phentolamine has been researched along with Aging in 58 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We analysed the influence of aging on the acute effect of clenbuterol, a beta(2)-adrenoceptor agonist, on the vasoconstrictor response induced by electrical field stimulation in mesenteric arteries from young and old spontaneously hypertensive rats (SHRs)." | 3.72 | Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats. ( Balfagón, G; Ferrer, M; Salaices, M; Sánchez, M, 2003) |
| "With phentolamine, peak ΔFVC was enhanced in older adults at each contraction intensity (100 ± 14, 147 ± 22, and 200 ± 26 ml·min(-1)·100 mmHg(-1), respectively, P < 0." | 1.38 | Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging. ( Casey, DP; Joyner, MJ, 2012) |
| "Pretreatment with phentolamine significantly increased the microvascular response in young rats at high (87 percent) and low (36 percent) frequency ES." | 1.30 | Age-related changes in sympathetic modulation of sensory nerve activity in rat skin. ( Helme, RD; Khalil, Z; Merhi, M, 1998) |
| "0 mg/kg intravenously) was administered after the highest phenylephrine infusion dosage to assure complete beta-blockade." | 1.27 | In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation. ( Gelband, H; McCormack, J; Pickoff, AS; Stolfi, A; Villafañe, J; Xu, H, 1988) |
| "Phentolamine (10(-6) M) pretreatment had no effect on the ouabain-induced contraction but partially suppressed it in both SHR and WKY aortas when diltiazem (10(-5) M) was also added." | 1.27 | Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine. ( Iwasaki, T; Kawai, Y; Miyata, S; Morita, S; Nagai, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (58.62) | 18.7374 |
| 1990's | 11 (18.97) | 18.2507 |
| 2000's | 5 (8.62) | 29.6817 |
| 2010's | 8 (13.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilalova, GA | 1 |
| Sitdikov, FG | 1 |
| Dikopol'skaya, NB | 1 |
| Shaikhelislamova, MV | 1 |
| Zefirov, TL | 1 |
| La Favor, JD | 1 |
| Kraus, RM | 1 |
| Carrithers, JA | 1 |
| Roseno, SL | 1 |
| Gavin, TP | 1 |
| Hickner, RC | 1 |
| Richards, JC | 1 |
| Luckasen, GJ | 1 |
| Larson, DG | 1 |
| Dinenno, FA | 2 |
| Segal, SS | 1 |
| Snyder, KA | 1 |
| Shamimi-Noori, S | 1 |
| Wilson, TE | 1 |
| Monahan, KD | 1 |
| Casey, DP | 2 |
| Padilla, J | 1 |
| Joyner, MJ | 2 |
| Barrett-O'Keefe, Z | 1 |
| Witman, MA | 1 |
| McDaniel, J | 1 |
| Fjeldstad, AS | 1 |
| Trinity, JD | 1 |
| Ives, SJ | 1 |
| Conklin, JD | 1 |
| Reese, V | 1 |
| Runnels, S | 1 |
| Morgan, DE | 1 |
| Sander, M | 1 |
| Richardson, RS | 1 |
| Wray, DW | 1 |
| Ferrer, M | 1 |
| Salaices, M | 1 |
| Sánchez, M | 1 |
| Balfagón, G | 1 |
| FARNER, D | 1 |
| Fujii, M | 1 |
| Umezawa, K | 1 |
