phentolamine has been researched along with Alloxan Diabetes in 34 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of adrenergic blockers on the glucagon response to insulin hypoglycemia were investigated in diabetic (10-15 days poststreptozocin [STZ] injection) and age-matched control rats." | 7.67 | Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats. ( Patel, DG, 1984) |
| "The sexual cycle ceases in rats with alloxan diabetes." | 7.66 | [Compensatory ovarian hypertrophy during alloxan diabetes and adrenoreceptor blockade]. ( Anishchenko, TG; Ivanova, II; Lapshina, VF; Smetanina, MD; Vunder, PA, 1980) |
| "The effects of adrenergic blockers on the glucagon response to insulin hypoglycemia were investigated in diabetic (10-15 days poststreptozocin [STZ] injection) and age-matched control rats." | 3.67 | Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats. ( Patel, DG, 1984) |
| "The sexual cycle ceases in rats with alloxan diabetes." | 3.66 | [Compensatory ovarian hypertrophy during alloxan diabetes and adrenoreceptor blockade]. ( Anishchenko, TG; Ivanova, II; Lapshina, VF; Smetanina, MD; Vunder, PA, 1980) |
| "Therapeutic potential of agomelatine on neuropathic pain was suppressed with α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis), phentolamine (a nonselective α-adrenoceptor antagonist), and propranolol (a nonselective β-adrenoceptor antagonist) administrations." | 1.43 | Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. ( Aydın, TH; Can, ÖD; Demir Özkay, Ü; Turan, N, 2016) |
| "Phentolamine pretreatment (5 mumol." | 1.28 | Increased vasoconstrictor response to noradrenaline in femoral vascular bed of diabetic dogs. Is thromboxane A2 involved? ( Ballagi-Pordány, G; Hadházy, P; Koltai, MZ; Pogátsa, G; Rösen, P, 1990) |
| "Methoxamine was given in incremental doses ranging from 0." | 1.27 | Enhanced sensitivity of diabetic hearts to alpha-adrenoceptor stimulation. ( Downing, SE; Fripp, RR; Lee, JC, 1983) |
| "When mannoheptulose was introduced 15 min after starting perfusion with 27 mM glucose, inhibition was apparent in non-diabetic rats, but not in STZ." | 1.27 | B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia. ( Grill, V; Ostenson, CG; Westberg, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (70.59) | 18.7374 |
| 1990's | 6 (17.65) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aydın, TH | 1 |
| Can, ÖD | 1 |
| Demir Özkay, Ü | 1 |
| Turan, N | 1 |
| Amour, J | 1 |
| Loyer, X | 1 |
| Michelet, P | 1 |
| Birenbaum, A | 1 |
| Riou, B | 1 |
| Heymes, C | 1 |
| Balsiger, B | 1 |
| Rickenbacher, A | 1 |
| Boden, PJ | 1 |
| Biecker, E | 1 |
| Tsui, J | 1 |
| Dashwood, M | 1 |
| Reichen, J | 1 |
| Shaw, SG | 1 |
| Setty, S | 1 |
| Sun, W | 1 |
| Martinez, R | 1 |
| Downey, HF | 1 |
| Tune, JD | 1 |
| Jackson, CV | 1 |
| Carrier, GO | 1 |
| Vunder, PA | 1 |
| Ivanova, II | 1 |
| Lapshina, VF | 1 |
| Anishchenko, TG | 2 |
| Smetanina, MD | 1 |
| MacLeod, KM | 1 |
| McNeill, JH | 1 |
| Patel, DG | 1 |
| Axelrod, L | 1 |
| Cornelius, P | 1 |
| Downing, SE | 2 |
| Lee, JC | 2 |
| Fripp, RR | 1 |
| Fujimoto, K | 1 |
| Sakaguchi, T | 1 |
| Ui, M | 1 |
| Liu, J | 1 |
| Wang, KM | 1 |
| He, LZ | 1 |
| Cao, DY | 1 |
| Talwalker, PK | 1 |
| Kaul, CL | 1 |
| Grewal, RS | 1 |
| Costa e Forti, A | 1 |
