phentermine has been researched along with Heart Valve Diseases in 91 studies
Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the echocardiographic changes over time of valvular heart lesions in patients who took the weight loss drugs fenfluramine and phentermine." | 5.09 | Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine. ( Bailey, KR; Connolly, HM; Grogan, M; Hensrud, DD; Jensen, MD; Miller, FA, 1999) |
| " In the late sixties, aminorex caused an epidemic of pulmonary hypertension with high mortality rates." | 4.80 | [Obesity: principles of drug therapy]. ( Ballmer, PE; Imoberdorf, R, 2000) |
| "To assess weight loss, as well as the prevalence of valvular heart disease, in 21 obese women who completed 2 years of treatment by fenfluramine and phentermine (fen-phen) in June 1997." | 3.70 | The fen-phen finale: a study of weight loss and valvular heart disease. ( Aber, JL; Berkowitz, RI; Foster, GD; Silvestry, F; St John Sutton, MG; Stunkard, AJ; Vogt, RA; Wadden, TA, 1998) |
| "22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss." | 3.70 | Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999) |
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| "To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine." | 3.70 | Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000) |
| "Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation." | 2.70 | Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001) |
| " Receptorome screening has implicated N-deethylation of fenfluramine and serotonin 5-hydroxy-t-ryptamine 2B receptors in the adverse effects of the drug; subsequent studies corroborated this finding." | 2.43 | Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. ( Roth, BL; Setola, V, 2005) |
| "Obesity is a chronic disorder that is associated with significant co-morbidity and early mortality." | 2.42 | Anorexigen-induced cardiac valvulopathy and female gender. ( Gross, SB; Naqvi, TZ, 2003) |
| "Phentermine is known to cause valvular disease with prolonged use, but aortic valve rupture was not previously reported as a complication of phentermine valvulopathy." | 1.33 | Cusp tear in bicuspid aortic valve possibly caused by phentermine. ( Beeri, R; Berman, M; Yosefy, C, 2006) |
| "The most common finding was mild aortic regurgitation." | 1.31 | Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000) |
| "To determine whether the severity of valvulopathy was associated with the dosage of fenfluramine taken by fenfluramine-phentermine users with valvulopathy." | 1.30 | Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy. ( Bowman, BA; Graham, DJ; Green, L; Li, R; Serdula, MK; Williamson, DF, 1999) |
| "Marked obesity is an independent risk factor for multi-system morbidity." | 1.30 | [Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants]. ( Goldstein, SE; Levy, Y; Shoenfeld, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 55 (60.44) | 18.2507 |
| 2000's | 28 (30.77) | 29.6817 |
| 2010's | 8 (8.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schoonjans, AS | 1 |
| Marchau, F | 1 |
| Paelinck, BP | 1 |
| Lagae, L | 1 |
| Gammaitoni, A | 1 |
| Pringsheim, M | 1 |
| Keane, MG | 2 |
| Ceulemans, B | 1 |
| Rajamannan, NM | 1 |
| Rothman, RB | 3 |
| Hendricks, EJ | 2 |
| Yosefy, C | 2 |
| Beeri, R | 2 |
| Malgarini, RB | 1 |
| Pimpinella, G | 1 |
| Surapaneni, P | 1 |