| Arata, A | 1 |
| Nomura, Y | 1 |
| Oki, K | 1 |
| Segawa, T | 1 |
| Herlihy, JT | 1 |
| Yu, BP | 1 |
| Bühler, FR | 1 |
| Kiowski, W | 1 |
| van Brummelen, P | 1 |
| Amann, FW | 1 |
| Bertel, O | 1 |
| Landmann, R | 1 |
| Lütold, BE | 1 |
| Bolli, P | 1 |
| Wemer, J | 1 |
| Mulder, AH | 1 |
| Beck, N | 1 |
| Park, MK | 2 |
| Brodde, OE | 1 |
| Yokoyama, M | 1 |
| Kusui, A | 1 |
| Sakamoto, S | 1 |
| Fukuzaki, H | 1 |
| Antonaccio, MJ | 1 |
| Cavaliere, T | 1 |
| Cote, D | 1 |
| Yorek, MA | 1 |
| Blair, JB | 1 |
| Ray, PD | 1 |
| Casteels, R | 1 |
| Tokuno, H | 1 |
| Mulvany, MJ | 1 |
| Nyborg, N | 1 |
| Thorin, E | 1 |
| Capdeville-Atkinson, C | 1 |
| Corman, B | 1 |
| Atkinson, J | 1 |
| Purvis, K | 1 |
| Brekke, I | 1 |
| Christiansen, E | 1 |
| Frank, SM | 1 |
| el-Gamal, N | 1 |
| Raja, SN | 1 |
| Wu, PK | 1 |
| Merhi, M | 2 |
| Helme, RD | 1 |
| Khalil, Z | 2 |
| Linderman, JR | 1 |
| Boegehold, MA | 1 |
| Fujii, K | 1 |
| Onaka, U | 1 |
| Abe, I | 1 |
| Fujishima, M | 1 |
| Suzuki, Y | 1 |
| Moriyama, N | 1 |
| Okaya, Y | 1 |
| Nishimatsu, H | 1 |
| Kawabe, K | 1 |
| Aisaka, K | 1 |
| Richter, S | 1 |
| Vardi, Y | 1 |
| Ringel, A | 1 |
| Shalev, M | 1 |
| Nissenkorn, I | 1 |
| Tanaka, H | 1 |
| Stauffer, BL | 1 |
| Seals, DR | 1 |
| Saarela, S | 1 |
| Mattila, T | 1 |
| Hissa, R | 1 |
| Hohtola, E | 1 |
| Sheridan, PH | 1 |
| Melville, GN | 1 |
| Iravani, J | 1 |
| Vassell, M | 1 |
| Minnis, J | 1 |
| Frol'kis, VV | 1 |
| Verkhratskiĭ, NS | 1 |
| Shevchuk, VG | 1 |
| Schulze, G | 1 |
| Bürgel, P | 1 |
| Illnerová, H | 1 |
| Skopová, J | 1 |
| Tive, LA | 1 |
| Barr, GA | 1 |
| Atkinson, BN | 1 |
| Minneman, KP | 1 |
| Sandroni, P | 1 |
| Benarroch, EE | 1 |
| Low, PA | 1 |
| Mollace, V | 1 |
| Masuda, Y | 1 |
| Pelaggi, T | 1 |
| Nisticò, G | 1 |
| Schoeffter, P | 1 |
| Godfraind, T | 1 |
| Schlicker, E | 1 |
| Betz, R | 1 |
| Göthert, M | 1 |
| McCormack, J | 1 |
| Gelband, H | 1 |
| Villafañe, J | 1 |
| Xu, H | 1 |
| Stolfi, A | 1 |
| Pickoff, AS | 1 |
| Nowak, G | 1 |
| Silberring, J | 1 |
| Toma, BS | 1 |
| Wangler, RD | 1 |
| Sparks, HV | 1 |
| Morita, S | 1 |
| Iwasaki, T | 1 |
| Nagai, K | 1 |
| Miyata, S | 1 |
| Kawai, Y | 1 |
| Rousseau, P | 1 |
| Toda, N | 1 |
| Okamura, T | 1 |
| Miyazaki, M | 1 |
| Westerink, BH | 1 |
| Koolstra, W | 1 |
| Buckley, NM | 1 |
| Brazeau, P | 1 |
| Frasier, ID | 1 |
| Gootman, PM | 1 |
| Perkins, JP | 1 |
| Moore, MM | 1 |
| Black, IB | 1 |
| Geen, SC | 1 |
| Weiss, B | 1 |
| Strada, SJ | 1 |
| Girard, JR | 1 |
| Caquet, D | 1 |
| Bal, D | 1 |
| Guillet, I | 1 |
| Means, BJ | 1 |
| Lamy, PP | 1 |
| Fleisch, JH | 1 |
1 review available for phentolamine and Aging
| Article | Year |
|---|---|
Impotence in elderly men.
