phentermine has been researched along with Hypertension, Pulmonary in 45 studies
Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5) received fenfluramine and phentermine (fen-phen) for 7 months, and pulmonary hypertension subsequently developed." | 7.71 | Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine. ( Tomita, T; Zhao, Q, 2002) |
| "Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension." | 7.70 | Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension. ( Fedullo, P; Masliah, E; Strother, J; Yi, ES, 1999) |
| "Phentermine has been considered a relatively safe drug to treat obesity, and further investigation is needed to decide the safety and dosage of phentermine." | 5.36 | Pulmonary hypertension associated with use of phentermine. ( Bang, WD; Chang, HJ; Cho, SS; Jang, JY; Joung, B; Kim, JY; Oh, CM; Yu, HT, 2010) |
| " In the late sixties, aminorex caused an epidemic of pulmonary hypertension with high mortality rates." | 4.80 | [Obesity: principles of drug therapy]. ( Ballmer, PE; Imoberdorf, R, 2000) |
| "5) received fenfluramine and phentermine (fen-phen) for 7 months, and pulmonary hypertension subsequently developed." | 3.71 | Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine. ( Tomita, T; Zhao, Q, 2002) |
| "Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension." | 3.70 | Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension. ( Fedullo, P; Masliah, E; Strother, J; Yi, ES, 1999) |
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| " Receptorome screening has implicated N-deethylation of fenfluramine and serotonin 5-hydroxy-t-ryptamine 2B receptors in the adverse effects of the drug; subsequent studies corroborated this finding." | 2.43 | Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. ( Roth, BL; Setola, V, 2005) |
| "Phentermine has been considered a relatively safe drug to treat obesity, and further investigation is needed to decide the safety and dosage of phentermine." | 1.36 | Pulmonary hypertension associated with use of phentermine. ( Bang, WD; Chang, HJ; Cho, SS; Jang, JY; Joung, B; Kim, JY; Oh, CM; Yu, HT, 2010) |
| "The most common finding was mild aortic regurgitation." | 1.31 | Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000) |
| "Marked obesity is an independent risk factor for multi-system morbidity." | 1.30 | [Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants]. ( Goldstein, SE; Levy, Y; Shoenfeld, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (11.11) | 18.7374 |
| 1990's | 23 (51.11) | 18.2507 |
| 2000's | 12 (26.67) | 29.6817 |
| 2010's | 4 (8.89) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, M | 1 |
| Daboul, J | 1 |
| Iftikhar, S | 1 |
| Burmeister, C | 1 |
| Ambati, A | 1 |
| Moukarbel, G | 1 |
| Assaly, R | 1 |
| Schoonjans, AS | 1 |
| Marchau, F | 1 |
| Paelinck, BP | 1 |
| Lagae, L | 1 |
| Gammaitoni, A | 1 |
| Pringsheim, M | 1 |
| Keane, MG | 1 |
| Ceulemans, B | 1 |
| Bang, WD | 1 |
| Kim, JY | 1 |
| Yu, HT | 1 |
| Cho, SS | 1 |
| Jang, JY | 1 |
| Oh, CM | 1 |
| Joung, B | 1 |
| Chang, HJ | 1 |
| Hendricks, EJ | 1 |
| Rothman, RB | 3 |
| Surapaneni, P | 1 |
| Vinales, KL | 1 |
| Najib, MQ | 1 |
| Chaliki, HP | 1 |
| Seghatol, FF | 1 |
| Rigolin, VH | 1 |
| Gross, SB | 2 |
| Lepor, NE | 1 |
| Horton, MR | 1 |
| Tuder, RM | 1 |
| Setola, V | 1 |
| Roth, BL | 1 |
| Connolly, HM | 3 |
| Crary, JL | 1 |
| McGoon, MD | 2 |
| Hensrud, DD | 1 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 1 |
| Mark, EJ | 1 |
| Patalas, ED | 1 |
| Chang, HT | 1 |
| Evans, RJ | 1 |
| Kessler, SC | 1 |
| Curfman, GD | 1 |
| Graham, DJ | 1 |
| Green, L | 1 |
| Hancock, EW | 1 |
| Spitzer, WO | 1 |
| Hirsch, J | 1 |
| Scheen, AJ | 1 |
| Cheng, TO | 1 |
| Connolly, J | 1 |
| Verni, C | 1 |
| Trilling, J | 1 |