| Vinales, KL | 1 |
| Najib, MQ | 1 |
| Chaliki, HP | 1 |
| Bello, NT | 1 |
| Campbell, SC | 1 |
| Vaughan, SF | 1 |
| Loke, YK | 1 |
| Derry, S | 1 |
| Pritchard-Copley, A | 1 |
| Seghatol, FF | 1 |
| Rigolin, VH | 1 |
| Roldan, CA | 1 |
| Gelgand, EA | 1 |
| Decker, P | 1 |
| Prasad, A | 1 |
| Shively, BK | 1 |
| Gross, SB | 3 |
| Lepor, NE | 1 |
| Sachdev, M | 1 |
| Miller, WC | 1 |
| Ryan, T | 1 |
| Jollis, JG | 1 |
| Naqvi, TZ | 1 |
| Rice, B | 1 |
| Hess, MA | 1 |
| Berman, M | 1 |
| Setola, V | 1 |
| Roth, BL | 1 |
| Whigham, LD | 1 |
| Dhurandhar, NV | 1 |
| Rahko, PS | 1 |
| Atkinson, RL | 1 |
| Donnelly, KB | 1 |
| Nightingale, SL | 1 |
| Connolly, HM | 5 |
| Crary, JL | 2 |
| McGoon, MD | 2 |
| Hensrud, DD | 2 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 2 |
| Curfman, GD | 1 |
| Graham, DJ | 2 |
| Green, L | 2 |
| Boughner, DR | 1 |
| SoRelle, R | 1 |
| Kassirer, JP | 1 |
| Angell, M | 1 |
| Josefson, D | 1 |
| Thompson, PD | 1 |
| Kurz, X | 1 |
| Van Ermen, A | 1 |
| Redmon, B | 1 |
| Raatz, S | 1 |
| Bantle, JP | 2 |
| Wolff, FW | 1 |
| Spitzer, WO | 1 |
| Griffen, L | 2 |
| Anchors, M | 2 |
| Hirsch, J | 1 |
| Scheen, AJ | 1 |
| Cheng, TO | 3 |
| Aurigemma, GP | 1 |
| Gaasch, WH | 1 |
| Sandrick, KM | 1 |
| Hilsen, K | 1 |
| Davis, S | 1 |
| Iyer, P | 1 |
| Wadden, TA | 2 |
| Berkowitz, RI | 2 |
| Silvestry, F | 1 |
| Vogt, RA | 1 |
| St John Sutton, MG | 1 |
| Stunkard, AJ | 1 |
| Foster, GD | 2 |
| Aber, JL | 2 |
| Shiffman, MA | 1 |
| Devereux, RB | 1 |
| Cannistra, LB | 1 |
| Cannistra, AJ | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 2 |
| Biron, CR | 1 |
| Shapiro, S | 1 |
| Cowley, G | 1 |
| Springen, K | 1 |
| Tovar, EA | 1 |
| Landa, DW | 1 |
| Borsari, BE | 1 |
| Silvestry, FE | 2 |
| Sutton, MG | 1 |
| St John Sutton, M | 1 |
| Li, R | 1 |
| Serdula, MK | 1 |
| Williamson, DF | 1 |
| Bowman, BA | 1 |
| Kimmel, SE | 1 |
| Jones, J | 1 |
| Kinman, JL | 1 |
| Beare, J | 1 |
| Sammel, M | 1 |
| Sutton, MS | 1 |
| Strom, BL | 1 |
| Alger, SA | 1 |
| Malone, M | 1 |
| Cerulli, J | 1 |
| Fein, S | 1 |
| Howard, L | 1 |
| Burger, AJ | 2 |
| Sherman, HB | 2 |
| Charlamb, MJ | 2 |
| Kim, J | 1 |
| Asinas, LA | 1 |
| Flickner, SR | 1 |
| Blackburn, GL | 2 |
| Schiller, NB | 1 |
| Pallasch, TJ | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Grogan, M | 2 |
| Miller, FA | 2 |
| Bailey, KR | 1 |
| Jensen, MD | 1 |
| Asinger, RW | 1 |
| Pollick, C | 1 |
| Sniderman, AD | 1 |
| Gardin, JM | 1 |
| Schumacher, D | 1 |
| Constantine, G | 1 |
| Davis, KD | 1 |
| Leung, C | 1 |
| Reid, CL | 1 |
| Jick, H | 1 |
| Redmon, JB | 1 |
| Raatz, SK | 1 |
| Kwong, CA | 1 |
| Swanson, JE | 1 |
| Teramae, CY | 1 |
| Allen, S | 1 |
| Henderson, J | 1 |
| Goldstein, SE | 1 |
| Levy, Y | 1 |
| Shoenfeld, Y | 1 |
| Wolf, I | 1 |
| Mouallem, M | 1 |
| Farfel, Z | 1 |
| Alexander, RE | 1 |
| Imoberdorf, R | 1 |
| Ballmer, PE | 1 |
| Weissman, NJ | 1 |
| Rudin, R | 1 |
| Carpenter, W | 1 |
| Singh, S | 1 |
| Notarianni, M | 1 |
| Caccitolo, JA | 1 |
| Rubenson, DS | 1 |
| Orszulak, TA | 1 |
| Vagelos, R | 1 |
| Jacobs, M | 1 |
| Popp, RL | 1 |
| Liang, D | 1 |
14 reviews available for phentermine and Heart Valve Diseases
| Article | Year |
|---|---|
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Disea | 2017 |
Appetite suppressants and valvular heart disease - a systematic review.
