phentolamine has been researched along with Cardiac Hypertrophy in 15 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 7.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Two types of vasodilators are used for treatment of acute myocardial infarction: Nitrates on the one hand with predominant venodilation and agents like Phentolamie and Nitroprusside on the other hand with venodilation as well as arteriolar vasodilation." | 4.76 | [Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators]. ( Zilcher, H, 1979) |
| "Cocaine increases adult cardiomyocyte protein content by protein kinase Calpha-dependent mechanisms, and this process can contribute to the cardiac hypertrophy and cardiomyopathy that results from chronic cocaine use." | 3.72 | Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. ( Henning, RJ; Li, Y, 2003) |
| "Development of cardiac hypertrophy and increases in systolic and diastolic blood pressure were dependent upon prolonged periods of thyroid-treatment lasting from 3 days to 4 weeks, whereas the maximal increase (about 55%) in heart rate was seen after the first week of thyroid-treatment." | 1.27 | Changes in cardiac myofibrillar ATPase activity during development of hyperthyroidism in the rabbit. ( Sakanashi, M; Takeo, S; Tomomatsu, E, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, YG | 1 |
| Wang, RZ | 1 |
| Ruan, ZB | 1 |
| Zhu, L | 1 |
| Henning, RJ | 1 |
| Li, Y | 1 |
| Simpson, P | 1 |
| Petkov, O | 1 |
| Takeo, S | 1 |
| Tomomatsu, E | 1 |
| Sakanashi, M | 1 |
| Bolte, HD | 1 |
| Bussmann, WD | 1 |
| Schnabel, P | 1 |
| Nohr, T | 1 |
| Nickenig, G | 1 |
| Paul, M | 1 |
| Böhm, M | 1 |
| McNamara, RF | 1 |
| Schmid, PG | 1 |
| Schmidt, JA | 1 |
| Lund, DD | 1 |
| Bhatnagar, RK | 1 |
| Zilcher, H | 1 |
| Bache, RJ | 1 |
| Homans, DC | 1 |
| Dai, XZ | 1 |
| Boréus, LO | 1 |
| Broberger, U | 1 |
| Nergårdh, A | 1 |
| Zetterqvist, P | 1 |
| Astorri, E | 1 |
| Mavilla, V | 1 |
| Bini, L | 1 |
| Majorano, C | 1 |
| Alday, LE | 1 |
| Moreyra, E | 1 |
| Amuchástegui, LM | 1 |
| Madoery, RJ | 1 |
| Goodwin, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phentolamine and Cardiac Hypertrophy
| Article | Year |
|---|---|
[Treatment of heart failure with vasodilators].
Topics: Captopril; Cardiomegaly; Cardiotonic Agents; Coronary Disease; Heart Failure; Heart Function Tests; | 1980 |
[Effect of vasodilator agents in chronic heart failure].
Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P | 1981 |
[Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators].
Topics: Arrhythmias, Cardiac; Cardiac Output; Cardiomegaly; Death, Sudden; Diuretics; Heart Block; Heart Ven | 1979 |
1 trial available for phentolamine and Cardiac Hypertrophy
| Article | Year |
|---|---|
[Effect of vasodilator agents in chronic heart failure].
Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P | 1981 |
12 other studies available for phentolamine and Cardiac Hypertrophy
| Article | Year |
|---|---|
RETRACTED: Effect of phentolamine on myocardial extracellular matrix of cardiac remodeling in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Collagen Type I; Extracellular Matrix; Heart; M | 2014 |
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Cells, Cultured; C | 2003 |
Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Isoproterenol; Myocardium; Norepinephrine; Phen | 1983 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
Changes in cardiac myofibrillar ATPase activity during development of hyperthyroidism in the rabbit.
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Calcium-Transporting ATPases; Cardiac Output; Ca | 1984 |
Alpha-adrenergic signal transduction in renin transgenic rats.
Topics: Animals; Animals, Genetically Modified; Cardiomegaly; Cell Membrane; GTP-Binding Proteins; Mice; Myo | 1997 |
Humoral regulation of vascular resistance after 30 days of pulmonary artery constriction.
Topics: Angiotensin II; Animals; Cardiomegaly; Catecholamines; Dopamine; Epinephrine; Guinea Pigs; Heart Fai | 1979 |
Adrenergic vasoconstriction limits coronary blood flow during exercise in hypertrophied left ventricle.
Topics: Animals; Cardiomegaly; Coronary Circulation; Dogs; Heart Ventricles; Hemodynamics; Myocardium; Oxyge | 1991 |
Malignant pheochromocytoma in a child: treatment with a combination of alpha- and beta-adrenergic blockade.
Topics: Adrenal Gland Neoplasms; Cardiomegaly; Child; Drug Synergism; Female; Humans; Hypertension; Lymphati | 1968 |
[Effects of intravenous administration of phentolamine and nitroglycerin on the electrocardiographic tracings of left ventricular hypertrophy].
Topics: Adult; Aged; Cardiomegaly; Electrocardiography; Female; Heart; Heart Ventricles; Humans; Hypertensio | 1969 |
Recognizing and treating muscular subaortic stenosis.
Topics: Aged; Amyl Nitrite; Angiography; Aortic Valve; Blood Pressure; Cardiac Catheterization; Cardiomegaly | 1973 |
Relationships among hypertrophy, hypertension, and coronary arterial patterns, and pharmacological responses in cardiomyopathies.
Topics: Cardiomegaly; Cardiomyopathy, Hypertrophic; Coronary Disease; Coronary Vessels; Glucagon; Heart Fail | 1973 |