| Kelso, E | 1 |
| Shiesha, S | 1 |
| Brown-Beasley, MW | 1 |
| Hilsen, K | 1 |
| Davis, S | 1 |
| Iyer, P | 1 |
| Shiffman, MA | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 2 |
| Biron, CR | 1 |
| Strother, J | 1 |
| Fedullo, P | 1 |
| Yi, ES | 1 |
| Masliah, E | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Rich, S | 1 |
| Rubin, L | 1 |
| Walker, AM | 1 |
| Schneeweiss, S | 1 |
| Abenhaim, L | 1 |
| Redmon, JB | 1 |
| Raatz, SK | 1 |
| Kwong, CA | 1 |
| Swanson, JE | 1 |
| Bantle, JP | 1 |
| Teramae, CY | 1 |
| Grogan, M | 1 |
| Miller, FA | 1 |
| Widgren, S | 1 |
| Allen, S | 1 |
| Henderson, J | 1 |
| Goldstein, SE | 1 |
| Levy, Y | 1 |
| Shoenfeld, Y | 1 |
| Wolf, I | 1 |
| Mouallem, M | 1 |
| Farfel, Z | 1 |
| Imoberdorf, R | 1 |
| Ballmer, PE | 1 |
| Tomita, T | 1 |
| Zhao, Q | 1 |
| Hasleton, PS | 1 |
| Kay, JM | 1 |
| Heath, D | 1 |
| Seiler, KU | 3 |
| Wasserman, O | 1 |
| Leuschner, F | 1 |
| Otto, H | 1 |
| Wagener, HH | 1 |
| Lüllmann, H | 1 |
| Parwaresch, MR | 1 |
| Sattler, M | 1 |
| Siegfriedt, A | 1 |
| Mielke, H | 1 |
| Stumpf, U | 1 |
| Wassermann, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Medications After Adolescent Bariatric Surgery Protocol for Inadequate Weight Loss Following Sleeve Gastrectomy in Adolescents and Young Adults: A Pilot Feasibility Study[NCT04572217] | Phase 2 | 0 participants (Actual) | Interventional | 2022-06-30 | Withdrawn (stopped due to No available funding) | ||
| National, Prospective, Multicenter,Observational Registry Study on Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension in China[NCT01417338] | 3,079 participants (Anticipated) | Observational | 2009-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for phentermine and Hypertension, Pulmonary
| Article | Year |
|---|---|
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Disea | 2017 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; | 2002 |
Anorexigen-related cardiopulmonary toxicity.
Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Disease | 2000 |
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related S | 2005 |
Selections from current literature: pharmacological treatment of obesity.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Humans; Hypertension, Pulmonary; Obes | 1998 |
Obesity drugs and the heart.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermi | 1999 |
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pul | 1999 |
[Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine].
Topics: Appetite Depressants; Cardiomyopathies; Drug Therapy, Combination; Fenfluramine; Heart Valve Disease | 1998 |
[Obesity: principles of drug therapy].
Topics: Aminorex; Anti-Obesity Agents; Appetite Depressants; Chronic Disease; Combined Modality Therapy; Cyc | 2000 |
1 trial available for phentermine and Hypertension, Pulmonary
| Article | Year |
|---|---|
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fem | 2000 |
35 other studies available for phentermine and Hypertension, Pulmonary
| Article | Year |
|---|---|
Weight Loss Supplement-Induced Pulmonary Hypertension: A Decades Delayed Presentation of Fenfluramine-Phentermine.
Topics: Fenfluramine; Humans; Hypertension, Pulmonary; Obesity; Phentermine; Weight Loss | 2023 |
Pulmonary hypertension associated with use of phentermine.
Topics: Adult; Antihypertensive Agents; Bosentan; Electrocardiography; Female; Humans; Hypertension, Pulmona | 2010 |
RE: Pulmonary hypertension associated with use of phentermine?
Topics: Female; Humans; Hypertension, Pulmonary; Phentermine | 2011 |
Valvular heart disease with the use of fenfluramine-phentermine.
Topics: Anti-Obesity Agents; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Gast | 2011 |
Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT.