| Fonteles, MC | 1 |
| Artemenko, OV | 1 |
| Koltai, MZ | 4 |
| Rösen, P | 4 |
| Hadházy, P | 3 |
| Aranyi, Z | 1 |
| Ballagi-Pordány, G | 3 |
| Pogátsa, G | 4 |
| Mantle, M | 1 |
| Thakore, E | 1 |
| Mathison, R | 1 |
| Davison, JS | 1 |
| Kubota, K | 1 |
| Ingbar, SH | 1 |
| Sunaga, K | 1 |
| Ogihara, M | 1 |
| Grill, V | 1 |
| Westberg, M | 1 |
| Ostenson, CG | 2 |
| Drukarch, B | 1 |
| Schepens, E | 1 |
| Heimans, JJ | 1 |
| Stoof, JC | 1 |
| Studer, RK | 1 |
| Ganas, L | 1 |
| Cattaneo, AG | 1 |
| Doxey, JC | 1 |
| Efendic, S | 1 |
| Maggi, CA | 1 |
| Santicioli, P | 1 |
| Manzini, S | 1 |
| Conti, S | 1 |
| Giuliani, S | 1 |
| Patacchini, R | 1 |
| Meli, A | 1 |
| Köszeghy, A | 1 |
| Werner, JC | 1 |
| Jansson, L | 1 |
| Sandler, S | 1 |
| Williams, ME | 1 |
| Spokes, K | 1 |
| Silva, P | 1 |
| Stock, K | 2 |
| Westermann, E | 1 |
| Lundquist, I | 1 |
| Cseuz, R | 1 |
| Wenger, TL | 1 |
| Kunos, G | 1 |
| Szentiványi, M | 1 |
34 other studies available for phentolamine and Alloxan Diabetes
| Article | Year |
|---|---|
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms.
Topics: Acetamides; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetic Neurop | 2016 |
Preservation of the positive lusitropic effect of beta-adrenoceptors stimulation in diabetic cardiomyopathy.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Colforsin; Diabete | 2008 |
Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function.
Topics: Animals; Atropine; Blood Glucose; Diabetes Mellitus, Experimental; Electric Stimulation; Endothelin | 2002 |
Alpha-adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in experimental diabetes mellitus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood | 2004 |
Supersensitivity of isolated mesenteric arteries to noradrenaline in the long-term experimental diabetic rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Blood Pressure; B | 1981 |
[Compensatory ovarian hypertrophy during alloxan diabetes and adrenoreceptor blockade].
Topics: Alloxan; Animals; Castration; Diabetes Mellitus, Experimental; Female; Gonadotropins, Pituitary; Hyp | 1980 |
Alpha adrenoceptor mediated responses in aorta from three month streptozotocin diabetic rats.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Dibenzylchlorethamine; Female; Norepinephrine; Phen | 1982 |
Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Insulin; Male; Phento | 1984 |
Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Glucose; Cyclooxygenase Inhibitors; Diabetes Mellitus, | 1984 |
Enhanced sensitivity of diabetic hearts to alpha-adrenoceptor stimulation.
Topics: Animals; Blood Pressure; Calcium; Diabetes Mellitus, Experimental; Heart; Heart Rate; Methoxamine; M | 1983 |
Adrenergic mechanisms in the hyperglycaemia and hyperinsulinaemia of diabetic KK mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Insulin; Insulin Resistance; M | 1981 |
[Effects of sympathetic efferent in diabetic hyperalgesia in rat].
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Dinoprostone; Efferent Pathways; Ganglia, Sym | 1996 |
Potentiation of the diabetogenic effect of streptozocin by phentolamine in the rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Syne | 1979 |
An alpha-adrenotropic study of the normal and diabetic rabbit kidney.
