phentermine and Depression

phentermine has been researched along with Depression in 5 studies

Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research

Studies (5)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Buffet Meal Intake

"At visit 4 subjects underwent imaging to measure the volume of their stomach, fasting and after ingesting a liquid nutrient drink. Four hours after the liquid meal, subjects were invited to eat, over a 30-minute period, a standard all you can eat meal vegetable lasagna, vanilla pudding, and skim milk. The total Kcal of the food consumed was analyzed by using validated software." (NCT01834404)
Timeframe: Day 13, approximately 4.5 hours after liquid meal

Change in Postprandial Gastric Volume

Change between postprandial and fasting whole gastric volume by 99mTc-SPECT Imaging. A noninvasive SPECT method was used to measure gastric volume during fasting and 32 min after a liquid nutritional supplement meal. Subjects reported to the clinic after an overnight fast. 99mTC was given by an intravenous injection in the forearm. The first fasting scan was obtained, and the study medication was given s.c. After 10 min, a 2nd fasting post medication scan was obtained, and the meal consumed; then two serial postprandial scans were obtained. Each scan required 9-12 min. Tomographic images of the gastric wall were obtained throughout the long axis of the stomach using a dual-head gamma camera that rotates around the body. This allows assessment of the radiolabeled circumference of the gastric wall, rather than the intragastric content. (NCT01834404)
Timeframe: Day 13, approximately approximately 30 min after liquid meal

Fasting Gastric Volume

Fasting whole gastric volume was measured by Technetium (99mTc)-SPECT Imaging. Subjects reported to the clinic after an overnight fast. 99mTC was given by an intravenous injection in the forearm. Tomographic images of the gastric wall were obtained throughout the long axis of the stomach using a dual-head gamma camera that rotates around the body. This allows assessment of the radiolabeled circumference of the gastric wall, rather than the intragastric content. (NCT01834404)
Timeframe: Day 13, approximately 10 minutes after Technetium (99mTC) injection

Fasting Ghrelin

Plasma gastrointestinal hormone total ghrelin was measured by radioimmunoassay. (NCT01834404)
Timeframe: Day 14, before liquid meal

Gastric Emptying of Solids Half-Time (T 1/2)

Gastric emptying of solids half-time is defined as the time for half of the ingested solids to leave the stomach. At visit 6 subjects took part in a gastric emptying by scintigraphy test. Subjects were given a scrambled egg breakfast with toast and a glass of milk. The eggs and milk contained a small amount of radioactive substance. At the completion of the meal, subjects stood in front of a special camera and pictures were taken at specific intervals. (NCT01834404)
Timeframe: Day 15, approximately 2 hours after radiolabeled meal was ingested

Maximum Tolerated Volume

At visit 5, subjects did a satiation/nutrient drink test. Participants recorded their sensations every 5 minutes using a numerical scale from 0-5, with level 0 being no symptoms, level 3 corresponding to fullness sensation after a typical meal, and level 5 corresponding to the maximal tolerated volume (maximum or unbearable fullness/satiation). This measure is the volume consumed when the fullness sensation reached level 5. (NCT01834404)
Timeframe: Day 14, approximately 30 minutes after liquid meal

Peak Postprandial Level of Cholecystokinin (CCK)

Plasma gastrointestinal hormone CCK was measured by radioimmunoassay based on an antibody with very low cross-reactivity to gastrin 17 and its sulfated counterpart, and to sensitivity to a concentration of 0.3 pmol/L. (NCT01834404)
Timeframe: Day 14, approximately 45 minutes after liquid meal

Peak Postprandial Level of Total Glucagon-Like Peptide-1 (GLP-1)

Plasma gastrointestinal hormone GLP-1 was measured by radioimmunoassay. (NCT01834404)
Timeframe: Day 14, approximately 45 minutes after liquid meal

Peak Postprandial Level of Total Peptide Tyrosine-Tyrosine (PYY)

Plasma gastrointestinal hormone PYY was measured by radioimmunoassay. (NCT01834404)
Timeframe: Day 14, approximately 45 minutes after liquid meal

Postprandial Gastric Volume

Postprandial gastric volume was measured by 99mTc-SPECT Imaging. Subjects reported to the clinic after an overnight fast. 99mTC was given by an intravenous injection in the forearm. After the liquid meal tomographic images of the gastric wall were obtained throughout the long axis of the stomach using a dual-head gamma camera that rotates around the body. This allows assessment of the radiolabeled circumference of the gastric wall, rather than the intragastric content. (NCT01834404)
Timeframe: Day 13, approximately 30 minutes after liquid meal

Solid Gastric Emptying: Proportion of Meal Emptied at 2 Hours

At visit 6 subjects took part in a gastric emptying by scintigraphy test. Subjects were given a scrambled egg breakfast with toast and a glass of milk. The eggs and milk contained a small amount of radioactive substance. At the completion of the meal, subjects stood in front of a special camera and pictures were taken at specific intervals. This outcome measure is the proportion of the radiolabeled meal emptied at 2 hours. (NCT01834404)
Timeframe: Day 15, approximately 2 hours after radiolabeled meal was ingested

Solid Gastric Emptying: Proportion Remaining at 4 Hours

At visit 6 subjects took part in a gastric emptying by scintigraphy test. Subjects were given a scrambled egg breakfast with toast and a glass of milk. The eggs and milk contained a small amount of radioactive substance. At the completion of the meal, subjects stood in front of a special camera and pictures were taken at specific intervals. This outcome measure is the proportion of the radiolabeled meal remaining at 4 hours. (NCT01834404)
Timeframe: Day 15, approximately 4 hours after radiolabeled meal was ingested

Volume to Fullness

At visit 5, subjects did a satiation/nutrient drink test. Participants recorded their sensations every 5 minutes using a numerical scale from 0-5, with level 0 being no symptoms, level 3 corresponding to fullness sensation after a typical meal, and level 5 corresponding to the maximal tolerated volume (maximum or unbearable fullness/satiation). This measure was the volume consumed when the fullness sensation reached level 3. (NCT01834404)
Timeframe: Day 14, approximately 30 minutes after liquid meal

Trials

2 trials available for phentermine and Depression

Other Studies

3 other studies available for phentermine and Depression