phentolamine has been researched along with Autonomic Dysreflexia in 2 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Autonomic Dysreflexia: A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autonomic dysreflexia is a hypertensive episode in spinal cord-injured individuals induced by exaggerated sympathetic activity and thought to be alpha-adrenergic mediated." | 2.75 | Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals. ( Danser, AH; Deinum, J; Geurts, AC; Groothuis, JT; Hopman, MT; Pickkers, P; Rongen, GA; Smits, P, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Groothuis, JT | 1 |
| Rongen, GA | 1 |
| Deinum, J | 1 |
| Pickkers, P | 1 |
| Danser, AH | 1 |
| Geurts, AC | 1 |
| Smits, P | 1 |
| Hopman, MT | 1 |
| Reitz, A | 1 |
| Schmid, DM | 1 |
| Curt, A | 1 |
| Knapp, PA | 1 |
| Schurch, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Mecamylamine for Autonomic Dysreflexia Prophylaxis[NCT03914677] | Phase 4 | 5 participants (Anticipated) | Interventional | 2019-06-13 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phentolamine and Autonomic Dysreflexia
| Article | Year |
|---|---|
Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin II; Autonomic Dysreflexia; Autonomic Nervous | 2010 |
1 other study available for phentolamine and Autonomic Dysreflexia
| Article | Year |
|---|---|
Autonomic dysreflexia in response to pudendal nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Autonomic Dysreflexia; Blood Pressure; Electric Stimulation; Heart Rat | 2003 |