phentermine has been researched along with Lipidoses in 38 studies
Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic treatment of rats with the amphipilic drugs chloroquine and chlorphentermine caused prominent anterior polar cataracts in virtually all rats." | 7.66 | Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine. ( Drenckhahn, D, 1978) |
| "Chronic treatment of rats with the amphipilic drugs chloroquine and chlorphentermine caused prominent anterior polar cataracts in virtually all rats." | 3.66 | Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine. ( Drenckhahn, D, 1978) |
| "Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group." | 3.65 | Effect of chlorphentermine on the lipids of rat lungs. ( Gloster, J; Harris, P; Hasleton, P; Heath, D, 1976) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "Furthermore, experimental lipidosis is considered as an useful model for inherited lipidosis bearing in mind the different pathogenesis underlying both conditions." | 1.27 | [Chlorphentermine-induced lipidosis of the cochlea and the cochlear nucleus]. ( Bichler, E, 1983) |
| "In addition to the phospholipidosis in utero, drug exposure results in toxicity to the offspring; newborn rats die within 48 h of birth." | 1.27 | Newborn response to cationic amphiphilic drugs. ( Kacew, S; Reasor, MJ, 1985) |
| "The observed lung phospholipidosis was accompanied by inhibition of phospholipase C activity." | 1.27 | Role of phospholipase C in chlorphentermine-induced pulmonary phospholipidosis in rat. ( Kacew, S, 1988) |
| "Chlorphentermine HCl (CP) was used to induce preexisting alveolar alterations resembling a pulmonary lipidosis in mice to study these effects on the severity and duration of nitrogen dioxide (NO2) toxicity." | 1.27 | The effect of chlorphentermine pretreatment on the toxicity of nitrogen dioxide in mice. ( Born, GS; DeNicola, DB; Hastings, CE; Kessler, WV; Rebar, AH; Turek, JJ, 1987) |
| "Initially the phospholipidosis is localized largely in the AMs with the disorder developing in other compartments of the lungs with increasing treatment time." | 1.27 | Role of the alveolar macrophage in the induction of pulmonary phospholipidosis by chlorphentermine. I. Drug and phospholipid levels. ( Heyneman, CA; Reasor, MJ, 1986) |
| "Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers." | 1.26 | Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals. ( Lüllmann-Rauch, R; Stoermer, B, 1982) |
| " Treatment with the high dosage caused a significant reduction of creatinine clearance and significant impairment of both abilities to concentrate and to dilute the urine." | 1.26 | Impairment of renal function in rats with generalized lipidosis as induced by chlorphentermine. ( Lüllmann, H; Lüllmann-Rauch, R; Mösinger, EU, 1981) |
| "The effects of 3 lipidosis-inducing drugs on the incorporation and turnover of palmitic acid-1-14C in lung phospholipids was studied." | 1.26 | Palmitic acid-1-14C incorporation and turnover in lung phospholipids of rats treated with chlorphentermine, RMI 10.393 and Ro 4-4318. ( Karabelnik, D; Zbinden, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (97.37) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Lüllmann-Rauch, R | 11 |
| Stoermer, B | 1 |
| Bichler, E | 1 |
| Albert, C | 1 |
| Reasor, MJ | 8 |
| Castranova, V | 1 |
| Gairola, C | 1 |
| Matulionis, DH | 1 |
| Lüllmann, H | 3 |
| Mösinger, EU | 2 |
| Kacew, S | 5 |
| Narbaitz, R | 1 |
| Ruddick, JA | 1 |
| Villeneuve, DC | 1 |
| Walker, ER | 1 |
| Koshut, RA | 1 |
| McNulty, MJ | 1 |
| Trush, MA | 1 |
| Reil, GH | 3 |
| Lüllmann-Rauch, B | 1 |
| Drenckhahn, D | 7 |
| Buchheim, W | 1 |
| Blaschke, G | 1 |
| Seydel, JK | 1 |
| Wassermann, O | 1 |
| Kleine, L | 1 |
| Karabelnik, D | 2 |
| Zbinden, G | 2 |
| Gloster, J | 1 |
| Heath, D | 1 |
| Hasleton, P | 1 |
| Harris, P | 1 |
| Coulombe, PA | 1 |
| Bendayan, M | 1 |
| Hastings, CE | 1 |
| DeNicola, DB | 1 |
| Rebar, AH | 1 |
| Turek, JJ | 1 |
| Born, GS | 1 |
| Kessler, WV | 1 |
| Heyneman, CA | 2 |
| Lüllmann Rauch, R | 1 |
| Blinzinger, K | 1 |
| Anzil, AP | 1 |
| Herrlinger, H | 1 |
38 other studies available for phentermine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Topics: Adrenal Glands; Animals; Chloroquine; Chlorphentermine; Female; Guinea Pigs; Hypothalamus; Kidney; L | 1982 |
[Chlorphentermine-induced lipidosis of the cochlea and the cochlear nucleus].
