phentolamine has been researched along with ANS (Autonomic Nervous System) Diseases in 9 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with multiple system atrophy (MSA) or pure autonomic failure (PAF), we studied the effect of oral yohimbine on seated systolic blood pressure (SBP), the effect of ganglionic blockade (with trimethaphan) on supine SBP and plasma catecholamine levels, and the effect of alpha(1)-adrenoreceptor blockade (phentolamine) on supine SBP." | 5.09 | Sympathetically mediated hypertension in autonomic failure. ( Biaggioni, I; Black, BK; Diedrich, A; Jordan, J; Pohar, B; Robertson, D; Shannon, JR, 2000) |
| "A comparative study of the effects of sympathetic blockade by stellate ganglion block (SGB) and intravenous phentolamine infusion (PhI) was carried out in 24 patients with presumed sympathetically maintained pain of an upper extremity." | 3.69 | The interpretation of pain relief and sensory changes following sympathetic blockade. ( Allen, RR; Dellemijn, PL; Fields, HL; McKay, WR; Rowbotham, MC, 1994) |
| "Autonomic dysreflexia is a hypertensive episode in spinal cord-injured individuals induced by exaggerated sympathetic activity and thought to be alpha-adrenergic mediated." | 2.75 | Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals. ( Danser, AH; Deinum, J; Geurts, AC; Groothuis, JT; Hopman, MT; Pickkers, P; Rongen, GA; Smits, P, 2010) |
| "Three subjects with severe orthostatic hypotension resulting from pure autonomic failure (PAF) were studied." | 1.29 | Effects of ibopamine on postural hypotension in pure autonomic failure. ( Boomsma, F; Man in 't Veld, AJ; Rensma, PL; Schalekamp, MA; van den Meiracker, AH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Groothuis, JT | 1 |
| Rongen, GA | 1 |
| Deinum, J | 1 |
| Pickkers, P | 1 |
| Danser, AH | 1 |
| Geurts, AC | 1 |
| Smits, P | 1 |
| Hopman, MT | 1 |
| Vinik, AI | 1 |
| Glowniak, JV | 1 |
| Rensma, PL | 1 |
| van den Meiracker, AH | 1 |
| Boomsma, F | 1 |
| Man in 't Veld, AJ | 1 |
| Schalekamp, MA | 1 |
| Dellemijn, PL | 1 |
| Fields, HL | 1 |
| Allen, RR | 1 |
| McKay, WR | 1 |
| Rowbotham, MC | 1 |
| Breivik, H | 1 |
| Murray, A | 1 |
| Pearson, GT | 1 |
| Cottrell, DF | 1 |
| Shannon, JR | 1 |
| Jordan, J | 1 |
| Diedrich, A | 1 |
| Pohar, B | 1 |
| Black, BK | 1 |
| Robertson, D | 1 |
| Biaggioni, I | 1 |
| Khaspekova, NB | 1 |
| Loseva, MM | 1 |
| Kuterman, EM | 1 |
| Sandroni, P | 1 |
| Benarroch, EE | 1 |
| Low, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Mecamylamine for Autonomic Dysreflexia Prophylaxis[NCT03914677] | Phase 4 | 5 participants (Anticipated) | Interventional | 2019-06-13 | Recruiting | ||
| The Pathophysiology and Treatment of Supine Hypertension in Patients With Autonomic Failure[NCT00223717] | Phase 1 | 152 participants (Actual) | Interventional | 2001-01-31 | Completed | ||
| Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves[NCT02963181] | Early Phase 1 | 10 participants (Actual) | Interventional | 2018-03-01 | Terminated (stopped due to PI leaving) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phentolamine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Hormonal secretion in diabetic autonomic neuropathy.
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Diabetic Neuropathies; Gastric Inhibito | 1982 |
3 trials available for phentolamine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Sympathetic nonadrenergic transmission contributes to autonomic dysreflexia in spinal cord-injured individuals.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin II; Autonomic Dysreflexia; Autonomic Nervous | 2010 |
Sympathetically mediated hypertension in autonomic failure.
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Autonomic Nervous System Diseases; Bloo | 2000 |
Sympathetically mediated hypertension in autonomic failure.
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Autonomic Nervous System Diseases; Bloo | 2000 |
Sympathetically mediated hypertension in autonomic failure.
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Autonomic Nervous System Diseases; Bloo | 2000 |
Sympathetically mediated hypertension in autonomic failure.
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Autonomic Nervous System Diseases; Bloo | 2000 |
[Evaluation of the effectiveness of drug therapy of autonomic paroxysms in relation to the variability of cardiac rhythm].
Topics: Adult; Anxiety Disorders; Autonomic Nervous System Diseases; Depressive Disorder; Diazepam; Heart Ra | 1991 |
5 other studies available for phentolamine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Effects of ibopamine on postural hypotension in pure autonomic failure.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Cardiotonic Agents; Deoxyepinephrine | 1993 |
The interpretation of pain relief and sensory changes following sympathetic blockade.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Body Temperature; Female; Humans; Male; Middle Aged; | 1994 |
Chronic pain and the sympathetic nervous system.
Topics: Autonomic Nervous System Diseases; Causalgia; Chronic Disease; Clinical Trials as Topic; Double-Blin | 1997 |
In vitro responses to noradrenaline of small intestine taken from normal and grass sickness-affected horses.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases; | 1997 |
Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure.
Topics: Adult; Aging; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Human | 1991 |