phentin-acetate and Body-Weight

phentin-acetate has been researched along with Body-Weight* in 2 studies

Other Studies

2 other study(ies) available for phentin-acetate and Body-Weight

Article	Year
Subchronic toxicity studies of tri-n-butyltin and triphenyltin acetates in rats. Veterinary and human toxicology, 1991, Volume: 33, Issue:5 The effects of a moderate but prolonged exposure of rats to tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), as might be encountered as residues in yam peel diets, were investigated in rats. These subchronic toxicity studies (16, 8, or 4 mg TBTA/kg and 20, 10 or 5 mg TPTA/kg) showed histopathologic lesions in lungs, liver, intestine and kidney. The hematologic parameters in the groups treated with either compound fell within the normal range for the rats. However, there was a reduction in mean lymphocyte count for rats receiving 10 or 20 mg TPTA/kg, and a reduction in monocyte count in the 20 mg TPTA/kg group. These data indicate a need for further toxicologic studies and cautionary measures to avoid ingestion, inhalation or contamination of dietary materials by these fungicides. Topics: Animals; Body Weight; Female; Fungicides, Industrial; Hemorrhage; Lung; Male; Organotin Compounds; Rats; Rats, Inbred Strains; Trialkyltin Compounds	1991
Effects of triphenyltin acetate on pregnancy in rats by oral administration. Toxicology letters, 1991, Volume: 56, Issue:1-2 A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregnant rats, 2 of 13 and 2 of 12 dams died at 9.0 and 12.0 mg/kg, respectively. Vaginal bleeding, bloody mouth and nose, somnolence and depression of body weight gain and food intake were observed at 9.0 and 12.0 mg/kg at late stages of pregnancy. No statistically significant reductions in maternal thymus and spleen weights were observed on day 20 of gestation. Increase in embryonic and fetal deaths and in dams with total resorption of fetuses were observed at doses of more than 6.0 mg/kg. The doses of TPTA in this experiment, however, induced no teratogenic effects in rats. Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Fetal Resorption; Fetus; Organotin Compounds; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Teratogens	1991

Article

Year

Subchronic toxicity studies of tri-n-butyltin and triphenyltin acetates in rats.

Veterinary and human toxicology, 1991, Volume: 33, Issue:5

The effects of a moderate but prolonged exposure of rats to tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), as might be encountered as residues in yam peel diets, were investigated in rats. These subchronic toxicity studies (16, 8, or 4 mg TBTA/kg and 20, 10 or 5 mg TPTA/kg) showed histopathologic lesions in lungs, liver, intestine and kidney. The hematologic parameters in the groups treated with either compound fell within the normal range for the rats. However, there was a reduction in mean lymphocyte count for rats receiving 10 or 20 mg TPTA/kg, and a reduction in monocyte count in the 20 mg TPTA/kg group. These data indicate a need for further toxicologic studies and cautionary measures to avoid ingestion, inhalation or contamination of dietary materials by these fungicides.

Topics: Animals; Body Weight; Female; Fungicides, Industrial; Hemorrhage; Lung; Male; Organotin Compounds; Rats; Rats, Inbred Strains; Trialkyltin Compounds

1991

Effects of triphenyltin acetate on pregnancy in rats by oral administration.

Toxicology letters, 1991, Volume: 56, Issue:1-2

A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregnant rats, 2 of 13 and 2 of 12 dams died at 9.0 and 12.0 mg/kg, respectively. Vaginal bleeding, bloody mouth and nose, somnolence and depression of body weight gain and food intake were observed at 9.0 and 12.0 mg/kg at late stages of pregnancy. No statistically significant reductions in maternal thymus and spleen weights were observed on day 20 of gestation. Increase in embryonic and fetal deaths and in dams with total resorption of fetuses were observed at doses of more than 6.0 mg/kg. The doses of TPTA in this experiment, however, induced no teratogenic effects in rats.

Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Fetal Resorption; Fetus; Organotin Compounds; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Teratogens

1991