Topics: Animals; Chlorphentermine; Cochlea; Hair Cells, Auditory, Inner; Inclusion Bodies; Labyrinth Disease | 1983 |
Ultrastructural alterations in peripheral nerve trunks of rats subchronically treated with chlorphentermine or perhexiline.
Topics: Animals; Chlorphentermine; Female; Lipidoses; Male; Perhexiline; Peripheral Nerves; Phentermine; Pip | 1983 |
Recovery from chlorphentermine-induced phospholipidosis in rat alveolar macrophages: biochemical and cellular features.
Topics: Acetylglucosaminidase; Animals; beta-Galactosidase; Chlorphentermine; Lipidoses; Lysosomes; Macropha | 1981 |
Chlorphentermine-induced alterations in the lungs of vitamin E-deficient and supplemented rats: 1. Biochemical and morphometric analysis of the pulmonary response.
Topics: Animals; Chlorphentermine; Foam Cells; Hemolysis; Lipid Peroxides; Lipidoses; Lung; Lung Diseases; M | 1983 |
Impairment of renal function in rats with generalized lipidosis as induced by chlorphentermine.
Topics: Animals; Blood Urea Nitrogen; Chlorphentermine; Creatinine; Dose-Response Relationship, Drug; Glomer | 1981 |
Chlorphentermine-induced phospholipidosis in rat alveolar macrophages--luminol-dependent chemiluminescence.
Topics: Animals; Chlorphentermine; Lipidoses; Luminescent Measurements; Luminol; Macrophages; Male; Phenterm | 1981 |
Role of drug metabolism in protection against chlorphentermine-induced pulmonary phospholipidosis in adult rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Chlorphentermine; Cytochrome P | 1981 |
Recovery from chlorphentermine-induced phospholipidosis in rat alveolar macrophages: morphological features.
Topics: Animals; Chlorphentermine; Intracellular Membranes; Lipidoses; Macrophages; Male; Microscopy, Electr | 1981 |
Chemiluminescence from rat alveolar macrophages following induction of phospholipidosis with chlorphentermine.
Topics: Animals; Catalase; Cell Count; Chlorphentermine; Hydrogen Peroxide; Immunity; In Vitro Techniques; L | 1980 |
Increased lysosomal enzyme activities in tissues of rats suffering from chlorphentermine induced lipidosis.
Topics: Acid Phosphatase; Adrenal Glands; Animals; beta-Galactosidase; Chlorphentermine; Glucuronidase; Kidn | 1979 |
Chlorphentermine-induced lipidosislike ultrastructural alterations in testicular Leydig and Sertoli cells.
Topics: Animals; Chlorphentermine; Crystallography; Disease Models, Animal; Inclusion Bodies; Leydig Cells; | 1975 |
Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Chlorphentermine; Female; Imipramine; Inclusion Bodies; I | 1975 |
Alterations in the neurohypophysis of rats treated with chlorphentermine or tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Chlorphentermine; Female; Inclusion Bodies; Lipidoses; Ma | 1976 |
Axonal and cellular alterations in the inner ear of rats treated with chlorphentermine or iprindole.
Topics: Animals; Axons; Chlorphentermine; Ear, Inner; Female; Inclusion Bodies; Indoles; Iprindole; Lipidose | 1977 |
Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine.
Topics: Acid Phosphatase; Animals; Cataract; Chloroquine; Chlorphentermine; Epithelium; Female; Inclusion Bo | 1978 |
[Ultrastructural changes of nerve endings and sensory cells of the rat inner ear following treatment with amphiphilic drugs].
Topics: Animals; Chlorphentermine; Ear, Inner; Inclusion Bodies; Indoles; Iprindole; Lipidoses; Nerve Ending | 1978 |
Freeze-fracture studies of cytoplasmic inclusions occurring in experimental lipidosis as induced by amphiphilic cationic drugs.
Topics: Adrenal Glands; Animals; Chlorphentermine; Freeze Fracturing; Inclusion Bodies; Lipidoses; Phentermi | 1979 |
[Drug-induced phospholipidosis. An example of the use of NMR spectroscopy in pharmacologic research].
Topics: Animals; Antidepressive Agents; Chlorphentermine; Guinea Pigs; Lipidoses; Magnetic Resonance Spectro | 1978 |
Myopathy in rats treated with chlorphentermine or iprindole.
