genetically diabetic KK mouse.
    Diabetes, 1974, Volume: 23, Issue:10

    Topics: Animals; Blood Glucose; Depression, Chemical; Diabetes Complications; Diabetes Mellitus; Disease Mod

1974
An abnormality of adrenaline, phentolamine stimulated lipolysis in adipose tissue from obese, maturity-onset diabetics.
    Diabetologia, 1972, Volume: 8, Issue:6

    Topics: Adipose Tissue; Aged; Anesthesia, General; Anesthesia, Local; Cyclic AMP; Diabetes Mellitus; Epineph

1972
Adrenergic modification of glucose-induced biphasic insulin release from perifused rat pancreas.
    European journal of clinical investigation, 1971, Volume: 1, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A

1971
[Six years' experience with a musculoplastic technic].
    The Journal of endocrinology, 1971, Volume: 51, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists

1971
Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics.
    Acta endocrinologica, 1972, Volume: 71, Issue:2

    Topics: Adult; Blood Glucose; Diabetes Mellitus; Drug Interactions; Humans; Injections, Intravenous; Insulin

1972
Growth hormoe and diabetic angiopathy.
    Advances in metabolic disorders, 1973, Volume: 2

    Topics: Adolescent; Blood Glucose; Capillary Permeability; Child; Diabetes Mellitus; Diabetes Mellitus, Type

1973
Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus; Drug Interactions; Drug Syne

1973
Diagnostic tests, drugs, and the geriatric patient.
    Journal of the American Geriatrics Society, 1974, Volume: 22, Issue:6

    Topics: Aged; Aging; Angiocardiography; Barium Sulfate; Cells; Contrast Media; Diabetes Mellitus; Diagnosis;

1974
Glucose intolerance in cystic fibrosis.
    The New England journal of medicine, 1969, Aug-28, Volume: 281, Issue:9

    Topics: Adolescent; Adult; Blood Glucose; Child; Cystic Fibrosis; Diabetes Mellitus; Diabetes Mellitus, Type

1969
[Case of ectopic pheochromocytoma].
    Nihon rinsho. Japanese journal of clinical medicine, 1968, Volume: 26, Issue:2

    Topics: Adrenal Gland Neoplasms; Catecholamines; Diabetes Mellitus; Diagnosis, Differential; Female; Humans;

1968