phentolamine has been researched along with Adverse Drug Event in 4 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic parameters estimated for phentolamine, lidocaine, and epinephrine included peak plasma concentration (Cmax), time to peak plasma concentration (Tmax), area under the plasma concentration-time curve from 0 to the last time point (AUClast) or from time 0 to infinity (AUCinf), elimination half-life (t1/2), clearance (CL), and volume of distribution (Vd)." | 2.73 | Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. ( Goodson, JM; Hersh, EV; Moore, PA; Navalta, L; Papas, AS; Rogy, S; Rutherford, B; Yagiela, JA, 2008) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Papas, AS | 1 |
| Goodson, JM | 1 |
| Yagiela, JA | 1 |
| Rutherford, B | 1 |
| Rogy, S | 1 |
| Navalta, L | 1 |
| Agich, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phentolamine Mesylate as a Reversal of Local Anesthesics[NCT03740386] | 90 participants (Actual) | Interventional | 2016-01-01 | Completed | |||
| A Phase 4, Multicenter, Randomized, Double-Blinded, Controlled Study of OraVerse® for Safety and Efficacy in Pediatric Dental Patients Undergoing Mandibular and Maxillary Procedures[NCT01474382] | Phase 4 | 150 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phentolamine and Adverse Drug Event
| Article | Year |
|---|---|
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Antagonists; Adult; Anesthesia Recovery Period; A | 2008 |
3 other studies available for phentolamine and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Say it ain't so: "60 Minutes" on NHBD.
Topics: Bioethics; Cadaver; Death; Drug-Related Side Effects and Adverse Reactions; Ethicists; Ethics; Hepar | 1999 |