phentermine has been researched along with Aortic Valve Insufficiency in 19 studies
Phentermine: A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nineteen participants, all of whom had hypertension, were being treated with fenfluramine or dexfenfluramine (5 on these agents alone, 14 also with phentermine)." | 3.71 | Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study. ( Arnett, DK; Bella, JN; de Simone, G; Devereux, RB; Hopkins, PN; Kitzman, DW; Liu, JE; Morgan, D; Oberman, A; Palmieri, V; Roman, MJ, 2002) |
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| "To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine." | 3.70 | Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000) |
| "Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation." | 2.70 | Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001) |
| "Mild or greater aortic regurgitation was present in 8." | 1.31 | Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities. ( Constantine, GD; Davis, KD; Jollis, JG; Kisslo, J; Landolfo, CK; Ryan, T, 2000) |
| "The most common finding was mild aortic regurgitation." | 1.31 | Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000) |
| "There were six cases of aortic regurgitation, two cases of mitral regurgitation, and three cases of combined aortic and mitral regurgitation." | 1.30 | A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. ( Derby, LE; Jick, H; Jick, SS; Meier, CR; Vasilakis, C; Weinrauch, LA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (47.37) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sachdev, M | 1 |
| Miller, WC | 1 |
| Ryan, T | 2 |
| Jollis, JG | 2 |
| Connolly, HM | 2 |
| Crary, JL | 1 |
| McGoon, MD | 1 |
| Hensrud, DD | 1 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 1 |
| Rasmussen, S | 1 |
| Corya, BC | 1 |
| Glassman, RD | 1 |
| Khan, MA | 1 |
| Herzog, CA | 1 |
| St Peter, JV | 1 |
| Hartley, GG | 1 |
| Madlon-Kay, R | 1 |
| Dick, CD | 1 |
| Asinger, RW | 1 |
| Vessey, JT | 1 |
| Jick, H | 1 |
| Vasilakis, C | 1 |
| Weinrauch, LA | 1 |
| Meier, CR | 1 |
| Jick, SS | 1 |
| Derby, LE | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 1 |
| Ryan, DH | 1 |
| Bray, GA | 1 |
| Helmcke, F | 1 |
| Sander, G | 1 |
| Volaufova, J | 1 |
| Greenway, F | 1 |
| Subramaniam, P | 1 |
| Glancy, DL | 1 |
| Pi-Sunyer, FX | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Kancherla, MK | 1 |
| Salti, HI | 1 |
| Mulderink, TA | 1 |
| Parker, M | 1 |
| Bonow, RO | 1 |
| Mehlman, DJ | 1 |
| Gardin, JM | 1 |
| Schumacher, D | 1 |
| Constantine, G | 1 |
| Davis, KD | 2 |
| Leung, C | 1 |
| Reid, CL | 1 |
| Landolfo, CK | 1 |
| Kisslo, J | 1 |
| Constantine, GD | 1 |
| Teramae, CY | 1 |
| Grogan, M | 1 |
| Miller, FA | 1 |
| Lepor, NE | 1 |
| Gross, SB | 1 |
| Daley, WL | 1 |
| Samuels, BA | 1 |
| Rizzo, MJ | 1 |
| Luko, SP | 1 |
| Hickey, A | 1 |
| Buchbinder, NA | 1 |
| Naqvi, TZ | 1 |
| St John Sutton, M | 1 |
| Burger, AJ | 1 |
| Charlamb, MJ | 1 |
| Singh, S | 1 |
| Notarianni, M | 1 |
| Blackburn, GL | 1 |
| Sherman, HB | 1 |
| Volmar, KE | 1 |
| Hutchins, GM | 1 |
| Dahl, CF | 1 |
| Allen, MR | 1 |
| Palmieri, V | 1 |
| Arnett, DK | 1 |
| Roman, MJ | 1 |
| Liu, JE | 1 |
| Bella, JN | 1 |
| Oberman, A | 1 |
| Kitzman, DW | 1 |
| Hopkins, PN | 1 |
| Morgan, D | 1 |
| de Simone, G | 1 |
| Devereux, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Sulphate-bicarbonate-calcium Water Consumption on the Body Weight and Gut Microbiota Composition in Overweight and Obese Patients Under Low-calorie Diet[NCT02154230] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to failure to enroll) | |||
| [NCT00005267] | 3,604 participants (Actual) | Observational | 1995-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phentermine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease | 2002 |
2 trials available for phentermine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; De | 1999 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur | 2001 |
16 other studies available for phentermine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Aortic Valve Insufficiency; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramin | 1997 |
The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Cross-Sectional Studi | 1998 |
A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinatio | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Counseling; Dexfenfluramine; Drug | 1999 |
Heart valve lesions in patients treated with appetite suppressants.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenflur | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography | 2000 |
Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinations; Female; F | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans | 2000 |
Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dose-Response Relationship, D | 2000 |
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Fenfluramine; Humans; Mitral | 2001 |
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combinati | 2001 |
Regression and progression of valvulopathy associated with fenfluramine and phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Drug Therapy, Combination; Ec | 2002 |
Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Drug Combinations; Female; Fenflu | 2002 |