phenprocoumon and Vascular-Diseases

Topics: Acenocoumarol; Algorithms; Anticoagulants; Blood Coagulation Disorders; Cross-Sectional Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Drug Administration Schedule; Genotype; Humans; Pharmacogenetics; Phenprocoumon; Polymorphism, Single Nucleotide; Vascular Diseases

A case of a 44-year-old patient with recurrent deep venous thrombosis (DVT) caused by congenital dysgenesis of the inferior vena cava (IVC) in coincidence with heterozygous factor V Leiden mutation is presented. The IVC malformation was a fortuitous finding because the vascular malformation of the collateral draining thoracic veins were suspected to be a malignant mass in chest X-ray. This vascular abnormality is a rare finding but recent epidemiological research suggests that there may be an association between the congenital absence of the IVC and DVT. In our case, the patient is even at higher risk combining the malformation probably affecting venous blood flow and the hypercoagulabilic state by heterozygous presence of the factor V Leidenmutation.

Topics: Adult; Anticoagulants; Factor V; Heterozygote; Humans; Male; Mutation; Phenprocoumon; Recurrence; Tomography, X-Ray Computed; Vascular Diseases; Vena Cava, Inferior; Venous Thrombosis

Topics: Anticoagulants; Humans; Male; Middle Aged; Phenprocoumon; Time Factors; Vascular Diseases