Topics: Aged; Aging; Erectile Dysfunction; Humans; Male; Papaverine; Penis; Phentolamine; Physical Examinati | 1988 |
3 trials available for phentolamine and Aging
| Article | Year |
|---|---|
Age- and limb-related differences in the vasoconstrictor response to limb dependency are not mediated by a sympathetic mechanism in humans.
Topics: Adrenergic Antagonists; Adult; Aged; Aging; Arm; Blood Pressure; Brachial Artery; Female; Heart Rate | 2012 |
Determinants of satisfactory rigidity after intracavernosal injection with prostaglandin E1 in men with erectile failure.
Topics: Adrenergic alpha-Antagonists; Aging; Alprostadil; Drug Combinations; Erectile Dysfunction; Gonadal S | 1996 |
alpha-Adrenoceptor mechanisms of thermoregulation during cold challenge in humans.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aging; Body Temperature Regulation; Cold Temperature; Fem | 1996 |
54 other studies available for phentolamine and Aging
| Article | Year |
|---|---|
Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Outbred Strains; | 2017 |
Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Enzyme I | 2014 |
Role of α-adrenergic vasoconstriction in regulating skeletal muscle blood flow and vascular conductance during forearm exercise in ageing humans.
Topics: Adrenergic alpha-Antagonists; Aging; Female; Forearm; Hand Strength; Humans; Male; Middle Aged; Musc | 2014 |
Blood flow restriction without sympathetic vasoconstriction in ageing skeletal muscle during exercise.
Topics: Adrenergic alpha-Antagonists; Aging; Female; Hand Strength; Humans; Male; Muscle, Skeletal; Phentola | 2014 |
α-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Adult; Aged; Aged, 80 and over; Aging; A | 2012 |
Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aging; Blood Flow Velocity; Blood Pressure; Brachial Arte | 2012 |
Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly.
Topics: Adult; Aged; Aging; Angiotensin II; Drug Synergism; Humans; Norepinephrine; Phentolamine; Receptors, | 2013 |
Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aging; Animals; Blood Pressure; Calcitonin G | 2003 |
[Studies on the effect of pharmacological agents on animals of different age. IV. The effect of Ritalin and Regitine on young and old rats].
Topics: Aging; Animals; Methylphenidate; Phentolamine; Rats; Sympatholytics | 1961 |
Adrenaline contributes to prenatal respiratory maturation in rat medulla-spinal cord preparation.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Cell Differentiat | 2006 |
Pharmacological characterization of central alpha-adrenoceptors which mediate clonidine-induced locomotor hypoactivity in the developing rat.
Topics: Aging; Animals; Central Nervous System; Clonidine; Female; Male; Motor Activity; Phentolamine; Piper | 1980 |
Dietary manipulation of age-related decline in vascular smooth muscle function.
Topics: Aging; Animals; Aorta; Food Deprivation; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth, Va | 1980 |
Plasma catecholamines and cardiac, renal and peripheral vascular adrenoceptor-mediated responses in different age groups of normal and hypertensive subjects.
Topics: Adult; Aging; Epinephrine; Heart Rate; Humans; Hypertension; Isoproterenol; Kidney; Middle Aged; Nor | 1980 |
Postnatal development of presynaptic alpha-adrenoceptors in rat cerebral cortex: studies with brain slices and synaptosomes.
Topics: Aging; alpha-Methyltyrosine; Animals; Cell Differentiation; Cerebral Cortex; Culture Techniques; Mal | 1981 |
Maturation-related changes in catecholamine-dependent cyclic AMP and protein kinase in the rabbit myocardium.