Topics: Adult; Appetite Depressants; Asthma; Drug Combinations; Female; Fenfluramine; Humans; Hypertension, | 2004 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Fatal Outcome; Female; Fenfluramine; Humans; Hyperte | 1997 |
Diet pills redux.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1997 |
Further cases of valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; | 1997 |
Obesity and an abnormal ECG.
Topics: Adult; Appetite Depressants; Drug Combinations; Electrocardiography; Female; Fenfluramine; Humans; H | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Bias; Drug and Narcotic Control; Drug Combinations; Female; Fenfluramine; Hear | 1997 |
The treatment of obesity with drugs.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
[Drug-clinics. The hue and cry over central appetite suppressants!].
Topics: Adrenergic Agents; Adult; Amphetamines; Appetite; Appetite Depressants; Female; Fenfluramine; Heart | 1997 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
After fen-phen/Redux: cardiac and pulmonary sequelae implications for patient assessment.
Topics: Adult; Appetite Depressants; Drug Combinations; Emergency Nursing; Female; Fenfluramine; Humans; Hyp | 1998 |
Fen-phen's message to dentists.
Topics: Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Fenfluramine; Heart Valve | 1998 |
Anesthesia risks in patients who have had antiobesity medication.
Topics: Anesthesia, General; Appetite Depressants; Contraindications; Fenfluramine; Heart Valve Diseases; Hu | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Former Fen-Phen users may need prophylactic antibiotic before treatment.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; En | 1998 |
Severe heart valve disease on appetite suppressants.
Topics: Adult; Appetite Depressants; Case-Control Studies; Diethylpropion; Drug Approval; Drug Combinations; | 1998 |
Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
Topics: Adult; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; P | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human | 1999 |
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Topics: Adult; Aged; Amphetamines; Appetite Depressants; Canada; Causality; Cross-Sectional Studies; Female; | 2000 |
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Topics: Adult; Aged; Amphetamines; Appetite Depressants; Canada; Causality; Cross-Sectional Studies; Female; | 2000 |
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Topics: Adult; Aged; Amphetamines; Appetite Depressants; Canada; Causality; Cross-Sectional Studies; Female; | 2000 |
Anorexigens and pulmonary hypertension in the United States: results from the surveillance of North American pulmonary hypertension.
Topics: Adult; Aged; Amphetamines; Appetite Depressants; Canada; Causality; Cross-Sectional Studies; Female; | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans | 2000 |
Complex vascular lesions at autopsy in a patient with phentermine-fenfluramin.
Topics: Appetite Depressants; Autopsy; Fatal Outcome; Female; Fenfluramine; Humans; Hypertension, Pulmonary; | 2000 |
Fen-phen manufacturers, not physicians, are liable.
Topics: Appetite Depressants; Drug Combinations; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; | 2000 |
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
Topics: Aged; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; H | 1998 |
The age-adjusted mortality rate from primary pulmonary hypertension, in age range 20 to 54 years, did not increase during the years of peak "phen/fen" use.
Topics: Adult; Age Factors; Appetite Depressants; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Mal | 2000 |
Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Humans; Hypertension, Pulmonar | 2002 |
Phentermine resinate and the pulmonary vasculature of the rat.
Topics: Animals; Blood Pressure; Body Weight; Heart; Hypertension, Pulmonary; Male; Organ Size; Phentermine; | 1977 |
MAO-inhibitory properties of anorectic drugs.
Topics: Animals; Appetite Depressants; Chlorphentermine; Dose-Response Relationship, Drug; Hypertension, Pul | 1973 |
[Tolerance to aminorex and some other compounds during prolonged administration to beagle dogs].
Topics: Amines; Amino Alcohols; Animals; Appetite Depressants; Dogs; Drug Tolerance; Hypertension, Pulmonary | 1970 |
The effects of anorectic agents on the pulmonary pressure and morphology of rat lungs after chronic administration.
Topics: Animals; Appetite Depressants; Blood Pressure; Carotid Arteries; Chlorphentermine; Ephedrine; Fenclo | 1972 |
[Relation between serotonin metabolism and pulmonary hypertension in rats following administration of various anorectic drugs].
Topics: Amines; Amphetamine; Animals; Appetite Depressants; Chlorphentermine; Hypertension, Pulmonary; Male; | 1973 |