Topics: Appetite Depressants; Clinical Trials as Topic; Cohort Studies; Dexfenfluramine; Fenfluramine; Heart | 2002 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; | 2002 |
Anorexigen-related cardiopulmonary toxicity.
Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Disease | 2000 |
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease | 2002 |
Anorexigen-induced cardiac valvulopathy and female gender.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenfluramine; Heart Valve Di | 2003 |
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related S | 2005 |
Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases.
Topics: Animals; Appetite Depressants; Disease Models, Animal; Dogs; Fenfluramine; Heart Valve Diseases; Hea | 2008 |
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug | 1999 |
Obesity drugs and the heart.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermi | 1999 |
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pul | 1999 |
[Valvular heart disease and primary pulmonary hypertension associated with fenfluramine-phentermine].
Topics: Appetite Depressants; Cardiomyopathies; Drug Therapy, Combination; Fenfluramine; Heart Valve Disease | 1998 |
[Obesity: principles of drug therapy].
Topics: Aminorex; Anti-Obesity Agents; Appetite Depressants; Chronic Disease; Combined Modality Therapy; Cyc | 2000 |
Appetite suppressants and valvular heart disease.
Topics: Age Factors; Appetite Depressants; Dexfenfluramine; Drug Therapy, Combination; Fenfluramine; Heart V | 2001 |
3 trials available for phentermine and Heart Valve Diseases
| Article | Year |
|---|---|
Echocardiographic improvement over time after cessation of use of fenfluramine and phentermine.
Topics: Adrenergic Agents; Adult; Appetite Depressants; Body Mass Index; Double-Blind Method; Echocardiograp | 1999 |
Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fem | 2000 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur | 2001 |
74 other studies available for phentermine and Heart Valve Diseases
| Article | Year |
|---|---|
Fenfluramine-Phentermine is Associated with an Increase in Cellular Proliferation Ex Vivo and In Vitro.
Topics: Animals; Anti-Obesity Agents; Aortic Valve; Cardiotoxicity; Case-Control Studies; Cell Proliferation | 2017 |
Phentermine cardiovascular safety. In response to Yosefy C, Berman M, Beeri R. Cusp tear in bicuspid aortic valve possibly caused by phentermine. International journal of cardiology 2006;106:262-3.
Topics: Aortic Valve; Appetite Depressants; Cardiovascular Diseases; Heart Valve Diseases; Humans; Obesity; | 2010 |
Phentermine cardiovascular safety II: response to Yosefy Int J Cardiol. 2009 Epub Mar 19.
Topics: Female; Heart Valve Diseases; Humans; Mitral Valve; Phentermine; Risk Factors | 2010 |
Phentermine cardiovascular safety II: response to Rothman Hendricks Int J Cardiol. 2009 epub Mar 19.
Topics: Heart Valve Diseases; Humans; Mitral Valve; Phentermine | 2010 |
Phentermine plus topiramate in the treatment of obesity.
Topics: Anti-Obesity Agents; Drug Combinations; Fructose; Heart Valve Diseases; Humans; Obesity; Phentermine | 2011 |
Valvular heart disease with the use of fenfluramine-phentermine.
Topics: Anti-Obesity Agents; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Gast | 2011 |
Two anti-obesity hopefuls and their safety.