Topics: Animals; Diabetes Mellitus, Experimental; Kidney; Kinetics; Norepinephrine; Perfusion; Phentolamine; | 1979 |
[Effect of phentolamine and obsidan on morphometric indices of the islets of Langerhans in rats receiving alloxan].
Topics: Animals; Diabetes Mellitus, Experimental; Islets of Langerhans; Male; Phentolamine; Propranolol; Rat | 1977 |
Disturbed lipid metabolism in diabetic coronary vessels.
Topics: Alloxan; Animals; Arachidonic Acids; Aspirin; Coronary Circulation; Coronary Vessels; Diabetes Melli | 1992 |
Intestinal mucin secretion in streptozotocin-diabetic rats: lack of response to cholinergic stimulation and cholera toxin.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Cholera Toxin; Diabetes Mellitus, Experimenta | 1991 |
Influences of thyroid status and sympathoadrenal system on extrarenal potassium disposal.
Topics: Adrenal Glands; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Diabetes Mellitus, E | 1990 |
Increased vasoconstrictor response to noradrenaline in femoral vascular bed of diabetic dogs. Is thromboxane A2 involved?
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Dogs; Dose-Response Re | 1990 |
Effects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, | 1990 |
B cell insensitivity in a rat model of non-insulin-dependent diabetes. Evidence for a rapidly reversible effect of previous hyperglycemia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Diabetes Melli | 1987 |
Diminished vasodilation; imbalance of synthesized cyclooxygenase products by adrenergic mediation in diabetic coronaries of the dog.
Topics: Animals; Coronary Vessels; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Dogs; Epopros | 1989 |
Alpha 2-adrenoceptor-mediated modulation of noradrenaline release is decreased in vas deferens but not in cerebral cortex of diabetic rats.
Topics: Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; Electric Stimulation; In Vitro Techniques | 1989 |
Effect of diabetes on hormone-stimulated and basal hepatocyte calcium metabolism.
Topics: Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Diabetes Mellitus, Experimental; Epinephrin | 1989 |
Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidi | 1989 |
Functional studies on the cholinergic and sympathetic innervation of the rat proximal urethra: effect of pelvic ganglionectomy or experimental diabetes.
Topics: Acetylcholine; Animals; Atropine; Capsaicin; Diabetes Mellitus, Experimental; Dimethylphenylpiperazi | 1989 |
Relationship between vascular adrenergic receptors and prostaglandin biosyntheses in canine diabetic coronary arteries.
Topics: Animals; Arteries; Blood Glucose; Coronary Vessels; Diabetes Mellitus, Experimental; Dogs; Epoproste | 1988 |
Coronary vascular responses to hypoxia in the diabetic lamb: independence from adenosine and autonomic mechanisms.
Topics: Acidosis; Adenosine; Animals; Cardiac Output; Coronary Circulation; Coronary Vessels; Diabetes Melli | 1986 |
Pancreatic islet circulation in relation to the diabetogenic action of streptozotocin in the rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Glucose; Islets of Langerhans; | 1985 |
Role of alpha-adrenergic hormones in potassium homeostasis in the rat.
Topics: Adrenalectomy; Animals; Bicarbonates; Blood Glucose; Diabetes Mellitus, Experimental; Homeostasis; H | 1987 |
Effects of adrenergic blockade and nicotinic acid on the mobilization of free fatty acids.
Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus, Experi | 1965 |
[Inhibition of lipolysis by alpha and beta sympatholytics, nicotinic acid and prostaglandin E1].
Topics: Adrenocorticotropic Hormone; Animals; Diabetes Mellitus, Experimental; Ethanolamines; Fasting; Fatty | 1966 |
Interaction of amines and aminergic blocking agents with blood glucose regulation. II. Alpha-adrenergic blockade.
Topics: Adipose Tissue; Adrenalectomy; Adrenergic alpha-Antagonists; Amines; Animals; Blood Glucose; Carbon | 1972 |
Changes of adrenergic reaction pattern in experimental diabetes mellitus.
Topics: Animals; Aorta; Cold Temperature; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; | 1973 |