phentolamine has been researched along with Cardiomegaly in 15 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 7.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Two types of vasodilators are used for treatment of acute myocardial infarction: Nitrates on the one hand with predominant venodilation and agents like Phentolamie and Nitroprusside on the other hand with venodilation as well as arteriolar vasodilation." | 4.76 | [Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators]. ( Zilcher, H, 1979) |
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 3.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Development of cardiac hypertrophy and increases in systolic and diastolic blood pressure were dependent upon prolonged periods of thyroid-treatment lasting from 3 days to 4 weeks, whereas the maximal increase (about 55%) in heart rate was seen after the first week of thyroid-treatment." | 1.27 | Changes in cardiac myofibrillar ATPase activity during development of hyperthyroidism in the rabbit. ( Sakanashi, M; Takeo, S; Tomomatsu, E, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, YG | 1 |
| Wang, RZ | 1 |
| Ruan, ZB | 1 |
| Zhu, L | 1 |
| Henning, RJ | 1 |
| Li, Y | 1 |
| Simpson, P | 1 |
| Petkov, O | 1 |
| Takeo, S | 1 |
| Tomomatsu, E | 1 |
| Sakanashi, M | 1 |
| Bolte, HD | 1 |
| Bussmann, WD | 1 |
| Schnabel, P | 1 |
| Nohr, T | 1 |
| Nickenig, G | 1 |
| Paul, M | 1 |
| Böhm, M | 1 |
| McNamara, RF | 1 |
| Schmid, PG | 1 |
| Schmidt, JA | 1 |
| Lund, DD | 1 |
| Bhatnagar, RK | 1 |
| Zilcher, H | 1 |
| Bache, RJ | 1 |
| Homans, DC | 1 |
| Dai, XZ | 1 |
| Boréus, LO | 1 |
| Broberger, U | 1 |
| Nergårdh, A | 1 |
| Zetterqvist, P | 1 |
| Astorri, E | 1 |
| Mavilla, V | 1 |
| Bini, L | 1 |
| Majorano, C | 1 |
| Alday, LE | 1 |
| Moreyra, E | 1 |
| Amuchástegui, LM | 1 |
| Madoery, RJ | 1 |
| Goodwin, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phentolamine and Cardiomegaly
| Article | Year |
|---|---|
[Treatment of heart failure with vasodilators].
Topics: Captopril; Cardiomegaly; Cardiotonic Agents; Coronary Disease; Heart Failure; Heart Function Tests; | 1980 |
[Effect of vasodilator agents in chronic heart failure].
Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P | 1981 |
[Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators].
Topics: Arrhythmias, Cardiac; Cardiac Output; Cardiomegaly; Death, Sudden; Diuretics; Heart Block; Heart Ven | 1979 |
1 trial available for phentolamine and Cardiomegaly
| Article | Year |
|---|---|
[Effect of vasodilator agents in chronic heart failure].
Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P | 1981 |
12 other studies available for phentolamine and Cardiomegaly
| Article | Year |
|---|---|
RETRACTED: Effect of phentolamine on myocardial extracellular matrix of cardiac remodeling in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Collagen Type I; Extracellular Matrix; Heart; M | 2014 |
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Cells, Cultured; C | 2003 |
Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Isoproterenol; Myocardium; Norepinephrine; Phen | 1983 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
Changes in cardiac myofibrillar ATPase activity during development of hyperthyroidism in the rabbit.
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Calcium-Transporting ATPases; Cardiac Output; Ca | 1984 |
Alpha-adrenergic signal transduction in renin transgenic rats.
Topics: Animals; Animals, Genetically Modified; Cardiomegaly; Cell Membrane; GTP-Binding Proteins; Mice; Myo | 1997 |
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Fai | 1979 |
Adrenergic vasoconstriction limits coronary blood flow during exercise in hypertrophied left ventricle.
Topics: Animals; Cardiomegaly; Coronary Circulation; Dogs; Heart Ventricles; Hemodynamics; Myocardium; Oxyge | 1991 |
Malignant pheochromocytoma in a child: treatment with a combination of alpha- and beta-adrenergic blockade.
Topics: Adrenal Gland Neoplasms; Cardiomegaly; Child; Drug Synergism; Female; Humans; Hypertension; Lymphati | 1968 |
[Effects of intravenous administration of phentolamine and nitroglycerin on the electrocardiographic tracings of left ventricular hypertrophy].
Topics: Adult; Aged; Cardiomegaly; Electrocardiography; Female; Heart; Heart Ventricles; Humans; Hypertensio | 1969 |
Recognizing and treating muscular subaortic stenosis.
Topics: Aged; Amyl Nitrite; Angiography; Aortic Valve; Blood Pressure; Cardiac Catheterization; Cardiomegaly | 1973 |
Relationships among hypertrophy, hypertension, and coronary arterial patterns, and pharmacological responses in cardiomyopathies.
Topics: Cardiomegaly; Cardiomyopathy, Hypertrophic; Coronary Disease; Coronary Vessels; Glucagon; Heart Fail | 1973 |