Topics: Adult; Anti-Obesity Agents; Benzazepines; Dose-Response Relationship, Drug; Drug Combinations; Drugs | 2012 |
Fen-Phen-noumenon: A mass tort litigation and settlement about to come and go.
Topics: Appetite Depressants; Central Nervous System Stimulants; Fenfluramine; Heart Valve Diseases; Humans; | 2002 |
Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography.
Topics: Adult; Aortic Valve; Appetite Depressants; Body Mass Index; Dexfenfluramine; Drug Combinations; Echo | 2002 |
Do these doctors give medicine a black eye?
Topics: Appetite Depressants; Compensation and Redress; Drug Industry; Electrocardiography; Expert Testimony | 2003 |
Taking things to heart.
Topics: Appetite Depressants; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans | 2004 |
Cusp tear in bicuspid aortic valve possibly caused by phentermine.
Topics: Adult; Aortic Valve; Appetite Depressants; Echocardiography, Transesophageal; Female; Heart Valve Di | 2006 |
Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.
Topics: Adult; Appetite Depressants; Body Mass Index; Drug Therapy, Combination; Fenfluramine; Fluoxetine; H | 2007 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Diabetes Mellitus; Emergency Medical Services; Fenfluramine; Heart Valve Disea | 1997 |
Report links appetite suppressants with heart disease. FDA encourages reporting of like events.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Obesity | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Diet pills redux.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1997 |
Further cases of valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; | 1997 |
A dangerous duo? A combination of common diet drugs (fen-phen) may lead to heart valve disease.
Topics: Appetite Depressants; Drug Combinations; Drug Synergism; Female; Fenfluramine; Heart Valve Diseases; | 1997 |
Fen-phen and risk of valvular disease.
Topics: Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Humans; Phenter | 1997 |
Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Appetite Depressants; Echocardiography; Female | 1997 |
From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography; Fenfluramine; Heart | 1997 |
Prepublication release of Journal articles.
Topics: Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Publishing | 1997 |
US journal finds lower risk from diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Ultrasonography | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diethylpropion; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Combinations; Female; Fenfluramine; Heart Valv | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Animals; Appetite Depressants; Drug Evaluation, Preclinical; Fenfluramine; Heart Valve Diseases; Hum | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Appetite Depressants; Bias; Drug and Narcotic Control; Drug Combinations; Female; Fenfluramine; Hear | 1997 |
Asymptomatic mitral and aortic valve disease is seen in half of the patients taking 'phen-fen'.
Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler, Color; Fenfluramine; Heart Valve Dise | 1998 |
The treatment of obesity with drugs.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
[Drug-clinics. The hue and cry over central appetite suppressants!].
Topics: Adrenergic Agents; Adult; Amphetamines; Appetite; Appetite Depressants; Female; Fenfluramine; Heart | 1997 |
Mitral valve disease associated with use of anorexigenic medications.
Topics: Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; Hyperte | 1998 |
Valve disease and diet pills--where do we stand?
Topics: Adult; Aged; Aged, 80 and over; Appetite Depressants; Dopamine Agents; Drug Therapy, Combination; Ec | 1998 |
Guidelines for users of diet pills.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine | 1998 |
Phen-fen fallout. Financial side effects.
Topics: Appetite Depressants; Echocardiography; Fenfluramine; Health Maintenance Organizations; Heart Valve | 1998 |
Fen-phen's message to dentists.
Topics: Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; Fenfluramine; Heart Valve | 1998 |
Anorectic drugs and valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Serotonin | 1998 |
The "phen-pro" diet drug combination is not associated with valvular heart disease.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Mitral Valve; Phentermine | 1998 |
The fen-phen finale: a study of weight loss and valvular heart disease.
Topics: Adult; Affect; Appetite; Behavior Therapy; Drug Therapy, Combination; Echocardiography, Doppler; Fem | 1998 |
Anesthesia risks in patients who have had antiobesity medication.
Topics: Anesthesia, General; Appetite Depressants; Contraindications; Fenfluramine; Heart Valve Diseases; Hu | 1998 |
Appetite suppressants and valvular heart disease.
