phentolamine has been researched along with Anorexia Nervosa in 3 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Anorexia Nervosa: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leibowitz, SF | 1 |
| Imura, H | 1 |
| Nakai, Y | 1 |
| Matsukura, S | 1 |
| Matsuyama, H | 1 |
| Santen, RJ | 1 |
| Bardin, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2[NCT01457703] | 62 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 3.8 |
| BMI 18-25 kg/m2 | 3.3 |
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 5.31 |
| BMI 18-25 kg/m2 | 6.18 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 4.1 |
| BMI 18-25 kg/m2 | 3.6 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 2.21 |
| BMI 18-25 kg/m2 | 4.44 |
Pregnanediol glucuronide (PdG) was collected daily over the course of one menstrual cycle and averaged. (NCT01457703)
Timeframe: Averaged over the length of menstrual cycle
| Intervention | ug/cycle (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 54.1 |
| BMI 18-25 kg/m2 | 88.7 |
3 other studies available for phentolamine and Anorexia Nervosa
| Article | Year |
|---|---|
Central adrenergic receptors and the regulation of hunger and thirst.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1972 |
Effect of intravenous infusion of L-DOPA on plasma growth hormone levels in man.
Topics: Adult; Aged; Anorexia Nervosa; Blood Glucose; Central Nervous System Diseases; Dihydroxyphenylalanin | 1973 |
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.
Topics: Adult; Amenorrhea; Anorexia Nervosa; Chlorpromazine; Female; Follicle Stimulating Hormone; Half-Life | 1973 |