Topics: Animals; Chlorphentermine; Female; Indoles; Iprindole; Lipidoses; Male; Muscles; Muscular Diseases; | 1976 |
Lens opacities associated with lipidosis-like ultrastructural alterations in rats treated with chloroquine, chlorphentermine, or iprindole.
Topics: Animals; Cataract; Chloroquine; Chlorphentermine; Cytoplasm; Epithelial Cells; Epithelium; Female; I | 1977 |
Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.
Topics: Acid Phosphatase; Animals; Antidepressive Agents, Tricyclic; Appetite Depressants; Chlorphentermine; | 1976 |
Palmitic acid-1-14C incorporation and turnover in lung phospholipids of rats treated with chlorphentermine, RMI 10.393 and Ro 4-4318.
Topics: Amitriptyline; Animals; Chlorphentermine; Female; Fluorenes; Lipidoses; Lung; Palmitic Acids; Phente | 1976 |
Effect of chlorphentermine on the lipids of rat lungs.
Topics: Animals; Body Weight; Chlorphentermine; Chromatography, Gas; Chromatography, Liquid; Chromatography, | 1976 |
Drug-induced foam cell reactions in rats, II. Chemical analysis of lipids stored in lungs and foam cells after treatment with chlorphentermine, 5-[p-(fluoren-9-ylidenemethyl)phenyl]-2-piperidineethanol (RMI 10.393) and 1-chloramitriptyline.
Topics: Amitriptyline; Animals; Chlorphentermine; Cholesterol; Cholesterol Esters; Fatty Acids, Nonesterifie | 1975 |
Newborn response to cationic amphiphilic drugs.
Topics: Animals; Animals, Newborn; Chlorphentermine; Dexamethasone; Drug Interactions; Female; Fetus; Gentam | 1985 |
Role of phospholipase C in chlorphentermine-induced pulmonary phospholipidosis in rat.
Topics: Alkaline Phosphatase; Animals; Chlorphentermine; Lipidoses; Lung; Lung Diseases; Male; Phentermine; | 1988 |
Cytochemical demonstration of increased phospholipid content in cell membranes in chlorphentermine-induced phospholipidosis.
Topics: Animals; Cell Membrane; Chlorphentermine; Gold; Histocytochemistry; Kidney; Lipidoses; Lung; Male; M | 1989 |
Cationic amphiphilic drug-induced renal cortical lysosomal phospholipidosis: an in vivo comparative study with gentamicin and chlorphentermine.
Topics: Animals; Chlorphentermine; Gentamicins; Kidney Cortex; Lipidoses; Lysosomes; Male; Phentermine; Phos | 1987 |
The effect of chlorphentermine pretreatment on the toxicity of nitrogen dioxide in mice.
Topics: Animals; Body Weight; Cell Count; Chlorphentermine; Hyperplasia; Lipidoses; Lung; Macrophages; Male; | 1987 |
Role of the alveolar macrophage in the induction of pulmonary phospholipidosis by chlorphentermine. I. Drug and phospholipid levels.
Topics: Animals; Chlorphentermine; Lipidoses; Lung Diseases; Macrophages; Male; Phentermine; Phospholipids; | 1986 |
Role of the alveolar macrophage in the induction of pulmonary phospholipidosis by chlorphentermine. II. Drug uptake into cells in vitro.
Topics: Animals; Biological Transport; Chlorphentermine; In Vitro Techniques; Kinetics; Lipidoses; Lung Dise | 1986 |
Gentamicin or chlorphentermine induction of phospholipidosis in the developing organism: role of tissue and species in manifestation of toxicity.
Topics: Animals; Animals, Newborn; Chlorphentermine; Female; Gentamicins; Kidney; Lipidoses; Liver; Lung; Ph | 1985 |
Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species.
Topics: Adrenal Cortex; Adrenal Glands; Anesthesia; Animals; Chlorphentermine; Cytoplasmic Granules; Guinea | 1974 |
Ultrastructural changes in adrenal, spleen and liver tissue, induced by chlorphentermine.
Topics: Adrenal Glands; Animals; Appetite Depressants; Guinea Pigs; Inclusion Bodies; Lipidoses; Liver; Male | 1973 |
[Intravital tellurium labeling of lysosomal storage organoids in exogenous lipoidosis].
Topics: Cerebral Cortex; Disease Models, Animal; Inclusion Bodies; Lipidoses; Lysosomes; Microscopy, Electro | 1974 |
Lipidosis-like alterations in spinal cord and cerebellar cortex of rats treated with chlorphentermine or tricylic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebellar Cortex; Chlorphentermine; Cytoplasmic Gran | 1974 |