Topics: Adenylyl Cyclases; Aging; Animals; Catecholamines; Cyclic AMP; Isoproterenol; Myocardium; Phentolami | 1981 |
Endogenous and exogenous regulation of human alpha- and beta-adrenergic receptors.
Topics: Adolescent; Adult; Aged; Aging; Blood Platelets; Clonidine; Estrogens; Female; Guanosine Triphosphat | 1983 |
Age-associated increments in human platelet alpha-adrenoceptor capacity. Possible mechanism for platelet hyperactivity to epinephrine in aging man.
Topics: Adult; Aged; Aging; Binding, Competitive; Blood Platelets; Dihydroergotoxine; Drug Hypersensitivity; | 1984 |
Ontogenesis of hypertension and responsiveness to antihypertensive agents in spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Guanethidine; Heart Rate; Hypertensi | 1980 |
The influences of glucagon, epinephrine and adrenergic agents on glycogen phosphorylase a and pyruvate kinase activities in hepatocytes from juvenile and adult rabbits.
Topics: Aging; Animals; Epinephrine; Glucagon; Isoproterenol; Liver; Male; Phentolamine; Phenylephrine; Phos | 1982 |
Effect of stimulation of noradrenergic nerve fibers on the activity of the smooth muscle cells of the ear artery.
Topics: Action Potentials; Aging; Animals; Arteries; Ear; Electric Stimulation; In Vitro Techniques; Microel | 1980 |
An increased calcium sensitivity of mesenteric resistance vessels in young and adult spontaneously hypertensive rats.
Topics: Aging; Animals; Calcium; Cocaine; Hypertension; Mesenteric Arteries; Muscle, Smooth, Vascular; Norep | 1980 |
Sympathetic neurotransmission in the tail artery of aging rats.
Topics: Aging; Anesthesia; Animals; Arteries; Body Weight; Cocaine; In Vitro Techniques; Male; Muscle, Smoot | 1994 |
Age-related changes in sympathetic modulation of sensory nerve activity in rat skin.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Capsaicin; Electric Stimulation; Male; | 1998 |
Modulation of arteriolar sympathetic constriction by local nitric oxide: onset during rapid juvenile growth.
Topics: Aging; Animals; Arterioles; Electric Stimulation; Enzyme Inhibitors; Male; Muscle, Skeletal; Nitric | 1998 |
Eicosanoids and membrane properties in arteries of aged spontaneously hypertensive rats.
Topics: Aging; Animals; Atropine; Blood Pressure; Calcium Channels; Cyclooxygenase Inhibitors; Eicosanoids; | 1999 |
Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aging; Animals; Autoradiograp | 1999 |
Effects of aging on neurogenic vasodilator responses evoked by transcutaneous electrical nerve stimulation: relevance to wound healing.
Topics: Aging; Animals; Guanethidine; Male; Peripheral Nervous System; Phentolamine; Rats; Rats, Sprague-Daw | 2000 |
Intracavernous injections: still the gold standard for treatment of erectile dysfunction in elderly men.
Topics: Aged; Aged, 80 and over; Aging; Alprostadil; Case-Control Studies; Dose-Response Relationship, Drug; | 2001 |
Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Body | 2001 |
Age-dependent response of neonate fowls to peripheral noradrenaline.
Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Body Temperature; Chickens; Epinephrine; Male; Nor | 1976 |
Alpha- and beta-adrenergic mechanisms in the aorta of newborn rabbits and guinea-pigs.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Aorta; Female | 1979 |
Airway response to adrenergic agonists and antagonists in 3-day- to 2-year-old rats.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Bronchi; Bronchitis; Epinephrine; Female; | 1979 |
[Nervous regulation of cardiac function during aging].
Topics: Acetylcholine; Aging; Animals; Atropine; Cardiac Output; Cats; Choline O-Acetyltransferase; Electric | 1977 |
The influence of age and drugs on the thermoregulatory behaviour of rats.
