phentermine has been researched along with Mitral Incompetence in 22 studies
Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| "To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine." | 3.70 | Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000) |
| "Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation." | 2.70 | Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001) |
| "Mild or greater aortic regurgitation was present in 8." | 1.31 | Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities. ( Constantine, GD; Davis, KD; Jollis, JG; Kisslo, J; Landolfo, CK; Ryan, T, 2000) |
| "There were six cases of aortic regurgitation, two cases of mitral regurgitation, and three cases of combined aortic and mitral regurgitation." | 1.30 | A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. ( Derby, LE; Jick, H; Jick, SS; Meier, CR; Vasilakis, C; Weinrauch, LA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (59.09) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koshkelashvili, N | 1 |
| Kohli, P | 1 |
| Linefsky, J | 1 |
| Sachdev, M | 1 |
| Miller, WC | 1 |
| Ryan, T | 2 |
| Jollis, JG | 2 |
| Newman, R | 1 |
| Connolly, HM | 1 |
| Crary, JL | 1 |
| McGoon, MD | 1 |
| Hensrud, DD | 1 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 1 |
| Rasmussen, S | 1 |
| Corya, BC | 1 |
| Glassman, RD | 1 |
| Khan, MA | 1 |
| Herzog, CA | 1 |
| St Peter, JV | 1 |
| Hartley, GG | 1 |
| Madlon-Kay, R | 1 |
| Dick, CD | 1 |
| Asinger, RW | 1 |
| Vessey, JT | 1 |
| Jick, H | 1 |
| Vasilakis, C | 1 |
| Weinrauch, LA | 1 |
| Meier, CR | 1 |
| Jick, SS | 1 |
| Derby, LE | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 1 |
| Garon, CF | 1 |
| Oury, JH | 1 |
| Duran, CM | 1 |
| Biswas, SS | 1 |
| Donovan, CL | 1 |
| Forbess, JM | 1 |
| Royal, SH | 1 |
| Landolfo, KP | 1 |
| Ryan, DH | 1 |
| Bray, GA | 1 |
| Helmcke, F | 1 |
| Sander, G | 1 |
| Volaufova, J | 1 |
| Greenway, F | 1 |
| Subramaniam, P | 1 |
| Glancy, DL | 1 |
| Pi-Sunyer, FX | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Prasad, A | 1 |
| Mehra, M | 1 |
| Park, M | 1 |
| Scott, R | 1 |
| Uber, PA | 1 |
| McFadden, PM | 1 |
| Kancherla, MK | 1 |
| Salti, HI | 1 |
| Mulderink, TA | 1 |
| Parker, M | 1 |
| Bonow, RO | 1 |
| Mehlman, DJ | 1 |
| Gardin, JM | 1 |
| Schumacher, D | 1 |
| Constantine, G | 1 |
| Davis, KD | 2 |
| Leung, C | 1 |
| Reid, CL | 1 |
| Landolfo, CK | 1 |
| Kisslo, J | 1 |
| Constantine, GD | 1 |
| Lepor, NE | 1 |
| Gross, SB | 1 |
| Daley, WL | 1 |
| Samuels, BA | 1 |
| Rizzo, MJ | 1 |
| Luko, SP | 1 |
| Hickey, A | 1 |
| Buchbinder, NA | 1 |
| Naqvi, TZ | 1 |
| St John Sutton, M | 1 |
| Burger, AJ | 1 |
| Charlamb, MJ | 1 |
| Singh, S | 1 |
| Notarianni, M | 1 |
| Blackburn, GL | 1 |
| Sherman, HB | 1 |
| Volmar, KE | 1 |
| Hutchins, GM | 1 |
| Dahl, CF | 1 |
| Allen, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Sulphate-bicarbonate-calcium Water Consumption on the Body Weight and Gut Microbiota Composition in Overweight and Obese Patients Under Low-calorie Diet[NCT02154230] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to failure to enroll) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phentermine and Mitral Incompetence
| Article | Year |
|---|---|
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease | 2002 |
2 trials available for phentermine and Mitral Incompetence
| Article | Year |
|---|---|
Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; De | 1999 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur | 2001 |
19 other studies available for phentermine and Mitral Incompetence
| Article | Year |
|---|---|
Fifty-seven-year-old man with progressive dyspnoea.
Topics: Appetite Depressants; Diagnosis, Differential; Dyspnea; Echocardiography, Transesophageal; Fenfluram | 2019 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Fenfluramine; Humans; Mitral Valve Insufficiency; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Aortic Valve Insufficiency; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramin | 1997 |
The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Cross-Sectional Studi | 1998 |
A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinatio | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Virus-like particles in the mitral and tricuspid valves explanted from a patient treated with Fenfluramine-Phentermine.
Topics: Adult; Female; Fenfluramine; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve | 1999 |
Valve replacement for appetite suppressant-induced valvular heart disease.
Topics: Adult; Appetite Depressants; Drug Therapy, Combination; Echocardiography, Transesophageal; Female; F | 1999 |
Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Counseling; Dexfenfluramine; Drug | 1999 |
Heart valve lesions in patients treated with appetite suppressants.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenflur | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
Cardiac allograft valvulopathy: a case of donor-anorexigen-induced valvular disease.
Topics: Adult; Appetite Depressants; Disease Progression; Echocardiography; Echocardiography, Doppler; Femal | 1999 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography | 2000 |
Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinations; Female; F | 2000 |
Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dose-Response Relationship, D | 2000 |
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Fenfluramine; Humans; Mitral | 2001 |
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combinati | 2001 |
Regression and progression of valvulopathy associated with fenfluramine and phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Drug Therapy, Combination; Ec | 2002 |