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente | 1998 |
Regression of multivalvular regurgitation after the cessation of fenfluramine and phentermine treatment.
Topics: Adult; Appetite Depressants; Drug Combinations; Female; Fenfluramine; Heart Valve Diseases; Humans; | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Former Fen-Phen users may need prophylactic antibiotic before treatment.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; En | 1998 |
Studies confirm link between fen-phen and heart-valve disease.
Topics: Appetite Depressants; Cyclobutanes; Dexfenfluramine; Drug Combinations; Fenfluramine; Heart Valve Di | 1998 |
Appetite-suppressant drugs and valvular heart disease.
Topics: Appetite Depressants; Bias; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Od | 1999 |
After fen-phen.
Topics: Antidepressive Agents, Second-Generation; Appetite Depressants; Consumer Product Safety; Fenfluramin | 1997 |
Severe heart valve disease on appetite suppressants.
Topics: Adult; Appetite Depressants; Case-Control Studies; Diethylpropion; Drug Approval; Drug Combinations; | 1998 |
Dose effect of fenfluramine-phentermine in the production of valvular heart disease.
Topics: Appetite Depressants; Diseases in Twins; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1999 |
Valvular heart disease in fenfluramine- phentermine-treated patients: a comparison with control patients.
Topics: Appetite Depressants; Body Mass Index; Diet, Reducing; Drug Combinations; Echocardiography; Female; | 1999 |
Anorectic therapy and valvular heart disease: a reappraisal.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Obesity; Phentermine | 1999 |
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.
Topics: Adult; Aortic Valve; Appetite Depressants; Dose-Response Relationship, Drug; Drug Combinations; Fema | 1999 |
Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Middl | 1999 |
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine; | 1999 |
Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 months.
Topics: Adult; Appetite Depressants; Echocardiography, Transesophageal; Female; Fenfluramine; Follow-Up Stud | 1999 |
Fen/phen and valvular heart disease: if it sounds too bad to be true, perhaps it isn't.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Appetite Depressants; Echocardiography, Transesophag | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
The fen-phen controversy: is regression another piece of the puzzle?
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human | 1999 |
Aminorex to Fen/Phen: an epidemic foretold.
Topics: Aminorex; Appetite Depressants; Drug Therapy, Combination; Fenfluramine; Heart Valve Diseases; Human | 1999 |
The need for greater involvement of regulatory agencies in assessing adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Drug Industry; Fenfluramine; Governme | 2000 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography | 2000 |
Heart valve disorders and appetite-suppressant drugs.
Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Sero | 2000 |
Anorectic-induced valvulopathy.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phentermine; Time Factors | 2000 |
Was the danger of diet pills overstated?
Topics: Appetite Depressants; Drug Combinations; Fenfluramine; Heart Valve Diseases; Humans; Obesity; Phente | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans | 2000 |
Fen-phen manufacturers, not physicians, are liable.
Topics: Appetite Depressants; Drug Combinations; Drug Industry; Fenfluramine; Heart Valve Diseases; Humans; | 2000 |
[Development of pulmonary hypertension and multi-valvular damage caused by appetite depressants].
Topics: Aged; Appetite Depressants; Drug Therapy, Combination; Female; Fenfluramine; Heart Valve Diseases; H | 1998 |
Cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Fenfluramine; Heart Valv | 2000 |
Diet drugs and cardiac valvulopathy: a survey of dental patients.
Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bac | 2000 |
Valve disease due to appetite suppressants (cont'd).
Topics: Aortic Valve; Appetite Depressants; Clinical Trials as Topic; Dexfenfluramine; Fenfluramine; Heart V | 1999 |
Operation for anorexigen-associated valvular heart disease.
Topics: Adult; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Mi | 2001 |
Reversal of Phen-Fen associated valvular regurgitation documented by serial echocardiography.
Topics: Appetite Depressants; Echocardiography; Female; Fenfluramine; Heart Valve Diseases; Humans; Middle A | 2002 |