Topics: Aging; Animals; Behavior, Animal; Body Temperature Regulation; Conditioning, Psychological; Female; | 1977 |
Regulation of the diurnal rhythm in rat pineal serotonin-N-acetyltransferase activity and serotonin content during ontogenesis.
Topics: Acetyltransferases; Aging; Animals; Circadian Rhythm; Phentolamine; Phenyl Ethers; Pineal Gland; Pro | 1976 |
Analgesia from the periaqueductal gray in the developing rat: focal injections of morphine or glutamate and effects of intrathecal injection of methysergide or phentolamine.
Topics: Aging; Analgesia; Animals; Animals, Newborn; Catheterization; Excitatory Amino Acid Antagonists; Glu | 1992 |
Multiple adrenergic receptor subtypes controlling cyclic AMP formation: comparison of brain slices and primary neuronal and glial cultures.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Colfo | 1991 |
Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure.
Topics: Adult; Aging; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Human | 1991 |
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M | 1990 |
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H | 1989 |
Investigation into the age-dependence of release of serotonin and noradrenaline in the rat brain cortex and of autoreceptor-mediated modulation of release.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Cerebral Cortex; Electric S | 1989 |
In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation.
Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Dogs; Heart Rate; Parasympathetic Nervous System; | 1988 |
Kinetics of [3H]-prazosin binding to the rat cortex during aging.
Topics: Aging; Animals; Cerebral Cortex; Male; Phentolamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Str | 1988 |
Metabolic hyperemia is reduced in adult vs. immature guinea pig hearts.
Topics: Adenosine; Aging; Animals; Coronary Circulation; Guinea Pigs; Heart; In Vitro Techniques; Isoprotere | 1988 |
Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium; Calcium Radioisotopes; Hydralazine; Hypertensi | 1988 |
Age-dependent changes in the response of isolated beagle coronary arteries to transmural electrical stimulation and catecholamines.
Topics: Acetylcholine; Aging; Animals; Catecholamines; Coronary Circulation; Coronary Vessels; Dinoprost; Do | 1986 |
Circadian variation of catecholamine excretion in rats: correlation with locomotor activity and effects of drugs.
Topics: Aging; Animals; Catecholamines; Circadian Rhythm; Dopamine; Epinephrine; Haloperidol; Male; Motor Ac | 1986 |
Circulatory effects of splanchnic nerve stimulation in developing swine.
Topics: Adrenalectomy; Aging; Animals; Animals, Newborn; Aorta; Blood Pressure; Electric Stimulation; Intest | 1985 |
Regulation of the adenosine cyclic 3',5'-monophosphate content of rat cerebral cortex: ontogenetic development of the responsiveness to catecholamines and adenosine.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adrenergic alp | 1973 |
Inhibition of the biochemical and morphological maturation of adrenergic neurons by nicotinic receptor blockade.
Topics: Aging; Animals; Animals, Newborn; Atropine; Chlorisondamine; Dopa Decarboxylase; Dopamine beta-Hydro | 1974 |
Neuroendocrine control of the cyclic AMP system of brain and pineal gland.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Circadian Rhythm; Cyclic AMP; Kinetics; Light; Norepinephr | 1972 |
Control of rat liver phosphorylase, glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities by insulin and glucagon during the perinatal period.
Topics: 1-Propanol; Adrenal Glands; Adrenalectomy; Aging; Animals; Animals, Newborn; Blood Glucose; Ergotami | 1973 |
Diagnostic tests, drugs, and the geriatric patient.
Topics: Aged; Aging; Angiocardiography; Barium Sulfate; Cells; Contrast Media; Diabetes Mellitus; Diagnosis; | 1974 |
Further studies on the effect of ageing on beta-adrenoceptor activity of rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; Female; In Vitro Techniques; Isoproterenol; Male; Nitrites; Phentol | 1971 |